Oscar cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oscar
Entrez Gene ID	232790
Full Name	osteoclast associated receptor
Synonyms	mOSCAR,mOSCAR-M1,mOSCAR-M2,mOSCAR-M3
General protein information	Preferred Names osteoclast associated receptor Names osteoclast-associated immunoglobulin-like receptor ocl178 osteoclast-associated receptor OSCAR
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001290377.1	NP_001277306.1	osteoclast-associated immunoglobulin-like receptor isoform 2 precursor
NM_175632.3	NP_783440.1	osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Oscar	NP_001171902.1
Pan troglodytes (chimpanzee)	OSCAR	XP_003316709.1
Mus musculus (house mouse)	Oscar	NP_783440.1
Homo sapiens (human)	OSCAR	NP_570127.3
Canis lupus familiaris (dog)	OSCAR	XP_541429.4
Bos taurus (cattle)	OSCAR	XP_002695502.1

Gene Ontology
Bibliography

Related articles in PubMed

Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro.
Sinningen K, Rauner M, Goettsch C, Al-Fakhri N, Schoppet M, Hofbauer LC
Biochemical and biophysical research communications437(2)314-8(2013 Jul)

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
Barrow AD, Raynal N, Andersen TL, Slatter DA, Bihan D, Pugh N, Cella M, Kim T, Rho J, Negishi-Koga T, Delaisse JM, Takayanagi H, Lorenzo J, Colonna M, Farndale RW, Choi Y, Trowsdale J
The Journal of clinical investigation121(9)3505-16(2011 Sep)

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells.
Schulze J, Bickert T, Beil FT, Zaiss MM, Albers J, Wintges K, Streichert T, Klaetschke K, Keller J, Hissnauer TN, Spiro AS, Gessner A, Schett G, Amling M, McKenzie AN, Horst AK, Schinke T
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research26(4)704-17(2011 Apr)

Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
Kim JH, Kim K, Jin HM, Youn BU, Song I, Choi HS, Kim N
Journal of molecular biology383(3)502-11(2008 Nov)

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.
Kim K, Lee J, Kim JH, Jin HM, Zhou B, Lee SY, Kim N
Journal of immunology (Baltimore, Md. : 1950)178(9)5588-94(2007 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis
Title: Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro.

Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.
Title: OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.

Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis.
Title: Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.

The overexpression of PIAS3 attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.
Title: Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.

analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts
Title: Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.

The following Oscar gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oscar cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13827	NM_175632.3 Latest version!	Mus musculus osteoclast associated receptor (Oscar), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu17332	NM_001290377.1 Latest version!	Mus musculus osteoclast associated receptor (Oscar), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oscar ( NM_175632.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_783440.1 Mus musculus osteoclast associated receptor (Oscar), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13827
Clone ID Related Accession (Same CDS sequence)	NM_175632.3
Accession Version	NM_175632.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	osteoclast-associated immunoglobulin-like receptor isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF391160.1 and AF391161.1. On Mar 13, 2014 this sequence version replaced NM_175632.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF391161.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTCCTGT CGCTGATACT CCAGCTGTCG ACTCTCTGTG AGCTGTCCCT CCCCTGGCCT 
GCATGCCGTG CTGACTTCAC ACCAACAGCG CCCCTAGCCT CATACCCCCA GCCATGGCTG 
GGAGCTCATC CTGCTGCAGT TGTGACTCCT GGGATCAACG TGACCTTGAC TTGCCGCGCA 
CCTCAATCTG CCTGGCGGTT TGCACTCTTC AAAAGTGGCC TTGTCACCCC TCTGCTCCTC 
CGGGATGTGT CCGTTGAGCT GGCTGAGTTC TTCCTGGAAG AAGTGACTCC GGCCCAAGGG 
GGCAGTTATC ACTGCCGCTA CCGCAAGACA GACTGGGGGC CAGGTGTCTG GTCTCAGCCC 
AGTAATGTTC TGGAACTGCT GGTAACGGAT CAGCTCCCCA GACCATCACT GGTGGCACTG 
CCTGGGCCTG TGGTGGCCCC GGGAGCCAAC GTAAGCCTGC GCTGTGCAGG CCGCATACCG 
GGCATGAGTT TTGCACTGTA CCGCGTAGGC GTGGCAACCC CTCTGCAGTA TATTGACTCT 
GTGCAGCCCT GGGCTGACTT CCTTTTGATC GGCACACACA CACCTGGCAC CTACTGTTGC 
TATTACCACA CGCCTTCTGC CCCCTATGTG CTATCACAGC GCAGCCAGCC ACTGGTCATC 
AGTTTCGAAG GTTCTGGCTC CTTGGACTAT ACCCAGGGAA ACCTCATCCG TTTGGGGCTG 
GCAGGAATGG TCCTCATCTG CTTGGGCATC ATAGTTACTT GTGATTGGCA CAGCAGGAGC 
TCTGCCTTTG ATGGTCTCCT GCCCCAGCAA AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_783440.1
CDS	81..896
Translation	MVLSLILQLSTLCELSLPWPACRADFTPTAPLASYPQPWLGAHPAAVVTPGINVTLTCRAPQSAWRFALFKSGLVTPLLLRDVSVELAEFFLEEVTPAQGGSYHCRYRKTDWGPGVWSQPSNVLELLVTDQLPRPSLVALPGPVVAPGANVSLRCAGRIPGMSFALYRVGVATPLQYIDSVQPWADFLLIGTHTPGTYCCYYHTPSAPYVLSQRSQPLVISFEGSGSLDYTQGNLIRLGLAGMVLICLGIIVTCDWHSRSSAFDGLLPQQN

Target ORF information:

RefSeq Version	NM_175632.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus osteoclast associated receptor (Oscar), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175632.3

ORF Insert Sequence:

ATGGTCCTGT CGCTGATACT CCAGCTGTCG ACTCTCTGTG AGCTGTCCCT CCCCTGGCCT 
GCATGCCGTG CTGACTTCAC ACCAACAGCG CCCCTAGCCT CATACCCCCA GCCATGGCTG 
GGAGCTCATC CTGCTGCAGT TGTGACTCCT GGGATCAACG TGACCTTGAC TTGCCGCGCA 
CCTCAATCTG CCTGGCGGTT TGCACTCTTC AAAAGTGGCC TTGTCACCCC TCTGCTCCTC 
CGGGATGTGT CCGTTGAGCT GGCTGAGTTC TTCCTGGAAG AAGTGACTCC GGCCCAAGGG 
GGCAGTTATC ACTGCCGCTA CCGCAAGACA GACTGGGGGC CAGGTGTCTG GTCTCAGCCC 
AGTAATGTTC TGGAACTGCT GGTAACGGAT CAGCTCCCCA GACCATCACT GGTGGCACTG 
CCTGGGCCTG TGGTGGCCCC GGGAGCCAAC GTAAGCCTGC GCTGTGCAGG CCGCATACCG 
GGCATGAGTT TTGCACTGTA CCGCGTAGGC GTGGCAACCC CTCTGCAGTA TATTGACTCT 
GTGCAGCCCT GGGCTGACTT CCTTTTGATC GGCACACACA CACCTGGCAC CTACTGTTGC 
TATTACCACA CGCCTTCTGC CCCCTATGTG CTATCACAGC GCAGCCAGCC ACTGGTCATC 
AGTTTCGAAG GTTCTGGCTC CTTGGACTAT ACCCAGGGAA ACCTCATCCG TTTGGGGCTG 
GCAGGAATGG TCCTCATCTG CTTGGGCATC ATAGTTACTT GTGATTGGCA CAGCAGGAGC 
TCTGCCTTTG ATGGTCTCCT GCCCCAGCAA AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Oscar ( NM_001290377.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277306.1 Mus musculus osteoclast associated receptor (Oscar), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17332
Clone ID Related Accession (Same CDS sequence)	NM_001290377.1
Accession Version	NM_001290377.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	osteoclast-associated immunoglobulin-like receptor isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF391160.1 and AF391159.1. On Mar 12, 2014 this sequence version replaced XM_006539749.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF391159.1, BC137776.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTCCTGT CGCTGATACT CCAGCTGTCG ACTCTCTGGC CTGCATGCCG TGCTGACTTC 
ACACCAACAG CGCCCCTAGC CTCATACCCC CAGCCATGGC TGGGAGCTCA TCCTGCTGCA 
GTTGTGACTC CTGGGATCAA CGTGACCTTG ACTTGCCGCG CACCTCAATC TGCCTGGCGG 
TTTGCACTCT TCAAAAGTGG CCTTGTCACC CCTCTGCTCC TCCGGGATGT GTCCGTTGAG 
CTGGCTGAGT TCTTCCTGGA AGAAGTGACT CCGGCCCAAG GGGGCAGTTA TCACTGCCGC 
TACCGCAAGA CAGACTGGGG GCCAGGTGTC TGGTCTCAGC CCAGTAATGT TCTGGAACTG 
CTGGTAACGG ATCAGCTCCC CAGACCATCA CTGGTGGCAC TGCCTGGGCC TGTGGTGGCC 
CCGGGAGCCA ACGTAAGCCT GCGCTGTGCA GGCCGCATAC CGGGCATGAG TTTTGCACTG 
TACCGCGTAG GCGTGGCAAC CCCTCTGCAG TATATTGACT CTGTGCAGCC CTGGGCTGAC 
TTCCTTTTGA TCGGCACACA CACACCTGGC ACCTACTGTT GCTATTACCA CACGCCTTCT 
GCCCCCTATG TGCTATCACA GCGCAGCCAG CCACTGGTCA TCAGTTTCGA AGGTTCTGGC 
TCCTTGGACT ATACCCAGGG AAACCTCATC CGTTTGGGGC TGGCAGGAAT GGTCCTCATC 
TGCTTGGGCA TCATAGTTAC TTGTGATTGG CACAGCAGGA GCTCTGCCTT TGATGGTCTC 
CTGCCCCAGC AAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277306.1
CDS	81..878
Translation	MVLSLILQLSTLWPACRADFTPTAPLASYPQPWLGAHPAAVVTPGINVTLTCRAPQSAWRFALFKSGLVTPLLLRDVSVELAEFFLEEVTPAQGGSYHCRYRKTDWGPGVWSQPSNVLELLVTDQLPRPSLVALPGPVVAPGANVSLRCAGRIPGMSFALYRVGVATPLQYIDSVQPWADFLLIGTHTPGTYCCYYHTPSAPYVLSQRSQPLVISFEGSGSLDYTQGNLIRLGLAGMVLICLGIIVTCDWHSRSSAFDGLLPQQN

Target ORF information:

RefSeq Version	NM_001290377.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus osteoclast associated receptor (Oscar), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290377.1

ORF Insert Sequence:

ATGGTCCTGT CGCTGATACT CCAGCTGTCG ACTCTCTGGC CTGCATGCCG TGCTGACTTC 
ACACCAACAG CGCCCCTAGC CTCATACCCC CAGCCATGGC TGGGAGCTCA TCCTGCTGCA 
GTTGTGACTC CTGGGATCAA CGTGACCTTG ACTTGCCGCG CACCTCAATC TGCCTGGCGG 
TTTGCACTCT TCAAAAGTGG CCTTGTCACC CCTCTGCTCC TCCGGGATGT GTCCGTTGAG 
CTGGCTGAGT TCTTCCTGGA AGAAGTGACT CCGGCCCAAG GGGGCAGTTA TCACTGCCGC 
TACCGCAAGA CAGACTGGGG GCCAGGTGTC TGGTCTCAGC CCAGTAATGT TCTGGAACTG 
CTGGTAACGG ATCAGCTCCC CAGACCATCA CTGGTGGCAC TGCCTGGGCC TGTGGTGGCC 
CCGGGAGCCA ACGTAAGCCT GCGCTGTGCA GGCCGCATAC CGGGCATGAG TTTTGCACTG 
TACCGCGTAG GCGTGGCAAC CCCTCTGCAG TATATTGACT CTGTGCAGCC CTGGGCTGAC 
TTCCTTTTGA TCGGCACACA CACACCTGGC ACCTACTGTT GCTATTACCA CACGCCTTCT 
GCCCCCTATG TGCTATCACA GCGCAGCCAG CCACTGGTCA TCAGTTTCGA AGGTTCTGGC 
TCCTTGGACT ATACCCAGGG AAACCTCATC CGTTTGGGGC TGGCAGGAAT GGTCCTCATC 
TGCTTGGGCA TCATAGTTAC TTGTGATTGG CACAGCAGGA GCTCTGCCTT TGATGGTCTC 
CTGCCCCAGC AAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro.
Biochemical and biophysical research communications437(2)314-8(2013 Jul)
Sinningen K,Rauner M,Goettsch C,Al-Fakhri N,Schoppet M,Hofbauer LC

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
The Journal of clinical investigation121(9)3505-16(2011 Sep)
Barrow AD,Raynal N,Andersen TL,Slatter DA,Bihan D,Pugh N,Cella M,Kim T,Rho J,Negishi-Koga T,Delaisse JM,Takayanagi H,Lorenzo J,Colonna M,Farndale RW,Choi Y,Trowsdale J

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research26(4)704-17(2011 Apr)
Schulze J,Bickert T,Beil FT,Zaiss MM,Albers J,Wintges K,Streichert T,Klaetschke K,Keller J,Hissnauer TN,Spiro AS,Gessner A,Schett G,Amling M,McKenzie AN,Horst AK,Schinke T

Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
Journal of molecular biology383(3)502-11(2008 Nov)
Kim JH,Kim K,Jin HM,Youn BU,Song I,Choi HS,Kim N

Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.
Journal of immunology (Baltimore, Md. : 1950)178(9)5588-94(2007 May)
Kim K,Lee J,Kim JH,Jin HM,Zhou B,Lee SY,Kim N