Xdh cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xdh
Entrez Gene ID	22436
Full Name	xanthine dehydrogenase
Synonyms	XO,Xor,Xox-1,Xox1
General protein information	Preferred Names xanthine dehydrogenase Names xanthine dehydrogenase/oxidase xanthine oxidase xanthine oxidoreductase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 E2\|17 45.25 cM
Summary	This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014].

mRNA and Protein(s)

mRNA	Protein	Name
XM_011246381.1	XP_011244683.1	xanthine dehydrogenase/oxidase isoform X1
NM_011723.3	NP_035853.2	xanthine dehydrogenase/oxidase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	XDH	XP_525729.2
Canis lupus familiaris (dog)	XDH	XP_540143.2
Bos taurus (cattle)	XDH	NP_776397.1
Gallus gallus (chicken)	XDH	NP_990458.1
Drosophila melanogaster (fruit fly)	ry	NP_524337.1
Arabidopsis thaliana (thale cress)	XDH1	NP_195215.2
Oryza sativa (rice)	Os03g0429800	NP_001050420.1
Homo sapiens (human)	XDH	NP_000370.2
Danio rerio (zebrafish)	xdh	XP_688983.3
Caenorhabditis elegans (roundworm)	F55B11.1	NP_502747.1
Arabidopsis thaliana (thale cress)	XDH2	NP_195216.2
Magnaporthe oryzae (rice blast fungus)	MGG_12738	XP_003716708.1
Neurospora crassa	NCU03350	XP_956459.2
Rattus norvegicus (Norway rat)	Xdh	NP_058850.1
Xenopus tropicalis (tropical clawed frog)	LOC100497499	XP_004914866.1
	XDH	XP_002808080.1
Mus musculus (house mouse)	Xdh	NP_035853.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007918	XP_317568.3

Gene Ontology
Bibliography

Related articles in PubMed

Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.
Nishino T, Okamoto K, Kawaguchi Y, Hori H, Matsumura T, Eger BT, Pai EF, Nishino T
The Journal of biological chemistry280(26)24888-94(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, these results demonstrate that XO inhibition protects against WD-induced vascular oxidative stress, fibrosis, impaired vasorelaxation, and aortic stiffness in females. Furthermore, excessive oxidative stress resulting from XO activation appears to play a key role in mediating vascular dysfunction induced by chronic exposure to WD consumption in females.
Title: Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice.

Extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos inhibit xanthine oxidase activity and prevent hyperuricemia.
Title: Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.

eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS. This interplay between XOR and eNOS is proposed to play a significant role in NO homeostasis and blood pressure regulation.
Title: Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.

Our results suggest that a possible relationship between xanthine oxidase-related reactive oxygen species and TRPV1 may exist during the events preceding eccentric exercise
Title: Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats.

NLRP3 inflammasome is decreased and IL-1beta secretion is inhibited in macrophages by hydroxysafflor yellow A and xanthine oxidase
Title: Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages.

The following Xdh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xdh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu69050	XM_011246381.1 Latest version!	Mus musculus xanthine dehydrogenase (Xdh), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu20221	NM_011723.3 Latest version!	Mus musculus xanthine dehydrogenase (Xdh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xdh ( XM_011246381.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011244683.1 Mus musculus xanthine dehydrogenase (Xdh), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu69050
Clone ID Related Accession (Same CDS sequence)	XM_011246381.1
Accession Version	XM_011246381.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2400bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	xanthine dehydrogenase/oxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTGGTA AACTGGACCC CACCTTTGCC AGCGCCACCC TGCTCTTTCA GAAGGATCCT 
CCAGCTAACG TCCAGCTTTT CCAAGAGGTG CCCAAGGGTC AGTCTGAGGA GGACATGGTG 
GGCAGGCCCA TGCCTCACCT GGCAGCAGAC ATGCAGGCAT CCGGGGAGGC TGTGTACTGT 
GATGACATTC CCCGCTATGA GAATGAGCTG TCCCTCAGGC TGGTCACCAG CACGCGGGCC 
CATGCTAAAA TCATGTCCAT CGACACTTCA GAAGCCAAGA AGGTGCCAGG GTTTGTTTGT 
TTCCTCACCT CAGAGGATGT CCCTGGTAGT AACATAACTG GCATTTTCAA TGATGAAACT 
GTCTTTGCGA AGGATGAGGT TACTTGTGTT GGGCACATCA TTGGTGCTGT GGTCGCTGAC 
ACCCCAGAAC ATGCACACAG AGCCGCTAGA GGGGTGAAAA TCACCTATGA AGACCTTCCA 
GCCATTATCA CAATCCAGGA TGCTATAAAG AACAACTCCT TTTATGGCCC CGAGGTAAAA 
ATCGAGAAAG GAGATCTCAA GAAAGGCTTT TCTGAAGCTG ACAATGTTGT CTCAGGAGAA 
TTATATATTG GTGGCCAGGA GCACTTCTAT CTGGAGACCC ACTGCACCAT TGCCGTGCCG 
AAAGGCGAGG CAGGCGAGAT GGAGCTCTTC GTGAGCACAC AGAACACCAT GAAAACCCAG 
AGCTTTATTG CAAAGATGTT GGGTGTTCCA GACAACAGAA TTGTAGTCCG AGTGAAAAGA 
ATGGGTGGAG GCTTTGGAGG GAAGGAGACC CGGAGCACTC TGATATCCAC AGCAGTGGCC 
TTGGCTGCAT ACAAGACAGG CCGCCCTGTA CGTTGCATGC TGGACCGAGA CGAGGACATG 
CTCATAACTG GTGGCAGACA TCCCTTCCTG GCTAAATACA AGGTGGGCTT CATGAAGACT 
GGGACTATAG TGGCACTGGA GGTGGCTCAC TTCAGCAATG GCGGGAACAG TGAGGATCTC 
TCTCGGAGTA TAATGGAAAG AGCTGTATTC CACATGGACA ACGCCTATAA GATCCCCAAC 
ATTCGCGGCA CCGGGAGGAT TTGTAAGACT AATCTGCCCT CTAACACAGC CTTCAGAGGC 
TTTGGGGGTC CTCAGGGGAT GCTAATCGCA GAATACTGGA TGAGTGAGGT CGCTGTCACC 
TGTGGGCTGC CTGCAGAGGA GGTACGGAGG AAAAACATGT ACAAAGAAGG GGACCTGACT 
CACTTCAACC AGAAGCTGGA GGGGTTCACC TTGCCCAGGT GCTGGGATGA GTGCATAGCG 
AGCTCCCAGT ATCAGGCTCG CAAGATGGAA GTGGAGAAAT TCAACAGGGA GAACTGTTGG 
AAAAAGAGAG GGCTGTGTAT AATCCCGACT AAGTTTGGAA TAAGCTTCAC ACTTTCTTTT 
CTGAACCAGG GGGGTGCCTT GGTCCACGTG TACACGGATG GGTCGGTGCT GCTGACACAT 
GGAGGTACTG AGATGGGTCA AGGCCTTCAC ACCAAGATGG TTCAGGTGGC CAGCAGAGCT 
CTGAAAATCC CCACTTCCAA GATCCATATA ACGGAGACAA GCACTAACAC TGTCCCTAAC 
ACCTCTCCCA CGGCTGCCTC TGCCAGCGCT GACCTCAATG GCCAGGCCAT TTATGAAGCC 
TGTCAGACCA TACTGAAAAG ACTGGAGCCC TTCAAGAAAA AGAATCCCTC AGGCTCCTGG 
GAGAGCTGGG TCATGGATGC CTACACTAGT GCAGTGAGCT TGTCTGCTAC TGGATTTTAT 
AAGACACCCA ACCTTGGTTA CAGCTTTGAG ACAAACTCTG GGAACCCCTT CCACTACTTC 
AGTTATGGGG TGGCTTGCTC AGAAGTAGAA ATTGACTGCT TAACAGGGGA CCATAAGAAT 
CTCCGTACAG ATATCGTCAT GGATGTTGGT TCCAGCTTGA ATCCTGCCAT TGATATCGGA 
CAGGTAGAAG GGGCATTTGT CCAGGGTCTT GGTCTTTTCA CCATGGAGGA GCTGCACTAC 
TCTCCCGAGG GGAGCCTGCA CACTCGTGGC CCCAGTACCT ACAAGATCCC TGCATTTGGC 
AGCATCCCCA TTGAGTTCAG AGTATCCCTG CTCCGCGACT GCCCCAACAA GAGGGCCATC 
TATGCATCCA AGGCTGTCGG CGAGCCACCT CTTTTCCTGG CTTCTTCGAT CTTCTTTGCC 
ATCAAAGATG CCATCCGCGC AGCTCGAGCT CAGCACGGAG ACAGTAACGC CAAACAGCTC 
TTCCAGCTAG ACAGCCCCGC CACTCCGGAG AAGATCCGAA ACGCTTGTGT GGATCAGTTC 
ACCACCCTGT GTGCCACTGG AACACCAGAA AACTGTAAAT CCTGGTCCGT GAGGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011244683.1
CDS	84..2483
Translation	MCGKLDPTFASATLLFQKDPPANVQLFQEVPKGQSEEDMVGRPMPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIMSIDTSEAKKVPGFVCFLTSEDVPGSNITGIFNDETVFAKDEVTCVGHIIGAVVADTPEHAHRAARGVKITYEDLPAIITIQDAIKNNSFYGPEVKIEKGDLKKGFSEADNVVSGELYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFIAKMLGVPDNRIVVRVKRMGGGFGGKETRSTLISTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTIVALEVAHFSNGGNSEDLSRSIMERAVFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAVTCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIASSQYQARKMEVEKFNRENCWKKRGLCIIPTKFGISFTLSFLNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHITETSTNTVPNTSPTAASASADLNGQAIYEACQTILKRLEPFKKKNPSGSWESWVMDAYTSAVSLSATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDSNAKQLFQLDSPATPEKIRNACVDQFTTLCATGTPENCKSWSVRI

Target ORF information:

RefSeq Version	XM_011246381.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus xanthine dehydrogenase (Xdh), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011246381.1

ORF Insert Sequence:

ATGTGTGGTA AACTGGACCC CACCTTTGCC AGCGCCACCC TGCTCTTTCA GAAGGATCCT 
CCAGCTAACG TCCAGCTTTT CCAAGAGGTG CCCAAGGGTC AGTCTGAGGA GGACATGGTG 
GGCAGGCCCA TGCCTCACCT GGCAGCAGAC ATGCAGGCAT CCGGGGAGGC TGTGTACTGT 
GATGACATTC CCCGCTATGA GAATGAGCTG TCCCTCAGGC TGGTCACCAG CACGCGGGCC 
CATGCTAAAA TCATGTCCAT CGACACTTCA GAAGCCAAGA AGGTGCCAGG GTTTGTTTGT 
TTCCTCACCT CAGAGGATGT CCCTGGTAGT AACATAACTG GCATTTTCAA TGATGAAACT 
GTCTTTGCGA AGGATGAGGT TACTTGTGTT GGGCACATCA TTGGTGCTGT GGTCGCTGAC 
ACCCCAGAAC ATGCACACAG AGCCGCTAGA GGGGTGAAAA TCACCTATGA AGACCTTCCA 
GCCATTATCA CAATCCAGGA TGCTATAAAG AACAACTCCT TTTATGGCCC CGAGGTAAAA 
ATCGAGAAAG GAGATCTCAA GAAAGGCTTT TCTGAAGCTG ACAATGTTGT CTCAGGAGAA 
TTATATATTG GTGGCCAGGA GCACTTCTAT CTGGAGACCC ACTGCACCAT TGCCGTGCCG 
AAAGGCGAGG CAGGCGAGAT GGAGCTCTTC GTGAGCACAC AGAACACCAT GAAAACCCAG 
AGCTTTATTG CAAAGATGTT GGGTGTTCCA GACAACAGAA TTGTAGTCCG AGTGAAAAGA 
ATGGGTGGAG GCTTTGGAGG GAAGGAGACC CGGAGCACTC TGATATCCAC AGCAGTGGCC 
TTGGCTGCAT ACAAGACAGG CCGCCCTGTA CGTTGCATGC TGGACCGAGA CGAGGACATG 
CTCATAACTG GTGGCAGACA TCCCTTCCTG GCTAAATACA AGGTGGGCTT CATGAAGACT 
GGGACTATAG TGGCACTGGA GGTGGCTCAC TTCAGCAATG GCGGGAACAG TGAGGATCTC 
TCTCGGAGTA TAATGGAAAG AGCTGTATTC CACATGGACA ACGCCTATAA GATCCCCAAC 
ATTCGCGGCA CCGGGAGGAT TTGTAAGACT AATCTGCCCT CTAACACAGC CTTCAGAGGC 
TTTGGGGGTC CTCAGGGGAT GCTAATCGCA GAATACTGGA TGAGTGAGGT CGCTGTCACC 
TGTGGGCTGC CTGCAGAGGA GGTACGGAGG AAAAACATGT ACAAAGAAGG GGACCTGACT 
CACTTCAACC AGAAGCTGGA GGGGTTCACC TTGCCCAGGT GCTGGGATGA GTGCATAGCG 
AGCTCCCAGT ATCAGGCTCG CAAGATGGAA GTGGAGAAAT TCAACAGGGA GAACTGTTGG 
AAAAAGAGAG GGCTGTGTAT AATCCCGACT AAGTTTGGAA TAAGCTTCAC ACTTTCTTTT 
CTGAACCAGG GGGGTGCCTT GGTCCACGTG TACACGGATG GGTCGGTGCT GCTGACACAT 
GGAGGTACTG AGATGGGTCA AGGCCTTCAC ACCAAGATGG TTCAGGTGGC CAGCAGAGCT 
CTGAAAATCC CCACTTCCAA GATCCATATA ACGGAGACAA GCACTAACAC TGTCCCTAAC 
ACCTCTCCCA CGGCTGCCTC TGCCAGCGCT GACCTCAATG GCCAGGCCAT TTATGAAGCC 
TGTCAGACCA TACTGAAAAG ACTGGAGCCC TTCAAGAAAA AGAATCCCTC AGGCTCCTGG 
GAGAGCTGGG TCATGGATGC CTACACTAGT GCAGTGAGCT TGTCTGCTAC TGGATTTTAT 
AAGACACCCA ACCTTGGTTA CAGCTTTGAG ACAAACTCTG GGAACCCCTT CCACTACTTC 
AGTTATGGGG TGGCTTGCTC AGAAGTAGAA ATTGACTGCT TAACAGGGGA CCATAAGAAT 
CTCCGTACAG ATATCGTCAT GGATGTTGGT TCCAGCTTGA ATCCTGCCAT TGATATCGGA 
CAGGTAGAAG GGGCATTTGT CCAGGGTCTT GGTCTTTTCA CCATGGAGGA GCTGCACTAC 
TCTCCCGAGG GGAGCCTGCA CACTCGTGGC CCCAGTACCT ACAAGATCCC TGCATTTGGC 
AGCATCCCCA TTGAGTTCAG AGTATCCCTG CTCCGCGACT GCCCCAACAA GAGGGCCATC 
TATGCATCCA AGGCTGTCGG CGAGCCACCT CTTTTCCTGG CTTCTTCGAT CTTCTTTGCC 
ATCAAAGATG CCATCCGCGC AGCTCGAGCT CAGCACGGAG ACAGTAACGC CAAACAGCTC 
TTCCAGCTAG ACAGCCCCGC CACTCCGGAG AAGATCCGAA ACGCTTGTGT GGATCAGTTC 
ACCACCCTGT GTGCCACTGG AACACCAGAA AACTGTAAAT CCTGGTCCGT GAGGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Xdh ( NM_011723.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035853.2 Mus musculus xanthine dehydrogenase (Xdh), mRNA.

Price & Availability↑

CloneID	OMu20221
Clone ID Related Accession (Same CDS sequence)	NM_011723.3
Accession Version	NM_011723.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	xanthine dehydrogenase/oxidase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY318674.1, AK143412.1, AK034256.1, AK008517.1, AK161529.1 and AI323529.1. On Jan 23, 2014 this sequence version replaced NM_011723.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144700.1, AK143412.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 12502743, 15878860 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGAGGA CAACGGTAGA TGAGTTGGTC TTCTTTGTGA ATGGCAAAAA GGTGGTGGAG 
AAAAATGCAG ACCCTGAAAC AACACTTCTG GTCTACCTTA GAAGAAAGTT GGGGCTGTGC 
GGGACCAAGC TTGGCTGTGG AGAAGGTGGC TGTGGGGCAT GCACCGTGAT GATCTCCAAG 
TATGACCGCC TTCAGAACAA GATCGTTCAT TTTTCCGTCA ATGCCTGCTT GACCCCCATC 
TGCTCCTTGC ATCATGTTGC TGTGACAACT GTGGAAGGCA TAGGAAACAC CAAGAAGCTG 
CATCCTGTCC AGGAGAGAAT TGCCAAAAGC CATGGTTCCC AGTGTGGGTT CTGTACCCCT 
GGTATTGTCA TGAGTATGTA CACACTGCTC CGAAACAAGC CTGAGCCTAC TGTCGAGGAG 
ATCGAGAATG CCTTCCAAGG AAACCTCTGC CGCTGTACAG GCTATAGACC CATCCTCCAG 
GGATTCCGGA CCTTTGCCAA GGATGGTGGG TGCTGTGGAG GAAGTGGAAA CAACCCAAAC 
TGCTGCATGA GCCAAACAAA GGACCAGACG ATTGCTCCCT CATCTTCTTT ATTCAACCCG 
GAGGATTTCA AACCTTTAGA TCCCACCCAA GAGCCCATCT TTCCCCCAGA GTTGCTGAGG 
CTGAAAGACA CTCCCCGGAA GACGTTGCGT TTTGAAGGGG AACGTGTGAC CTGGATCCAG 
GTTTCAACCA TGGAGGAACT GCTTGACCTC AAAGCCCAGC ACCCTGATGC CAAGCTGGTG 
GTGGGAAACA CAGAGATAGG CATTGAAATG AAATTTAAAA ATATGCTATT TCCTCTGATC 
ATCTGCCCAG CCTGGATCCT TGAACTGACC TCAGTGGCAC ATGGGCCTGA GGGAATCTCC 
TTTGGAGCCG CTTGCCCCCT TAGCTTGGTG GAAAGTGTCC TGGCGGACGC GATTGCTACA 
CTTCCAGAGC AGAGGACAGA GGTGTTCAGA GGCGTGATGG AGCAGCTGCG CTGGTTTGCT 
GGCAAGCAGG TCAAGTCCGT GGCGTCCATT GGCGGGAACA TCATCACCGC GAGCCCCATC 
TCTGACCTCA ACCCTGTGCT CATGGCCAGT CGAGCCAAGC TGACCCTCGC ATCTAGAGGT 
ACCAAGAGAA CGGTCTGGAT GGACCATACC TTCTTCCCTG GCTATAGAAG GACTCTGCTC 
AGTCCAGAGG AGATATTGGT GTCCATTGTG ATCCCCTACA GCAGGAAGGG TGAGTTTTTC 
TCAGCCTTCA AGCAGGCCTC CAGGAGAGAA GATGACATTG CCAAGGTGAC CAGTGGCATG 
AGAGTCCTGT TCAAGCCAGG GACCACTGAA GTGCAGGAAC TGTCCCTTTG CTTTGGAGGG 
ATGGCTGACA GAACTGTCTC AGCCCTCAAG ACCACTCCGA AGCAGCTGTC CAAGTCCTGG 
AATGAGGAGT TGCTGCAGGA TGTGTGTGCT GGCTTGGCAG AGGAGCTGCA CCTGGCCCCC 
GACGCCCCTG GTGGGATGGT GGAATTCCGG CGCACCCTCA CCCTCAGCTT CTTCTTCAAG 
TTCTACCTGA CAGTGCTTCA GAAGCTGGGC AGAGCGGACC TTGAGGGTAT GTGTGGTAAA 
CTGGACCCCA CCTTTGCCAG CGCCACCCTG CTCTTTCAGA AGGATCCTCC AGCTAACGTC 
CAGCTTTTCC AAGAGGTGCC CAAGGGTCAG TCTGAGGAGG ACATGGTGGG CAGGCCCATG 
CCTCACCTGG CAGCAGACAT GCAGGCATCC GGGGAGGCTG TGTACTGTGA TGACATTCCC 
CGCTATGAGA ATGAGCTGTC CCTCAGGCTG GTCACCAGCA CGCGGGCCCA TGCTAAAATC 
ATGTCCATCG ACACTTCAGA AGCCAAGAAG GTGCCAGGGT TTGTTTGTTT CCTCACCTCA 
GAGGATGTCC CTGGTAGTAA CATAACTGGC ATTTTCAATG ATGAAACTGT CTTTGCGAAG 
GATGAGGTTA CTTGTGTTGG GCACATCATT GGTGCTGTGG TCGCTGACAC CCCAGAACAT 
GCACACAGAG CCGCTAGAGG GGTGAAAATC ACCTATGAAG ACCTTCCAGC CATTATCACA 
ATCCAGGATG CTATAAAGAA CAACTCCTTT TATGGCCCCG AGGTAAAAAT CGAGAAAGGA 
GATCTCAAGA AAGGCTTTTC TGAAGCTGAC AATGTTGTCT CAGGAGAATT ATATATTGGT 
GGCCAGGAGC ACTTCTATCT GGAGACCCAC TGCACCATTG CCGTGCCGAA AGGCGAGGCA 
GGCGAGATGG AGCTCTTCGT GAGCACACAG AACACCATGA AAACCCAGAG CTTTATTGCA 
AAGATGTTGG GTGTTCCAGA CAACAGAATT GTAGTCCGAG TGAAAAGAAT GGGTGGAGGC 
TTTGGAGGGA AGGAGACCCG GAGCACTCTG ATATCCACAG CAGTGGCCTT GGCTGCATAC 
AAGACAGGCC GCCCTGTACG TTGCATGCTG GACCGAGACG AGGACATGCT CATAACTGGT 
GGCAGACATC CCTTCCTGGC TAAATACAAG GTGGGCTTCA TGAAGACTGG GACTATAGTG 
GCACTGGAGG TGGCTCACTT CAGCAATGGC GGGAACAGTG AGGATCTCTC TCGGAGTATA 
ATGGAAAGAG CTGTATTCCA CATGGACAAC GCCTATAAGA TCCCCAACAT TCGCGGCACC 
GGGAGGATTT GTAAGACTAA TCTGCCCTCT AACACAGCCT TCAGAGGCTT TGGGGGTCCT 
CAGGGGATGC TAATCGCAGA ATACTGGATG AGTGAGGTCG CTGTCACCTG TGGGCTGCCT 
GCAGAGGAGG TACGGAGGAA AAACATGTAC AAAGAAGGGG ACCTGACTCA CTTCAACCAG 
AAGCTGGAGG GGTTCACCTT GCCCAGGTGC TGGGATGAGT GCATAGCGAG CTCCCAGTAT 
CAGGCTCGCA AGATGGAAGT GGAGAAATTC AACAGGGAGA ACTGTTGGAA AAAGAGAGGG 
CTGTGTATAA TCCCGACTAA GTTTGGAATA AGCTTCACAC TTTCTTTTCT GAACCAGGGG 
GGTGCCTTGG TCCACGTGTA CACGGATGGG TCGGTGCTGC TGACACATGG AGGTACTGAG 
ATGGGTCAAG GCCTTCACAC CAAGATGGTT CAGGTGGCCA GCAGAGCTCT GAAAATCCCC 
ACTTCCAAGA TCCATATAAC GGAGACAAGC ACTAACACTG TCCCTAACAC CTCTCCCACG 
GCTGCCTCTG CCAGCGCTGA CCTCAATGGC CAGGCCATTT ATGAAGCCTG TCAGACCATA 
CTGAAAAGAC TGGAGCCCTT CAAGAAAAAG AATCCCTCAG GCTCCTGGGA GAGCTGGGTC 
ATGGATGCCT ACACTAGTGC AGTGAGCTTG TCTGCTACTG GATTTTATAA GACACCCAAC 
CTTGGTTACA GCTTTGAGAC AAACTCTGGG AACCCCTTCC ACTACTTCAG TTATGGGGTG 
GCTTGCTCAG AAGTAGAAAT TGACTGCTTA ACAGGGGACC ATAAGAATCT CCGTACAGAT 
ATCGTCATGG ATGTTGGTTC CAGCTTGAAT CCTGCCATTG ATATCGGACA GGTAGAAGGG 
GCATTTGTCC AGGGTCTTGG TCTTTTCACC ATGGAGGAGC TGCACTACTC TCCCGAGGGG 
AGCCTGCACA CTCGTGGCCC CAGTACCTAC AAGATCCCTG CATTTGGCAG CATCCCCATT 
GAGTTCAGAG TATCCCTGCT CCGCGACTGC CCCAACAAGA GGGCCATCTA TGCATCCAAG 
GCTGTCGGCG AGCCACCTCT TTTCCTGGCT TCTTCGATCT TCTTTGCCAT CAAAGATGCC 
ATCCGCGCAG CTCGAGCTCA GCACGGAGAC AGTAACGCCA AACAGCTCTT CCAGCTAGAC 
AGCCCCGCCA CTCCGGAGAA GATCCGAAAC GCTTGTGTGG ATCAGTTCAC CACCCTGTGT 
GCCACTGGAA CACCAGAAAA CTGTAAATCC TGGTCCGTGA GGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035853.2
CDS	69..4076
Translation	MTRTTVDELVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSVNACLTPICSLHHVAVTTVEGIGNTKKLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNKPEPTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCMSQTKDQTIAPSSSLFNPEDFKPLDPTQEPIFPPELLRLKDTPRKTLRFEGERVTWIQVSTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIICPAWILELTSVAHGPEGISFGAACPLSLVESVLADAIATLPEQRTEVFRGVMEQLRWFAGKQVKSVASIGGNIITASPISDLNPVLMASRAKLTLASRGTKRTVWMDHTFFPGYRRTLLSPEEILVSIVIPYSRKGEFFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELSLCFGGMADRTVSALKTTPKQLSKSWNEELLQDVCAGLAEELHLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEGMCGKLDPTFASATLLFQKDPPANVQLFQEVPKGQSEEDMVGRPMPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIMSIDTSEAKKVPGFVCFLTSEDVPGSNITGIFNDETVFAKDEVTCVGHIIGAVVADTPEHAHRAARGVKITYEDLPAIITIQDAIKNNSFYGPEVKIEKGDLKKGFSEADNVVSGELYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFIAKMLGVPDNRIVVRVKRMGGGFGGKETRSTLISTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTIVALEVAHFSNGGNSEDLSRSIMERAVFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAVTCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIASSQYQARKMEVEKFNRENCWKKRGLCIIPTKFGISFTLSFLNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHITETSTNTVPNTSPTAASASADLNGQAIYEACQTILKRLEPFKKKNPSGSWESWVMDAYTSAVSLSATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDSNAKQLFQLDSPATPEKIRNACVDQFTTLCATGTPENCKSWSVRI

Target ORF information:

RefSeq Version	NM_011723.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus xanthine dehydrogenase (Xdh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011723.3

ORF Insert Sequence:

ATGACGAGGA CAACGGTAGA TGAGTTGGTC TTCTTTGTGA ATGGCAAAAA GGTGGTGGAG 
AAAAATGCAG ACCCTGAAAC AACACTTCTG GTCTACCTTA GAAGAAAGTT GGGGCTGTGC 
GGGACCAAGC TTGGCTGTGG AGAAGGTGGC TGTGGGGCAT GCACCGTGAT GATCTCCAAG 
TATGACCGCC TTCAGAACAA GATCGTTCAT TTTTCCGTCA ATGCCTGCTT GACCCCCATC 
TGCTCCTTGC ATCATGTTGC TGTGACAACT GTGGAAGGCA TAGGAAACAC CAAGAAGCTG 
CATCCTGTCC AGGAGAGAAT TGCCAAAAGC CATGGTTCCC AGTGTGGGTT CTGTACCCCT 
GGTATTGTCA TGAGTATGTA CACACTGCTC CGAAACAAGC CTGAGCCTAC TGTCGAGGAG 
ATCGAGAATG CCTTCCAAGG AAACCTCTGC CGCTGTACAG GCTATAGACC CATCCTCCAG 
GGATTCCGGA CCTTTGCCAA GGATGGTGGG TGCTGTGGAG GAAGTGGAAA CAACCCAAAC 
TGCTGCATGA GCCAAACAAA GGACCAGACG ATTGCTCCCT CATCTTCTTT ATTCAACCCG 
GAGGATTTCA AACCTTTAGA TCCCACCCAA GAGCCCATCT TTCCCCCAGA GTTGCTGAGG 
CTGAAAGACA CTCCCCGGAA GACGTTGCGT TTTGAAGGGG AACGTGTGAC CTGGATCCAG 
GTTTCAACCA TGGAGGAACT GCTTGACCTC AAAGCCCAGC ACCCTGATGC CAAGCTGGTG 
GTGGGAAACA CAGAGATAGG CATTGAAATG AAATTTAAAA ATATGCTATT TCCTCTGATC 
ATCTGCCCAG CCTGGATCCT TGAACTGACC TCAGTGGCAC ATGGGCCTGA GGGAATCTCC 
TTTGGAGCCG CTTGCCCCCT TAGCTTGGTG GAAAGTGTCC TGGCGGACGC GATTGCTACA 
CTTCCAGAGC AGAGGACAGA GGTGTTCAGA GGCGTGATGG AGCAGCTGCG CTGGTTTGCT 
GGCAAGCAGG TCAAGTCCGT GGCGTCCATT GGCGGGAACA TCATCACCGC GAGCCCCATC 
TCTGACCTCA ACCCTGTGCT CATGGCCAGT CGAGCCAAGC TGACCCTCGC ATCTAGAGGT 
ACCAAGAGAA CGGTCTGGAT GGACCATACC TTCTTCCCTG GCTATAGAAG GACTCTGCTC 
AGTCCAGAGG AGATATTGGT GTCCATTGTG ATCCCCTACA GCAGGAAGGG TGAGTTTTTC 
TCAGCCTTCA AGCAGGCCTC CAGGAGAGAA GATGACATTG CCAAGGTGAC CAGTGGCATG 
AGAGTCCTGT TCAAGCCAGG GACCACTGAA GTGCAGGAAC TGTCCCTTTG CTTTGGAGGG 
ATGGCTGACA GAACTGTCTC AGCCCTCAAG ACCACTCCGA AGCAGCTGTC CAAGTCCTGG 
AATGAGGAGT TGCTGCAGGA TGTGTGTGCT GGCTTGGCAG AGGAGCTGCA CCTGGCCCCC 
GACGCCCCTG GTGGGATGGT GGAATTCCGG CGCACCCTCA CCCTCAGCTT CTTCTTCAAG 
TTCTACCTGA CAGTGCTTCA GAAGCTGGGC AGAGCGGACC TTGAGGGTAT GTGTGGTAAA 
CTGGACCCCA CCTTTGCCAG CGCCACCCTG CTCTTTCAGA AGGATCCTCC AGCTAACGTC 
CAGCTTTTCC AAGAGGTGCC CAAGGGTCAG TCTGAGGAGG ACATGGTGGG CAGGCCCATG 
CCTCACCTGG CAGCAGACAT GCAGGCATCC GGGGAGGCTG TGTACTGTGA TGACATTCCC 
CGCTATGAGA ATGAGCTGTC CCTCAGGCTG GTCACCAGCA CGCGGGCCCA TGCTAAAATC 
ATGTCCATCG ACACTTCAGA AGCCAAGAAG GTGCCAGGGT TTGTTTGTTT CCTCACCTCA 
GAGGATGTCC CTGGTAGTAA CATAACTGGC ATTTTCAATG ATGAAACTGT CTTTGCGAAG 
GATGAGGTTA CTTGTGTTGG GCACATCATT GGTGCTGTGG TCGCTGACAC CCCAGAACAT 
GCACACAGAG CCGCTAGAGG GGTGAAAATC ACCTATGAAG ACCTTCCAGC CATTATCACA 
ATCCAGGATG CTATAAAGAA CAACTCCTTT TATGGCCCCG AGGTAAAAAT CGAGAAAGGA 
GATCTCAAGA AAGGCTTTTC TGAAGCTGAC AATGTTGTCT CAGGAGAATT ATATATTGGT 
GGCCAGGAGC ACTTCTATCT GGAGACCCAC TGCACCATTG CCGTGCCGAA AGGCGAGGCA 
GGCGAGATGG AGCTCTTCGT GAGCACACAG AACACCATGA AAACCCAGAG CTTTATTGCA 
AAGATGTTGG GTGTTCCAGA CAACAGAATT GTAGTCCGAG TGAAAAGAAT GGGTGGAGGC 
TTTGGAGGGA AGGAGACCCG GAGCACTCTG ATATCCACAG CAGTGGCCTT GGCTGCATAC 
AAGACAGGCC GCCCTGTACG TTGCATGCTG GACCGAGACG AGGACATGCT CATAACTGGT 
GGCAGACATC CCTTCCTGGC TAAATACAAG GTGGGCTTCA TGAAGACTGG GACTATAGTG 
GCACTGGAGG TGGCTCACTT CAGCAATGGC GGGAACAGTG AGGATCTCTC TCGGAGTATA 
ATGGAAAGAG CTGTATTCCA CATGGACAAC GCCTATAAGA TCCCCAACAT TCGCGGCACC 
GGGAGGATTT GTAAGACTAA TCTGCCCTCT AACACAGCCT TCAGAGGCTT TGGGGGTCCT 
CAGGGGATGC TAATCGCAGA ATACTGGATG AGTGAGGTCG CTGTCACCTG TGGGCTGCCT 
GCAGAGGAGG TACGGAGGAA AAACATGTAC AAAGAAGGGG ACCTGACTCA CTTCAACCAG 
AAGCTGGAGG GGTTCACCTT GCCCAGGTGC TGGGATGAGT GCATAGCGAG CTCCCAGTAT 
CAGGCTCGCA AGATGGAAGT GGAGAAATTC AACAGGGAGA ACTGTTGGAA AAAGAGAGGG 
CTGTGTATAA TCCCGACTAA GTTTGGAATA AGCTTCACAC TTTCTTTTCT GAACCAGGGG 
GGTGCCTTGG TCCACGTGTA CACGGATGGG TCGGTGCTGC TGACACATGG AGGTACTGAG 
ATGGGTCAAG GCCTTCACAC CAAGATGGTT CAGGTGGCCA GCAGAGCTCT GAAAATCCCC 
ACTTCCAAGA TCCATATAAC GGAGACAAGC ACTAACACTG TCCCTAACAC CTCTCCCACG 
GCTGCCTCTG CCAGCGCTGA CCTCAATGGC CAGGCCATTT ATGAAGCCTG TCAGACCATA 
CTGAAAAGAC TGGAGCCCTT CAAGAAAAAG AATCCCTCAG GCTCCTGGGA GAGCTGGGTC 
ATGGATGCCT ACACTAGTGC AGTGAGCTTG TCTGCTACTG GATTTTATAA GACACCCAAC 
CTTGGTTACA GCTTTGAGAC AAACTCTGGG AACCCCTTCC ACTACTTCAG TTATGGGGTG 
GCTTGCTCAG AAGTAGAAAT TGACTGCTTA ACAGGGGACC ATAAGAATCT CCGTACAGAT 
ATCGTCATGG ATGTTGGTTC CAGCTTGAAT CCTGCCATTG ATATCGGACA GGTAGAAGGG 
GCATTTGTCC AGGGTCTTGG TCTTTTCACC ATGGAGGAGC TGCACTACTC TCCCGAGGGG 
AGCCTGCACA CTCGTGGCCC CAGTACCTAC AAGATCCCTG CATTTGGCAG CATCCCCATT 
GAGTTCAGAG TATCCCTGCT CCGCGACTGC CCCAACAAGA GGGCCATCTA TGCATCCAAG 
GCTGTCGGCG AGCCACCTCT TTTCCTGGCT TCTTCGATCT TCTTTGCCAT CAAAGATGCC 
ATCCGCGCAG CTCGAGCTCA GCACGGAGAC AGTAACGCCA AACAGCTCTT CCAGCTAGAC 
AGCCCCGCCA CTCCGGAGAA GATCCGAAAC GCTTGTGTGG ATCAGTTCAC CACCCTGTGT 
GCCACTGGAA CACCAGAAAA CTGTAAATCC TGGTCCGTGA GGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.
The Journal of biological chemistry280(26)24888-94(2005 Jul)
Nishino T,Okamoto K,Kawaguchi Y,Hori H,Matsumura T,Eger BT,Pai EF,Nishino T

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Xdh cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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