Hypk cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hypk
Entrez Gene ID	67693
Full Name	huntingtin interacting protein K
Synonyms	2310003F16Rik,HSPC136
General protein information	Preferred Names huntingtin interacting protein K Names huntingtin-interacting protein K huntingtin yeast partner K
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 E5

mRNA and Protein(s)

mRNA	Protein	Name
NM_026318.3	NP_080594.2	huntingtin-interacting protein K

Pathways from BioSystems

Homologies

Homo sapiens (human)	HYPK	NP_057484.3
	HYPK	XP_002804793.1
Bos taurus (cattle)	C21H15orf63	NP_001193315.1
Gallus gallus (chicken)	HYPK	NP_001264583.1
Canis lupus familiaris (dog)	HYPK	XP_544652.3
Mus musculus (house mouse)	Hypk	NP_080594.2
Xenopus tropicalis (tropical clawed frog)	hypk	NP_001120475.1
Pan troglodytes (chimpanzee)	LOC745332	XP_003951231.1
Rattus norvegicus (Norway rat)	Hypk	XP_006234935.1
Danio rerio (zebrafish)	hypk	NP_001120942.1
Drosophila melanogaster (fruit fly)	CG9922	NP_001262556.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004606	XP_315218.4

Gene Ontology
Bibliography

Related articles in PubMed

Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease.
Das S, Bhattacharyya NP
Experimental cell research343(2)107-117(2016 05)

Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity.
Choudhury KR, Bhattacharyya NP
Biochemical and biophysical research communications456(1)66-73(2015 Jan)

Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.
Choudhury KR, Raychaudhuri S, Bhattacharyya NP
PloS one7(12)e51415(2012)

Identification of transcripts with enriched expression in the developing and adult pancreas.
Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD
Genome biology9(6)R99(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HYPK can act as negative regulator of heat shock response by repressing transcriptional activity of HSF1.
Title: Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease.

specific interaction of HYPK with HTT-N17 is crucial for the chaperone activity of HYPK
Title: Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity.

HYPK has roles in regulating cell growth, cell cycle, unfolded protein response and cell death
Title: Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.

The following Hypk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hypk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15378	NM_026318.3 Latest version!	Mus musculus huntingtin interacting protein K (Hypk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hypk ( NM_026318.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080594.2 Mus musculus huntingtin interacting protein K (Hypk), mRNA.

Price & Availability↑

CloneID	OMu15378
Clone ID Related Accession (Same CDS sequence)	NM_026318.3
Accession Version	NM_026318.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	huntingtin-interacting protein K
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY165803.1 and AI847440.1. On Apr 25, 2009 this sequence version replaced NM_026318.2. ##Evidence-Data-START## Transcript exon combination :: CF738229.1, BC038469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGCGGC GCGGTGAGAT CGAAATGGCG ACCGAGGGAG ACGTGGAGTT GGAGTTAGAG 
ACCGAGACCA GCGGCCCGGA GCGGCCTCCC GAGAAGCCAA GGAAACATGA CAGTGGTGCT 
GCTGACCTAG AGCGGGTTAC TGACTATGCG GAGGAGAAGG AGATCCAGAG TTCGAATCTT 
GAAACGGCTA TGTCCGTCAT TGGAGACAGA CGGTCCAGGG AACAAAAGGC CAAACAAGAG 
CGGGAGAAGG AACTGGCGAA GGTCACTATC AAGAAGGAAG ATCTGGAGTT GATAATGACG 
GAAATGGAGA TCTCTCGAGC AGCAGCAGAA AGGAGCTTGA GGGAACACAT GGGCAATGTG 
GTGGAGGCTC TTATTGCCCT AACCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080594.2
CDS	19..408
Translation	MRRRGEIEMATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALIALTN

Target ORF information:

RefSeq Version	NM_026318.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus huntingtin interacting protein K (Hypk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026318.3

ORF Insert Sequence:

ATGCGGCGGC GCGGTGAGAT CGAAATGGCG ACCGAGGGAG ACGTGGAGTT GGAGTTAGAG 
ACCGAGACCA GCGGCCCGGA GCGGCCTCCC GAGAAGCCAA GGAAACATGA CAGTGGTGCT 
GCTGACCTAG AGCGGGTTAC TGACTATGCG GAGGAGAAGG AGATCCAGAG TTCGAATCTT 
GAAACGGCTA TGTCCGTCAT TGGAGACAGA CGGTCCAGGG AACAAAAGGC CAAACAAGAG 
CGGGAGAAGG AACTGGCGAA GGTCACTATC AAGAAGGAAG ATCTGGAGTT GATAATGACG 
GAAATGGAGA TCTCTCGAGC AGCAGCAGAA AGGAGCTTGA GGGAACACAT GGGCAATGTG 
GTGGAGGCTC TTATTGCCCT AACCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease.
Experimental cell research343(2)107-117(2016 05)
Das S,Bhattacharyya NP

Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity.
Biochemical and biophysical research communications456(1)66-73(2015 Jan)
Choudhury KR,Bhattacharyya NP

Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.
PloS one7(12)e51415(2012)
Choudhury KR,Raychaudhuri S,Bhattacharyya NP

Identification of transcripts with enriched expression in the developing and adult pancreas.
Genome biology9(6)R99(2008)
Hoffman BG,Zavaglia B,Witzsche J,Ruiz de Algara T,Beach M,Hoodless PA,Jones SJ,Marra MA,Helgason CD