Dmkn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dmkn
Entrez Gene ID	73712
Full Name	dermokine
Synonyms	1110014F24Rik,AW561900,C130074A08,SK30,SK89,cI-36
General protein information	Preferred Names dermokine Names dermokine epidermis-specific secreted protein SK30/SK89
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006540390.2	XP_006540453.1	dermokine isoform X1
NM_001166174.1	NP_001159646.1	dermokine isoform d precursor
NM_001166173.1	NP_001159645.1	dermokine isoform c precursor
NM_172899.4	NP_766487.3	dermokine isoform b precursor
NM_001369359.1	NP_001356288.1	dermokine isoform e precursor
NM_028618.2	NP_082894.1	dermokine isoform a precursor

Pathways from BioSystems

Homologies

	LOC718709	XP_001111764.2
Mus musculus (house mouse)	Dmkn	NP_001159645.1
Homo sapiens (human)	DMKN	NP_001177276.1
Pan troglodytes (chimpanzee)	DMKN	XP_003316324.1

Gene Ontology
Bibliography

Related articles in PubMed

Mice deficient for the epidermal dermokine ? and ? isoforms display transient cornification defects.
Leclerc EA, Huchenq A, Kezic S, Serre G, Jonca N
Journal of cell science127(Pt 13)2862-72(2014 Jul)

Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.
Hasegawa M, Higashi K, Matsushita T, Hamaguchi Y, Saito K, Fujimoto M, Takehara K
Journal of dermatological science70(1)34-41(2013 Apr)

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD
Journal of cell science124(Pt 5)745-54(2011 Mar)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

Dermokine: an extensively differentially spliced gene expressed in epithelial cells.
Naso MF, Liang B, Huang CC, Song XY, Shahied-Arruda L, Belkowski SM, D'Andrea MR, Polkovitch DA, Lawrence DR, Griswold DE, Sweet RW, Amegadzie BY
The Journal of investigative dermatology127(7)1622-31(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors improved the knowledge of Dmkn expression in mouse and highlighted a role for Dmkn beta and gamma in cornification.
Title: Mice deficient for the epidermal dermokine ? and ? isoforms display transient cornification defects.

These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif.
Title: Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.

Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex.
Title: Dermokine: an extensively differentially spliced gene expressed in epithelial cells.

Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice.
Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.

identification of a novel gene (dermokine)giving rise to two splicing variants, both of which are expressed in the spinous layer of epidermis
Title: Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.

The following Dmkn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dmkn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu05870	NM_028618.2 Latest version!	Mus musculus dermokine (Dmkn), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu04268	NM_172899.4 Latest version!	Mus musculus dermokine (Dmkn), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OMu10317	NM_001166173.1 Latest version!	Mus musculus dermokine (Dmkn), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OMu10319	NM_001166174.1 Latest version!	Mus musculus dermokine (Dmkn), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$286.30 $409.00
OMu38517	NM_001369359.1 Latest version!	Mus musculus dermokine (Dmkn), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OMu38517	XM_006540390.2 Latest version!	Mus musculus dermokine (Dmkn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dmkn ( NM_028618.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082894.1 Mus musculus dermokine (Dmkn), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05870
Clone ID Related Accession (Same CDS sequence)	NM_028618.2
Accession Version	NM_028618.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	dermokine isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK003695.1 and AC165340.3. On Oct 10, 2009 this sequence version replaced NM_028618.1. Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1, also called alpha) has the same N- and C-termini but is shorter compared to isoform 3. ##Evidence-Data-START## Transcript exon combination :: BI248879.1, BY703955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACCAG TCACGGCCTC TGCTCTGCTG CTTATCCTGC TGGGTGTGGC CTGGCGTGGA 
GACAGCCACA GCTGGGGTTC AGATCTGTCA TCTCTGCAGA AGAGGGCAGG TGGAGCTGAC 
CAGTTTTCTA AGCCTGAAGC AAGACAAGAT CTTTCAGCTG ACTCATCCAA GAACTACTAC 
AATAACCAGC AGGTGAATCC TACTTACAAC TGGCAATACT ATACCAAGAC CACTGCCAAG 
GCGGGAGTCA CACCTTCATC TTCCTCGGCT TCCCGGGCAC AACCTGGCCT GCTGAAGTGG 
CTGAAGTTTT GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082894.1
CDS	20..334
Translation	MKPVTASALLLILLGVAWRGDSHSWGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW

Target ORF information:

RefSeq Version	NM_028618.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dermokine (Dmkn), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028618.2

ORF Insert Sequence:

ATGAAACCAG TCACGGCCTC TGCTCTGCTG CTTATCCTGC TGGGTGTGGC CTGGCGTGGA 
GACAGCCACA GCTGGGGTTC AGATCTGTCA TCTCTGCAGA AGAGGGCAGG TGGAGCTGAC 
CAGTTTTCTA AGCCTGAAGC AAGACAAGAT CTTTCAGCTG ACTCATCCAA GAACTACTAC 
AATAACCAGC AGGTGAATCC TACTTACAAC TGGCAATACT ATACCAAGAC CACTGCCAAG 
GCGGGAGTCA CACCTTCATC TTCCTCGGCT TCCCGGGCAC AACCTGGCCT GCTGAAGTGG 
CTGAAGTTTT GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dmkn ( NM_172899.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766487.3 Mus musculus dermokine (Dmkn), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04268
Clone ID Related Accession (Same CDS sequence)	NM_172899.4
Accession Version	NM_172899.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	dermokine isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK081753.1, BC064724.1 and AC165340.3. On Oct 10, 2009 this sequence version replaced NM_172899.3. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2, also called beta) has a shorter and distinct N-terminus compared to isoform 3. ##Evidence-Data-START## Transcript exon combination :: BC064724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GACATAGAAA CATCTAATTT TGATGAAGGC 
TATTCGGTCT CCAGGGGAAC CGGCAGCAGG GGTGGAAGTG GTGGAAGTGG TGGAAGTGGT 
GGTGGAAACA AACCCGAGTG TAACAACCCA GGGAATGATG TGCGCATGGC CGGAGGATCT 
GGGAGTCAGG GGCATGGGTC CAATGGTGGC AATATACAAA AAGAAGCTGT CAATGGACTC 
AACACTATGA ACTCGGATGC ATCTACCTTG CCCTTCAACA TTGACAATTT CTGGGAGAAT 
CTTAAGTCCA AGACGCGCTT CATTAACTGG GATGCCATAA ACAAGGGTCA TGCCCCATCT 
CCCAGCACTC GGGCTTTACT CTACTTCCGC AAACTGTGGG AGAATTTCAA ACGCAGCACT 
CCTTTCTTCA ACTGGAAACA GATTGAGGGT TCAGATCTGT CATCTCTGCA GAAGAGGGCA 
GGTGGAGCTG ACCAGTTTTC TAAGCCTGAA GCAAGACAAG ATCTTTCAGC TGACTCATCC 
AAGAACTACT ACAATAACCA GCAGGTGAAT CCTACTTACA ACTGGCAATA CTATACCAAG 
ACCACTGCCA AGGCGGGAGT CACACCTTCA TCTTCCTCGG CTTCCCGGGC ACAACCTGGC 
CTGCTGAAGT GGCTGAAGTT TTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766487.3
CDS	169..1695
Translation	MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAISHGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAGNEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNYGTNSLGGSVGQGGNGGPLNYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGNSNSGNSGNSGSGSRDIETSNFDEGYSVSRGTGSRGGSGGSGGSGGGNKPECNNPGNDVRMAGGSGSQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDNFWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW

Target ORF information:

RefSeq Version	NM_172899.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus dermokine (Dmkn), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172899.4

ORF Insert Sequence:

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GACATAGAAA CATCTAATTT TGATGAAGGC 
TATTCGGTCT CCAGGGGAAC CGGCAGCAGG GGTGGAAGTG GTGGAAGTGG TGGAAGTGGT 
GGTGGAAACA AACCCGAGTG TAACAACCCA GGGAATGATG TGCGCATGGC CGGAGGATCT 
GGGAGTCAGG GGCATGGGTC CAATGGTGGC AATATACAAA AAGAAGCTGT CAATGGACTC 
AACACTATGA ACTCGGATGC ATCTACCTTG CCCTTCAACA TTGACAATTT CTGGGAGAAT 
CTTAAGTCCA AGACGCGCTT CATTAACTGG GATGCCATAA ACAAGGGTCA TGCCCCATCT 
CCCAGCACTC GGGCTTTACT CTACTTCCGC AAACTGTGGG AGAATTTCAA ACGCAGCACT 
CCTTTCTTCA ACTGGAAACA GATTGAGGGT TCAGATCTGT CATCTCTGCA GAAGAGGGCA 
GGTGGAGCTG ACCAGTTTTC TAAGCCTGAA GCAAGACAAG ATCTTTCAGC TGACTCATCC 
AAGAACTACT ACAATAACCA GCAGGTGAAT CCTACTTACA ACTGGCAATA CTATACCAAG 
ACCACTGCCA AGGCGGGAGT CACACCTTCA TCTTCCTCGG CTTCCCGGGC ACAACCTGGC 
CTGCTGAAGT GGCTGAAGTT TTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dmkn ( NM_001166173.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001159645.1 Mus musculus dermokine (Dmkn), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu10317
Clone ID Related Accession (Same CDS sequence)	NM_001166173.1
Accession Version	NM_001166173.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	dermokine isoform c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK081753.1 and AC165340.3. Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3). ##Evidence-Data-START## Transcript exon combination :: AK081753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GACATAGAAA CATCTAATTT TGATGAAGGC 
TATTCGGTCT CCAGGGGAAC CGGCAGCAGG GGTGGAAGTG GTGGAAGTGG TGGAAGTGGT 
GGTGGAAACA AACCCGAGTG TAACAACCCA GGGAATGATG TGCGCATGGC CGGAGGATCT 
GGGAGTCAGG AAAGTAAAGA AAGCAGTCAT CTCCTTGGAG GCTCCCATGA CTACCAGGGG 
CATGGGTCCA ATGGTGGCAA TATACAAAAA GAAGCTGTCA ATGGACTCAA CACTATGAAC 
TCGGATGCAT CTACCTTGCC CTTCAACATT GACAATTTCT GGGAGAATCT TAAGTCCAAG 
ACGCGCTTCA TTAACTGGGA TGCCATAAAC AAGGGTCATG CCCCATCTCC CAGCACTCGG 
GCTTTACTCT ACTTCCGCAA ACTGTGGGAG AATTTCAAAC GCAGCACTCC TTTCTTCAAC 
TGGAAACAGA TTGAGGGTTC AGATCTGTCA TCTCTGCAGA AGAGGGCAGG TGGAGCTGAC 
CAGTTTTCTA AGCCTGAAGC AAGACAAGAT CTTTCAGCTG ACTCATCCAA GAACTACTAC 
AATAACCAGC AGGTGAATCC TACTTACAAC TGGCAATACT ATACCAAGAC CACTGCCAAG 
GCGGGAGTCA CACCTTCATC TTCCTCGGCT TCCCGGGCAC AACCTGGCCT GCTGAAGTGG 
CTGAAGTTTT GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159645.1
CDS	169..1743
Translation	MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAISHGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAGNEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNYGTNSLGGSVGQGGNGGPLNYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGNSNSGNSGNSGSGSRDIETSNFDEGYSVSRGTGSRGGSGGSGGSGGGNKPECNNPGNDVRMAGGSGSQESKESSHLLGGSHDYQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDNFWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW

Target ORF information:

RefSeq Version	NM_001166173.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dermokine (Dmkn), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166173.1

ORF Insert Sequence:

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GACATAGAAA CATCTAATTT TGATGAAGGC 
TATTCGGTCT CCAGGGGAAC CGGCAGCAGG GGTGGAAGTG GTGGAAGTGG TGGAAGTGGT 
GGTGGAAACA AACCCGAGTG TAACAACCCA GGGAATGATG TGCGCATGGC CGGAGGATCT 
GGGAGTCAGG AAAGTAAAGA AAGCAGTCAT CTCCTTGGAG GCTCCCATGA CTACCAGGGG 
CATGGGTCCA ATGGTGGCAA TATACAAAAA GAAGCTGTCA ATGGACTCAA CACTATGAAC 
TCGGATGCAT CTACCTTGCC CTTCAACATT GACAATTTCT GGGAGAATCT TAAGTCCAAG 
ACGCGCTTCA TTAACTGGGA TGCCATAAAC AAGGGTCATG CCCCATCTCC CAGCACTCGG 
GCTTTACTCT ACTTCCGCAA ACTGTGGGAG AATTTCAAAC GCAGCACTCC TTTCTTCAAC 
TGGAAACAGA TTGAGGGTTC AGATCTGTCA TCTCTGCAGA AGAGGGCAGG TGGAGCTGAC 
CAGTTTTCTA AGCCTGAAGC AAGACAAGAT CTTTCAGCTG ACTCATCCAA GAACTACTAC 
AATAACCAGC AGGTGAATCC TACTTACAAC TGGCAATACT ATACCAAGAC CACTGCCAAG 
GCGGGAGTCA CACCTTCATC TTCCTCGGCT TCCCGGGCAC AACCTGGCCT GCTGAAGTGG 
CTGAAGTTTT GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dmkn ( NM_001166174.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001159646.1 Mus musculus dermokine (Dmkn), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu10319
Clone ID Related Accession (Same CDS sequence)	NM_001166174.1
Accession Version	NM_001166174.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	dermokine isoform d precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK081753.1, BC064724.1 and AC165340.3. Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3. ##Evidence-Data-START## Transcript exon combination :: AY444557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GGAACCGGCA GCAGGGGTGG AAGTGGTGGA 
AGTGGTGGAA GTGGTGGTGG AAACAAACCC GAGTGTAACA ACCCAGGGAA TGATGTGCGC 
ATGGCCGGAG GATCTGGGAG TCAGGGGCAT GGGTCCAATG GTGGCAATAT ACAAAAAGAA 
GCTGTCAATG GACTCAACAC TATGAACTCG GATGCATCTA CCTTGCCCTT CAACATTGAC 
AATTTCTGGG AGAATCTTAA GTCCAAGACG CGCTTCATTA ACTGGGATGC CATAAACAAG 
GGTCATGCCC CATCTCCCAG CACTCGGGCT TTACTCTACT TCCGCAAACT GTGGGAGAAT 
TTCAAACGCA GCACTCCTTT CTTCAACTGG AAACAGATTG AGGGTTCAGA TCTGTCATCT 
CTGCAGAAGA GGGCAGGTGG AGCTGACCAG TTTTCTAAGC CTGAAGCAAG ACAAGATCTT 
TCAGCTGACT CATCCAAGAA CTACTACAAT AACCAGCAGG TGAATCCTAC TTACAACTGG 
CAATACTATA CCAAGACCAC TGCCAAGGCG GGAGTCACAC CTTCATCTTC CTCGGCTTCC 
CGGGCACAAC CTGGCCTGCT GAAGTGGCTG AAGTTTTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159646.1
CDS	169..1650
Translation	MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAISHGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAGNEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNYGTNSLGGSVGQGGNGGPLNYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGNSNSGNSGNSGSGSRGTGSRGGSGGSGGSGGGNKPECNNPGNDVRMAGGSGSQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDNFWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW

Target ORF information:

RefSeq Version	NM_001166174.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dermokine (Dmkn), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166174.1

ORF Insert Sequence:

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GGAACCGGCA GCAGGGGTGG AAGTGGTGGA 
AGTGGTGGAA GTGGTGGTGG AAACAAACCC GAGTGTAACA ACCCAGGGAA TGATGTGCGC 
ATGGCCGGAG GATCTGGGAG TCAGGGGCAT GGGTCCAATG GTGGCAATAT ACAAAAAGAA 
GCTGTCAATG GACTCAACAC TATGAACTCG GATGCATCTA CCTTGCCCTT CAACATTGAC 
AATTTCTGGG AGAATCTTAA GTCCAAGACG CGCTTCATTA ACTGGGATGC CATAAACAAG 
GGTCATGCCC CATCTCCCAG CACTCGGGCT TTACTCTACT TCCGCAAACT GTGGGAGAAT 
TTCAAACGCA GCACTCCTTT CTTCAACTGG AAACAGATTG AGGGTTCAGA TCTGTCATCT 
CTGCAGAAGA GGGCAGGTGG AGCTGACCAG TTTTCTAAGC CTGAAGCAAG ACAAGATCTT 
TCAGCTGACT CATCCAAGAA CTACTACAAT AACCAGCAGG TGAATCCTAC TTACAACTGG 
CAATACTATA CCAAGACCAC TGCCAAGGCG GGAGTCACAC CTTCATCTTC CTCGGCTTCC 
CGGGCACAAC CTGGCCTGCT GAAGTGGCTG AAGTTTTGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dmkn ( NM_001369359.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001356288.1 Mus musculus dermokine (Dmkn), transcript variant 5, mRNA.

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CloneID	OMu38517
Clone ID Related Accession (Same CDS sequence)	XM_006540390.2 , NM_001369359.1
Accession Version	NM_001369359.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	dermokine isoform e precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC165340.3. On Apr 5, 2019 this sequence version replaced XM_006540390.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR5189676.75143.1, SRR5189676.95040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GGAACCGGCA GCAGGGGTGG AAGTGGTGGA 
AGTGGTGGAA GTGGTGGTGG AAACAAACCC GAGTGTAACA ACCCAGGGAA TGATGTGCGC 
ATGGCCGGAG GATCTGGGAG TCAGGAAAGT AAAGAAAGCA GTCATCTCCT TGGAGGCTCC 
CATGACTACC AGGGGCATGG GTCCAATGGT GGCAATATAC AAAAAGAAGC TGTCAATGGA 
CTCAACACTA TGAACTCGGA TGCATCTACC TTGCCCTTCA ACATTGACAA TTTCTGGGAG 
AATCTTAAGT CCAAGACGCG CTTCATTAAC TGGGATGCCA TAAACAAGGG TCATGCCCCA 
TCTCCCAGCA CTCGGGCTTT ACTCTACTTC CGCAAACTGT GGGAGAATTT CAAACGCAGC 
ACTCCTTTCT TCAACTGGAA ACAGATTGAG GGTTCAGATC TGTCATCTCT GCAGAAGAGG 
GCAGGTGGAG CTGACCAGTT TTCTAAGCCT GAAGCAAGAC AAGATCTTTC AGCTGACTCA 
TCCAAGAACT ACTACAATAA CCAGCAGGTG AATCCTACTT ACAACTGGCA ATACTATACC 
AAGACCACTG CCAAGGCGGG AGTCACACCT TCATCTTCCT CGGCTTCCCG GGCACAACCT 
GGCCTGCTGA AGTGGCTGAA GTTTTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001356288.1
CDS	167..1696
Translation	MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAISHGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAGNEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNYGTNSLGGSVGQGGNGGPLNYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGNSNSGNSGNSGSGSRGTGSRGGSGGSGGSGGGNKPECNNPGNDVRMAGGSGSQESKESSHLLGGSHDYQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDNFWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW

Target ORF information:

RefSeq Version	NM_001369359.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dermokine (Dmkn), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001369359.1

ORF Insert Sequence:

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GGAACCGGCA GCAGGGGTGG AAGTGGTGGA 
AGTGGTGGAA GTGGTGGTGG AAACAAACCC GAGTGTAACA ACCCAGGGAA TGATGTGCGC 
ATGGCCGGAG GATCTGGGAG TCAGGAAAGT AAAGAAAGCA GTCATCTCCT TGGAGGCTCC 
CATGACTACC AGGGGCATGG GTCCAATGGT GGCAATATAC AAAAAGAAGC TGTCAATGGA 
CTCAACACTA TGAACTCGGA TGCATCTACC TTGCCCTTCA ACATTGACAA TTTCTGGGAG 
AATCTTAAGT CCAAGACGCG CTTCATTAAC TGGGATGCCA TAAACAAGGG TCATGCCCCA 
TCTCCCAGCA CTCGGGCTTT ACTCTACTTC CGCAAACTGT GGGAGAATTT CAAACGCAGC 
ACTCCTTTCT TCAACTGGAA ACAGATTGAG GGTTCAGATC TGTCATCTCT GCAGAAGAGG 
GCAGGTGGAG CTGACCAGTT TTCTAAGCCT GAAGCAAGAC AAGATCTTTC AGCTGACTCA 
TCCAAGAACT ACTACAATAA CCAGCAGGTG AATCCTACTT ACAACTGGCA ATACTATACC 
AAGACCACTG CCAAGGCGGG AGTCACACCT TCATCTTCCT CGGCTTCCCG GGCACAACCT 
GGCCTGCTGA AGTGGCTGAA GTTTTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dmkn ( XM_006540390.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540453.1 Mus musculus dermokine (Dmkn), transcript variant X1, mRNA.

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CloneID	OMu38517
Clone ID Related Accession (Same CDS sequence)	XM_006540390.2 , NM_001369359.1
Accession Version	XM_006540390.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	dermokine isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006540390.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GGAACCGGCA GCAGGGGTGG AAGTGGTGGA 
AGTGGTGGAA GTGGTGGTGG AAACAAACCC GAGTGTAACA ACCCAGGGAA TGATGTGCGC 
ATGGCCGGAG GATCTGGGAG TCAGGAAAGT AAAGAAAGCA GTCATCTCCT TGGAGGCTCC 
CATGACTACC AGGGGCATGG GTCCAATGGT GGCAATATAC AAAAAGAAGC TGTCAATGGA 
CTCAACACTA TGAACTCGGA TGCATCTACC TTGCCCTTCA ACATTGACAA TTTCTGGGAG 
AATCTTAAGT CCAAGACGCG CTTCATTAAC TGGGATGCCA TAAACAAGGG TCATGCCCCA 
TCTCCCAGCA CTCGGGCTTT ACTCTACTTC CGCAAACTGT GGGAGAATTT CAAACGCAGC 
ACTCCTTTCT TCAACTGGAA ACAGATTGAG GGTTCAGATC TGTCATCTCT GCAGAAGAGG 
GCAGGTGGAG CTGACCAGTT TTCTAAGCCT GAAGCAAGAC AAGATCTTTC AGCTGACTCA 
TCCAAGAACT ACTACAATAA CCAGCAGGTG AATCCTACTT ACAACTGGCA ATACTATACC 
AAGACCACTG CCAAGGCGGG AGTCACACCT TCATCTTCCT CGGCTTCCCG GGCACAACCT 
GGCCTGCTGA AGTGGCTGAA GTTTTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540453.1
CDS	201..1730
Translation	MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAISHGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAGNEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNYGTNSLGGSVGQGGNGGPLNYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGNSNSGNSGNSGSGSRGTGSRGGSGGSGGSGGGNKPECNNPGNDVRMAGGSGSQESKESSHLLGGSHDYQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDNFWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLSSLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSSSASRAQPGLLKWLKFW

Target ORF information:

RefSeq Version	XM_006540390.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dermokine (Dmkn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006540390.2

ORF Insert Sequence:

ATGAAGCTAC AGGGCTCTCT GGCCTGCCTC CTGCTGGCCC TATGTCTGGG TGGTGGGGCA 
GCTAACCCGC TGCACAGTGG AGGGGAGGGC ACAGGGGCAA GTGCTGCCCA TGGAGCAGGA 
GATGCCATTA GCCATGGAAT TGGAGAGGCT GTGGGCCAAG GGGCTAAAGA AGCAGCCAGC 
TCTGGAATCC AGAATGCCCT AGGCCAGGGG CACGGAGAGG AAGGTGGCTC CACATTGATG 
GGGAGCAGAG GCGATGTTTT TGAGCACCGG CTTGGGGAAG CAGCAAGATC TCTGGGGAAC 
GCTGGGAATG AGATTGGCAG ACAGGCTGAG GATATCATTC GCCAAGGGGT AGATGCTGTC 
CACAACGCTG GGTCCTGGGG GACATCTGGA GGTCATGGCG CATATGGCTC TCAAGGTGGT 
GCTGGAGTCC AGGGCAATCC TGGTCCTCAA GGGACACCCT GGGCCTCAGG AGGCAACTAT 
GGGACTAACT CTCTGGGTGG CTCTGTGGGT CAGGGTGGCA ATGGCGGACC ACTCAACTAT 
GAAACCAATG CCCAGGGAGC TGTGGCTCAG CCTGGCTACG GGACAGTGAG AGGCAACAAC 
CAGAACTCAG GGTGTACCAA CCCCCCACCT TCTGGCTCCC ATGAAAGCTT CAGTAACTCT 
GGGGGAAGCA GCAATGATGG CAGTCGTGGT AGCCAAGGCA GTCATGGCAG TAATGGTCAG 
GGCAGCAGCG GTAGAGGCGG TGGCCAAGGC AACAGCGACA ACAATGGCAG CAGTAGCAGT 
AGCAGCGGCA GCAACAGTGG CAACAGCAAC AGTGGCAACA GCGGCAACAG CAACAGTGGC 
AACAGCGGCA ACAGCGGTTC TGGGTCCCGG GGAACCGGCA GCAGGGGTGG AAGTGGTGGA 
AGTGGTGGAA GTGGTGGTGG AAACAAACCC GAGTGTAACA ACCCAGGGAA TGATGTGCGC 
ATGGCCGGAG GATCTGGGAG TCAGGAAAGT AAAGAAAGCA GTCATCTCCT TGGAGGCTCC 
CATGACTACC AGGGGCATGG GTCCAATGGT GGCAATATAC AAAAAGAAGC TGTCAATGGA 
CTCAACACTA TGAACTCGGA TGCATCTACC TTGCCCTTCA ACATTGACAA TTTCTGGGAG 
AATCTTAAGT CCAAGACGCG CTTCATTAAC TGGGATGCCA TAAACAAGGG TCATGCCCCA 
TCTCCCAGCA CTCGGGCTTT ACTCTACTTC CGCAAACTGT GGGAGAATTT CAAACGCAGC 
ACTCCTTTCT TCAACTGGAA ACAGATTGAG GGTTCAGATC TGTCATCTCT GCAGAAGAGG 
GCAGGTGGAG CTGACCAGTT TTCTAAGCCT GAAGCAAGAC AAGATCTTTC AGCTGACTCA 
TCCAAGAACT ACTACAATAA CCAGCAGGTG AATCCTACTT ACAACTGGCA ATACTATACC 
AAGACCACTG CCAAGGCGGG AGTCACACCT TCATCTTCCT CGGCTTCCCG GGCACAACCT 
GGCCTGCTGA AGTGGCTGAA GTTTTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mice deficient for the epidermal dermokine ? and ? isoforms display transient cornification defects.
Journal of cell science127(Pt 13)2862-72(2014 Jul)
Leclerc EA,Huchenq A,Kezic S,Serre G,Jonca N

Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.
Journal of dermatological science70(1)34-41(2013 Apr)
Hasegawa M,Higashi K,Matsushita T,Hamaguchi Y,Saito K,Fujimoto M,Takehara K

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
Journal of cell science124(Pt 5)745-54(2011 Mar)
Jheon AH,Mostowfi P,Snead ML,Ihrie RA,Sone E,Pramparo T,Attardi LD,Klein OD

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

Dermokine: an extensively differentially spliced gene expressed in epithelial cells.
The Journal of investigative dermatology127(7)1622-31(2007 Jul)
Naso MF,Liang B,Huang CC,Song XY,Shahied-Arruda L,Belkowski SM,D'Andrea MR,Polkovitch DA,Lawrence DR,Griswold DE,Sweet RW,Amegadzie BY

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Dmkn cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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