Enho cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Enho
Entrez Gene ID	69638
Full Name	energy homeostasis associated
Synonyms	1110065P19Rik,2310040A07Rik
General protein information	Preferred Names energy homeostasis associated Names adropin energy homeostasis-associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 A5

mRNA and Protein(s)

mRNA	Protein	Name
NM_027147.1	NP_081423.1	adropin precursor

Pathways from BioSystems

Homologies

	ENHO	XP_001097511.1
Rattus norvegicus (Norway rat)	LOC100912292	NP_001269265.1
Pan troglodytes (chimpanzee)	ENHO	XP_003312104.1
Canis lupus familiaris (dog)	ENHO	XP_003431614.1
Homo sapiens (human)	ENHO	NP_940975.2
Mus musculus (house mouse)	Enho	NP_081423.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of Chronic and Intermittent Calorie Restriction on Adropin Levels in Breast Cancer.
Tuna BG, Atalay PB, Altunbek M, Kalkan BM, Dogan S
Nutrition and cancer69(7)1003-1010(2017 Oct)

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.
Gao S, McMillan RP, Jacas J, Zhu Q, Li X, Kumar GK, Casals N, Hegardt FG, Robbins PD, Lopaschuk GD, Hulver MW, Butler AA
Diabetes63(10)3242-52(2014 Oct)

Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice.
Wong CM, Wang Y, Lee JT, Huang Z, Wu D, Xu A, Lam KS
The Journal of biological chemistry289(37)25976-86(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggest a role for adropin in regulating muscle substrate preference under various nutritional states.
Title: Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.

our data suggest that adropin is a membrane-bound protein that interacts with the brain-specific Notch1 ligand NB3.
Title: Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice.

Adropin has an endothelial protective function mediated via upregulation of eNOS expression through the VEGFR2-PI3K-Akt and VEGFR2-ERK1/2 pathways. Adropin therapy may thus be useful for limiting diseases characterized by endothelial dysfunction.
Title: Adropin is a novel regulator of endothelial function.

Adropin regulated expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma, a major regulator of lipogenesis.
Title: Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.

The following Enho gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Enho cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03705	NM_027147.1 Latest version!	Mus musculus energy homeostasis associated (Enho), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Enho ( NM_027147.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081423.1 Mus musculus energy homeostasis associated (Enho), mRNA.

Price & Availability↑

CloneID	OMu03705
Clone ID Related Accession (Same CDS sequence)	NM_027147.1
Accession Version	NM_027147.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	adropin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ554924.1, AK050496.1 and BQ030577.1. On or before Aug 22, 2008 this sequence version replaced XM_912979.2, XM_001473388.1, XM_001478385.1. ##Evidence-Data-START## Transcript exon combination :: AK009710.1, AK050496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGCAG CCATCTCCCA AGGGGCTCTC ATCGCCATCG TCTGCAATGG CCTCGTAGGC 
TTCTTGCTGC TACTGCTCTG GGTCATTCTC TGCTGGGCCT GCCATTCTCG ATCTGCTGAC 
GTCGATTCTC TCTCGGAATC CAGTCCCAAC TCCAGCCCTG GCCCCTGTCC TGAGAAGGCG 
CCACCACCCC AGAAGCCCAG CCATGAAGGC AGCTACCTGC TGCAGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081423.1
CDS	549..779
Translation	MGAAISQGALIAIVCNGLVGFLLLLLWVILCWACHSRSADVDSLSESSPNSSPGPCPEKAPPPQKPSHEGSYLLQP

Target ORF information:

RefSeq Version	NM_027147.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus energy homeostasis associated (Enho), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027147.1

ORF Insert Sequence:

ATGGGGGCAG CCATCTCCCA AGGGGCTCTC ATCGCCATCG TCTGCAATGG CCTCGTAGGC 
TTCTTGCTGC TACTGCTCTG GGTCATTCTC TGCTGGGCCT GCCATTCTCG ATCTGCTGAC 
GTCGATTCTC TCTCGGAATC CAGTCCCAAC TCCAGCCCTG GCCCCTGTCC TGAGAAGGCG 
CCACCACCCC AGAAGCCCAG CCATGAAGGC AGCTACCTGC TGCAGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of Chronic and Intermittent Calorie Restriction on Adropin Levels in Breast Cancer.
Nutrition and cancer69(7)1003-1010(2017 Oct)
Tuna BG,Atalay PB,Altunbek M,Kalkan BM,Dogan S

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.
Diabetes63(10)3242-52(2014 Oct)
Gao S,McMillan RP,Jacas J,Zhu Q,Li X,Kumar GK,Casals N,Hegardt FG,Robbins PD,Lopaschuk GD,Hulver MW,Butler AA

Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice.
The Journal of biological chemistry289(37)25976-86(2014 Sep)
Wong CM,Wang Y,Lee JT,Huang Z,Wu D,Xu A,Lam KS