Adamts4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adamts4
Entrez Gene ID	240913
Full Name	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
Synonyms	ADAM-TS4,ADAMTS-2,ADMP-1
General protein information	Preferred Names a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 Names A disintegrin and metalloproteinase with thrombospondin motifs 4 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 aggrecanase-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H3\|1 79.28 cM
Summary	This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172845.2	NP_766433.1	A disintegrin and metalloproteinase with thrombospondin motifs 4
NM_172845.3	NP_766433.2	A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ADAMTS4	XP_513940.2
Canis lupus familiaris (dog)	ADAMTS4	XP_545768.3
Xenopus tropicalis (tropical clawed frog)	adamts4	XP_004919795.1
Rattus norvegicus (Norway rat)	Adamts4	NP_076449.1
Homo sapiens (human)	ADAMTS4	NP_005090.3
	ADAMTS4	XP_002808295.1
Bos taurus (cattle)	ADAMTS4	NP_858053.1
Mus musculus (house mouse)	Adamts4	NP_766433.1

Gene Ontology
Bibliography

Related articles in PubMed

Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhang L, Wu D, Zhang C, Curci JA, Coselli JS, Milewicz DM, LeMaire SA, Shen YH
Scientific reports7(1)12351(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues
Title: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.

Results show that ADAMTS15 and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
Title: Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex.

aggrecan and brevican proteolysis is compensated in Adamts4-/- or Adamts5-/- mice by ADAMTS proteoglycanase family members but a threshold of versican proteolysis is sensitive to the loss of a single ADAMTS proteoglycanase during spinal cord injury
Title: ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.

ADAMTS4 has roles in melanoma growth and angiogenesis in mice
Title: ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.

The serine protease tissue plasminogen activator (tPA) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5, were identified as Reelin cleaving enzymes.
Title: Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators.

The following Adamts4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adamts4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu83512	NM_172845.3 Latest version!	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$475.30 $679.00
OMu04151	NM_172845.2 Latest version!	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$496.30 $709.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adamts4 ( NM_172845.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766433.2 Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), mRNA.

Price & Availability↑

CloneID	OMu83512
Clone ID Related Accession (Same CDS sequence)	NM_172845.3
Accession Version	NM_172845.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2502bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084821.26 and AK083534.1. On Jul 13, 2016 this sequence version replaced NM_172845.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.23608.1, SRR1660813.225470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END##

ATGTCCCAGA TGGGCTTGCA TCCCAGGAGG GGCTTGACTG GGCACTGGCT GCAAAGATTC 
CAACCCTGCT TGCCGCTTCA CACTGTGCAG TGGCGGAGGC TGCTGCTGCT GGCCTTCCTC 
CTGTCCTTAG CGTGGCCCGC CAGCCCCCTC CCCCGGGAGG AGGAGATCGT GTTTCCAGAG 
AAGCTCAATG GCAGTAGCAT CCTACCTGGA TCAGGCGTTC CTGCCAGGCT GCTGTACCGA 
TTGCCAGCCT TTGGGGAGAT GTTGCTACTA GAACTAGAAC AGGACCCTGG GGTGCAGGTA 
GAGGGTTTGA CTGTACAGTA CCTGGGCCAG GCACCTGAGA TGCTGGGTGG GGCAGAGCCA 
GGTACCTACC TGACTGGCAC CATCAATGGA GATCCGGAGT CGGTGGCATC TCTGCACTGG 
GACGGGGGAG CCCTATTAGG GGTACTGCAG TACCGTGGGG CCGAACTCCA CCTCCAGCCT 
CTGGAAGGAG GCGCCCTTAA CTCTGCTGGG GGACCGGGGG CTCACATCCT ACGCCGGAAG 
AGTCCTGCCA GCAGCCAAGG TCCCATGTGC ACCGTCAAGG CTCCTTCTGG GAGCCCGAGT 
CCCATTTCCC GCAGAACCAA GCGCTTCGCT TCTCTGAGTA GATTCGTGGA GACACTGGTG 
GTAGCAGATG ACAAGATGGC AGCATTCCAT GGTACAGGGT TAAAGCGCTA CCTGCTGACG 
GTTATGGCAG CTGCCGCTAA AGCCTTTAAA CACCCAAGCA TCCGAAACCC TGTCAACTTG 
GTGGTGACGC GCCTGGTGAT CCTGGGGTCC GGCCAGGAAG GGCCCCAAGT GGGGCCAAGT 
GCCGCCCAGA CCCTACGCAG CTTCTGCACC TGGCAGCGGG GCCTCAACAC CCCTAACGAC 
TCAGATCCTG ACCACTTTGA CACAGCCATT CTGTTCACCC GGCAGGACCT GTGTGGGGTC 
TCCACTTGTG ACACCCTGGG TATGGCTGAT GTGGGCACAG TGTGTGATCC AGCTAGGAGC 
TGTGCTATTG TGGAAGATGA TGGGCTCCAG TCAGCCTTCA CTGCTGCTCA TGAACTGGGC 
CATGTCTTCA ACATGCTCCA TGATAACTCC AAGCCATGCA CTAACTTGAA TGGGCAGGGG 
GGTTCCTCTC GCCATGTCAT GGCTCCTGTC ATGGCCCATG TGGACCCTGA AGAGCCCTGG 
TCGCCCTGCA GTGCCCGATT CATCACTGAC TTCCTGGACA ATGGTTATGG GCACTGCCTC 
TTAGACAAAC CGGAGGCTCC CCTCCATCTA CCAGCGACTT TTCCTGGCAA GGACTATGAC 
GCTGACCGCC AATGCCAACT GACCTTCGGT CCTGACTCAA GCCATTGTCC ACAGCTGCCA 
CCGCCCTGTG CTGCCCTCTG GTGCTCTGGC CACCTCAATG GCCATGCCAT GTGCCAGACG 
AAGCACTCAC CTTGGGCTGA TGGCACTCCC TGCGGGTCTT CACAGGCCTG CATGGGTGGC 
CGCTGTCTGC ACGTGGACCA GCTCAAGGAC TTCAATGTTC CTCAGGCTGG AGGCTGGGGC 
CCCTGGGGAC CATGGGGTGA CTGCTCCAGG ACTTGTGGGG GTGGTGTCCA GTTCTCCTCC 
CGGGATTGCA CGAGGCCCGT CCCCCGGAAC GGTGGCAAGT ATTGTGAGGG CCGCCGGACT 
CGCTTCCGCT CCTGCAACAC GGAGAACTGC CCACACGGCT CAGCATTGAC CTTCCGTGAA 
GAGCAGTGTG CTGCCTACAA CCACCGAACC GACCTCTTCA AGAGCTTTCC AGGGCCCATG 
GACTGGGTTC CGCGCTACAC AGGTGTGGCC CCTCGAGACC AATGCAAACT CACCTGCCAG 
GCCCGGGCAC TGGGCTACTA CTACGTATTG GAGCCCCGGG TGGCAGATGG GACTCCCTGC 
TCCCCAGACA CCTCCTCTGT CTGTGTCCAG GGCCGCTGTA TCCATGCTGG CTGTGACCGG 
ATCATTGGCT CCAAAAAGAA ATTTGACAAG TGCATGGTGT GCGGCGGGGA TGGCTCTCGC 
TGCAGCAAGC AGTCGGGCTC CTTCAAAAAA TTCAGGTATG GATACAGCGA TGTGGTCACG 
ATCCCTGCGG GGGCCACCCA TATCCTTGTA CGGCAGCAGG GGGGGTCTGG TCTCAAGAGC 
ATCTACCTGG CCCTGAAGCT TTCTGACGGT TCTTACGCCC TCAATGGTGA ATACACGCTG 
ATGCCCTCCC CAACAGATGT GGTTCTTCCT GGGGCAGTCA GCTTGCGCTA CAGCGGAGCC 
ACAGCAGCCT CAGAGACACT GTCTGGACAT GGGCCGCTGG CCCAGCCCTT GACGCTGCAA 
GTCCTGGTGG CTGGCAACCC ACAGAATGCA CGTCTGCGGT ACAGTTTCTT TGTCCCGCGG 
CCAGTCCCTT CAACACCACG CCCTCCTCCC CAAGACTGGC TGCAACGCAG GGCAGAGATA 
CTGAAGATCC TTCGGAAGCG TCCCTGGGCA GGCCGGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766433.2
CDS	721..3222
Translation	MSQMGLHPRRGLTGHWLQRFQPCLPLHTVQWRRLLLLAFLLSLAWPASPLPREEEIVFPEKLNGSSILPGSGVPARLLYRLPAFGEMLLLELEQDPGVQVEGLTVQYLGQAPEMLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGALNSAGGPGAHILRRKSPASSQGPMCTVKAPSGSPSPISRRTKRFASLSRFVETLVVADDKMAAFHGTGLKRYLLTVMAAAAKAFKHPSIRNPVNLVVTRLVILGSGQEGPQVGPSAAQTLRSFCTWQRGLNTPNDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCTNLNGQGGSSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPATFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGSSQACMGGRCLHVDQLKDFNVPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTENCPHGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCSPDTSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSRCSKQSGSFKKFRYGYSDVVTIPAGATHILVRQQGGSGLKSIYLALKLSDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQNARLRYSFFVPRPVPSTPRPPPQDWLQRRAEILKILRKRPWAGRK

Target ORF information:

RefSeq Version	NM_172845.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172845.3

ORF Insert Sequence:

ATGTCCCAGA TGGGCTTGCA TCCCAGGAGG GGCTTGACTG GGCACTGGCT GCAAAGATTC 
CAACCCTGCT TGCCGCTTCA CACTGTGCAG TGGCGGAGGC TGCTGCTGCT GGCCTTCCTC 
CTGTCCTTAG CGTGGCCCGC CAGCCCCCTC CCCCGGGAGG AGGAGATCGT GTTTCCAGAG 
AAGCTCAATG GCAGTAGCAT CCTACCTGGA TCAGGCGTTC CTGCCAGGCT GCTGTACCGA 
TTGCCAGCCT TTGGGGAGAT GTTGCTACTA GAACTAGAAC AGGACCCTGG GGTGCAGGTA 
GAGGGTTTGA CTGTACAGTA CCTGGGCCAG GCACCTGAGA TGCTGGGTGG GGCAGAGCCA 
GGTACCTACC TGACTGGCAC CATCAATGGA GATCCGGAGT CGGTGGCATC TCTGCACTGG 
GACGGGGGAG CCCTATTAGG GGTACTGCAG TACCGTGGGG CCGAACTCCA CCTCCAGCCT 
CTGGAAGGAG GCGCCCTTAA CTCTGCTGGG GGACCGGGGG CTCACATCCT ACGCCGGAAG 
AGTCCTGCCA GCAGCCAAGG TCCCATGTGC ACCGTCAAGG CTCCTTCTGG GAGCCCGAGT 
CCCATTTCCC GCAGAACCAA GCGCTTCGCT TCTCTGAGTA GATTCGTGGA GACACTGGTG 
GTAGCAGATG ACAAGATGGC AGCATTCCAT GGTACAGGGT TAAAGCGCTA CCTGCTGACG 
GTTATGGCAG CTGCCGCTAA AGCCTTTAAA CACCCAAGCA TCCGAAACCC TGTCAACTTG 
GTGGTGACGC GCCTGGTGAT CCTGGGGTCC GGCCAGGAAG GGCCCCAAGT GGGGCCAAGT 
GCCGCCCAGA CCCTACGCAG CTTCTGCACC TGGCAGCGGG GCCTCAACAC CCCTAACGAC 
TCAGATCCTG ACCACTTTGA CACAGCCATT CTGTTCACCC GGCAGGACCT GTGTGGGGTC 
TCCACTTGTG ACACCCTGGG TATGGCTGAT GTGGGCACAG TGTGTGATCC AGCTAGGAGC 
TGTGCTATTG TGGAAGATGA TGGGCTCCAG TCAGCCTTCA CTGCTGCTCA TGAACTGGGC 
CATGTCTTCA ACATGCTCCA TGATAACTCC AAGCCATGCA CTAACTTGAA TGGGCAGGGG 
GGTTCCTCTC GCCATGTCAT GGCTCCTGTC ATGGCCCATG TGGACCCTGA AGAGCCCTGG 
TCGCCCTGCA GTGCCCGATT CATCACTGAC TTCCTGGACA ATGGTTATGG GCACTGCCTC 
TTAGACAAAC CGGAGGCTCC CCTCCATCTA CCAGCGACTT TTCCTGGCAA GGACTATGAC 
GCTGACCGCC AATGCCAACT GACCTTCGGT CCTGACTCAA GCCATTGTCC ACAGCTGCCA 
CCGCCCTGTG CTGCCCTCTG GTGCTCTGGC CACCTCAATG GCCATGCCAT GTGCCAGACG 
AAGCACTCAC CTTGGGCTGA TGGCACTCCC TGCGGGTCTT CACAGGCCTG CATGGGTGGC 
CGCTGTCTGC ACGTGGACCA GCTCAAGGAC TTCAATGTTC CTCAGGCTGG AGGCTGGGGC 
CCCTGGGGAC CATGGGGTGA CTGCTCCAGG ACTTGTGGGG GTGGTGTCCA GTTCTCCTCC 
CGGGATTGCA CGAGGCCCGT CCCCCGGAAC GGTGGCAAGT ATTGTGAGGG CCGCCGGACT 
CGCTTCCGCT CCTGCAACAC GGAGAACTGC CCACACGGCT CAGCATTGAC CTTCCGTGAA 
GAGCAGTGTG CTGCCTACAA CCACCGAACC GACCTCTTCA AGAGCTTTCC AGGGCCCATG 
GACTGGGTTC CGCGCTACAC AGGTGTGGCC CCTCGAGACC AATGCAAACT CACCTGCCAG 
GCCCGGGCAC TGGGCTACTA CTACGTATTG GAGCCCCGGG TGGCAGATGG GACTCCCTGC 
TCCCCAGACA CCTCCTCTGT CTGTGTCCAG GGCCGCTGTA TCCATGCTGG CTGTGACCGG 
ATCATTGGCT CCAAAAAGAA ATTTGACAAG TGCATGGTGT GCGGCGGGGA TGGCTCTCGC 
TGCAGCAAGC AGTCGGGCTC CTTCAAAAAA TTCAGGTATG GATACAGCGA TGTGGTCACG 
ATCCCTGCGG GGGCCACCCA TATCCTTGTA CGGCAGCAGG GGGGGTCTGG TCTCAAGAGC 
ATCTACCTGG CCCTGAAGCT TTCTGACGGT TCTTACGCCC TCAATGGTGA ATACACGCTG 
ATGCCCTCCC CAACAGATGT GGTTCTTCCT GGGGCAGTCA GCTTGCGCTA CAGCGGAGCC 
ACAGCAGCCT CAGAGACACT GTCTGGACAT GGGCCGCTGG CCCAGCCCTT GACGCTGCAA 
GTCCTGGTGG CTGGCAACCC ACAGAATGCA CGTCTGCGGT ACAGTTTCTT TGTCCCGCGG 
CCAGTCCCTT CAACACCACG CCCTCCTCCC CAAGACTGGC TGCAACGCAG GGCAGAGATA 
CTGAAGATCC TTCGGAAGCG TCCCTGGGCA GGCCGGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Adamts4 ( NM_172845.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766433.1 Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), mRNA.

Price & Availability↑

CloneID	OMu04151
Clone ID Related Accession (Same CDS sequence)	NM_172845.2
Accession Version	NM_172845.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2538bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 4
Comment

ATGGCCTCAA TCCATCCCAG CTGCAGCCCG GGTACCATGT CCCAGATGGG CTTGCATCCC 
AGGAGGGGCT TGACTGGGCA CTGGCTGCAA AGATTCCAAC CCTGCTTGCC GCTTCACACT 
GTGCAGTGGC GGAGGCTGCT GCTGCTGGCC TTCCTCCTGT CCTTAGCGTG GCCCGCCAGC 
CCCCTCCCCC GGGAGGAGGA GATCGTGTTT CCAGAGAAGC TCAATGGCAG TAGCATCCTA 
CCTGGATCAG GCGTTCCTGC CAGGCTGCTG TACCGATTGC CAGCCTTTGG GGAGATGTTG 
CTACTAGAAC TAGAACAGGA CCCTGGGGTG CAGGTAGAGG GTTTGACTGT ACAGTACCTG 
GGCCAGGCAC CTGAGATGCT GGGTGGGGCA GAGCCAGGTA CCTACCTGAC TGGCACCATC 
AATGGAGATC CGGAGTCGGT GGCATCTCTG CACTGGGACG GGGGAGCCCT ATTAGGGGTA 
CTGCAGTACC GTGGGGCCGA ACTCCACCTC CAGCCTCTGG AAGGAGGCGC CCTTAACTCT 
GCTGGGGGAC CGGGGGCTCA CATCCTACGC CGGAAGAGTC CTGCCAGCAG CCAAGGTCCC 
ATGTGCACCG TCAAGGCTCC TTCTGGGAGC CCGAGTCCCA TTTCCCGCAG AACCAAGCGC 
TTCGCTTCTC TGAGTAGATT CGTGGAGACA CTGGTGGTAG CAGATGACAA GATGGCAGCA 
TTCCATGGTA CAGGGTTAAA GCGCTACCTG CTGACGGTTA TGGCAGCTGC CGCTAAAGCC 
TTTAAACACC CAAGCATCCG AAACCCTGTC AACTTGGTGG TGACGCGCCT GGTGATCCTG 
GGGTCCGGCC AGGAAGGGCC CCAAGTGGGG CCAAGTGCCG CCCAGACCCT ACGCAGCTTC 
TGCACCTGGC AGCGGGGCCT CAACACCCCT AACGACTCAG ATCCTGACCA CTTTGACACA 
GCCATTCTGT TCACCCGGCA GGACCTGTGT GGGGTCTCCA CTTGTGACAC CCTGGGTATG 
GCTGATGTGG GCACAGTGTG TGATCCAGCT AGGAGCTGTG CTATTGTGGA AGATGATGGG 
CTCCAGTCAG CCTTCACTGC TGCTCATGAA CTGGGCCATG TCTTCAACAT GCTCCATGAT 
AACTCCAAGC CATGCACTAA CTTGAATGGG CAGGGGGGTT CCTCTCGCCA TGTCATGGCT 
CCTGTCATGG CCCATGTGGA CCCTGAAGAG CCCTGGTCGC CCTGCAGTGC CCGATTCATC 
ACTGACTTCC TGGACAATGG TTATGGGCAC TGCCTCTTAG ACAAACCGGA GGCTCCCCTC 
CATCTACCAG CGACTTTTCC TGGCAAGGAC TATGACGCTG ACCGCCAATG CCAACTGACC 
TTCGGTCCTG ACTCAAGCCA TTGTCCACAG CTGCCACCGC CCTGTGCTGC CCTCTGGTGC 
TCTGGCCACC TCAATGGCCA TGCCATGTGC CAGACGAAGC ACTCACCTTG GGCTGATGGC 
ACTCCCTGCG GGTCTTCACA GGCCTGCATG GGTGGCCGCT GTCTGCACGT GGACCAGCTC 
AAGGACTTCA ATGTTCCTCA GGCTGGAGGC TGGGGCCCCT GGGGACCATG GGGTGACTGC 
TCCAGGACTT GTGGGGGTGG TGTCCAGTTC TCCTCCCGGG ATTGCACGAG GCCCGTCCCC 
CGGAACGGTG GCAAGTATTG TGAGGGCCGC CGGACTCGCT TCCGCTCCTG CAACACGGAG 
AACTGCCCAC ACGGCTCAGC ATTGACCTTC CGTGAAGAGC AGTGTGCTGC CTACAACCAC 
CGAACCGACC TCTTCAAGAG CTTTCCAGGG CCCATGGACT GGGTTCCGCG CTACACAGGT 
GTGGCCCCTC GAGACCAATG CAAACTCACC TGCCAGGCCC GGGCACTGGG CTACTACTAC 
GTATTGGAGC CCCGGGTGGC AGATGGGACT CCCTGCTCCC CAGACACCTC CTCTGTCTGT 
GTCCAGGGCC GCTGTATCCA TGCTGGCTGT GACCGGATCA TTGGCTCCAA AAAGAAATTT 
GACAAGTGCA TGGTGTGCGG CGGGGATGGC TCTCGCTGCA GCAAGCAGTC GGGCTCCTTC 
AAAAAATTCA GGTATGGATA CAGCGATGTG GTCACGATCC CTGCGGGGGC CACCCATATC 
CTTGTACGGC AGCAGGGGGG GTCTGGTCTC AAGAGCATCT ACCTGGCCCT GAAGCTTTCT 
GACGGTTCTT ACGCCCTCAA TGGTGAATAC ACGCTGATGC CCTCCCCAAC AGATGTGGTT 
CTTCCTGGGG CAGTCAGCTT GCGCTACAGC GGAGCCACAG CAGCCTCAGA GACACTGTCT 
GGACATGGGC CGCTGGCCCA GCCCTTGACG CTGCAAGTCC TGGTGGCTGG CAACCCACAG 
AATGCACGTC TGCGGTACAG TTTCTTTGTC CCGCGGCCAG TCCCTTCAAC ACCACGCCCT 
CCTCCCCAAG ACTGGCTGCA ACGCAGGGCA GAGATACTGA AGATCCTTCG GAAGCGTCCC 
TGGGCAGGCC GGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_766433.1

Translation

MASIHPSCSPGTMSQMGLHPRRGLTGHWLQRFQPCLPLHTVQWRRLLLLAFLLSLAWPASPLPREEEIVFPEKLNGSSILPGSGVPARLLYRLPAFGEMLLLELEQDPGVQVEGLTVQYLGQAPEMLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGALNSAGGPGAHILRRKSPASSQGPMCTVKAPSGSPSPISRRTKRFASLSRFVETLVVADDKMAAFHGTGLKRYLLTVMAAAAKAFKHPSIRNPVNLVVTRLVILGSGQEGPQVGPSAAQTLRSFCTWQRGLNTPNDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCTNLNGQGGSSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPATFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGSSQACMGGRCLHVDQLKDFNVPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTENCPHGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCSPDTSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSRCSKQSGSFKKFRYGYSDVVTIPAGATHILVRQQGGSGLKSIYLALKLSDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQNARLRYSFFVPRPVPSTPRPPPQDWLQRRAEILKILRKRPWAGRK

Target ORF information:

RefSeq Version	NM_172845.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172845.2

ORF Insert Sequence:

ATGGCCTCAA TCCATCCCAG CTGCAGCCCG GGTACCATGT CCCAGATGGG CTTGCATCCC 
AGGAGGGGCT TGACTGGGCA CTGGCTGCAA AGATTCCAAC CCTGCTTGCC GCTTCACACT 
GTGCAGTGGC GGAGGCTGCT GCTGCTGGCC TTCCTCCTGT CCTTAGCGTG GCCCGCCAGC 
CCCCTCCCCC GGGAGGAGGA GATCGTGTTT CCAGAGAAGC TCAATGGCAG TAGCATCCTA 
CCTGGATCAG GCGTTCCTGC CAGGCTGCTG TACCGATTGC CAGCCTTTGG GGAGATGTTG 
CTACTAGAAC TAGAACAGGA CCCTGGGGTG CAGGTAGAGG GTTTGACTGT ACAGTACCTG 
GGCCAGGCAC CTGAGATGCT GGGTGGGGCA GAGCCAGGTA CCTACCTGAC TGGCACCATC 
AATGGAGATC CGGAGTCGGT GGCATCTCTG CACTGGGACG GGGGAGCCCT ATTAGGGGTA 
CTGCAGTACC GTGGGGCCGA ACTCCACCTC CAGCCTCTGG AAGGAGGCGC CCTTAACTCT 
GCTGGGGGAC CGGGGGCTCA CATCCTACGC CGGAAGAGTC CTGCCAGCAG CCAAGGTCCC 
ATGTGCACCG TCAAGGCTCC TTCTGGGAGC CCGAGTCCCA TTTCCCGCAG AACCAAGCGC 
TTCGCTTCTC TGAGTAGATT CGTGGAGACA CTGGTGGTAG CAGATGACAA GATGGCAGCA 
TTCCATGGTA CAGGGTTAAA GCGCTACCTG CTGACGGTTA TGGCAGCTGC CGCTAAAGCC 
TTTAAACACC CAAGCATCCG AAACCCTGTC AACTTGGTGG TGACGCGCCT GGTGATCCTG 
GGGTCCGGCC AGGAAGGGCC CCAAGTGGGG CCAAGTGCCG CCCAGACCCT ACGCAGCTTC 
TGCACCTGGC AGCGGGGCCT CAACACCCCT AACGACTCAG ATCCTGACCA CTTTGACACA 
GCCATTCTGT TCACCCGGCA GGACCTGTGT GGGGTCTCCA CTTGTGACAC CCTGGGTATG 
GCTGATGTGG GCACAGTGTG TGATCCAGCT AGGAGCTGTG CTATTGTGGA AGATGATGGG 
CTCCAGTCAG CCTTCACTGC TGCTCATGAA CTGGGCCATG TCTTCAACAT GCTCCATGAT 
AACTCCAAGC CATGCACTAA CTTGAATGGG CAGGGGGGTT CCTCTCGCCA TGTCATGGCT 
CCTGTCATGG CCCATGTGGA CCCTGAAGAG CCCTGGTCGC CCTGCAGTGC CCGATTCATC 
ACTGACTTCC TGGACAATGG TTATGGGCAC TGCCTCTTAG ACAAACCGGA GGCTCCCCTC 
CATCTACCAG CGACTTTTCC TGGCAAGGAC TATGACGCTG ACCGCCAATG CCAACTGACC 
TTCGGTCCTG ACTCAAGCCA TTGTCCACAG CTGCCACCGC CCTGTGCTGC CCTCTGGTGC 
TCTGGCCACC TCAATGGCCA TGCCATGTGC CAGACGAAGC ACTCACCTTG GGCTGATGGC 
ACTCCCTGCG GGTCTTCACA GGCCTGCATG GGTGGCCGCT GTCTGCACGT GGACCAGCTC 
AAGGACTTCA ATGTTCCTCA GGCTGGAGGC TGGGGCCCCT GGGGACCATG GGGTGACTGC 
TCCAGGACTT GTGGGGGTGG TGTCCAGTTC TCCTCCCGGG ATTGCACGAG GCCCGTCCCC 
CGGAACGGTG GCAAGTATTG TGAGGGCCGC CGGACTCGCT TCCGCTCCTG CAACACGGAG 
AACTGCCCAC ACGGCTCAGC ATTGACCTTC CGTGAAGAGC AGTGTGCTGC CTACAACCAC 
CGAACCGACC TCTTCAAGAG CTTTCCAGGG CCCATGGACT GGGTTCCGCG CTACACAGGT 
GTGGCCCCTC GAGACCAATG CAAACTCACC TGCCAGGCCC GGGCACTGGG CTACTACTAC 
GTATTGGAGC CCCGGGTGGC AGATGGGACT CCCTGCTCCC CAGACACCTC CTCTGTCTGT 
GTCCAGGGCC GCTGTATCCA TGCTGGCTGT GACCGGATCA TTGGCTCCAA AAAGAAATTT 
GACAAGTGCA TGGTGTGCGG CGGGGATGGC TCTCGCTGCA GCAAGCAGTC GGGCTCCTTC 
AAAAAATTCA GGTATGGATA CAGCGATGTG GTCACGATCC CTGCGGGGGC CACCCATATC 
CTTGTACGGC AGCAGGGGGG GTCTGGTCTC AAGAGCATCT ACCTGGCCCT GAAGCTTTCT 
GACGGTTCTT ACGCCCTCAA TGGTGAATAC ACGCTGATGC CCTCCCCAAC AGATGTGGTT 
CTTCCTGGGG CAGTCAGCTT GCGCTACAGC GGAGCCACAG CAGCCTCAGA GACACTGTCT 
GGACATGGGC CGCTGGCCCA GCCCTTGACG CTGCAAGTCC TGGTGGCTGG CAACCCACAG 
AATGCACGTC TGCGGTACAG TTTCTTTGTC CCGCGGCCAG TCCCTTCAAC ACCACGCCCT 
CCTCCCCAAG ACTGGCTGCA ACGCAGGGCA GAGATACTGA AGATCCTTCG GAAGCGTCCC 
TGGGCAGGCC GGAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Scientific reports7(1)12351(2017 Sep)
Ren P,Hughes M,Krishnamoorthy S,Zou S,Zhang L,Wu D,Zhang C,Curci JA,Coselli JS,Milewicz DM,LeMaire SA,Shen YH

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Adamts4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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