Cdca5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdca5
Entrez Gene ID	67849
Full Name	cell division cycle associated 5
Synonyms	2610036L13Rik,AL024086,AW536684,C85404
General protein information	Preferred Names cell division cycle associated 5 Names sororin cell division cycle-associated protein 5 sororin p35
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 A

mRNA and Protein(s)

mRNA	Protein	Name
NM_026410.3	NP_080686.1	sororin

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC612071	XP_854890.2
Pan troglodytes (chimpanzee)	CDCA5	XP_508541.3
Mus musculus (house mouse)	Cdca5	NP_080686.1
Rattus norvegicus (Norway rat)	LOC686151	XP_006231032.1
Rattus norvegicus (Norway rat)	Cdca5	NP_001108514.2
Bos taurus (cattle)	CDCA5	NP_001069738.1
Rattus norvegicus (Norway rat)	LOC100910252	XP_003749104.2
Homo sapiens (human)	CDCA5	NP_542399.1
Xenopus tropicalis (tropical clawed frog)	cdca5	NP_001120072.1

Gene Ontology
Bibliography

Related articles in PubMed

Sororin is enriched at the central region of synapsed meiotic chromosomes.
Jordan PW, Eyster C, Chen J, Pezza RJ, Rankin S
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology25(2)115-128(2017 Jun)

The cohesion stabilizer sororin favors DNA repair and chromosome segregation during mouse oocyte meiosis.
Huang CJ, Yuan YF, Wu D, Khan FA, Jiao XF, Huo LJ
In vitro cellular & developmental biology. Animal53(3)258-264(2017 Mar)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Sororin actively maintains sister chromatid?cohesion.
Ladurner R, Kreidl E, Ivanov MP, Ekker H, Idarraga-Amado MH, Busslinger GA, Wutz G, Cisneros DA, Peters JM
The EMBO journal35(6)635-53(2016 Mar)

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J
Immunity43(4)690-702(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results define Sororin as a determinant during mouse oocyte meiotic maturation by favoring DNA damage repair and chromosome separation, and thereby, maintaining the genome stability and generating haploid gametes.
Title: The cohesion stabilizer sororin favors DNA repair and chromosome segregation during mouse oocyte meiosis.

The authors show that sororin is essential for embryonic development, cohesion maintenance, and proper chromosome segregation.
Title: Sororin actively maintains sister chromatid?cohesion.

The following Cdca5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdca5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15674	NM_026410.3 Latest version!	Mus musculus cell division cycle associated 5 (Cdca5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdca5 ( NM_026410.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080686.1 Mus musculus cell division cycle associated 5 (Cdca5), mRNA.

Price & Availability↑

CloneID	OMu15674
Clone ID Related Accession (Same CDS sequence)	NM_026410.3
Accession Version	NM_026410.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	sororin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC131692.5. On Apr 29, 2007 this sequence version replaced NM_026410.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK011701.1, BC052904.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGC GGCGAACACG ATCAGGAGGG GCTGCCCAGC GGTCTGGGCC CAGGACTTCA 
CTTACTAAGC CTTCGAAGTC GTCCAAGCGG AAATCTGGCT CAGATCTCCC GAACTCGTTC 
TCTGAAATCT GGCCGAGGAC AACTCCAGCG GTCCCAGTCA GAAAGGCCAT CGTCTTGAAG 
AAGATCGTAG CTCATGCAGT AGAGGTCCCA GATGTCCACA CGGTTCGAAG AAGTCCTAGG 
ATCTCTTTTA TTTTGGAAAA AGAGAACAAC CCTCCGCTCA AGGTACCCAC GAAAGAAGAC 
CTCTTCAAGA CTTGTAGTGT CCCTGGTACT CCCTCCAGCA CCCCCGTGCT GTACACTCAG 
AATGTTGAGC CTGACTCTGG AGAAGCAGAG CTGGACAGCA GAGACCTGGA AATGTCTCAG 
AAAGTCAGGC GGTCGTACAG TCGGCTACAG AGCCTTGGTT GTGCCTCAAC CTCCACCCCT 
GGCCGCCGAT CCTTCTTTGG CTTTGAGGGA CCTGACGACT TGCCTGGAGT CTCACCTGTC 
GTGTGTTCAA AGTTAATCGA GACCCCAAAG GTACCTGCAA AGGACTTGGT TCCGGCTAGA 
ACGAAGGACT TGGTTCCAGA TAGTACGAAG GACTTGGTTC CGGCTAGAAC GCTCCCTGGA 
ATCTCTCCCC CAGTTGTGAA AGAGAAACGA AAGAAGAAGG TTCCTGAAAT CCTGAAATCA 
GAGCTGGATA AGTGGGCTGT GGCCATGAAT GCTGAATTTG AAGCTGCCGA GCAGTTTGAG 
CTTCTGATTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080686.1
CDS	67..861
Translation	MAERRTRSGGAAQRSGPRTSLTKPSKSSKRKSGSDLPNSFSEIWPRTTPAVPVRKAIVLKKIVAHAVEVPDVHTVRRSPRISFILEKENNPPLKVPTKEDLFKTCSVPGTPSSTPVLYTQNVEPDSGEAELDSRDLEMSQKVRRSYSRLQSLGCASTSTPGRRSFFGFEGPDDLPGVSPVVCSKLIETPKVPAKDLVPARTKDLVPDSTKDLVPARTLPGISPPVVKEKRKKKVPEILKSELDKWAVAMNAEFEAAEQFELLIE

Target ORF information:

RefSeq Version	NM_026410.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cell division cycle associated 5 (Cdca5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026410.3

ORF Insert Sequence:

ATGGCGGAGC GGCGAACACG ATCAGGAGGG GCTGCCCAGC GGTCTGGGCC CAGGACTTCA 
CTTACTAAGC CTTCGAAGTC GTCCAAGCGG AAATCTGGCT CAGATCTCCC GAACTCGTTC 
TCTGAAATCT GGCCGAGGAC AACTCCAGCG GTCCCAGTCA GAAAGGCCAT CGTCTTGAAG 
AAGATCGTAG CTCATGCAGT AGAGGTCCCA GATGTCCACA CGGTTCGAAG AAGTCCTAGG 
ATCTCTTTTA TTTTGGAAAA AGAGAACAAC CCTCCGCTCA AGGTACCCAC GAAAGAAGAC 
CTCTTCAAGA CTTGTAGTGT CCCTGGTACT CCCTCCAGCA CCCCCGTGCT GTACACTCAG 
AATGTTGAGC CTGACTCTGG AGAAGCAGAG CTGGACAGCA GAGACCTGGA AATGTCTCAG 
AAAGTCAGGC GGTCGTACAG TCGGCTACAG AGCCTTGGTT GTGCCTCAAC CTCCACCCCT 
GGCCGCCGAT CCTTCTTTGG CTTTGAGGGA CCTGACGACT TGCCTGGAGT CTCACCTGTC 
GTGTGTTCAA AGTTAATCGA GACCCCAAAG GTACCTGCAA AGGACTTGGT TCCGGCTAGA 
ACGAAGGACT TGGTTCCAGA TAGTACGAAG GACTTGGTTC CGGCTAGAAC GCTCCCTGGA 
ATCTCTCCCC CAGTTGTGAA AGAGAAACGA AAGAAGAAGG TTCCTGAAAT CCTGAAATCA 
GAGCTGGATA AGTGGGCTGT GGCCATGAAT GCTGAATTTG AAGCTGCCGA GCAGTTTGAG 
CTTCTGATTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sororin is enriched at the central region of synapsed meiotic chromosomes.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology25(2)115-128(2017 Jun)
Jordan PW,Eyster C,Chen J,Pezza RJ,Rankin S

The cohesion stabilizer sororin favors DNA repair and chromosome segregation during mouse oocyte meiosis.
In vitro cellular & developmental biology. Animal53(3)258-264(2017 Mar)
Huang CJ,Yuan YF,Wu D,Khan FA,Jiao XF,Huo LJ

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Sororin actively maintains sister chromatid?cohesion.
The EMBO journal35(6)635-53(2016 Mar)
Ladurner R,Kreidl E,Ivanov MP,Ekker H,Idarraga-Amado MH,Busslinger GA,Wutz G,Cisneros DA,Peters JM

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Immunity43(4)690-702(2015 Oct)
Ray JP,Staron MM,Shyer JA,Ho PC,Marshall HD,Gray SM,Laidlaw BJ,Araki K,Ahmed R,Kaech SM,Craft J