KLK7 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLK7
Entrez Gene ID	23993
Full Name	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
Synonyms	Prss6,SCCE
General protein information	Preferred Names kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Names kallikrein-7 kallikrein 7 (chymotryptic, stratum corneum) serine protease 6 stratum corneum chymotryptic enzyme thymopsin
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 28.27 cM
Summary	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011872.3	NP_036002.1	kallikrein-7 preproprotein
NM_011872.2	NP_036002.1	kallikrein-7 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KLK7	NP_001068724.1
Mus musculus (house mouse)	Klk7	NP_036002.1
Homo sapiens (human)	KLK7	NP_644806.1
Pan troglodytes (chimpanzee)	KLK7	XP_524357.3
	LOC722683	XP_001118798.1
Rattus norvegicus (Norway rat)	Klk7	NP_001099724.1
Canis lupus familiaris (dog)	KLK7	NP_001184094.1

Gene Ontology
Bibliography

Related articles in PubMed

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high?fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.
Zieger K, Weiner J, Kunath A, Gericke M, Krause K, Kern M, Stumvoll M, Kl?ting N, Bl?her M, Heiker JT
Cellular and molecular life sciences : CMLS75(4)727-742(2018 Feb)

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T
EMBO molecular medicine(2018 Jan)

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R
PLoS genetics13(1)e1006566(2017 Jan)

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.
Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR
PloS one11(8)e0161465(2016)

Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains.
Murakami K, Tanaka T, Bando Y, Yoshida S
Protein and peptide letters22(3)204-11(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ablation of KLK7 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK7 and KLK5 completely rescues Netherton Syndrome-like phenotype.
Title: KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.

Prolonged Klk7 neutralization provokes profound abnormalities in Klk7 function, due to pH-induced high serine protease activity that degrades lipid processing enzymes and corneodesmosomes proteins.
Title: Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.

Higher hK7 expression is associated with cervical adenocarcinomas
Title: Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas.

The following KLK7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLK7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09046	NM_011872.3 Latest version!	Mus musculus kallikrein related-peptidase 7 (chymotryptic, stratum corneum) (Klk7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu09046	NM_011872.2	Mus musculus kallikrein related-peptidase 7 (chymotryptic, stratum corneum) (Klk7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLK7 ( NM_011872.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_036002.1 Mus musculus kallikrein related-peptidase 7 (chymotryptic, stratum corneum) (Klk7), mRNA.

Price & Availability↑

CloneID	OMu09046
Clone ID Related Accession (Same CDS sequence)	NM_011872.3 , NM_011872.2
Accession Version	NM_011872.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	kallikrein-7 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC151989.4 and AK029477.1. On May 3, 2016 this sequence version replaced NM_011872.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029477.1, AK077406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGTCT GGCTCCTTTC CCTGATAACT GTGCTGCTGT CTTTAGCCCT GGAAACCGCT 
GGACAAGGAG AAAGGATTAT AGATGGCTAC AAATGTAAAG AAGGCTCGCA CCCATGGCAG 
GTGGCTCTGC TCAAAGGCAA TCAGCTTCAC TGTGGAGGGG TGCTGGTGGA CAAATACTGG 
GTGCTCACAG CAGCCCACTG CAAAATGGGT CAGTACCAAG TACAGCTGGG CAGTGATAAA 
ATAGGGGACC AGAGTGCCCA GAAGATCAAG GCTACAAAGT CATTCCGGCA CCCTGGCTAC 
TCCACAAAGA CCCACGTCAA TGACATCATG CTTGTGAGGT TGGATGAGCC AGTCAAGATG 
TCATCCAAAG TGGAGGCAGT CCAGCTTCCT GAACACTGTG AACCCCCAGG GACGTCATGT 
ACCGTCTCTG GATGGGGCAC CACAACCAGC CCAGACGTGA CCTTTCCCTC GGATCTTATG 
TGCTCGGATG TGAAGCTCAT CTCCTCCAGG GAGTGCAAGA AGGTGTACAA GGACCTGCTG 
GGGAAAACCA TGCTGTGTGC TGGCATTCCT GACTCTAAGA CCAACACGTG CAATGGTGAC 
TCAGGGGGGC CCTTGGTGTG CAACGACACC CTCCAAGGTC TGGTGTCCTG GGGTACCTAC 
CCTTGTGGCC AGCCCAACGA CCCAGGCGTC TACACTCAAG TCTGCAAGTA CAAACGGTGG 
GTGATGGAGA CCATGAAAAC CCATCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036002.1
CDS	239..988
Translation	MGVWLLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQLGSDKIGDQSAQKIKATKSFRHPGYSTKTHVNDIMLVRLDEPVKMSSKVEAVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWGTYPCGQPNDPGVYTQVCKYKRWVMETMKTHR

Target ORF information:

RefSeq Version	NM_011872.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus kallikrein related-peptidase 7 (chymotryptic, stratum corneum) (Klk7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011872.3

ORF Insert Sequence:

ATGGGAGTCT GGCTCCTTTC CCTGATAACT GTGCTGCTGT CTTTAGCCCT GGAAACCGCT 
GGACAAGGAG AAAGGATTAT AGATGGCTAC AAATGTAAAG AAGGCTCGCA CCCATGGCAG 
GTGGCTCTGC TCAAAGGCAA TCAGCTTCAC TGTGGAGGGG TGCTGGTGGA CAAATACTGG 
GTGCTCACAG CAGCCCACTG CAAAATGGGT CAGTACCAAG TACAGCTGGG CAGTGATAAA 
ATAGGGGACC AGAGTGCCCA GAAGATCAAG GCTACAAAGT CATTCCGGCA CCCTGGCTAC 
TCCACAAAGA CCCACGTCAA TGACATCATG CTTGTGAGGT TGGATGAGCC AGTCAAGATG 
TCATCCAAAG TGGAGGCAGT CCAGCTTCCT GAACACTGTG AACCCCCAGG GACGTCATGT 
ACCGTCTCTG GATGGGGCAC CACAACCAGC CCAGACGTGA CCTTTCCCTC GGATCTTATG 
TGCTCGGATG TGAAGCTCAT CTCCTCCAGG GAGTGCAAGA AGGTGTACAA GGACCTGCTG 
GGGAAAACCA TGCTGTGTGC TGGCATTCCT GACTCTAAGA CCAACACGTG CAATGGTGAC 
TCAGGGGGGC CCTTGGTGTG CAACGACACC CTCCAAGGTC TGGTGTCCTG GGGTACCTAC 
CCTTGTGGCC AGCCCAACGA CCCAGGCGTC TACACTCAAG TCTGCAAGTA CAAACGGTGG 
GTGATGGAGA CCATGAAAAC CCATCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLK7 ( NM_011872.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_036002.1 Mus musculus kallikrein related-peptidase 7 (chymotryptic, stratum corneum) (Klk7), mRNA.

Price & Availability↑

CloneID	OMu09046
Clone ID Related Accession (Same CDS sequence)	NM_011872.3 , NM_011872.2
Accession Version	NM_011872.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	kallikrein-7 precursor
Comment

ATGGGAGTCT GGCTCCTTTC CCTGATAACT GTGCTGCTGT CTTTAGCCCT GGAAACCGCT 
GGACAAGGAG AAAGGATTAT AGATGGCTAC AAATGTAAAG AAGGCTCGCA CCCATGGCAG 
GTGGCTCTGC TCAAAGGCAA TCAGCTTCAC TGTGGAGGGG TGCTGGTGGA CAAATACTGG 
GTGCTCACAG CAGCCCACTG CAAAATGGGT CAGTACCAAG TACAGCTGGG CAGTGATAAA 
ATAGGGGACC AGAGTGCCCA GAAGATCAAG GCTACAAAGT CATTCCGGCA CCCTGGCTAC 
TCCACAAAGA CCCACGTCAA TGACATCATG CTTGTGAGGT TGGATGAGCC AGTCAAGATG 
TCATCCAAAG TGGAGGCAGT CCAGCTTCCT GAACACTGTG AACCCCCAGG GACGTCATGT 
ACCGTCTCTG GATGGGGCAC CACAACCAGC CCAGACGTGA CCTTTCCCTC GGATCTTATG 
TGCTCGGATG TGAAGCTCAT CTCCTCCAGG GAGTGCAAGA AGGTGTACAA GGACCTGCTG 
GGGAAAACCA TGCTGTGTGC TGGCATTCCT GACTCTAAGA CCAACACGTG CAATGGTGAC 
TCAGGGGGGC CCTTGGTGTG CAACGACACC CTCCAAGGTC TGGTGTCCTG GGGTACCTAC 
CCTTGTGGCC AGCCCAACGA CCCAGGCGTC TACACTCAAG TCTGCAAGTA CAAACGGTGG 
GTGATGGAGA CCATGAAAAC CCATCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036002.1
Translation	MGVWLLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQLGSDKIGDQSAQKIKATKSFRHPGYSTKTHVNDIMLVRLDEPVKMSSKVEAVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWGTYPCGQPNDPGVYTQVCKYKRWVMETMKTHR

Target ORF information:

RefSeq Version	NM_011872.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus kallikrein related-peptidase 7 (chymotryptic, stratum corneum) (Klk7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011872.2

ORF Insert Sequence:

ATGGGAGTCT GGCTCCTTTC CCTGATAACT GTGCTGCTGT CTTTAGCCCT GGAAACCGCT 
GGACAAGGAG AAAGGATTAT AGATGGCTAC AAATGTAAAG AAGGCTCGCA CCCATGGCAG 
GTGGCTCTGC TCAAAGGCAA TCAGCTTCAC TGTGGAGGGG TGCTGGTGGA CAAATACTGG 
GTGCTCACAG CAGCCCACTG CAAAATGGGT CAGTACCAAG TACAGCTGGG CAGTGATAAA 
ATAGGGGACC AGAGTGCCCA GAAGATCAAG GCTACAAAGT CATTCCGGCA CCCTGGCTAC 
TCCACAAAGA CCCACGTCAA TGACATCATG CTTGTGAGGT TGGATGAGCC AGTCAAGATG 
TCATCCAAAG TGGAGGCAGT CCAGCTTCCT GAACACTGTG AACCCCCAGG GACGTCATGT 
ACCGTCTCTG GATGGGGCAC CACAACCAGC CCAGACGTGA CCTTTCCCTC GGATCTTATG 
TGCTCGGATG TGAAGCTCAT CTCCTCCAGG GAGTGCAAGA AGGTGTACAA GGACCTGCTG 
GGGAAAACCA TGCTGTGTGC TGGCATTCCT GACTCTAAGA CCAACACGTG CAATGGTGAC 
TCAGGGGGGC CCTTGGTGTG CAACGACACC CTCCAAGGTC TGGTGTCCTG GGGTACCTAC 
CCTTGTGGCC AGCCCAACGA CCCAGGCGTC TACACTCAAG TCTGCAAGTA CAAACGGTGG 
GTGATGGAGA CCATGAAAAC CCATCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high?fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.
Cellular and molecular life sciences : CMLS75(4)727-742(2018 Feb)
Zieger K,Weiner J,Kunath A,Gericke M,Krause K,Kern M,Stumvoll M,Kl?ting N,Bl?her M,Heiker JT

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
EMBO molecular medicine(2018 Jan)
Kidana K,Tatebe T,Ito K,Hara N,Kakita A,Saito T,Takatori S,Ouchi Y,Ikeuchi T,Makino M,Saido TC,Akishita M,Iwatsubo T,Hori Y,Tomita T

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
PLoS genetics13(1)e1006566(2017 Jan)
Kasparek P,Ileninova Z,Zbodakova O,Kanchev I,Benada O,Chalupsky K,Brattsand M,Beck IM,Sedlacek R

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.
PloS one11(8)e0161465(2016)
Zhang L,Ferreyros M,Feng W,Hupe M,Crumrine DA,Chen J,Elias PM,Holleran WM,Niswander L,Hohl D,Williams T,Torchia EC,Roop DR

Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains.
Protein and peptide letters22(3)204-11(2014)
Murakami K,Tanaka T,Bando Y,Yoshida S

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KLK7 cDNA ORF clone, Mus musculus(House mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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