Klhl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klhl2
Entrez Gene ID	77113
Full Name	kelch-like 2, Mayven
Synonyms	6030411N21Rik,ABP-KELCH,AU020744,Mav
General protein information	Preferred Names kelch-like 2, Mayven Names kelch-like protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 B3.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_017313012.1	XP_017168501.1	kelch-like protein 2 isoform X2
XM_017313012.2	XP_017168501.1	kelch-like protein 2 isoform X2
XM_017313011.1	XP_017168500.1	kelch-like protein 2 isoform X1
NM_178633.3	NP_848748.2	kelch-like protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KLHL2	XP_001150182.1
	KLHL2	XP_001100501.1
Homo sapiens (human)	KLHL2	NP_009177.3
Gallus gallus (chicken)	KLHL2	NP_001264749.1
Xenopus tropicalis (tropical clawed frog)	klhl2	XP_002934798.2
Canis lupus familiaris (dog)	KLHL2	XP_005629448.1
Bos taurus (cattle)	KLHL2	NP_001095630.1
Mus musculus (house mouse)	Klhl2	NP_848748.2
Danio rerio (zebrafish)	klhl2	XP_696369.5
Rattus norvegicus (Norway rat)	Klhl2	XP_006253118.1

Gene Ontology
Bibliography

Related articles in PubMed

Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.
Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E
Biochemical and biophysical research communications487(2)368-374(2017 05)

Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
Zhang C, Meermeier NP, Terker AS, Blankenstein KI, Singer JD, Hadchouel J, Ellison DH, Yang CL
Biochemical and biophysical research communications469(1)44-48(2016 Jan)

Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.
Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S
Journal of the American Society of Nephrology : JASN26(9)2129-38(2015 Sep)

Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.
Tseng LA, Bixby JL
Molecular and cellular neurosciences47(4)254-64(2011 Aug)

Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Chiellini C, Costa M, Novelli SE, Amri EZ, Benzi L, Bertacca A, Cohen P, Del Prato S, Friedman JM, Maffei M
Journal of cellular physiology195(2)309-21(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Accordingly, medullary WNK4 protein levels were significantly increased in the kidneys of KLHL2(-/-) mice. KLHL2 is indeed a physiological regulator of WNK4 in vivo; however, its function might be different from that of KLHL3 because KLHL2 mainly localized in medulla.
Title: Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.

These results suggest that KLHL2 likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4.
Title: Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.

This study showed that KLHL2 is involved in the physiologic regulation of the WNK signal cascade.
Title: Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.

The following Klhl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klhl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19056	NM_178633.3 Latest version!	Mus musculus kelch-like 2, Mayven (Klhl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$349.30 $499.00
OMu82595	XM_017313011.1 Latest version!	Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu82596	XM_017313012.2 Latest version!	Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu82596	XM_017313012.1	Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klhl2 ( NM_178633.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848748.2 Mus musculus kelch-like 2, Mayven (Klhl2), mRNA.

Price & Availability↑

CloneID	OMu19056
Clone ID Related Accession (Same CDS sequence)	NM_178633.3
Accession Version	NM_178633.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	kelch-like protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC242529.3, AC140351.2 and AC152168.2. On Apr 29, 2014 this sequence version replaced NM_178633.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTCCTCCTC CCAGCAGCTG GCCTGCTACA GTTACAGGAT 
GTGAAGAAGA CATGCTGTGA ATTTTTAGAA TCCCAGCTTC ACCCTGTCAA CTGCTTAGGA 
ATCCGGGCTT TTGCTGATAT GCATGCATGC ACAGACCTCC TGAATAAGGC CAACACGTAT 
GCAGAACAAC ATTTTGCAGA TGTCGTACTT AGTGAAGAGT TTCTTAACCT CGGCATCGAG 
CAGGTGTGCA GCTTAATCTC CAGTGATAAA CTCACCATTT CCTCCGAGGA GAAGGTATTT 
GAAGCAGTCA TCGCCTGGGT AAACCACGAT AAGGACGTAA GACAGGAGTT CATGGCTCGG 
CTCATGGAGC ATGTCCGATT ACCTCTGCTT CCTCGGGAGT ACTTGGTGCA GCGGGTTGAA 
GAGGAAGCAT TGGTGAAGAA CAGCAGTGCG TGCAAAGATT ACCTCATTGA AGCCATGAAG 
TACCACCTGC TGCCGACAGA GCAGCGCATG TTAATGAAGA GCGTGCGGAC CCGCCTGAGG 
ACGCCCATGA ACCTTCCCAA ATTGATGGTG GTGGTCGGGG GCCAGGCACC AAAGGCTATC 
CGAAGTGTGG AATGCTACGA CTTCAAAGAA GAACGGTGGC ACCAGGTGGC AGAGCTGCCT 
TCCAGGAGGT GCAGGGCAGG GATGGTCTAT ATGGCTGGGC TGGTCTTTGC TGTTGGTGGC 
TTCAATGGCT CACTAAGAGT TCGCACTGTA GATTCCTATG ACCCCGTGAA AGACCAGTGG 
ACCAGCGTGG CGAACATGCG AGACCGAAGA AGCACACTTG GAGCCGCGGT GCTGAATGGG 
CTGCTGTACG CCGTGGGGGG CTTTGACGGC AGCACAGGTC TATCGTCTGT GGAAGCATAC 
AACATAAAAT CTAATGAGTG GTTTCATGTC GCCCCAATGA ACACGAGGAG GAGCAGTGTG 
GGTGTTGGCG TTGTTGGAGG TTTGCTCTAT GCCGTGGGGG GTTACGATGG AGCATCGCGC 
CAGTGTCTTA GCACAGTAGA ATGCTATAAT GCTACTGCAA ACGAGTGGAC TTACATAGCA 
GAAATGAGCA CCAGACGGAG CGGAGCAGGT GTTGGTGTGT TAAACAACTT ATTATATGCT 
GTAGGAGGTC ATGATGGTCC TTTAGTACGA AAAAGTGTTG AAGTATATGA CCCCACCACA 
AATGCCTGGA GACAGGTTGC AGATATGAAC ATGTGCAGAA GAAATGCAGG TGTCTGTGCA 
GTTAATGGTC TGTTGTATGT TGTCGGAGGA GATGATGGTT CCTGTAACTT GGCGTCGGTA 
GAGTATTATA ACCCCACCAC GGATAAATGG ACAGTTGTGT CCTCTTGTAT GAGCACGGGG 
AGAAGCTACG CAGGGGTCAC AGTTATTGAT AAACCGTTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848748.2
CDS	267..2048
Translation	METPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLVDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

Target ORF information:

RefSeq Version	NM_178633.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 2, Mayven (Klhl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178633.3

ORF Insert Sequence:

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTCCTCCTC CCAGCAGCTG GCCTGCTACA GTTACAGGAT 
GTGAAGAAGA CATGCTGTGA ATTTTTAGAA TCCCAGCTTC ACCCTGTCAA CTGCTTAGGA 
ATCCGGGCTT TTGCTGATAT GCATGCATGC ACAGACCTCC TGAATAAGGC CAACACGTAT 
GCAGAACAAC ATTTTGCAGA TGTCGTACTT AGTGAAGAGT TTCTTAACCT CGGCATCGAG 
CAGGTGTGCA GCTTAATCTC CAGTGATAAA CTCACCATTT CCTCCGAGGA GAAGGTATTT 
GAAGCAGTCA TCGCCTGGGT AAACCACGAT AAGGACGTAA GACAGGAGTT CATGGCTCGG 
CTCATGGAGC ATGTCCGATT ACCTCTGCTT CCTCGGGAGT ACTTGGTGCA GCGGGTTGAA 
GAGGAAGCAT TGGTGAAGAA CAGCAGTGCG TGCAAAGATT ACCTCATTGA AGCCATGAAG 
TACCACCTGC TGCCGACAGA GCAGCGCATG TTAATGAAGA GCGTGCGGAC CCGCCTGAGG 
ACGCCCATGA ACCTTCCCAA ATTGATGGTG GTGGTCGGGG GCCAGGCACC AAAGGCTATC 
CGAAGTGTGG AATGCTACGA CTTCAAAGAA GAACGGTGGC ACCAGGTGGC AGAGCTGCCT 
TCCAGGAGGT GCAGGGCAGG GATGGTCTAT ATGGCTGGGC TGGTCTTTGC TGTTGGTGGC 
TTCAATGGCT CACTAAGAGT TCGCACTGTA GATTCCTATG ACCCCGTGAA AGACCAGTGG 
ACCAGCGTGG CGAACATGCG AGACCGAAGA AGCACACTTG GAGCCGCGGT GCTGAATGGG 
CTGCTGTACG CCGTGGGGGG CTTTGACGGC AGCACAGGTC TATCGTCTGT GGAAGCATAC 
AACATAAAAT CTAATGAGTG GTTTCATGTC GCCCCAATGA ACACGAGGAG GAGCAGTGTG 
GGTGTTGGCG TTGTTGGAGG TTTGCTCTAT GCCGTGGGGG GTTACGATGG AGCATCGCGC 
CAGTGTCTTA GCACAGTAGA ATGCTATAAT GCTACTGCAA ACGAGTGGAC TTACATAGCA 
GAAATGAGCA CCAGACGGAG CGGAGCAGGT GTTGGTGTGT TAAACAACTT ATTATATGCT 
GTAGGAGGTC ATGATGGTCC TTTAGTACGA AAAAGTGTTG AAGTATATGA CCCCACCACA 
AATGCCTGGA GACAGGTTGC AGATATGAAC ATGTGCAGAA GAAATGCAGG TGTCTGTGCA 
GTTAATGGTC TGTTGTATGT TGTCGGAGGA GATGATGGTT CCTGTAACTT GGCGTCGGTA 
GAGTATTATA ACCCCACCAC GGATAAATGG ACAGTTGTGT CCTCTTGTAT GAGCACGGGG 
AGAAGCTACG CAGGGGTCAC AGTTATTGAT AAACCGTTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klhl2 ( XM_017313011.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168500.1 Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu82595
Clone ID Related Accession (Same CDS sequence)	XM_017313011.1
Accession Version	XM_017313011.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	kelch-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTGCAATGT AAGTCACTGC ATAGAGGATG GAAGAACAGA 
AAAGAATCAA AGACAACCAG CGGCCGGCCA TCTGGAGTAT CCTATAGTTT GTATGAACAG 
GTCCTCCTCC CAGCAGCTGG CCTGCTACAG TTACAGGATG TGAAGAAGAC ATGCTGTGAA 
TTTTTAGAAT CCCAGCTTCA CCCTGTCAAC TGCTTAGGAA TCCGGGCTTT TGCTGATATG 
CATGCATGCA CAGACCTCCT GAATAAGGCC AACACGTATG CAGAACAACA TTTTGCAGAT 
GTCGTACTTA GTGAAGAGTT TCTTAACCTC GGCATCGAGC AGGTGTGCAG CTTAATCTCC 
AGTGATAAAC TCACCATTTC CTCCGAGGAG AAGGTATTTG AAGCAGTCAT CGCCTGGGTA 
AACCACGATA AGGACGTAAG ACAGGAGTTC ATGGCTCGGC TCATGGAGCA TGTCCGATTA 
CCTCTGCTTC CTCGGGAGTA CTTGGTGCAG CGGGTTGAAG AGGAAGCATT GGTGAAGAAC 
AGCAGTGCGT GCAAAGATTA CCTCATTGAA GCCATGAAGT ACCACCTGCT GCCGACAGAG 
CAGCGCATGT TAATGAAGAG CGTGCGGACC CGCCTGAGGA CGCCCATGAA CCTTCCCAAA 
TTGATGGTGG TGGTCGGGGG CCAGGCACCA AAGGCTATCC GAAGTGTGGA ATGCTACGAC 
TTCAAAGAAG AACGGTGGCA CCAGGTGGCA GAGCTGCCTT CCAGGAGGTG CAGGGCAGGG 
ATGGTCTATA TGGCTGGGCT GGTCTTTGCT GTTGGTGGCT TCAATGGCTC ACTAAGAGTT 
CGCACTGTAG ATTCCTATGA CCCCGTGAAA GACCAGTGGA CCAGCGTGGC GAACATGCGA 
GACCGAAGAA GCACACTTGG AGCCGCGGTG CTGAATGGGC TGCTGTACGC CGTGGGGGGC 
TTTGACGGCA GCACAGGTCT ATCGTCTGTG GAAGCATACA ACATAAAATC TAATGAGTGG 
TTTCATGTCG CCCCAATGAA CACGAGGAGG AGCAGTGTGG GTGTTGGCGT TGTTGGAGGT 
TTGCTCTATG CCGTGGGGGG TTACGATGGA GCATCGCGCC AGTGTCTTAG CACAGTAGAA 
TGCTATAATG CTACTGCAAA CGAGTGGACT TACATAGCAG AAATGAGCAC CAGACGGAGC 
GGAGCAGGTG TTGGTGTGTT AAACAACTTA TTATATGCTG TAGGAGGTCA TGATGGTCCT 
TTAGTACGAA AAAGTGTTGA AGTATATGAC CCCACCACAA ATGCCTGGAG ACAGGTTGCA 
GATATGAACA TGTGCAGAAG AAATGCAGGT GTCTGTGCAG TTAATGGTCT GTTGTATGTT 
GTCGGAGGAG ATGATGGTTC CTGTAACTTG GCGTCGGTAG AGTATTATAA CCCCACCACG 
GATAAATGGA CAGTTGTGTC CTCTTGTATG AGCACGGGGA GAAGCTACGC AGGGGTCACA 
GTTATTGATA AACCGTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168500.1
CDS	372..2252
Translation	METPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLVDYVYTAEIQVTEENVQVQCKSLHRGWKNRKESKTTSGRPSGVSYSLYEQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

Target ORF information:

RefSeq Version	XM_017313011.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313011.1

ORF Insert Sequence:

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTGCAATGT AAGTCACTGC ATAGAGGATG GAAGAACAGA 
AAAGAATCAA AGACAACCAG CGGCCGGCCA TCTGGAGTAT CCTATAGTTT GTATGAACAG 
GTCCTCCTCC CAGCAGCTGG CCTGCTACAG TTACAGGATG TGAAGAAGAC ATGCTGTGAA 
TTTTTAGAAT CCCAGCTTCA CCCTGTCAAC TGCTTAGGAA TCCGGGCTTT TGCTGATATG 
CATGCATGCA CAGACCTCCT GAATAAGGCC AACACGTATG CAGAACAACA TTTTGCAGAT 
GTCGTACTTA GTGAAGAGTT TCTTAACCTC GGCATCGAGC AGGTGTGCAG CTTAATCTCC 
AGTGATAAAC TCACCATTTC CTCCGAGGAG AAGGTATTTG AAGCAGTCAT CGCCTGGGTA 
AACCACGATA AGGACGTAAG ACAGGAGTTC ATGGCTCGGC TCATGGAGCA TGTCCGATTA 
CCTCTGCTTC CTCGGGAGTA CTTGGTGCAG CGGGTTGAAG AGGAAGCATT GGTGAAGAAC 
AGCAGTGCGT GCAAAGATTA CCTCATTGAA GCCATGAAGT ACCACCTGCT GCCGACAGAG 
CAGCGCATGT TAATGAAGAG CGTGCGGACC CGCCTGAGGA CGCCCATGAA CCTTCCCAAA 
TTGATGGTGG TGGTCGGGGG CCAGGCACCA AAGGCTATCC GAAGTGTGGA ATGCTACGAC 
TTCAAAGAAG AACGGTGGCA CCAGGTGGCA GAGCTGCCTT CCAGGAGGTG CAGGGCAGGG 
ATGGTCTATA TGGCTGGGCT GGTCTTTGCT GTTGGTGGCT TCAATGGCTC ACTAAGAGTT 
CGCACTGTAG ATTCCTATGA CCCCGTGAAA GACCAGTGGA CCAGCGTGGC GAACATGCGA 
GACCGAAGAA GCACACTTGG AGCCGCGGTG CTGAATGGGC TGCTGTACGC CGTGGGGGGC 
TTTGACGGCA GCACAGGTCT ATCGTCTGTG GAAGCATACA ACATAAAATC TAATGAGTGG 
TTTCATGTCG CCCCAATGAA CACGAGGAGG AGCAGTGTGG GTGTTGGCGT TGTTGGAGGT 
TTGCTCTATG CCGTGGGGGG TTACGATGGA GCATCGCGCC AGTGTCTTAG CACAGTAGAA 
TGCTATAATG CTACTGCAAA CGAGTGGACT TACATAGCAG AAATGAGCAC CAGACGGAGC 
GGAGCAGGTG TTGGTGTGTT AAACAACTTA TTATATGCTG TAGGAGGTCA TGATGGTCCT 
TTAGTACGAA AAAGTGTTGA AGTATATGAC CCCACCACAA ATGCCTGGAG ACAGGTTGCA 
GATATGAACA TGTGCAGAAG AAATGCAGGT GTCTGTGCAG TTAATGGTCT GTTGTATGTT 
GTCGGAGGAG ATGATGGTTC CTGTAACTTG GCGTCGGTAG AGTATTATAA CCCCACCACG 
GATAAATGGA CAGTTGTGTC CTCTTGTATG AGCACGGGGA GAAGCTACGC AGGGGTCACA 
GTTATTGATA AACCGTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klhl2 ( XM_017313012.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168501.1 Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu82596
Clone ID Related Accession (Same CDS sequence)	XM_017313012.1 , XM_017313012.2
Accession Version	XM_017313012.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	kelch-like protein 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTCCTCCTC CCAGCAGCTG GCCTGCTACA GTTACAGGAT 
GTGAAGAAGA CATGCTGTGA ATTTTTAGAA TCCCAGCTTC ACCCTGTCAA CTGCTTAGGA 
ATCCGGGCTT TTGCTGATAT GCATGCATGC ACAGACCTCC TGAATAAGGC CAACACGTAT 
GCAGAACAAC ATTTTGCAGA TGTCGTACTT AGTGAAGAGT TTCTTAACCT CGGCATCGAG 
CAGGTGTGCA GCTTAATCTC CAGTGATAAA CTCACCATTT CCTCCGAGGA GAAGGTATTT 
GAAGCAGTCA TCGCCTGGGT AAACCACGAT AAGGACGTAA GACAGGAGTT CATGGCTCGG 
CTCATGGAGC ATGTCCGATT ACCTCTGCTT CCTCGGGAGT ACTTGGTGCA GCGGGTTGAA 
GAGGAAGCAT TGGTGAAGAA CAGCAGTGCG TGCAAAGATT ACCTCATTGA AGCCATGAAG 
TACCACCTGC TGCCGACAGA GCAGCGCATG TTAATGAAGA GCGTGCGGAC CCGCCTGAGG 
ACGCCCATGA ACCTTCCCAA ATTGATGGTG GTGGTCGGGG GCCAGGCACC AAAGGCTATC 
CGAAGTGTGG AATGCTACGA CTTCAAAGAA GAACGGTGGC ACCAGGTGGC AGAGCTGCCT 
TCCAGGAGGT GCAGGGCAGG GATGGTCTAT ATGGCTGGGC TGGTCTTTGC TGTTGGTGGC 
TTCAATGGCT CACTAAGAGT TCGCACTGTA GATTCCTATG ACCCCGTGAA AGACCAGTGG 
ACCAGCGTGG CGAACATGCG AGACCGAAGA AGCACACTTG GAGCCGCGGT GCTGAATGGG 
CTGCTGTACG CCGTGGGGGG CTTTGACGGC AGCACAGGTC TATCGTCTGT GGAAGCATAC 
AACATAAAAT CTAATGAGTG GTTTCATGTC GCCCCAATGA ACACGAGGAG GAGCAGTGTG 
GGTGTTGGCG TTGTTGGAGG TTTGCTCTAT GCCGTGGGGG GTTACGATGG AGCATCGCGC 
CAGTGTCTTA GCACAGTAGA ATGCTATAAT GCTACTGCAA ACGAGTGGAC TTACATAGCA 
GAAATGAGCA CCAGACGGAG CGGAGCAGGT GTTGGTGTGT TAAACAACTT ATTATATGCT 
GTAGGAGGTC ATGATGGTCC TTTAGTACGA AAAAGTGTTG AAGTATATGA CCCCACCACA 
AATGCCTGGA GACAGGTTGC AGATATGAAC ATGTGCAGAA GAAATGCAGG TGTCTGTGCA 
GTTAATGGTC TGTTGTATGT TGTCGGAGGA GATGATGGTT CCTGTAACTT GGCGTCGGTA 
GAGTATTATA ACCCCACCAC GGATAAATGG ACAGTTGTGT CCTCTTGTAT GAGCACGGGG 
AGAAGCTACG CAGGTAAGGC TACGTCATCC TGTCTTCTGG CATATAGCGA AACTGATATC 
AGTTTCCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168501.1
CDS	372..2183
Translation	METPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLVDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGKATSSCLLAYSETDISFL

Target ORF information:

RefSeq Version	XM_017313012.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313012.1

ORF Insert Sequence:

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTCCTCCTC CCAGCAGCTG GCCTGCTACA GTTACAGGAT 
GTGAAGAAGA CATGCTGTGA ATTTTTAGAA TCCCAGCTTC ACCCTGTCAA CTGCTTAGGA 
ATCCGGGCTT TTGCTGATAT GCATGCATGC ACAGACCTCC TGAATAAGGC CAACACGTAT 
GCAGAACAAC ATTTTGCAGA TGTCGTACTT AGTGAAGAGT TTCTTAACCT CGGCATCGAG 
CAGGTGTGCA GCTTAATCTC CAGTGATAAA CTCACCATTT CCTCCGAGGA GAAGGTATTT 
GAAGCAGTCA TCGCCTGGGT AAACCACGAT AAGGACGTAA GACAGGAGTT CATGGCTCGG 
CTCATGGAGC ATGTCCGATT ACCTCTGCTT CCTCGGGAGT ACTTGGTGCA GCGGGTTGAA 
GAGGAAGCAT TGGTGAAGAA CAGCAGTGCG TGCAAAGATT ACCTCATTGA AGCCATGAAG 
TACCACCTGC TGCCGACAGA GCAGCGCATG TTAATGAAGA GCGTGCGGAC CCGCCTGAGG 
ACGCCCATGA ACCTTCCCAA ATTGATGGTG GTGGTCGGGG GCCAGGCACC AAAGGCTATC 
CGAAGTGTGG AATGCTACGA CTTCAAAGAA GAACGGTGGC ACCAGGTGGC AGAGCTGCCT 
TCCAGGAGGT GCAGGGCAGG GATGGTCTAT ATGGCTGGGC TGGTCTTTGC TGTTGGTGGC 
TTCAATGGCT CACTAAGAGT TCGCACTGTA GATTCCTATG ACCCCGTGAA AGACCAGTGG 
ACCAGCGTGG CGAACATGCG AGACCGAAGA AGCACACTTG GAGCCGCGGT GCTGAATGGG 
CTGCTGTACG CCGTGGGGGG CTTTGACGGC AGCACAGGTC TATCGTCTGT GGAAGCATAC 
AACATAAAAT CTAATGAGTG GTTTCATGTC GCCCCAATGA ACACGAGGAG GAGCAGTGTG 
GGTGTTGGCG TTGTTGGAGG TTTGCTCTAT GCCGTGGGGG GTTACGATGG AGCATCGCGC 
CAGTGTCTTA GCACAGTAGA ATGCTATAAT GCTACTGCAA ACGAGTGGAC TTACATAGCA 
GAAATGAGCA CCAGACGGAG CGGAGCAGGT GTTGGTGTGT TAAACAACTT ATTATATGCT 
GTAGGAGGTC ATGATGGTCC TTTAGTACGA AAAAGTGTTG AAGTATATGA CCCCACCACA 
AATGCCTGGA GACAGGTTGC AGATATGAAC ATGTGCAGAA GAAATGCAGG TGTCTGTGCA 
GTTAATGGTC TGTTGTATGT TGTCGGAGGA GATGATGGTT CCTGTAACTT GGCGTCGGTA 
GAGTATTATA ACCCCACCAC GGATAAATGG ACAGTTGTGT CCTCTTGTAT GAGCACGGGG 
AGAAGCTACG CAGGTAAGGC TACGTCATCC TGTCTTCTGG CATATAGCGA AACTGATATC 
AGTTTCCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klhl2 ( XM_017313012.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017168501.1 Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X2, mRNA.

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CloneID	OMu82596
Clone ID Related Accession (Same CDS sequence)	XM_017313012.1 , XM_017313012.2
Accession Version	XM_017313012.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	kelch-like protein 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017313012.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTCCTCCTC CCAGCAGCTG GCCTGCTACA GTTACAGGAT 
GTGAAGAAGA CATGCTGTGA ATTTTTAGAA TCCCAGCTTC ACCCTGTCAA CTGCTTAGGA 
ATCCGGGCTT TTGCTGATAT GCATGCATGC ACAGACCTCC TGAATAAGGC CAACACGTAT 
GCAGAACAAC ATTTTGCAGA TGTCGTACTT AGTGAAGAGT TTCTTAACCT CGGCATCGAG 
CAGGTGTGCA GCTTAATCTC CAGTGATAAA CTCACCATTT CCTCCGAGGA GAAGGTATTT 
GAAGCAGTCA TCGCCTGGGT AAACCACGAT AAGGACGTAA GACAGGAGTT CATGGCTCGG 
CTCATGGAGC ATGTCCGATT ACCTCTGCTT CCTCGGGAGT ACTTGGTGCA GCGGGTTGAA 
GAGGAAGCAT TGGTGAAGAA CAGCAGTGCG TGCAAAGATT ACCTCATTGA AGCCATGAAG 
TACCACCTGC TGCCGACAGA GCAGCGCATG TTAATGAAGA GCGTGCGGAC CCGCCTGAGG 
ACGCCCATGA ACCTTCCCAA ATTGATGGTG GTGGTCGGGG GCCAGGCACC AAAGGCTATC 
CGAAGTGTGG AATGCTACGA CTTCAAAGAA GAACGGTGGC ACCAGGTGGC AGAGCTGCCT 
TCCAGGAGGT GCAGGGCAGG GATGGTCTAT ATGGCTGGGC TGGTCTTTGC TGTTGGTGGC 
TTCAATGGCT CACTAAGAGT TCGCACTGTA GATTCCTATG ACCCCGTGAA AGACCAGTGG 
ACCAGCGTGG CGAACATGCG AGACCGAAGA AGCACACTTG GAGCCGCGGT GCTGAATGGG 
CTGCTGTACG CCGTGGGGGG CTTTGACGGC AGCACAGGTC TATCGTCTGT GGAAGCATAC 
AACATAAAAT CTAATGAGTG GTTTCATGTC GCCCCAATGA ACACGAGGAG GAGCAGTGTG 
GGTGTTGGCG TTGTTGGAGG TTTGCTCTAT GCCGTGGGGG GTTACGATGG AGCATCGCGC 
CAGTGTCTTA GCACAGTAGA ATGCTATAAT GCTACTGCAA ACGAGTGGAC TTACATAGCA 
GAAATGAGCA CCAGACGGAG CGGAGCAGGT GTTGGTGTGT TAAACAACTT ATTATATGCT 
GTAGGAGGTC ATGATGGTCC TTTAGTACGA AAAAGTGTTG AAGTATATGA CCCCACCACA 
AATGCCTGGA GACAGGTTGC AGATATGAAC ATGTGCAGAA GAAATGCAGG TGTCTGTGCA 
GTTAATGGTC TGTTGTATGT TGTCGGAGGA GATGATGGTT CCTGTAACTT GGCGTCGGTA 
GAGTATTATA ACCCCACCAC GGATAAATGG ACAGTTGTGT CCTCTTGTAT GAGCACGGGG 
AGAAGCTACG CAGGTAAGGC TACGTCATCC TGTCTTCTGG CATATAGCGA AACTGATATC 
AGTTTCCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017168501.1
CDS	512..2323
Translation	METPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLVDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGKATSSCLLAYSETDISFL

Target ORF information:

RefSeq Version	XM_017313012.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 2, Mayven (Klhl2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313012.2

ORF Insert Sequence:

ATGGAGACGC CGCCACTGCC TCCCGCATGC ACAAAGCAGG GTCATCAGAA GCCCCTCGAT 
TCAAAAGACG AGAATCCTGA GAAACATTGC CCACTGACGG TGAACCCCTG GCACATGAAG 
AAAGCCTTTA AAGTCATGAA CGAACTCAGA AGTCAAAATC TGCTGTGTGA CGTCACGATT 
GTGGCAGAAG ACATGGAGAT CCCTGCTCAC CGCGTGGTGC TGGCGGCCTG CAGTCCGTAC 
TTCCACGCCA TGTTTACAGG TGAGATGAGC GAGAGCCGAG CAAAGAGAGT TCGAATAAAG 
GAGGTGGACG GCTGGACCCT GAGGATGCTG GTCGATTACG TTTACACGGC AGAGATTCAG 
GTCACAGAGG AGAACGTGCA GGTCCTCCTC CCAGCAGCTG GCCTGCTACA GTTACAGGAT 
GTGAAGAAGA CATGCTGTGA ATTTTTAGAA TCCCAGCTTC ACCCTGTCAA CTGCTTAGGA 
ATCCGGGCTT TTGCTGATAT GCATGCATGC ACAGACCTCC TGAATAAGGC CAACACGTAT 
GCAGAACAAC ATTTTGCAGA TGTCGTACTT AGTGAAGAGT TTCTTAACCT CGGCATCGAG 
CAGGTGTGCA GCTTAATCTC CAGTGATAAA CTCACCATTT CCTCCGAGGA GAAGGTATTT 
GAAGCAGTCA TCGCCTGGGT AAACCACGAT AAGGACGTAA GACAGGAGTT CATGGCTCGG 
CTCATGGAGC ATGTCCGATT ACCTCTGCTT CCTCGGGAGT ACTTGGTGCA GCGGGTTGAA 
GAGGAAGCAT TGGTGAAGAA CAGCAGTGCG TGCAAAGATT ACCTCATTGA AGCCATGAAG 
TACCACCTGC TGCCGACAGA GCAGCGCATG TTAATGAAGA GCGTGCGGAC CCGCCTGAGG 
ACGCCCATGA ACCTTCCCAA ATTGATGGTG GTGGTCGGGG GCCAGGCACC AAAGGCTATC 
CGAAGTGTGG AATGCTACGA CTTCAAAGAA GAACGGTGGC ACCAGGTGGC AGAGCTGCCT 
TCCAGGAGGT GCAGGGCAGG GATGGTCTAT ATGGCTGGGC TGGTCTTTGC TGTTGGTGGC 
TTCAATGGCT CACTAAGAGT TCGCACTGTA GATTCCTATG ACCCCGTGAA AGACCAGTGG 
ACCAGCGTGG CGAACATGCG AGACCGAAGA AGCACACTTG GAGCCGCGGT GCTGAATGGG 
CTGCTGTACG CCGTGGGGGG CTTTGACGGC AGCACAGGTC TATCGTCTGT GGAAGCATAC 
AACATAAAAT CTAATGAGTG GTTTCATGTC GCCCCAATGA ACACGAGGAG GAGCAGTGTG 
GGTGTTGGCG TTGTTGGAGG TTTGCTCTAT GCCGTGGGGG GTTACGATGG AGCATCGCGC 
CAGTGTCTTA GCACAGTAGA ATGCTATAAT GCTACTGCAA ACGAGTGGAC TTACATAGCA 
GAAATGAGCA CCAGACGGAG CGGAGCAGGT GTTGGTGTGT TAAACAACTT ATTATATGCT 
GTAGGAGGTC ATGATGGTCC TTTAGTACGA AAAAGTGTTG AAGTATATGA CCCCACCACA 
AATGCCTGGA GACAGGTTGC AGATATGAAC ATGTGCAGAA GAAATGCAGG TGTCTGTGCA 
GTTAATGGTC TGTTGTATGT TGTCGGAGGA GATGATGGTT CCTGTAACTT GGCGTCGGTA 
GAGTATTATA ACCCCACCAC GGATAAATGG ACAGTTGTGT CCTCTTGTAT GAGCACGGGG 
AGAAGCTACG CAGGTAAGGC TACGTCATCC TGTCTTCTGG CATATAGCGA AACTGATATC 
AGTTTCCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.
Biochemical and biophysical research communications487(2)368-374(2017 05)
Kasagi Y,Takahashi D,Aida T,Nishida H,Nomura N,Zeniya M,Mori T,Sasaki E,Ando F,Rai T,Uchida S,Sohara E

Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
Biochemical and biophysical research communications469(1)44-48(2016 Jan)
Zhang C,Meermeier NP,Terker AS,Blankenstein KI,Singer JD,Hadchouel J,Ellison DH,Yang CL

Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.
Journal of the American Society of Nephrology : JASN26(9)2129-38(2015 Sep)
Zeniya M,Morimoto N,Takahashi D,Mori Y,Mori T,Ando F,Araki Y,Yoshizaki Y,Inoue Y,Isobe K,Nomura N,Oi K,Nishida H,Sasaki S,Sohara E,Rai T,Uchida S

Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.
Molecular and cellular neurosciences47(4)254-64(2011 Aug)
Tseng LA,Bixby JL

Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Journal of cellular physiology195(2)309-21(2003 May)
Chiellini C,Costa M,Novelli SE,Amri EZ,Benzi L,Bertacca A,Cohen P,Del Prato S,Friedman JM,Maffei M

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Klhl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム