Kcnk16 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnk16
Entrez Gene ID	74571
Full Name	potassium channel, subfamily K, member 16
Synonyms	4731413G05Rik,TALK-1,TALK1
General protein information	Preferred Names potassium channel, subfamily K, member 16 Names potassium channel, subfamily K, member 16
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 A3\|14

mRNA and Protein(s)

mRNA	Protein	Name
NM_029006.2	NP_083282.1	potassium channel, subfamily K, member 16
NM_029006.1	NP_083282.1	potassium channel, subfamily K, member 16

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnk16	NP_001102990.1
Danio rerio (zebrafish)	LOC101882139	XP_005158968.1
	LOC719585	XP_001117127.1
Gallus gallus (chicken)	KCNK16	XP_001235224.1
Xenopus tropicalis (tropical clawed frog)	kcnk16	XP_002942063.2
Canis lupus familiaris (dog)	KCNK16	XP_538902.2
Mus musculus (house mouse)	Kcnk16	NP_083282.1
Homo sapiens (human)	KCNK16	NP_001128578.1
Bos taurus (cattle)	KCNK16	XP_003587722.1

Gene Ontology
Bibliography

Related articles in PubMed

TALK-1 channels control ? cell endoplasmic reticulum Ca
Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA
Science signaling10(497)(2017 Sep)

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ?-cells.
Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA
PloS one12(4)e0175069(2017)

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ?-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA
Diabetes64(11)3818-28(2015 Nov)

Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.
Han J, Kang D, Kim D
American journal of physiology. Cell physiology285(3)C529-38(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kcnk16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnk16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06421	NM_029006.2 Latest version!	Mus musculus potassium channel, subfamily K, member 16 (Kcnk16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OMu06421	NM_029006.1	Mus musculus potassium channel, subfamily K, member 16 (Kcnk16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnk16 ( NM_029006.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083282.1 Mus musculus potassium channel, subfamily K, member 16 (Kcnk16), mRNA.

Price & Availability↑

CloneID	OMu06421
Clone ID Related Accession (Same CDS sequence)	NM_029006.2 , NM_029006.1
Accession Version	NM_029006.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	potassium channel, subfamily K, member 16
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159106.3. On Jun 20, 2019 this sequence version replaced NM_029006.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGCCCCGTG CTGGGGTCTG CGGCTGCTGG GGTGGCCAAG TATTGCCCCT GCTTCTGGCC 
TATATCTGCT ACCTACTGCT TGGGGCCACC ATCTTCCAGC TGCTGGAGAA GCAGGCAGAG 
GCTCAATCCA GGGACCAGTT CCAGCTGGAA AAGCTACGCT TCTTAGAGAA CTACACCTGC 
CTAGACCAGC AGGCCCTGGA GCAGTTTGTA CAGGTCATCC TGGAAGCCTG GGTGAAGGGT 
GTGAACCCCA AAGGCAACTC CACCAATCCC AGCAACTGGG ACTTCGGGAG CAGCTTCTTC 
TTTGCAGGCA CAGTGGTCAC CACCATAGGT TATGGAAACC TGGCCCCCAG CACGGAGGCA 
GGGCAGGTCT TCTGTGTCTT CTATGCTCTG ATGGGGATCC CACTCAATGT GGTCTTCCTC 
AACCATCTGG GCACAGGGCT GCGGGCCCAC CTGACCACAT TGGACAGGTG GGAGGACCAC 
CCCAGGCATT CCCAGCTCCT GCAGGTCCTG GGCCTGGCTC TGTTCCTGAC CTTGGGGACC 
CTGGTCATTC TCATCTTCCC ACCCATGTTC TTCAGCCACG TGGAGGGCTG GAGCTTCCGT 
GAGGGCTTCT ACTTCGCGTT TATCACCCTC AGCACCATTG GCTTCGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTACATCGCT GTGTATCGGA GCTTGGCAGC TATATGGATC 
CTCCTAGGAC TGGCATGGCT GGCGGTGGTC CTCAGCCTGG GATCCCTGCT TCTGCACAGG 
TGCTCCCGGC TCTGGCAGCT CATCAGAGGC CTGGACCTTA AGGATGGAGC AGCCCCTGAC 
TCTGAGCCTA GATCACAGAA AATCCCCATC TCTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083282.1
CDS	108..986
Translation	MPRAGVCGCWGGQVLPLLLAYICYLLLGATIFQLLEKQAEAQSRDQFQLEKLRFLENYTCLDQQALEQFVQVILEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALMGIPLNVVFLNHLGTGLRAHLTTLDRWEDHPRHSQLLQVLGLALFLTLGTLVILIFPPMFFSHVEGWSFREGFYFAFITLSTIGFGDYVVGTDPSKHYIAVYRSLAAIWILLGLAWLAVVLSLGSLLLHRCSRLWQLIRGLDLKDGAAPDSEPRSQKIPISA

Target ORF information:

RefSeq Version	NM_029006.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium channel, subfamily K, member 16 (Kcnk16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029006.2

ORF Insert Sequence:

ATGCCCCGTG CTGGGGTCTG CGGCTGCTGG GGTGGCCAAG TATTGCCCCT GCTTCTGGCC 
TATATCTGCT ACCTACTGCT TGGGGCCACC ATCTTCCAGC TGCTGGAGAA GCAGGCAGAG 
GCTCAATCCA GGGACCAGTT CCAGCTGGAA AAGCTACGCT TCTTAGAGAA CTACACCTGC 
CTAGACCAGC AGGCCCTGGA GCAGTTTGTA CAGGTCATCC TGGAAGCCTG GGTGAAGGGT 
GTGAACCCCA AAGGCAACTC CACCAATCCC AGCAACTGGG ACTTCGGGAG CAGCTTCTTC 
TTTGCAGGCA CAGTGGTCAC CACCATAGGT TATGGAAACC TGGCCCCCAG CACGGAGGCA 
GGGCAGGTCT TCTGTGTCTT CTATGCTCTG ATGGGGATCC CACTCAATGT GGTCTTCCTC 
AACCATCTGG GCACAGGGCT GCGGGCCCAC CTGACCACAT TGGACAGGTG GGAGGACCAC 
CCCAGGCATT CCCAGCTCCT GCAGGTCCTG GGCCTGGCTC TGTTCCTGAC CTTGGGGACC 
CTGGTCATTC TCATCTTCCC ACCCATGTTC TTCAGCCACG TGGAGGGCTG GAGCTTCCGT 
GAGGGCTTCT ACTTCGCGTT TATCACCCTC AGCACCATTG GCTTCGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTACATCGCT GTGTATCGGA GCTTGGCAGC TATATGGATC 
CTCCTAGGAC TGGCATGGCT GGCGGTGGTC CTCAGCCTGG GATCCCTGCT TCTGCACAGG 
TGCTCCCGGC TCTGGCAGCT CATCAGAGGC CTGGACCTTA AGGATGGAGC AGCCCCTGAC 
TCTGAGCCTA GATCACAGAA AATCCCCATC TCTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnk16 ( NM_029006.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083282.1 Mus musculus potassium channel, subfamily K, member 16 (Kcnk16), mRNA.

Price & Availability↑

CloneID	OMu06421
Clone ID Related Accession (Same CDS sequence)	NM_029006.2 , NM_029006.1
Accession Version	NM_029006.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Mus musculus(house mouse)
Product	potassium channel, subfamily K, member 16
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159106.3. On or before Jul 9, 2009 this sequence version replaced XM_907162.1, XM_138942.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCCCGTG CTGGGGTCTG CGGCTGCTGG GGTGGCCAAG TATTGCCCCT GCTTCTGGCC 
TATATCTGCT ACCTACTGCT TGGGGCCACC ATCTTCCAGC TGCTGGAGAA GCAGGCAGAG 
GCTCAATCCA GGGACCAGTT CCAGCTGGAA AAGCTACGCT TCTTAGAGAA CTACACCTGC 
CTAGACCAGC AGGCCCTGGA GCAGTTTGTA CAGGTCATCC TGGAAGCCTG GGTGAAGGGT 
GTGAACCCCA AAGGCAACTC CACCAATCCC AGCAACTGGG ACTTCGGGAG CAGCTTCTTC 
TTTGCAGGCA CAGTGGTCAC CACCATAGGT TATGGAAACC TGGCCCCCAG CACGGAGGCA 
GGGCAGGTCT TCTGTGTCTT CTATGCTCTG ATGGGGATCC CACTCAATGT GGTCTTCCTC 
AACCATCTGG GCACAGGGCT GCGGGCCCAC CTGACCACAT TGGACAGGTG GGAGGACCAC 
CCCAGGCATT CCCAGCTCCT GCAGGTCCTG GGCCTGGCTC TGTTCCTGAC CTTGGGGACC 
CTGGTCATTC TCATCTTCCC ACCCATGTTC TTCAGCCACG TGGAGGGCTG GAGCTTCCGT 
GAGGGCTTCT ACTTCGCGTT TATCACCCTC AGCACCATTG GCTTCGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTACATCGCT GTGTATCGGA GCTTGGCAGC TATATGGATC 
CTCCTAGGAC TGGCATGGCT GGCGGTGGTC CTCAGCCTGG GATCCCTGCT TCTGCACAGG 
TGCTCCCGGC TCTGGCAGCT CATCAGAGGC CTGGACCTTA AGGATGGAGC AGCCCCTGAC 
TCTGAGCCTA GATCACAGAA AATCCCCATC TCTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083282.1
CDS	1..879
Translation	MPRAGVCGCWGGQVLPLLLAYICYLLLGATIFQLLEKQAEAQSRDQFQLEKLRFLENYTCLDQQALEQFVQVILEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALMGIPLNVVFLNHLGTGLRAHLTTLDRWEDHPRHSQLLQVLGLALFLTLGTLVILIFPPMFFSHVEGWSFREGFYFAFITLSTIGFGDYVVGTDPSKHYIAVYRSLAAIWILLGLAWLAVVLSLGSLLLHRCSRLWQLIRGLDLKDGAAPDSEPRSQKIPISA

Target ORF information:

RefSeq Version	NM_029006.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium channel, subfamily K, member 16 (Kcnk16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029006.1

ORF Insert Sequence:

ATGCCCCGTG CTGGGGTCTG CGGCTGCTGG GGTGGCCAAG TATTGCCCCT GCTTCTGGCC 
TATATCTGCT ACCTACTGCT TGGGGCCACC ATCTTCCAGC TGCTGGAGAA GCAGGCAGAG 
GCTCAATCCA GGGACCAGTT CCAGCTGGAA AAGCTACGCT TCTTAGAGAA CTACACCTGC 
CTAGACCAGC AGGCCCTGGA GCAGTTTGTA CAGGTCATCC TGGAAGCCTG GGTGAAGGGT 
GTGAACCCCA AAGGCAACTC CACCAATCCC AGCAACTGGG ACTTCGGGAG CAGCTTCTTC 
TTTGCAGGCA CAGTGGTCAC CACCATAGGT TATGGAAACC TGGCCCCCAG CACGGAGGCA 
GGGCAGGTCT TCTGTGTCTT CTATGCTCTG ATGGGGATCC CACTCAATGT GGTCTTCCTC 
AACCATCTGG GCACAGGGCT GCGGGCCCAC CTGACCACAT TGGACAGGTG GGAGGACCAC 
CCCAGGCATT CCCAGCTCCT GCAGGTCCTG GGCCTGGCTC TGTTCCTGAC CTTGGGGACC 
CTGGTCATTC TCATCTTCCC ACCCATGTTC TTCAGCCACG TGGAGGGCTG GAGCTTCCGT 
GAGGGCTTCT ACTTCGCGTT TATCACCCTC AGCACCATTG GCTTCGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTACATCGCT GTGTATCGGA GCTTGGCAGC TATATGGATC 
CTCCTAGGAC TGGCATGGCT GGCGGTGGTC CTCAGCCTGG GATCCCTGCT TCTGCACAGG 
TGCTCCCGGC TCTGGCAGCT CATCAGAGGC CTGGACCTTA AGGATGGAGC AGCCCCTGAC 
TCTGAGCCTA GATCACAGAA AATCCCCATC TCTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TALK-1 channels control ? cell endoplasmic reticulum Ca
Science signaling10(497)(2017 Sep)
Vierra NC,Dadi PK,Milian SC,Dickerson MT,Jordan KL,Gilon P,Jacobson DA

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ?-cells.
PloS one12(4)e0175069(2017)
Dickerson MT,Vierra NC,Milian SC,Dadi PK,Jacobson DA

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ?-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
Diabetes64(11)3818-28(2015 Nov)
Vierra NC,Dadi PK,Jeong I,Dickerson M,Powell DR,Jacobson DA

Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.
American journal of physiology. Cell physiology285(3)C529-38(2003 Sep)
Han J,Kang D,Kim D