Txk cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Txk
Entrez Gene ID	22165
Full Name	TXK tyrosine kinase
Synonyms	A130089B16Rik,Btkl,PTK-RL-18,PTK4,Rlk
General protein information	Preferred Names TXK tyrosine kinase Names tyrosine-protein kinase TXK resting lymphocyte kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 C3.2\|5 38.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001289494.1	NP_001276423.1	tyrosine-protein kinase TXK isoform 3
NM_013698.3	NP_038726.2	tyrosine-protein kinase TXK isoform 2
NM_001289495.1	NP_001276424.1	tyrosine-protein kinase TXK isoform 4
XM_011240722.1	XP_011239024.1	tyrosine-protein kinase TXK isoform X1
NM_001122754.2	NP_001116226.1	tyrosine-protein kinase TXK isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TXK	NP_003319.2
Mus musculus (house mouse)	Txk	NP_038726.2
Rattus norvegicus (Norway rat)	Txk	NP_001019426.1
Canis lupus familiaris (dog)	TXK	XP_539258.3
Bos taurus (cattle)	TXK	NP_001193077.1
Danio rerio (zebrafish)	LOC100534735	XP_003201292.2
Pan troglodytes (chimpanzee)	TXK	XP_517311.3
	TXK	XP_001103052.1
Gallus gallus (chicken)	TXK	XP_004936109.1

Gene Ontology
Bibliography

Related articles in PubMed

A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.
Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ
Journal of immunology (Baltimore, Md. : 1950)195(10)4822-31(2015 Nov)

A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.
Qi Q, Huang W, Bai Y, Balmus G, Weiss RS, August A
Journal of immunology (Baltimore, Md. : 1950)188(8)3611-9(2012 Apr)

Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell.
Qi Q, Xia M, Bai Y, Yu S, Cantorna M, August A
The Journal of biological chemistry286(1)138-46(2011 Jan)

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Rochman Y, Kashyap M, Robinson GW, Sakamoto K, Gomez-Rodriguez J, Wagner KU, Leonard WJ
Proceedings of the National Academy of Sciences of the United States of America107(45)19455-60(2010 Nov)

Locus category based analysis of a large genome-wide association study of rheumatoid arthritis.
Freudenberg J, Lee AT, Siminovitch KA, Amos CI, Ballard D, Li W, Gregersen PK
Human molecular genetics19(19)3863-72(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, these data indicate that ITK plus RLK inhibition may have therapeutic potential in Th1-mediated inflammatory diseases.
Title: A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.

TXK plays an overlapping role with ITK in iNKT cell development and function. ITK also has a unique function in the survival of iNKT cells, likely via a p53-dependent pathway.
Title: A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.

Tec kinases Rlk and Itk together provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of natural killer T (NKT) cells.
Title: The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.

indicate a critical role for Itk and Rlk in conventional CD8(+) T cell development in the thymus
Title: The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.

Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes
Title: Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

The following Txk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Txk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu57942	NM_001289495.1 Latest version!	Mus musculus TXK tyrosine kinase (Txk), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu57948	NM_013698.3 Latest version!	Mus musculus TXK tyrosine kinase (Txk), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu57953	NM_001289494.1 Latest version!	Mus musculus TXK tyrosine kinase (Txk), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu57961	NM_001122754.2 Latest version!	Mus musculus TXK tyrosine kinase (Txk), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu57942	XM_011240722.1 Latest version!	Mus musculus TXK tyrosine kinase (Txk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Txk ( NM_001289495.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276424.1 Mus musculus TXK tyrosine kinase (Txk), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu57942
Clone ID Related Accession (Same CDS sequence)	NM_001289495.1 , XM_011240722.1
Accession Version	NM_001289495.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase TXK isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC099698.14, AK138786.1 and AC122733.11. On Jan 23, 2014 this sequence version replaced XM_006503861.1. Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK138786.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849383, SAMN00849384 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAAA CTCAATCCAA CAGAGGCGGG GTGCAACCCT CGAAGCGCAA GCCGCTGCCC 
CCCCTCCCGC AGGAGCCTCC AGATGAGAGA ATCCAGGTCA AGGCTCTTTA TGACTTCCTG 
CCTCGGGAGC CTGGTAATTT GGCACTGAAG AGAGCGGAGG AATATCTGAT ATTGGAGAGG 
TGTGATCCTC ACTGGTGGAA GGCCAGAGAC CGCTTCGGGA ATGAAGGCTT AATCCCAAGC 
AACTATGTGA CAGAAAACAG ACTCGCCAAC TTAGAAATCT ATGAATGGTA CCACAAGAAC 
ATTACGAGAA ACCAGACCGA ACGCCTATTG AGGCAAGAGG CTAAAGAAGG TGCCTTTATC 
GTGAGAGATT CGAGACACTT GGGGTCTTAC ACAATCTCTG TGTTTACAAG AGCTCGAAGG 
CATACACAGT CTTCAATAAA ACATTATCAG ATAAAAAAGA ATGACTCCGG ACAGTGGTAC 
ATCACCGAAA GACATCTCTT CCCCTCAGTC CCCGAGTTGA TCCAGTATCA CCAGTACAAT 
GCAGCTGGTC TCATATCTCG TCTCCGCTAT CCCATTGGGC TCCTGGGCAG CTGTTTACCA 
GCCACATCTG GTTTTAGCTA TGAAAAGTGG GAGATAGATC CATCAGAGTT GGCTTTTGTC 
AAGGAGATCG GAAGTGGTCA GTTTGGGGTT GTCCACTTAG GAGAATGGAG AGCACATATC 
CCGGTCGCCA TCAAGGCCAT CAATGAAGGT TCCATGTCTG AAGAAGACTT CATTGAGGAA 
GCCAAGGTGA TGATGAAACT GTCACATTCG AGGTTAGTTC AACTTTACGG GGTGTGTATA 
CAGCAGAAGC CCCTGTACAT AGTGACGGAG TTCATGGAGA ACGGCTGCCT GCTTGACTAT 
CTCAGGGAGA GGAAAGGCCA GCTTCAGAAG GCGCTGCTCT TGAGCATGTG CCAAGACATA 
TGTGAAGGGA TGGCGTACCT GGAGAGGAGC TGCTATATTC ACAGGGATCT GGCTGCCAGG 
AACTGTTTGG TCAGTTCTGC CTGCGTAGTA AAGATCTCAG ACTTCGGCAT GGCGAGGTAT 
GTTTTGGACG ATGAATATAT CAGTTCTTCT GGAGCTAAGT TCCCAGTCAA GTGGTGCCCA 
CCTGAAGTCT TTCATTTCAA CAAATACAGT AGCAAGTCTG ATGTCTGGTC GTTCGGAGTT 
TTAATGTGGG AAGTTTTTAC AGAAGGAAAA ATGCCTTTTG AAAATAAGTC AAATTTGCAA 
GTGGTGGAAG CCATTTCTCA AGGTTTCCGG CTGTATCGTC CTCACCTGGC CCCCATGACC 
ATATACAGAG TGATGTACAG TTGCTGGCAT GAGAGCCCTA AAGGCCGTCC GACATTTGCT 
GAGCTGCTTC AGGTTCTCAC GGAGATCGCA GAAACGTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276424.1
CDS	263..1684
Translation	MGKTQSNRGGVQPSKRKPLPPLPQEPPDERIQVKALYDFLPREPGNLALKRAEEYLILERCDPHWWKARDRFGNEGLIPSNYVTENRLANLEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELLQVLTEIAETW

Target ORF information:

RefSeq Version	NM_001289495.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus TXK tyrosine kinase (Txk), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289495.1

ORF Insert Sequence:

ATGGGCAAAA CTCAATCCAA CAGAGGCGGG GTGCAACCCT CGAAGCGCAA GCCGCTGCCC 
CCCCTCCCGC AGGAGCCTCC AGATGAGAGA ATCCAGGTCA AGGCTCTTTA TGACTTCCTG 
CCTCGGGAGC CTGGTAATTT GGCACTGAAG AGAGCGGAGG AATATCTGAT ATTGGAGAGG 
TGTGATCCTC ACTGGTGGAA GGCCAGAGAC CGCTTCGGGA ATGAAGGCTT AATCCCAAGC 
AACTATGTGA CAGAAAACAG ACTCGCCAAC TTAGAAATCT ATGAATGGTA CCACAAGAAC 
ATTACGAGAA ACCAGACCGA ACGCCTATTG AGGCAAGAGG CTAAAGAAGG TGCCTTTATC 
GTGAGAGATT CGAGACACTT GGGGTCTTAC ACAATCTCTG TGTTTACAAG AGCTCGAAGG 
CATACACAGT CTTCAATAAA ACATTATCAG ATAAAAAAGA ATGACTCCGG ACAGTGGTAC 
ATCACCGAAA GACATCTCTT CCCCTCAGTC CCCGAGTTGA TCCAGTATCA CCAGTACAAT 
GCAGCTGGTC TCATATCTCG TCTCCGCTAT CCCATTGGGC TCCTGGGCAG CTGTTTACCA 
GCCACATCTG GTTTTAGCTA TGAAAAGTGG GAGATAGATC CATCAGAGTT GGCTTTTGTC 
AAGGAGATCG GAAGTGGTCA GTTTGGGGTT GTCCACTTAG GAGAATGGAG AGCACATATC 
CCGGTCGCCA TCAAGGCCAT CAATGAAGGT TCCATGTCTG AAGAAGACTT CATTGAGGAA 
GCCAAGGTGA TGATGAAACT GTCACATTCG AGGTTAGTTC AACTTTACGG GGTGTGTATA 
CAGCAGAAGC CCCTGTACAT AGTGACGGAG TTCATGGAGA ACGGCTGCCT GCTTGACTAT 
CTCAGGGAGA GGAAAGGCCA GCTTCAGAAG GCGCTGCTCT TGAGCATGTG CCAAGACATA 
TGTGAAGGGA TGGCGTACCT GGAGAGGAGC TGCTATATTC ACAGGGATCT GGCTGCCAGG 
AACTGTTTGG TCAGTTCTGC CTGCGTAGTA AAGATCTCAG ACTTCGGCAT GGCGAGGTAT 
GTTTTGGACG ATGAATATAT CAGTTCTTCT GGAGCTAAGT TCCCAGTCAA GTGGTGCCCA 
CCTGAAGTCT TTCATTTCAA CAAATACAGT AGCAAGTCTG ATGTCTGGTC GTTCGGAGTT 
TTAATGTGGG AAGTTTTTAC AGAAGGAAAA ATGCCTTTTG AAAATAAGTC AAATTTGCAA 
GTGGTGGAAG CCATTTCTCA AGGTTTCCGG CTGTATCGTC CTCACCTGGC CCCCATGACC 
ATATACAGAG TGATGTACAG TTGCTGGCAT GAGAGCCCTA AAGGCCGTCC GACATTTGCT 
GAGCTGCTTC AGGTTCTCAC GGAGATCGCA GAAACGTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txk ( NM_013698.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038726.2 Mus musculus TXK tyrosine kinase (Txk), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu57948
Clone ID Related Accession (Same CDS sequence)	NM_013698.3
Accession Version	NM_013698.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase TXK isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D43963.1, BC137710.1, AK138786.1 and AC122733.11. On Jan 23, 2014 this sequence version replaced NM_013698.2. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus but is the same size as isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D43963.1, BC137710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCTCCT TTTCAGATAG CTCCTTCCAG TCTGTTCTCT GCTGCTGCTG TTGCCGCTGC 
TCAGTACAGA AGAGACAGGT GAGAACTCAG ATAAGCCTGA GCAGAGAGGA AGAACTCTCA 
GAAAAACATT CCCAGCGTCA GAGGCCGTGG TTCGCCAAAC TGATGGGCAA AACTCAATCC 
AACAGAGGCG GGGTGCAACC CTCGAAGCGC AAGCCGCTGC CCCCCCTCCC GCAGGAGCCT 
CCAGATGAGA GAATCCAGGT CAAGGCTCTT TATGACTTCC TGCCTCGGGA GCCTGGTAAT 
TTGGCACTGA AGAGAGCGGA GGAATATCTG ATATTGGAGA GGTGTGATCC TCACTGGTGG 
AAGGCCAGAG ACCGCTTCGG GAATGAAGGC TTAATCCCAA GCAACTATGT GACAGAAAAC 
AGACTCGCCA ACTTAGAAAT CTATGAATGG TACCACAAGA ACATTACGAG AAACCAGACC 
GAACGCCTAT TGAGGCAAGA GGCTAAAGAA GGTGCCTTTA TCGTGAGAGA TTCGAGACAC 
TTGGGGTCTT ACACAATCTC TGTGTTTACA AGAGCTCGAA GGCATACACA GTCTTCAATA 
AAACATTATC AGATAAAAAA GAATGACTCC GGACAGTGGT ACATCACCGA AAGACATCTC 
TTCCCCTCAG TCCCCGAGTT GATCCAGTAT CACCAGTACA ATGCAGCTGG TCTCATATCT 
CGTCTCCGCT ATCCCATTGG GCTCCTGGGC AGCTGTTTAC CAGCCACATC TGGTTTTAGC 
TATGAAAAGT GGGAGATAGA TCCATCAGAG TTGGCTTTTG TCAAGGAGAT CGGAAGTGGT 
CAGTTTGGGG TTGTCCACTT AGGAGAATGG AGAGCACATA TCCCGGTCGC CATCAAGGCC 
ATCAATGAAG GTTCCATGTC TGAAGAAGAC TTCATTGAGG AAGCCAAGGT GATGATGAAA 
CTGTCACATT CGAGGTTAGT TCAACTTTAC GGGGTGTGTA TACAGCAGAA GCCCCTGTAC 
ATAGTGACGG AGTTCATGGA GAACGGCTGC CTGCTTGACT ATCTCAGGGA GAGGAAAGGC 
CAGCTTCAGA AGGCGCTGCT CTTGAGCATG TGCCAAGACA TATGTGAAGG GATGGCGTAC 
CTGGAGAGGA GCTGCTATAT TCACAGGGAT CTGGCTGCCA GGAACTGTTT GGTCAGTTCT 
GCCTGCGTAG TAAAGATCTC AGACTTCGGC ATGGCGAGGT ATGTTTTGGA CGATGAATAT 
ATCAGTTCTT CTGGAGCTAA GTTCCCAGTC AAGTGGTGCC CACCTGAAGT CTTTCATTTC 
AACAAATACA GTAGCAAGTC TGATGTCTGG TCGTTCGGAG TTTTAATGTG GGAAGTTTTT 
ACAGAAGGAA AAATGCCTTT TGAAAATAAG TCAAATTTGC AAGTGGTGGA AGCCATTTCT 
CAAGGTTTCC GGCTGTATCG TCCTCACCTG GCCCCCATGA CCATATACAG AGTGATGTAC 
AGTTGCTGGC ATGAGAGCCC TAAAGGCCGT CCGACATTTG CTGAGCTGCT TCAGGTTCTC 
ACGGAGATCG CAGAAACGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038726.2
CDS	168..1751
Translation	MISFSDSSFQSVLCCCCCRCSVQKRQVRTQISLSREEELSEKHSQRQRPWFAKLMGKTQSNRGGVQPSKRKPLPPLPQEPPDERIQVKALYDFLPREPGNLALKRAEEYLILERCDPHWWKARDRFGNEGLIPSNYVTENRLANLEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELLQVLTEIAETW

Target ORF information:

RefSeq Version	NM_013698.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus TXK tyrosine kinase (Txk), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013698.3

ORF Insert Sequence:

ATGATCTCCT TTTCAGATAG CTCCTTCCAG TCTGTTCTCT GCTGCTGCTG TTGCCGCTGC 
TCAGTACAGA AGAGACAGGT GAGAACTCAG ATAAGCCTGA GCAGAGAGGA AGAACTCTCA 
GAAAAACATT CCCAGCGTCA GAGGCCGTGG TTCGCCAAAC TGATGGGCAA AACTCAATCC 
AACAGAGGCG GGGTGCAACC CTCGAAGCGC AAGCCGCTGC CCCCCCTCCC GCAGGAGCCT 
CCAGATGAGA GAATCCAGGT CAAGGCTCTT TATGACTTCC TGCCTCGGGA GCCTGGTAAT 
TTGGCACTGA AGAGAGCGGA GGAATATCTG ATATTGGAGA GGTGTGATCC TCACTGGTGG 
AAGGCCAGAG ACCGCTTCGG GAATGAAGGC TTAATCCCAA GCAACTATGT GACAGAAAAC 
AGACTCGCCA ACTTAGAAAT CTATGAATGG TACCACAAGA ACATTACGAG AAACCAGACC 
GAACGCCTAT TGAGGCAAGA GGCTAAAGAA GGTGCCTTTA TCGTGAGAGA TTCGAGACAC 
TTGGGGTCTT ACACAATCTC TGTGTTTACA AGAGCTCGAA GGCATACACA GTCTTCAATA 
AAACATTATC AGATAAAAAA GAATGACTCC GGACAGTGGT ACATCACCGA AAGACATCTC 
TTCCCCTCAG TCCCCGAGTT GATCCAGTAT CACCAGTACA ATGCAGCTGG TCTCATATCT 
CGTCTCCGCT ATCCCATTGG GCTCCTGGGC AGCTGTTTAC CAGCCACATC TGGTTTTAGC 
TATGAAAAGT GGGAGATAGA TCCATCAGAG TTGGCTTTTG TCAAGGAGAT CGGAAGTGGT 
CAGTTTGGGG TTGTCCACTT AGGAGAATGG AGAGCACATA TCCCGGTCGC CATCAAGGCC 
ATCAATGAAG GTTCCATGTC TGAAGAAGAC TTCATTGAGG AAGCCAAGGT GATGATGAAA 
CTGTCACATT CGAGGTTAGT TCAACTTTAC GGGGTGTGTA TACAGCAGAA GCCCCTGTAC 
ATAGTGACGG AGTTCATGGA GAACGGCTGC CTGCTTGACT ATCTCAGGGA GAGGAAAGGC 
CAGCTTCAGA AGGCGCTGCT CTTGAGCATG TGCCAAGACA TATGTGAAGG GATGGCGTAC 
CTGGAGAGGA GCTGCTATAT TCACAGGGAT CTGGCTGCCA GGAACTGTTT GGTCAGTTCT 
GCCTGCGTAG TAAAGATCTC AGACTTCGGC ATGGCGAGGT ATGTTTTGGA CGATGAATAT 
ATCAGTTCTT CTGGAGCTAA GTTCCCAGTC AAGTGGTGCC CACCTGAAGT CTTTCATTTC 
AACAAATACA GTAGCAAGTC TGATGTCTGG TCGTTCGGAG TTTTAATGTG GGAAGTTTTT 
ACAGAAGGAA AAATGCCTTT TGAAAATAAG TCAAATTTGC AAGTGGTGGA AGCCATTTCT 
CAAGGTTTCC GGCTGTATCG TCCTCACCTG GCCCCCATGA CCATATACAG AGTGATGTAC 
AGTTGCTGGC ATGAGAGCCC TAAAGGCCGT CCGACATTTG CTGAGCTGCT TCAGGTTCTC 
ACGGAGATCG CAGAAACGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txk ( NM_001289494.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276423.1 Mus musculus TXK tyrosine kinase (Txk), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu57953
Clone ID Related Accession (Same CDS sequence)	NM_001289494.1
Accession Version	NM_001289494.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1518bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase TXK isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC099698.14 and AC122733.11. Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK088209.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCTGT CCTCTTATAG CTCCTTCCAG TCTGTTCTCT GCTGCTGCTG TTGCCGCTGC 
TCAGTACAGA AGAGACAGGT GAGAACTCAG ATAAGCCTGA GCAGAGAGGA AGAACTCTCA 
GAAAAACATT CCCAGCGTCA GAGGCCGTGG TTCGCCAAAC TGATGGGCAA AACTCAATCC 
AACAGAGGCG GGGTGCAACC CTCGAAGCGC AAGCCGCTGC CCCCCCTCCC GCAGGAGCCT 
CCAGATGAGA GAATCCAGGT CAAGGCTCTT TATGACTTCC TGCCTCGGGA GCCTGGTAAT 
TTGGCACTGA AGAGAGCGGA GGAATATCTG ATATTGGAGA GGTGTGATCC TCACTGGTGG 
AAGGCCAGAG ACCGCTTCGG ATGGTACCAC AAGAACATTA CGAGAAACCA GACCGAACGC 
CTATTGAGGC AAGAGGCTAA AGAAGGTGCC TTTATCGTGA GAGATTCGAG ACACTTGGGG 
TCTTACACAA TCTCTGTGTT TACAAGAGCT CGAAGGCATA CACAGTCTTC AATAAAACAT 
TATCAGATAA AAAAGAATGA CTCCGGACAG TGGTACATCA CCGAAAGACA TCTCTTCCCC 
TCAGTCCCCG AGTTGATCCA GTATCACCAG TACAATGCAG CTGGTCTCAT ATCTCGTCTC 
CGCTATCCCA TTGGGCTCCT GGGCAGCTGT TTACCAGCCA CATCTGGTTT TAGCTATGAA 
AAGTGGGAGA TAGATCCATC AGAGTTGGCT TTTGTCAAGG AGATCGGAAG TGGTCAGTTT 
GGGGTTGTCC ACTTAGGAGA ATGGAGAGCA CATATCCCGG TCGCCATCAA GGCCATCAAT 
GAAGGTTCCA TGTCTGAAGA AGACTTCATT GAGGAAGCCA AGGTGATGAT GAAACTGTCA 
CATTCGAGGT TAGTTCAACT TTACGGGGTG TGTATACAGC AGAAGCCCCT GTACATAGTG 
ACGGAGTTCA TGGAGAACGG CTGCCTGCTT GACTATCTCA GGGAGAGGAA AGGCCAGCTT 
CAGAAGGCGC TGCTCTTGAG CATGTGCCAA GACATATGTG AAGGGATGGC GTACCTGGAG 
AGGAGCTGCT ATATTCACAG GGATCTGGCT GCCAGGAACT GTTTGGTCAG TTCTGCCTGC 
GTAGTAAAGA TCTCAGACTT CGGCATGGCG AGGTATGTTT TGGACGATGA ATATATCAGT 
TCTTCTGGAG CTAAGTTCCC AGTCAAGTGG TGCCCACCTG AAGTCTTTCA TTTCAACAAA 
TACAGTAGCA AGTCTGATGT CTGGTCGTTC GGAGTTTTAA TGTGGGAAGT TTTTACAGAA 
GGAAAAATGC CTTTTGAAAA TAAGTCAAAT TTGCAAGTGG TGGAAGCCAT TTCTCAAGGT 
TTCCGGCTGT ATCGTCCTCA CCTGGCCCCC ATGACCATAT ACAGAGTGAT GTACAGTTGC 
TGGCATGAGA GCCCTAAAGG CCGTCCGACA TTTGCTGAGC TGCTTCAGGT TCTCACGGAG 
ATCGCAGAAA CGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276423.1
CDS	84..1601
Translation	MILSSYSSFQSVLCCCCCRCSVQKRQVRTQISLSREEELSEKHSQRQRPWFAKLMGKTQSNRGGVQPSKRKPLPPLPQEPPDERIQVKALYDFLPREPGNLALKRAEEYLILERCDPHWWKARDRFGWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELLQVLTEIAETW

Target ORF information:

RefSeq Version	NM_001289494.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus TXK tyrosine kinase (Txk), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289494.1

ORF Insert Sequence:

ATGATCCTGT CCTCTTATAG CTCCTTCCAG TCTGTTCTCT GCTGCTGCTG TTGCCGCTGC 
TCAGTACAGA AGAGACAGGT GAGAACTCAG ATAAGCCTGA GCAGAGAGGA AGAACTCTCA 
GAAAAACATT CCCAGCGTCA GAGGCCGTGG TTCGCCAAAC TGATGGGCAA AACTCAATCC 
AACAGAGGCG GGGTGCAACC CTCGAAGCGC AAGCCGCTGC CCCCCCTCCC GCAGGAGCCT 
CCAGATGAGA GAATCCAGGT CAAGGCTCTT TATGACTTCC TGCCTCGGGA GCCTGGTAAT 
TTGGCACTGA AGAGAGCGGA GGAATATCTG ATATTGGAGA GGTGTGATCC TCACTGGTGG 
AAGGCCAGAG ACCGCTTCGG ATGGTACCAC AAGAACATTA CGAGAAACCA GACCGAACGC 
CTATTGAGGC AAGAGGCTAA AGAAGGTGCC TTTATCGTGA GAGATTCGAG ACACTTGGGG 
TCTTACACAA TCTCTGTGTT TACAAGAGCT CGAAGGCATA CACAGTCTTC AATAAAACAT 
TATCAGATAA AAAAGAATGA CTCCGGACAG TGGTACATCA CCGAAAGACA TCTCTTCCCC 
TCAGTCCCCG AGTTGATCCA GTATCACCAG TACAATGCAG CTGGTCTCAT ATCTCGTCTC 
CGCTATCCCA TTGGGCTCCT GGGCAGCTGT TTACCAGCCA CATCTGGTTT TAGCTATGAA 
AAGTGGGAGA TAGATCCATC AGAGTTGGCT TTTGTCAAGG AGATCGGAAG TGGTCAGTTT 
GGGGTTGTCC ACTTAGGAGA ATGGAGAGCA CATATCCCGG TCGCCATCAA GGCCATCAAT 
GAAGGTTCCA TGTCTGAAGA AGACTTCATT GAGGAAGCCA AGGTGATGAT GAAACTGTCA 
CATTCGAGGT TAGTTCAACT TTACGGGGTG TGTATACAGC AGAAGCCCCT GTACATAGTG 
ACGGAGTTCA TGGAGAACGG CTGCCTGCTT GACTATCTCA GGGAGAGGAA AGGCCAGCTT 
CAGAAGGCGC TGCTCTTGAG CATGTGCCAA GACATATGTG AAGGGATGGC GTACCTGGAG 
AGGAGCTGCT ATATTCACAG GGATCTGGCT GCCAGGAACT GTTTGGTCAG TTCTGCCTGC 
GTAGTAAAGA TCTCAGACTT CGGCATGGCG AGGTATGTTT TGGACGATGA ATATATCAGT 
TCTTCTGGAG CTAAGTTCCC AGTCAAGTGG TGCCCACCTG AAGTCTTTCA TTTCAACAAA 
TACAGTAGCA AGTCTGATGT CTGGTCGTTC GGAGTTTTAA TGTGGGAAGT TTTTACAGAA 
GGAAAAATGC CTTTTGAAAA TAAGTCAAAT TTGCAAGTGG TGGAAGCCAT TTCTCAAGGT 
TTCCGGCTGT ATCGTCCTCA CCTGGCCCCC ATGACCATAT ACAGAGTGAT GTACAGTTGC 
TGGCATGAGA GCCCTAAAGG CCGTCCGACA TTTGCTGAGC TGCTTCAGGT TCTCACGGAG 
ATCGCAGAAA CGTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txk ( NM_001122754.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001116226.1 Mus musculus TXK tyrosine kinase (Txk), transcript variant 1, mRNA.

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CloneID	OMu57961
Clone ID Related Accession (Same CDS sequence)	NM_001122754.2
Accession Version	NM_001122754.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase TXK isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC099698.14, U16145.1, AK138786.1 and AC122733.11. On Jan 23, 2014 this sequence version replaced NM_001122754.1. Transcript Variant: This variant (1) encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U19607.1, U16145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCTGT CCTCTTATAG CTCCTTCCAG TCTGTTCTCT GCTGCTGCTG TTGCCGCTGC 
TCAGTACAGA AGAGACAGGT GAGAACTCAG ATAAGCCTGA GCAGAGAGGA AGAACTCTCA 
GAAAAACATT CCCAGCGTCA GAGGCCGTGG TTCGCCAAAC TGATGGGCAA AACTCAATCC 
AACAGAGGCG GGGTGCAACC CTCGAAGCGC AAGCCGCTGC CCCCCCTCCC GCAGGAGCCT 
CCAGATGAGA GAATCCAGGT CAAGGCTCTT TATGACTTCC TGCCTCGGGA GCCTGGTAAT 
TTGGCACTGA AGAGAGCGGA GGAATATCTG ATATTGGAGA GGTGTGATCC TCACTGGTGG 
AAGGCCAGAG ACCGCTTCGG GAATGAAGGC TTAATCCCAA GCAACTATGT GACAGAAAAC 
AGACTCGCCA ACTTAGAAAT CTATGAATGG TACCACAAGA ACATTACGAG AAACCAGACC 
GAACGCCTAT TGAGGCAAGA GGCTAAAGAA GGTGCCTTTA TCGTGAGAGA TTCGAGACAC 
TTGGGGTCTT ACACAATCTC TGTGTTTACA AGAGCTCGAA GGCATACACA GTCTTCAATA 
AAACATTATC AGATAAAAAA GAATGACTCC GGACAGTGGT ACATCACCGA AAGACATCTC 
TTCCCCTCAG TCCCCGAGTT GATCCAGTAT CACCAGTACA ATGCAGCTGG TCTCATATCT 
CGTCTCCGCT ATCCCATTGG GCTCCTGGGC AGCTGTTTAC CAGCCACATC TGGTTTTAGC 
TATGAAAAGT GGGAGATAGA TCCATCAGAG TTGGCTTTTG TCAAGGAGAT CGGAAGTGGT 
CAGTTTGGGG TTGTCCACTT AGGAGAATGG AGAGCACATA TCCCGGTCGC CATCAAGGCC 
ATCAATGAAG GTTCCATGTC TGAAGAAGAC TTCATTGAGG AAGCCAAGGT GATGATGAAA 
CTGTCACATT CGAGGTTAGT TCAACTTTAC GGGGTGTGTA TACAGCAGAA GCCCCTGTAC 
ATAGTGACGG AGTTCATGGA GAACGGCTGC CTGCTTGACT ATCTCAGGGA GAGGAAAGGC 
CAGCTTCAGA AGGCGCTGCT CTTGAGCATG TGCCAAGACA TATGTGAAGG GATGGCGTAC 
CTGGAGAGGA GCTGCTATAT TCACAGGGAT CTGGCTGCCA GGAACTGTTT GGTCAGTTCT 
GCCTGCGTAG TAAAGATCTC AGACTTCGGC ATGGCGAGGT ATGTTTTGGA CGATGAATAT 
ATCAGTTCTT CTGGAGCTAA GTTCCCAGTC AAGTGGTGCC CACCTGAAGT CTTTCATTTC 
AACAAATACA GTAGCAAGTC TGATGTCTGG TCGTTCGGAG TTTTAATGTG GGAAGTTTTT 
ACAGAAGGAA AAATGCCTTT TGAAAATAAG TCAAATTTGC AAGTGGTGGA AGCCATTTCT 
CAAGGTTTCC GGCTGTATCG TCCTCACCTG GCCCCCATGA CCATATACAG AGTGATGTAC 
AGTTGCTGGC ATGAGAGCCC TAAAGGCCGT CCGACATTTG CTGAGCTGCT TCAGGTTCTC 
ACGGAGATCG CAGAAACGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116226.1
CDS	84..1667
Translation	MILSSYSSFQSVLCCCCCRCSVQKRQVRTQISLSREEELSEKHSQRQRPWFAKLMGKTQSNRGGVQPSKRKPLPPLPQEPPDERIQVKALYDFLPREPGNLALKRAEEYLILERCDPHWWKARDRFGNEGLIPSNYVTENRLANLEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELLQVLTEIAETW

Target ORF information:

RefSeq Version	NM_001122754.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus TXK tyrosine kinase (Txk), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122754.2

ORF Insert Sequence:

ATGATCCTGT CCTCTTATAG CTCCTTCCAG TCTGTTCTCT GCTGCTGCTG TTGCCGCTGC 
TCAGTACAGA AGAGACAGGT GAGAACTCAG ATAAGCCTGA GCAGAGAGGA AGAACTCTCA 
GAAAAACATT CCCAGCGTCA GAGGCCGTGG TTCGCCAAAC TGATGGGCAA AACTCAATCC 
AACAGAGGCG GGGTGCAACC CTCGAAGCGC AAGCCGCTGC CCCCCCTCCC GCAGGAGCCT 
CCAGATGAGA GAATCCAGGT CAAGGCTCTT TATGACTTCC TGCCTCGGGA GCCTGGTAAT 
TTGGCACTGA AGAGAGCGGA GGAATATCTG ATATTGGAGA GGTGTGATCC TCACTGGTGG 
AAGGCCAGAG ACCGCTTCGG GAATGAAGGC TTAATCCCAA GCAACTATGT GACAGAAAAC 
AGACTCGCCA ACTTAGAAAT CTATGAATGG TACCACAAGA ACATTACGAG AAACCAGACC 
GAACGCCTAT TGAGGCAAGA GGCTAAAGAA GGTGCCTTTA TCGTGAGAGA TTCGAGACAC 
TTGGGGTCTT ACACAATCTC TGTGTTTACA AGAGCTCGAA GGCATACACA GTCTTCAATA 
AAACATTATC AGATAAAAAA GAATGACTCC GGACAGTGGT ACATCACCGA AAGACATCTC 
TTCCCCTCAG TCCCCGAGTT GATCCAGTAT CACCAGTACA ATGCAGCTGG TCTCATATCT 
CGTCTCCGCT ATCCCATTGG GCTCCTGGGC AGCTGTTTAC CAGCCACATC TGGTTTTAGC 
TATGAAAAGT GGGAGATAGA TCCATCAGAG TTGGCTTTTG TCAAGGAGAT CGGAAGTGGT 
CAGTTTGGGG TTGTCCACTT AGGAGAATGG AGAGCACATA TCCCGGTCGC CATCAAGGCC 
ATCAATGAAG GTTCCATGTC TGAAGAAGAC TTCATTGAGG AAGCCAAGGT GATGATGAAA 
CTGTCACATT CGAGGTTAGT TCAACTTTAC GGGGTGTGTA TACAGCAGAA GCCCCTGTAC 
ATAGTGACGG AGTTCATGGA GAACGGCTGC CTGCTTGACT ATCTCAGGGA GAGGAAAGGC 
CAGCTTCAGA AGGCGCTGCT CTTGAGCATG TGCCAAGACA TATGTGAAGG GATGGCGTAC 
CTGGAGAGGA GCTGCTATAT TCACAGGGAT CTGGCTGCCA GGAACTGTTT GGTCAGTTCT 
GCCTGCGTAG TAAAGATCTC AGACTTCGGC ATGGCGAGGT ATGTTTTGGA CGATGAATAT 
ATCAGTTCTT CTGGAGCTAA GTTCCCAGTC AAGTGGTGCC CACCTGAAGT CTTTCATTTC 
AACAAATACA GTAGCAAGTC TGATGTCTGG TCGTTCGGAG TTTTAATGTG GGAAGTTTTT 
ACAGAAGGAA AAATGCCTTT TGAAAATAAG TCAAATTTGC AAGTGGTGGA AGCCATTTCT 
CAAGGTTTCC GGCTGTATCG TCCTCACCTG GCCCCCATGA CCATATACAG AGTGATGTAC 
AGTTGCTGGC ATGAGAGCCC TAAAGGCCGT CCGACATTTG CTGAGCTGCT TCAGGTTCTC 
ACGGAGATCG CAGAAACGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txk ( XM_011240722.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239024.1 Mus musculus TXK tyrosine kinase (Txk), transcript variant X1, mRNA.

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CloneID	OMu57942
Clone ID Related Accession (Same CDS sequence)	NM_001289495.1 , XM_011240722.1
Accession Version	XM_011240722.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	tyrosine-protein kinase TXK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAAAA CTCAATCCAA CAGAGGCGGG GTGCAACCCT CGAAGCGCAA GCCGCTGCCC 
CCCCTCCCGC AGGAGCCTCC AGATGAGAGA ATCCAGGTCA AGGCTCTTTA TGACTTCCTG 
CCTCGGGAGC CTGGTAATTT GGCACTGAAG AGAGCGGAGG AATATCTGAT ATTGGAGAGG 
TGTGATCCTC ACTGGTGGAA GGCCAGAGAC CGCTTCGGGA ATGAAGGCTT AATCCCAAGC 
AACTATGTGA CAGAAAACAG ACTCGCCAAC TTAGAAATCT ATGAATGGTA CCACAAGAAC 
ATTACGAGAA ACCAGACCGA ACGCCTATTG AGGCAAGAGG CTAAAGAAGG TGCCTTTATC 
GTGAGAGATT CGAGACACTT GGGGTCTTAC ACAATCTCTG TGTTTACAAG AGCTCGAAGG 
CATACACAGT CTTCAATAAA ACATTATCAG ATAAAAAAGA ATGACTCCGG ACAGTGGTAC 
ATCACCGAAA GACATCTCTT CCCCTCAGTC CCCGAGTTGA TCCAGTATCA CCAGTACAAT 
GCAGCTGGTC TCATATCTCG TCTCCGCTAT CCCATTGGGC TCCTGGGCAG CTGTTTACCA 
GCCACATCTG GTTTTAGCTA TGAAAAGTGG GAGATAGATC CATCAGAGTT GGCTTTTGTC 
AAGGAGATCG GAAGTGGTCA GTTTGGGGTT GTCCACTTAG GAGAATGGAG AGCACATATC 
CCGGTCGCCA TCAAGGCCAT CAATGAAGGT TCCATGTCTG AAGAAGACTT CATTGAGGAA 
GCCAAGGTGA TGATGAAACT GTCACATTCG AGGTTAGTTC AACTTTACGG GGTGTGTATA 
CAGCAGAAGC CCCTGTACAT AGTGACGGAG TTCATGGAGA ACGGCTGCCT GCTTGACTAT 
CTCAGGGAGA GGAAAGGCCA GCTTCAGAAG GCGCTGCTCT TGAGCATGTG CCAAGACATA 
TGTGAAGGGA TGGCGTACCT GGAGAGGAGC TGCTATATTC ACAGGGATCT GGCTGCCAGG 
AACTGTTTGG TCAGTTCTGC CTGCGTAGTA AAGATCTCAG ACTTCGGCAT GGCGAGGTAT 
GTTTTGGACG ATGAATATAT CAGTTCTTCT GGAGCTAAGT TCCCAGTCAA GTGGTGCCCA 
CCTGAAGTCT TTCATTTCAA CAAATACAGT AGCAAGTCTG ATGTCTGGTC GTTCGGAGTT 
TTAATGTGGG AAGTTTTTAC AGAAGGAAAA ATGCCTTTTG AAAATAAGTC AAATTTGCAA 
GTGGTGGAAG CCATTTCTCA AGGTTTCCGG CTGTATCGTC CTCACCTGGC CCCCATGACC 
ATATACAGAG TGATGTACAG TTGCTGGCAT GAGAGCCCTA AAGGCCGTCC GACATTTGCT 
GAGCTGCTTC AGGTTCTCAC GGAGATCGCA GAAACGTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239024.1
CDS	457..1878
Translation	MGKTQSNRGGVQPSKRKPLPPLPQEPPDERIQVKALYDFLPREPGNLALKRAEEYLILERCDPHWWKARDRFGNEGLIPSNYVTENRLANLEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELLQVLTEIAETW

Target ORF information:

RefSeq Version	XM_011240722.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus TXK tyrosine kinase (Txk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011240722.1

ORF Insert Sequence:

ATGGGCAAAA CTCAATCCAA CAGAGGCGGG GTGCAACCCT CGAAGCGCAA GCCGCTGCCC 
CCCCTCCCGC AGGAGCCTCC AGATGAGAGA ATCCAGGTCA AGGCTCTTTA TGACTTCCTG 
CCTCGGGAGC CTGGTAATTT GGCACTGAAG AGAGCGGAGG AATATCTGAT ATTGGAGAGG 
TGTGATCCTC ACTGGTGGAA GGCCAGAGAC CGCTTCGGGA ATGAAGGCTT AATCCCAAGC 
AACTATGTGA CAGAAAACAG ACTCGCCAAC TTAGAAATCT ATGAATGGTA CCACAAGAAC 
ATTACGAGAA ACCAGACCGA ACGCCTATTG AGGCAAGAGG CTAAAGAAGG TGCCTTTATC 
GTGAGAGATT CGAGACACTT GGGGTCTTAC ACAATCTCTG TGTTTACAAG AGCTCGAAGG 
CATACACAGT CTTCAATAAA ACATTATCAG ATAAAAAAGA ATGACTCCGG ACAGTGGTAC 
ATCACCGAAA GACATCTCTT CCCCTCAGTC CCCGAGTTGA TCCAGTATCA CCAGTACAAT 
GCAGCTGGTC TCATATCTCG TCTCCGCTAT CCCATTGGGC TCCTGGGCAG CTGTTTACCA 
GCCACATCTG GTTTTAGCTA TGAAAAGTGG GAGATAGATC CATCAGAGTT GGCTTTTGTC 
AAGGAGATCG GAAGTGGTCA GTTTGGGGTT GTCCACTTAG GAGAATGGAG AGCACATATC 
CCGGTCGCCA TCAAGGCCAT CAATGAAGGT TCCATGTCTG AAGAAGACTT CATTGAGGAA 
GCCAAGGTGA TGATGAAACT GTCACATTCG AGGTTAGTTC AACTTTACGG GGTGTGTATA 
CAGCAGAAGC CCCTGTACAT AGTGACGGAG TTCATGGAGA ACGGCTGCCT GCTTGACTAT 
CTCAGGGAGA GGAAAGGCCA GCTTCAGAAG GCGCTGCTCT TGAGCATGTG CCAAGACATA 
TGTGAAGGGA TGGCGTACCT GGAGAGGAGC TGCTATATTC ACAGGGATCT GGCTGCCAGG 
AACTGTTTGG TCAGTTCTGC CTGCGTAGTA AAGATCTCAG ACTTCGGCAT GGCGAGGTAT 
GTTTTGGACG ATGAATATAT CAGTTCTTCT GGAGCTAAGT TCCCAGTCAA GTGGTGCCCA 
CCTGAAGTCT TTCATTTCAA CAAATACAGT AGCAAGTCTG ATGTCTGGTC GTTCGGAGTT 
TTAATGTGGG AAGTTTTTAC AGAAGGAAAA ATGCCTTTTG AAAATAAGTC AAATTTGCAA 
GTGGTGGAAG CCATTTCTCA AGGTTTCCGG CTGTATCGTC CTCACCTGGC CCCCATGACC 
ATATACAGAG TGATGTACAG TTGCTGGCAT GAGAGCCCTA AAGGCCGTCC GACATTTGCT 
GAGCTGCTTC AGGTTCTCAC GGAGATCGCA GAAACGTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.
Journal of immunology (Baltimore, Md. : 1950)195(10)4822-31(2015 Nov)
Cho HS,Shin HM,Haberstock-Debic H,Xing Y,Owens TD,Funk JO,Hill RJ,Bradshaw JM,Berg LJ

A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.
Journal of immunology (Baltimore, Md. : 1950)188(8)3611-9(2012 Apr)
Qi Q,Huang W,Bai Y,Balmus G,Weiss RS,August A

Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell.
The Journal of biological chemistry286(1)138-46(2011 Jan)
Qi Q,Xia M,Bai Y,Yu S,Cantorna M,August A

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Proceedings of the National Academy of Sciences of the United States of America107(45)19455-60(2010 Nov)
Rochman Y,Kashyap M,Robinson GW,Sakamoto K,Gomez-Rodriguez J,Wagner KU,Leonard WJ

Locus category based analysis of a large genome-wide association study of rheumatoid arthritis.
Human molecular genetics19(19)3863-72(2010 Oct)
Freudenberg J,Lee AT,Siminovitch KA,Amos CI,Ballard D,Li W,Gregersen PK

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Txk cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

オンラインフォーム