Klf6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klf6
Entrez Gene ID	23849
Full Name	Kruppel-like factor 6
Synonyms	AI448727,BCD1,C86813,CPBP,Copeb,FM2,FM6,Ierepo1,Ierepo3,R75280,Zf9
General protein information	Preferred Names Kruppel-like factor 6 Names Krueppel-like factor 6 core promoter element binding protein immediate early response, erythropoietin 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_011803.2	NP_035933.2	Krueppel-like factor 6

Pathways from BioSystems

Homologies

Homo sapiens (human)	KLF6	NP_001291.3
Canis lupus familiaris (dog)	KLF6	XP_544279.3
Mus musculus (house mouse)	Klf6	NP_035933.2
	LOC710784	XP_001102983.2
Rattus norvegicus (Norway rat)	Klf6	NP_113830.2
Danio rerio (zebrafish)	klf6a	NP_958869.1
Bos taurus (cattle)	KLF6	NP_001030348.2
Pan troglodytes (chimpanzee)	KLF6	XP_001141364.1
Gallus gallus (chicken)	KLF6	NP_001026140.1
Xenopus tropicalis (tropical clawed frog)	klf6	NP_001007506.1

Gene Ontology
Bibliography

Related articles in PubMed

NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6.
Yu F, Jiang Z, Chen B, Dong P, Zheng J
Journal of molecular medicine (Berlin, Germany)95(11)1191-1202(2017 Nov)

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Title: A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination.

observations reveal that KLF6 repress BCL6 to enhance macrophage inflammatory gene expression and function.
Title: Kruppel-like Factor 6 Promotes Macrophage-mediated Inflammation by Suppressing B Cell Leukemia/Lymphoma 6 Expression.

The study highlights the central role of myeloid KLF6 in promoting intestinal inflammation.
Title: KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation.

Klf6 as required for developmental central nervous system myelination.Klf6 promotes oligodendrocyte differentiation and viability.
Title: The Transcriptional Activator Kr?ppel-like Factor-6 Is Required for CNS Myelination.

KLF6-mediated activation of the human INSL3 promoter required an intact KLF element as well as Leydig/Sertoli-enriched factors. KLF6 transcriptionally cooperates with NUR77 and SF1. our results identify KLF6 as a regulator of human INSL3 transcription.
Title: KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.

The following Klf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08880	NM_011803.2 Latest version!	Mus musculus Kruppel-like factor 6 (Klf6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klf6 ( NM_011803.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035933.2 Mus musculus Kruppel-like factor 6 (Klf6), mRNA.

Price & Availability↑

CloneID	OMu08880
Clone ID Related Accession (Same CDS sequence)	NM_011803.2
Accession Version	NM_011803.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Mus musculus(house mouse)
Product	Krueppel-like factor 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY128594.1 and AK146615.1. On Jan 12, 2006 this sequence version replaced NM_011803.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146615.1, SRR1660811.111821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAACTTT CACCTGCGCT CCCGGGAACA GTTTCTGCTC GGACTCCTGA TCGTTCACCT 
CCCTGTTTTC CCGACAGCGA GGACTGTCTT TTCCAACCCG ACATGGATGT GCTCCCAATG 
TGTAGCATCT TCCAGGAACT ACAGATTGTG CACGAAACGG GCTACTTCTC GGCTCTGCCG 
TCCCTGGAGG AATATTGGCA ACAGACCTGC CTGGAGTTGG AACGCTATCT TCAGAGTGAG 
CCCTGCTACG TGTCAGCCTC TGAGATAAAA TTTGACAGCC AGGAAGACCT GTGGACCAAA 
TTCATTCTAG CTCGGGGGGA GAAGAAGGAG GAATCAGAAC TGAAGATTTC TTCTAGTCCC 
CCAGAGGACT CTCTGATCAG CTCCAGCTTT AATTATAACT TAGAGACCAA TAGCCTGAAC 
TCTGATGTCA GCAGTGAGTC TTCGGACAGT TCAGAGGAAC TTTCACCCAC GACCAAATTT 
ACCTCTGATC CCATTGGTGA AGTCTTAGTC AATTCAGGAA ATCTGAGTTC CTCCGTCATT 
TCCACACCTC CATCTTCTCC AGAAGTGAAC AGGGAATCTT CTCAACTATG GGGCTGTGGG 
CCAGGAGACC TGCCCTCACC TGGGAAGGTT CGAAGTGGGA CCTCTGGGAA GTCTGGTGAC 
AAGGGTAATG GCGACGCCTC CCCAGATGGC AGAAGACGGG TACATCGGTG CCACTTTAAT 
GGCTGCAGGA AAGTTTACAC GAAAAGCTCC CACTTGAAAG CACATCAGCG CACTCACACA 
GGAGAAAAGC CTTACAGATG CTCATGGGAA GGTTGTGAGT GGCGTTTTGC AAGAAGTGAT 
GAGTTGACCA GACACTTCCG AAAGCATACC GGTGCCAAGC CTTTTAAATG CTCCCACTGT 
GACAGGTGTT TCTCCAGGTC TGACCACCTG GCCCTGCACA TGAAGAGGCA CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035933.2
CDS	151..1107
Translation	MKLSPALPGTVSARTPDRSPPCFPDSEDCLFQPDMDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKFILARGEKKEESELKISSSPPEDSLISSSFNYNLETNSLNSDVSSESSDSSEELSPTTKFTSDPIGEVLVNSGNLSSSVISTPPSSPEVNRESSQLWGCGPGDLPSPGKVRSGTSGKSGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMKRHL

Target ORF information:

RefSeq Version	NM_011803.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Kruppel-like factor 6 (Klf6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011803.2

ORF Insert Sequence:

ATGAAACTTT CACCTGCGCT CCCGGGAACA GTTTCTGCTC GGACTCCTGA TCGTTCACCT 
CCCTGTTTTC CCGACAGCGA GGACTGTCTT TTCCAACCCG ACATGGATGT GCTCCCAATG 
TGTAGCATCT TCCAGGAACT ACAGATTGTG CACGAAACGG GCTACTTCTC GGCTCTGCCG 
TCCCTGGAGG AATATTGGCA ACAGACCTGC CTGGAGTTGG AACGCTATCT TCAGAGTGAG 
CCCTGCTACG TGTCAGCCTC TGAGATAAAA TTTGACAGCC AGGAAGACCT GTGGACCAAA 
TTCATTCTAG CTCGGGGGGA GAAGAAGGAG GAATCAGAAC TGAAGATTTC TTCTAGTCCC 
CCAGAGGACT CTCTGATCAG CTCCAGCTTT AATTATAACT TAGAGACCAA TAGCCTGAAC 
TCTGATGTCA GCAGTGAGTC TTCGGACAGT TCAGAGGAAC TTTCACCCAC GACCAAATTT 
ACCTCTGATC CCATTGGTGA AGTCTTAGTC AATTCAGGAA ATCTGAGTTC CTCCGTCATT 
TCCACACCTC CATCTTCTCC AGAAGTGAAC AGGGAATCTT CTCAACTATG GGGCTGTGGG 
CCAGGAGACC TGCCCTCACC TGGGAAGGTT CGAAGTGGGA CCTCTGGGAA GTCTGGTGAC 
AAGGGTAATG GCGACGCCTC CCCAGATGGC AGAAGACGGG TACATCGGTG CCACTTTAAT 
GGCTGCAGGA AAGTTTACAC GAAAAGCTCC CACTTGAAAG CACATCAGCG CACTCACACA 
GGAGAAAAGC CTTACAGATG CTCATGGGAA GGTTGTGAGT GGCGTTTTGC AAGAAGTGAT 
GAGTTGACCA GACACTTCCG AAAGCATACC GGTGCCAAGC CTTTTAAATG CTCCCACTGT 
GACAGGTGTT TCTCCAGGTC TGACCACCTG GCCCTGCACA TGAAGAGGCA CCTCTGA