Acot6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acot6
Entrez Gene ID	217700
Full Name	acyl-CoA thioesterase 6
Synonyms	4632408A20Rik,A330054B07,BE688602
General protein information	Preferred Names acyl-CoA thioesterase 6 Names acyl-coenzyme A thioesterase 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_172580.1	NP_766168.1	acyl-coenzyme A thioesterase 6

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ACOT6	XP_547894.3
Bos taurus (cattle)	LOC516537	XP_002691047.1
Pan troglodytes (chimpanzee)	LOC453019	XP_003314514.2
Rattus norvegicus (Norway rat)	Acot6	XP_234402.5
Mus musculus (house mouse)	Acot6	NP_766168.1

Gene Ontology
Bibliography

Related articles in PubMed

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Adissu HA, Estabel J, Sunter D, Tuck E, Hooks Y, Carragher DM, Clarke K, Karp NA, , Newbigging S, Jones N, Morikawa L, White JK, McKerlie C
Disease models & mechanisms7(5)515-24(2014 May)

Peroxisomes contain a specific phytanoyl-CoA/pristanoyl-CoA thioesterase acting as a novel auxiliary enzyme in alpha- and beta-oxidation of methyl-branched fatty acids in mouse.
Westin MA, Hunt MC, Alexson SE
The Journal of biological chemistry282(37)26707-16(2007 Sep)

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.
Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(11)1855-64(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Acot6 was identified as a target gene of the peroxisome proliferator-activated receptor alpha (PPARalpha) and is up-regulated in mouse liver in a PPARalpha-dependent manner.
Title: Peroxisomes contain a specific phytanoyl-CoA/pristanoyl-CoA thioesterase acting as a novel auxiliary enzyme in alpha- and beta-oxidation of methyl-branched fatty acids in mouse.

The following Acot6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acot6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03712	NM_172580.1 Latest version!	Mus musculus acyl-CoA thioesterase 6 (Acot6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acot6 ( NM_172580.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766168.1 Mus musculus acyl-CoA thioesterase 6 (Acot6), mRNA.

Price & Availability↑

CloneID	OMu03712
Clone ID Related Accession (Same CDS sequence)	NM_172580.1
Accession Version	NM_172580.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	acyl-coenzyme A thioesterase 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY999300.1. On or before Jul 24, 2006 this sequence version replaced XM_126946.5, XM_900185.2, XM_907178.2, XM_920238.2, XM_992697.1, XM_992647.1, XM_992672.1. ##Evidence-Data-START## Transcript exon combination :: AY999300.1, AK014558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGA CACTGAGCGT GGAGCCCGCG GGCCGCAGCT GCTGGGACGA ACCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCA TGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCACGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA TGTGCAGATA 
CCCTTCGTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CGGATGGCGG GCAGCGGCTG 
GCGCGGGCGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGGCA AGGGCCAGTT CCCTGGGATC 
ATCGATTTGT ATGGAAGTAT CGGTGGCTTA TGTGAACATA GAGCCAGCCT TCTGGCTGGG 
CATGGTTTTG CCGTGCTTGC CCTGGCTTAT TTCCAGTTTG AAGACCTCCC TGAAAATCTG 
AGTGACGTTC GCCTGGAGTA CTTTGAAGAA GCCTTAGCTT TGATGCTACG CCATCCTCAG 
GTGAAAGGCC CAAATATTGG ACTTATTGGT GTCTCCAAAG GTGCTGATCT GTGCCTCTCG 
ATGGCTGCTT TCCTGAAGGA CAACATCACA GCCACTGTCC TTATAAATGC CTGTGTGGCC 
AACACATTAG TACCTCTGTA TTACAAGGAT CTGTTTGTTC CTGAGCTTGG GTGTGATCAA 
ACAAAAAATA AGTCAGGCCT TATGGATTTG AGGGATATGT GGAACAATCC ACTGGAGGAA 
CCCAACCACC AGAGTCTTAT CCCATTGGAA AAGGCCCAGG GACCCTTCCT GTTTCTTGTG 
GGCATGGATG ATCACAACTG GAAGAGTGAC GTCTATGCTC GTATAGCCTG TGAACGCCTG 
CAAGCCCATG GAAAAGACAG ACCCCAGATA ATCTACTATC CAGAAACTGG TCACTGTATT 
GAGCCACCTT ATTTTCCTCC TCCCATAGCC ACTGTACACT TCGTGTTGGG TGAAGCAGTC 
TTCAATGGAG GTAAGCCACG TGCTCAATCA AGGGCACAGC TGGATGCCTG GCAACGCATT 
CAAACTTTCT TCCAAAAATA TCTCAATGGT GAAAAGCCTG CCAGGCACAG CAAACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766168.1
CDS	319..1578
Translation	MAATLSVEPAGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGMLFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQIPFVVELEVLDGHEPDGGQRLARAVHERHFMAPGVRRVPVREGRVRATLFLPPGKGQFPGIIDLYGSIGGLCEHRASLLAGHGFAVLALAYFQFEDLPENLSDVRLEYFEEALALMLRHPQVKGPNIGLIGVSKGADLCLSMAAFLKDNITATVLINACVANTLVPLYYKDLFVPELGCDQTKNKSGLMDLRDMWNNPLEEPNHQSLIPLEKAQGPFLFLVGMDDHNWKSDVYARIACERLQAHGKDRPQIIYYPETGHCIEPPYFPPPIATVHFVLGEAVFNGGKPRAQSRAQLDAWQRIQTFFQKYLNGEKPARHSKL

Target ORF information:

RefSeq Version	NM_172580.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus acyl-CoA thioesterase 6 (Acot6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172580.1

ORF Insert Sequence:

ATGGCGGCGA CACTGAGCGT GGAGCCCGCG GGCCGCAGCT GCTGGGACGA ACCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCA TGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCACGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA TGTGCAGATA 
CCCTTCGTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CGGATGGCGG GCAGCGGCTG 
GCGCGGGCGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGGCA AGGGCCAGTT CCCTGGGATC 
ATCGATTTGT ATGGAAGTAT CGGTGGCTTA TGTGAACATA GAGCCAGCCT TCTGGCTGGG 
CATGGTTTTG CCGTGCTTGC CCTGGCTTAT TTCCAGTTTG AAGACCTCCC TGAAAATCTG 
AGTGACGTTC GCCTGGAGTA CTTTGAAGAA GCCTTAGCTT TGATGCTACG CCATCCTCAG 
GTGAAAGGCC CAAATATTGG ACTTATTGGT GTCTCCAAAG GTGCTGATCT GTGCCTCTCG 
ATGGCTGCTT TCCTGAAGGA CAACATCACA GCCACTGTCC TTATAAATGC CTGTGTGGCC 
AACACATTAG TACCTCTGTA TTACAAGGAT CTGTTTGTTC CTGAGCTTGG GTGTGATCAA 
ACAAAAAATA AGTCAGGCCT TATGGATTTG AGGGATATGT GGAACAATCC ACTGGAGGAA 
CCCAACCACC AGAGTCTTAT CCCATTGGAA AAGGCCCAGG GACCCTTCCT GTTTCTTGTG 
GGCATGGATG ATCACAACTG GAAGAGTGAC GTCTATGCTC GTATAGCCTG TGAACGCCTG 
CAAGCCCATG GAAAAGACAG ACCCCAGATA ATCTACTATC CAGAAACTGG TCACTGTATT 
GAGCCACCTT ATTTTCCTCC TCCCATAGCC ACTGTACACT TCGTGTTGGG TGAAGCAGTC 
TTCAATGGAG GTAAGCCACG TGCTCAATCA AGGGCACAGC TGGATGCCTG GCAACGCATT 
CAAACTTTCT TCCAAAAATA TCTCAATGGT GAAAAGCCTG CCAGGCACAG CAAACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Disease models & mechanisms7(5)515-24(2014 May)
Adissu HA,Estabel J,Sunter D,Tuck E,Hooks Y,Carragher DM,Clarke K,Karp NA,,Newbigging S,Jones N,Morikawa L,White JK,McKerlie C

Peroxisomes contain a specific phytanoyl-CoA/pristanoyl-CoA thioesterase acting as a novel auxiliary enzyme in alpha- and beta-oxidation of methyl-branched fatty acids in mouse.
The Journal of biological chemistry282(37)26707-16(2007 Sep)
Westin MA,Hunt MC,Alexson SE

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(11)1855-64(2006 Sep)
Hunt MC,Rautanen A,Westin MA,Svensson LT,Alexson SE