Slc5a2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc5a2
Entrez Gene ID	246787
Full Name	solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms	Sglt2
General protein information	Preferred Names solute carrier family 5 (sodium/glucose cotransporter), member 2 Names sodium/glucose cotransporter 2 Na(+)/glucose cotransporter 2 low affinity sodium-dependent glucose cotransporter low affinity sodium-glucose cotransporter solute carrier family 5 member 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_133254.3	NP_573517.1	sodium/glucose cotransporter 2
NM_133254.4	NP_573517.1	sodium/glucose cotransporter 2
NM_133254.5	NP_573517.1	sodium/glucose cotransporter 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Slc5a2	NP_573517.1
Bos taurus (cattle)	SLC5A2	NP_976236.1
Rattus norvegicus (Norway rat)	Slc5a2	NP_072112.2
Pan troglodytes (chimpanzee)	SLC5A2	XP_003315117.1
	SLC5A2	XP_001113206.1
Danio rerio (zebrafish)	slc5a2	NP_998091.1
Xenopus tropicalis (tropical clawed frog)	slc5a2	XP_002940641.2
Homo sapiens (human)	SLC5A2	NP_003032.1
Canis lupus familiaris (dog)	SLC5A2	XP_005621284.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.
Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N
Biochemical and biophysical research communications493(1)40-45(2017 11)

Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B
The American journal of pathology187(7)1496-1511(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, it was concluded that the effect of SGLT2 inhibition on weight loss is in part mediated via the liver-brain-adipose neurocircuitry.
Title: Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.

SGLT-2 inhibition with dapagliflozin reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. Effects are augmentated of the by DPP4 inhibitor Saxagliptin.
Title: SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.

Tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, suppress albuminuria and tubulointerstitial injury in obese and type 2 diabetic mice. Inhibition of glucose entry into tubular cells by tofogliflozin may exert renoprotective properties in diabetes.
Title: Tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, suppresses renal damage in KKAy/Ta mice, obese and type 2 diabetic animals.

these results suggest that SGLT2i treatment acutely suppresses energy expenditure in BAT via regulation of an inter-organ neural network consisting of the common hepatic vagal branch and sympathetic nerves.
Title: Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice.

SGLT2 inhibition induced gluconeogenesis mainly in the kidney, whereas for low carbohydrate diet, it was predominantly in the liver.
Title: Sodium-Glucose Cotransporter 2 Inhibitor and a Low Carbohydrate Diet Affect Gluconeogenesis and Glycogen Content Differently in the Kidney and the Liver of Non-Diabetic Mice.

The following Slc5a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc5a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13413	NM_133254.5 Latest version!	Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$398.30 $569.00
View Old Accession Versions >>
OMu13413	NM_133254.3	Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$398.30 $569.00
OMu13413	NM_133254.4	Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$398.30 $569.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc5a2 ( NM_133254.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573517.1 Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.

Price & Availability↑

CloneID	OMu13413
Clone ID Related Accession (Same CDS sequence)	NM_133254.3 , NM_133254.4 , NM_133254.5
Accession Version	NM_133254.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Mus musculus(house mouse)
Product	sodium/glucose cotransporter 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC124566.5. On Mar 21, 2007 this sequence version replaced NM_133254.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022226.1, AK128900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTTAT CGCTGCCTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCCTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCAG GGACTGGCGC AGCAAGTGGC TTGGCGGTGG CTGGATTTGA GTGGAATGCG 
CTCTTCGTGG TGCTGCTCCT CGGATGGCTT TTTGTGCCAG TGTATCTGAC CGCTGGTGTG 
ATCACAATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC ACCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCTGGG 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCGGTCAT CGCTCTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCGGGTCT CTTCGACAAA TACCTGGGAG CAATGACTTC ACTGACGGTG 
TCCAAGGATC CATCTGTTGG CAACATCTCC AGCACCTGCT ACCAGCCGAG GCCTGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCAT GGCCTGCGCT GCTCCTGGGG 
CTTACCATTG TCTCGGGCTG GTATTGGTGC AGCGATCAGG TAATAGTGCA GCGGTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAAGCT GGGTGCATCT TGTGTGGCTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATCAGCC GCATTCTCTA CCCAGATGAG 
GTGGCATGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT CGTGGTGAAG CTCATGCCCA ATGGTCTGCG CGGACTCATG 
CTGGCAGTCA TGCTGGCTGC CCTCATGTCT TCTCTGGCAT CCATCTTTAA CAGCAGTAGC 
ACGCTCTTCA CCATGGATAT CTACACGCGC CTGCGGCCCC GTGCAGGTGA TAAGGAGCTG 
CTGCTAGTTG GAAGGCTCTG GGTGGTATTC ATCGTGGCGG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCTCAGGG TGGGCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAT 
CTGGCACCTC CAGTGTCTGC GGTCTTTGTG CTTGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGAGCCT TCTGGGGACT AGTTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCTCGGG CAGCTGTGTG CGACCCTCAG CGTGCCCGGC ACTCTTCTGT 
CGGGTACACT ACCTCTATTT CGCCATCATT CTCTTCATCT GCTCTGGCAT CCTCACACTT 
GGAATCTCCC TGTGCACTGC GCCCATCCCT CAGAAGCATC TCCATCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAC CTGGATGCTG ATGAGTTAGA AGGTCCAGCC 
CCTGCTCCTG TGCAGAACGG GGGCCAGGAA TGTGCAATGG AGATGGAAGA GGTCCAGTCC 
CCGGCTCCAG GCCTGCTCCG CCGGTGCCTG CTTTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCGCCCAC TACCGAGGAG GTGGCGGCAA CCACCAGGCG GCTGGAGGAC 
ATCAGTGAGG ATCCCCGCTG GGCACGAGTA GTCAACCTCA ATGCCCTACT CATGATGACC 
GTGGCTGTGT TCCTCTGGGG CTTCTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573517.1
CDS	1..2013
Translation	MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTLGISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQSPAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMTVAVFLWGFYA

Target ORF information:

RefSeq Version	NM_133254.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133254.3

ORF Insert Sequence:

ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTTAT CGCTGCCTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCCTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCAG GGACTGGCGC AGCAAGTGGC TTGGCGGTGG CTGGATTTGA GTGGAATGCG 
CTCTTCGTGG TGCTGCTCCT CGGATGGCTT TTTGTGCCAG TGTATCTGAC CGCTGGTGTG 
ATCACAATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC ACCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCTGGG 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCGGTCAT CGCTCTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCGGGTCT CTTCGACAAA TACCTGGGAG CAATGACTTC ACTGACGGTG 
TCCAAGGATC CATCTGTTGG CAACATCTCC AGCACCTGCT ACCAGCCGAG GCCTGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCAT GGCCTGCGCT GCTCCTGGGG 
CTTACCATTG TCTCGGGCTG GTATTGGTGC AGCGATCAGG TAATAGTGCA GCGGTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAAGCT GGGTGCATCT TGTGTGGCTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATCAGCC GCATTCTCTA CCCAGATGAG 
GTGGCATGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT CGTGGTGAAG CTCATGCCCA ATGGTCTGCG CGGACTCATG 
CTGGCAGTCA TGCTGGCTGC CCTCATGTCT TCTCTGGCAT CCATCTTTAA CAGCAGTAGC 
ACGCTCTTCA CCATGGATAT CTACACGCGC CTGCGGCCCC GTGCAGGTGA TAAGGAGCTG 
CTGCTAGTTG GAAGGCTCTG GGTGGTATTC ATCGTGGCGG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCTCAGGG TGGGCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAT 
CTGGCACCTC CAGTGTCTGC GGTCTTTGTG CTTGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGAGCCT TCTGGGGACT AGTTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCTCGGG CAGCTGTGTG CGACCCTCAG CGTGCCCGGC ACTCTTCTGT 
CGGGTACACT ACCTCTATTT CGCCATCATT CTCTTCATCT GCTCTGGCAT CCTCACACTT 
GGAATCTCCC TGTGCACTGC GCCCATCCCT CAGAAGCATC TCCATCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAC CTGGATGCTG ATGAGTTAGA AGGTCCAGCC 
CCTGCTCCTG TGCAGAACGG GGGCCAGGAA TGTGCAATGG AGATGGAAGA GGTCCAGTCC 
CCGGCTCCAG GCCTGCTCCG CCGGTGCCTG CTTTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCGCCCAC TACCGAGGAG GTGGCGGCAA CCACCAGGCG GCTGGAGGAC 
ATCAGTGAGG ATCCCCGCTG GGCACGAGTA GTCAACCTCA ATGCCCTACT CATGATGACC 
GTGGCTGTGT TCCTCTGGGG CTTCTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc5a2 ( NM_133254.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573517.1 Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.

Price & Availability↑

CloneID	OMu13413
Clone ID Related Accession (Same CDS sequence)	NM_133254.3 , NM_133254.4 , NM_133254.5
Accession Version	NM_133254.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-26
Organism	Mus musculus(house mouse)
Product	sodium/glucose cotransporter 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124566.5. On Jun 9, 2018 this sequence version replaced NM_133254.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128900.1, AY033886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTTAT CGCTGCCTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCCTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCAG GGACTGGCGC AGCAAGTGGC TTGGCGGTGG CTGGATTTGA GTGGAATGCG 
CTCTTCGTGG TGCTGCTCCT CGGATGGCTT TTTGTGCCAG TGTATCTGAC CGCTGGTGTG 
ATCACAATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC ACCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCTGGG 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCGGTCAT CGCTCTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCGGGTCT CTTCGACAAA TACCTGGGAG CAATGACTTC ACTGACGGTG 
TCCAAGGATC CATCTGTTGG CAACATCTCC AGCACCTGCT ACCAGCCGAG GCCTGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCAT GGCCTGCGCT GCTCCTGGGG 
CTTACCATTG TCTCGGGCTG GTATTGGTGC AGCGATCAGG TAATAGTGCA GCGGTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAAGCT GGGTGCATCT TGTGTGGCTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATCAGCC GCATTCTCTA CCCAGATGAG 
GTGGCATGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT CGTGGTGAAG CTCATGCCCA ATGGTCTGCG CGGACTCATG 
CTGGCAGTCA TGCTGGCTGC CCTCATGTCT TCTCTGGCAT CCATCTTTAA CAGCAGTAGC 
ACGCTCTTCA CCATGGATAT CTACACGCGC CTGCGGCCCC GTGCAGGTGA TAAGGAGCTG 
CTGCTAGTTG GAAGGCTCTG GGTGGTATTC ATCGTGGCGG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCTCAGGG TGGGCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAT 
CTGGCACCTC CAGTGTCTGC GGTCTTTGTG CTTGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGAGCCT TCTGGGGACT AGTTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCTCGGG CAGCTGTGTG CGACCCTCAG CGTGCCCGGC ACTCTTCTGT 
CGGGTACACT ACCTCTATTT CGCCATCATT CTCTTCATCT GCTCTGGCAT CCTCACACTT 
GGAATCTCCC TGTGCACTGC GCCCATCCCT CAGAAGCATC TCCATCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAC CTGGATGCTG ATGAGTTAGA AGGTCCAGCC 
CCTGCTCCTG TGCAGAACGG GGGCCAGGAA TGTGCAATGG AGATGGAAGA GGTCCAGTCC 
CCGGCTCCAG GCCTGCTCCG CCGGTGCCTG CTTTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCGCCCAC TACCGAGGAG GTGGCGGCAA CCACCAGGCG GCTGGAGGAC 
ATCAGTGAGG ATCCCCGCTG GGCACGAGTA GTCAACCTCA ATGCCCTACT CATGATGACC 
GTGGCTGTGT TCCTCTGGGG CTTCTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573517.1
CDS	15..2027
Translation	MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTLGISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQSPAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMTVAVFLWGFYA

Target ORF information:

RefSeq Version	NM_133254.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133254.4

ORF Insert Sequence:

ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTTAT CGCTGCCTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCCTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCAG GGACTGGCGC AGCAAGTGGC TTGGCGGTGG CTGGATTTGA GTGGAATGCG 
CTCTTCGTGG TGCTGCTCCT CGGATGGCTT TTTGTGCCAG TGTATCTGAC CGCTGGTGTG 
ATCACAATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC ACCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCTGGG 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCGGTCAT CGCTCTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCGGGTCT CTTCGACAAA TACCTGGGAG CAATGACTTC ACTGACGGTG 
TCCAAGGATC CATCTGTTGG CAACATCTCC AGCACCTGCT ACCAGCCGAG GCCTGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCAT GGCCTGCGCT GCTCCTGGGG 
CTTACCATTG TCTCGGGCTG GTATTGGTGC AGCGATCAGG TAATAGTGCA GCGGTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAAGCT GGGTGCATCT TGTGTGGCTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATCAGCC GCATTCTCTA CCCAGATGAG 
GTGGCATGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT CGTGGTGAAG CTCATGCCCA ATGGTCTGCG CGGACTCATG 
CTGGCAGTCA TGCTGGCTGC CCTCATGTCT TCTCTGGCAT CCATCTTTAA CAGCAGTAGC 
ACGCTCTTCA CCATGGATAT CTACACGCGC CTGCGGCCCC GTGCAGGTGA TAAGGAGCTG 
CTGCTAGTTG GAAGGCTCTG GGTGGTATTC ATCGTGGCGG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCTCAGGG TGGGCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAT 
CTGGCACCTC CAGTGTCTGC GGTCTTTGTG CTTGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGAGCCT TCTGGGGACT AGTTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCTCGGG CAGCTGTGTG CGACCCTCAG CGTGCCCGGC ACTCTTCTGT 
CGGGTACACT ACCTCTATTT CGCCATCATT CTCTTCATCT GCTCTGGCAT CCTCACACTT 
GGAATCTCCC TGTGCACTGC GCCCATCCCT CAGAAGCATC TCCATCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAC CTGGATGCTG ATGAGTTAGA AGGTCCAGCC 
CCTGCTCCTG TGCAGAACGG GGGCCAGGAA TGTGCAATGG AGATGGAAGA GGTCCAGTCC 
CCGGCTCCAG GCCTGCTCCG CCGGTGCCTG CTTTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCGCCCAC TACCGAGGAG GTGGCGGCAA CCACCAGGCG GCTGGAGGAC 
ATCAGTGAGG ATCCCCGCTG GGCACGAGTA GTCAACCTCA ATGCCCTACT CATGATGACC 
GTGGCTGTGT TCCTCTGGGG CTTCTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc5a2 ( NM_133254.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573517.1 Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.

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CloneID	OMu13413
Clone ID Related Accession (Same CDS sequence)	NM_133254.3 , NM_133254.4 , NM_133254.5
Accession Version	NM_133254.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Mus musculus(house mouse)
Product	sodium/glucose cotransporter 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124566.5. On Jun 17, 2019 this sequence version replaced NM_133254.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128900.1, BC022226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTTAT CGCTGCCTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCCTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCAG GGACTGGCGC AGCAAGTGGC TTGGCGGTGG CTGGATTTGA GTGGAATGCG 
CTCTTCGTGG TGCTGCTCCT CGGATGGCTT TTTGTGCCAG TGTATCTGAC CGCTGGTGTG 
ATCACAATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC ACCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCTGGG 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCGGTCAT CGCTCTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCGGGTCT CTTCGACAAA TACCTGGGAG CAATGACTTC ACTGACGGTG 
TCCAAGGATC CATCTGTTGG CAACATCTCC AGCACCTGCT ACCAGCCGAG GCCTGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCAT GGCCTGCGCT GCTCCTGGGG 
CTTACCATTG TCTCGGGCTG GTATTGGTGC AGCGATCAGG TAATAGTGCA GCGGTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAAGCT GGGTGCATCT TGTGTGGCTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATCAGCC GCATTCTCTA CCCAGATGAG 
GTGGCATGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT CGTGGTGAAG CTCATGCCCA ATGGTCTGCG CGGACTCATG 
CTGGCAGTCA TGCTGGCTGC CCTCATGTCT TCTCTGGCAT CCATCTTTAA CAGCAGTAGC 
ACGCTCTTCA CCATGGATAT CTACACGCGC CTGCGGCCCC GTGCAGGTGA TAAGGAGCTG 
CTGCTAGTTG GAAGGCTCTG GGTGGTATTC ATCGTGGCGG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCTCAGGG TGGGCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAT 
CTGGCACCTC CAGTGTCTGC GGTCTTTGTG CTTGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGAGCCT TCTGGGGACT AGTTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCTCGGG CAGCTGTGTG CGACCCTCAG CGTGCCCGGC ACTCTTCTGT 
CGGGTACACT ACCTCTATTT CGCCATCATT CTCTTCATCT GCTCTGGCAT CCTCACACTT 
GGAATCTCCC TGTGCACTGC GCCCATCCCT CAGAAGCATC TCCATCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAC CTGGATGCTG ATGAGTTAGA AGGTCCAGCC 
CCTGCTCCTG TGCAGAACGG GGGCCAGGAA TGTGCAATGG AGATGGAAGA GGTCCAGTCC 
CCGGCTCCAG GCCTGCTCCG CCGGTGCCTG CTTTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCGCCCAC TACCGAGGAG GTGGCGGCAA CCACCAGGCG GCTGGAGGAC 
ATCAGTGAGG ATCCCCGCTG GGCACGAGTA GTCAACCTCA ATGCCCTACT CATGATGACC 
GTGGCTGTGT TCCTCTGGGG CTTCTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573517.1
CDS	15..2027
Translation	MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTLGISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQSPAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMTVAVFLWGFYA

Target ORF information:

RefSeq Version	NM_133254.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133254.5

ORF Insert Sequence:

ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTTAT CGCTGCCTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCCTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCAG GGACTGGCGC AGCAAGTGGC TTGGCGGTGG CTGGATTTGA GTGGAATGCG 
CTCTTCGTGG TGCTGCTCCT CGGATGGCTT TTTGTGCCAG TGTATCTGAC CGCTGGTGTG 
ATCACAATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC ACCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCTGGG 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCGGTCAT CGCTCTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCGGGTCT CTTCGACAAA TACCTGGGAG CAATGACTTC ACTGACGGTG 
TCCAAGGATC CATCTGTTGG CAACATCTCC AGCACCTGCT ACCAGCCGAG GCCTGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCAT GGCCTGCGCT GCTCCTGGGG 
CTTACCATTG TCTCGGGCTG GTATTGGTGC AGCGATCAGG TAATAGTGCA GCGGTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAAGCT GGGTGCATCT TGTGTGGCTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATCAGCC GCATTCTCTA CCCAGATGAG 
GTGGCATGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT CGTGGTGAAG CTCATGCCCA ATGGTCTGCG CGGACTCATG 
CTGGCAGTCA TGCTGGCTGC CCTCATGTCT TCTCTGGCAT CCATCTTTAA CAGCAGTAGC 
ACGCTCTTCA CCATGGATAT CTACACGCGC CTGCGGCCCC GTGCAGGTGA TAAGGAGCTG 
CTGCTAGTTG GAAGGCTCTG GGTGGTATTC ATCGTGGCGG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCTCAGGG TGGGCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAT 
CTGGCACCTC CAGTGTCTGC GGTCTTTGTG CTTGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGAGCCT TCTGGGGACT AGTTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCTCGGG CAGCTGTGTG CGACCCTCAG CGTGCCCGGC ACTCTTCTGT 
CGGGTACACT ACCTCTATTT CGCCATCATT CTCTTCATCT GCTCTGGCAT CCTCACACTT 
GGAATCTCCC TGTGCACTGC GCCCATCCCT CAGAAGCATC TCCATCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAC CTGGATGCTG ATGAGTTAGA AGGTCCAGCC 
CCTGCTCCTG TGCAGAACGG GGGCCAGGAA TGTGCAATGG AGATGGAAGA GGTCCAGTCC 
CCGGCTCCAG GCCTGCTCCG CCGGTGCCTG CTTTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCGCCCAC TACCGAGGAG GTGGCGGCAA CCACCAGGCG GCTGGAGGAC 
ATCAGTGAGG ATCCCCGCTG GGCACGAGTA GTCAACCTCA ATGCCCTACT CATGATGACC 
GTGGCTGTGT TCCTCTGGGG CTTCTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.
Biochemical and biophysical research communications493(1)40-45(2017 11)
Sawada Y,Izumida Y,Takeuchi Y,Aita Y,Wada N,Li E,Murayama Y,Piao X,Shikama A,Masuda Y,Nishi-Tatsumi M,Kubota M,Sekiya M,Matsuzaka T,Nakagawa Y,Sugano Y,Iwasaki H,Kobayashi K,Yatoh S,Suzuki H,Yagyu H,Kawakami Y,Kadowaki T,Shimano H,Yahagi N

Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
The American journal of pathology187(7)1496-1511(2017 Jul)
Gerl K,Steppan D,Fuchs M,Wagner C,Willam C,Kurtz A,Kurt B

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Slc5a2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

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