Bag4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bag4
Entrez Gene ID	67384
Full Name	BCL2-associated athanogene 4
Synonyms	2410112I15Rik,SODD
General protein information	Preferred Names BCL2-associated athanogene 4 Names BAG family molecular chaperone regulator 4 BAG-4 bcl-2-associated athanogene 4 silencer of death domains
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_026121.3	NP_080397.1	BAG family molecular chaperone regulator 4

Pathways from BioSystems

Homologies

	BAG4	XP_001092290.2
Bos taurus (cattle)	BAG4	NP_001104002.1
Homo sapiens (human)	BAG4	NP_004865.1
Canis lupus familiaris (dog)	BAG4	XP_849918.1
Mus musculus (house mouse)	Bag4	NP_080397.1
Xenopus tropicalis (tropical clawed frog)	bag4	XP_002932772.1
Rattus norvegicus (Norway rat)	Bag4	NP_001020301.1
Gallus gallus (chicken)	BAG4	XP_424388.4

Gene Ontology
Bibliography

Related articles in PubMed

Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA
The Journal of biological chemistry286(34)29758-70(2011 Aug)

Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ
Hepatology (Baltimore, Md.)44(1)252-62(2006 Jul)

A proteomics strategy for the enrichment of receptor-associated complexes.
Cross M, Nguyen T, Bogdanoska V, Reynolds E, Hamilton JA
Proteomics5(18)4754-63(2005 Dec)

Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.
Lau PP, Chan L
The Journal of biological chemistry278(52)52988-96(2003 Dec)

Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains.
Endres R, H?cker G, Brosch I, Pfeffer K
Molecular and cellular biology23(18)6609-17(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
Title: Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.

The proapoptotic proteins Bak (Bcl-2 antagonistic killer) and Bax (Bcl-2-associated X protein) were depleted in livers from TCPOBOP-treated CAR+/+ mice.
Title: Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

BAG-4 functions as a negative regulator for apobec-1-mediated apoB mRNA editing
Title: Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.

our data do not support the concept of a unique, nonredundant role of SODD for the functions of TNFR1, Hsp70, and DR3.
Title: Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains.

Results suggest that silencer of death domains protein (SODD) is critical for the regulation of tumor necrosis factor signaling.
Title: Role of SODD in regulation of tumor necrosis factor responses.

The following Bag4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bag4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01614	NM_026121.3 Latest version!	Mus musculus BCL2-associated athanogene 4 (Bag4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bag4 ( NM_026121.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080397.1 Mus musculus BCL2-associated athanogene 4 (Bag4), mRNA.

Price & Availability↑

CloneID	OMu01614
Clone ID Related Accession (Same CDS sequence)	NM_026121.3
Accession Version	NM_026121.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1374bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	BAG family molecular chaperone regulator 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC162367.5 and AC156990.11. On Oct 26, 2006 this sequence version replaced NM_026121.2. Sequence Note: This RefSeq record was created using sequence from the reference genome strain C57BL/6J because transcripts from the reference strain were not available for the full length of the gene. ##Evidence-Data-START## Transcript exon combination :: AK162658.1, SRR1660817.109569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GCCCTTCTTA CGGCCGCTAC 
TACGGGCCCG GGGGAGGCGA TGTCCCGGTG CACGTACCTC CGCCCTTATA CCCCCCTCTT 
CGTCCGGAGC CTCCCCAGCC TCCGGTTTCC TGGCGAGGGC GCGGGGGCGC CCCGGCCGAG 
ACCACCTGGC CGGGCGAAGG CGCAGGTGGC GATGGCTACT ACCCCTCGGG AGGCGCCTGG 
GCAGAAGCGA GCAGAGCCGG GGGAGGCCAC CAGGAACAGC CACCATATCC TGGCTATAAC 
TCCAACTACT GGAATTCTGT GCGACCCAGG GCTCCATACC CAGGCTCCTA CTCTGTGAGG 
CCAGAGTTAC AAGGCCAGAG CCTGAATTCT TATGCAAATG GAGCATATGG ACCGCCTTAC 
CCTCCTGGCC CTGGAGCAAG TACTGCCTCC TACTCTGGGG CTTACTATGT ACCTGGCTAT 
ACACAGAGCA ATTACTCCAC GGAAGTTCCA AACACCTACC GTTCACCTGG TAACAGCCCA 
ACTCCAATGT CTCGTTGGAT GTATTCCCAG CAGGACTGTC CAACAGAAGC ACCTCCTCTG 
AGGGGACAGG TGCCAGGATA TCCTGCTTCA CAGAACCCTG GAATGACCTT GCCCCATTAT 
CCTTATGGAG ATGGCAACCG CGCTGTGCCG CAGTCAGGAG GGACTGGACG ACCACAAGAC 
GATGCCTGGG CTTCCAGCGC TTATGGGATG GGAGCCCGTT ACCCCTGGCC TTCAGCTGCA 
CCCTCAGCCC CCTCGGCTGG GAGCCTGTAC ATGACGGAAA GTGCTTCACC GTGGCCAGGC 
AACAGTTCTC CTCAGCCGCC TCCTTCACCC CCACCTCAGC AGCCTAAGGA CCCCTCGTAC 
TCCTACAACC CATCGGGTCA AGGCCTGAGC CGGCACAGCT TTCCCTGCAG CGTCCATCAG 
TATGAATCTC CGGGAGCAGT GAACAATGAC AACTCAGACC TTTTGGATTC TCAAGTCCAG 
TATAGTGCTG AGCCTCAGTT ATATGGTAAT GCCAGCAGCG AGCATCCCAG CAACCAAGTT 
CCGAGTAATA ATCTCCCAGA AGAGTGTTTC TCTTCAGATG AGGGCACTCC TCCAAGTATT 
AAAAAGATCA TACATGTGCT GGAGAAGGTG CAGTTTCTTG AGCAAGAAGT AGAAGAGTTT 
GTAGGAAAAA AGACAGACAA AGCGTATTGG CTTCTGGAAG AAATGCTGAC AAAGGAACTT 
TTAGAACTGG ATTCTGTTGA AACTGGGGGC CAGGACTCTG TCCGTCAGGC CAGGAAAGAA 
GCTGTTTGTA AGATCCAGGC CATACTGGAA AAATTAGAAA AAAAGGGACT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080397.1
CDS	39..1412
Translation	MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHVPPPLYPPLRPEPPQPPVSWRGRGGAPAETTWPGEGAGGDGYYPSGGAWAEASRAGGGHQEQPPYPGYNSNYWNSVRPRAPYPGSYSVRPELQGQSLNSYANGAYGPPYPPGPGASTASYSGAYYVPGYTQSNYSTEVPNTYRSPGNSPTPMSRWMYSQQDCPTEAPPLRGQVPGYPASQNPGMTLPHYPYGDGNRAVPQSGGTGRPQDDAWASSAYGMGARYPWPSAAPSAPSAGSLYMTESASPWPGNSSPQPPPSPPPQQPKDPSYSYNPSGQGLSRHSFPCSVHQYESPGAVNNDNSDLLDSQVQYSAEPQLYGNASSEHPSNQVPSNNLPEECFSSDEGTPPSIKKIIHVLEKVQFLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL

Target ORF information:

RefSeq Version	NM_026121.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus BCL2-associated athanogene 4 (Bag4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026121.3

ORF Insert Sequence:

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GCCCTTCTTA CGGCCGCTAC 
TACGGGCCCG GGGGAGGCGA TGTCCCGGTG CACGTACCTC CGCCCTTATA CCCCCCTCTT 
CGTCCGGAGC CTCCCCAGCC TCCGGTTTCC TGGCGAGGGC GCGGGGGCGC CCCGGCCGAG 
ACCACCTGGC CGGGCGAAGG CGCAGGTGGC GATGGCTACT ACCCCTCGGG AGGCGCCTGG 
GCAGAAGCGA GCAGAGCCGG GGGAGGCCAC CAGGAACAGC CACCATATCC TGGCTATAAC 
TCCAACTACT GGAATTCTGT GCGACCCAGG GCTCCATACC CAGGCTCCTA CTCTGTGAGG 
CCAGAGTTAC AAGGCCAGAG CCTGAATTCT TATGCAAATG GAGCATATGG ACCGCCTTAC 
CCTCCTGGCC CTGGAGCAAG TACTGCCTCC TACTCTGGGG CTTACTATGT ACCTGGCTAT 
ACACAGAGCA ATTACTCCAC GGAAGTTCCA AACACCTACC GTTCACCTGG TAACAGCCCA 
ACTCCAATGT CTCGTTGGAT GTATTCCCAG CAGGACTGTC CAACAGAAGC ACCTCCTCTG 
AGGGGACAGG TGCCAGGATA TCCTGCTTCA CAGAACCCTG GAATGACCTT GCCCCATTAT 
CCTTATGGAG ATGGCAACCG CGCTGTGCCG CAGTCAGGAG GGACTGGACG ACCACAAGAC 
GATGCCTGGG CTTCCAGCGC TTATGGGATG GGAGCCCGTT ACCCCTGGCC TTCAGCTGCA 
CCCTCAGCCC CCTCGGCTGG GAGCCTGTAC ATGACGGAAA GTGCTTCACC GTGGCCAGGC 
AACAGTTCTC CTCAGCCGCC TCCTTCACCC CCACCTCAGC AGCCTAAGGA CCCCTCGTAC 
TCCTACAACC CATCGGGTCA AGGCCTGAGC CGGCACAGCT TTCCCTGCAG CGTCCATCAG 
TATGAATCTC CGGGAGCAGT GAACAATGAC AACTCAGACC TTTTGGATTC TCAAGTCCAG 
TATAGTGCTG AGCCTCAGTT ATATGGTAAT GCCAGCAGCG AGCATCCCAG CAACCAAGTT 
CCGAGTAATA ATCTCCCAGA AGAGTGTTTC TCTTCAGATG AGGGCACTCC TCCAAGTATT 
AAAAAGATCA TACATGTGCT GGAGAAGGTG CAGTTTCTTG AGCAAGAAGT AGAAGAGTTT 
GTAGGAAAAA AGACAGACAA AGCGTATTGG CTTCTGGAAG AAATGCTGAC AAAGGAACTT 
TTAGAACTGG ATTCTGTTGA AACTGGGGGC CAGGACTCTG TCCGTCAGGC CAGGAAAGAA 
GCTGTTTGTA AGATCCAGGC CATACTGGAA AAATTAGAAA AAAAGGGACT ATGA