Slc22a12 cDNA ORF clone, Mus musculus(house mouse)

Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain.
Tomioka NH, Tamura Y, Takada T, Shibata S, Suzuki H, Uchida S, Hosoyamada M
Fluids and barriers of the CNS13(1)22(2016 Dec)

Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury.
Hosoyamada M, Tsurumi Y, Hirano H, Tomioka NH, Sekine Y, Morisaki T, Uchida S
Nucleosides, nucleotides & nucleic acids35(10-12)543-549(2016 Dec)

The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice.
Doshi M, Takiue Y, Saito H, Hosoyamada M
Nucleosides, nucleotides & nucleic acids30(12)1290-4(2011 Dec)

Establishment and analysis of SLC22A12 (URAT1) knockout mouse.
Hosoyamada M, Takiue Y, Morisaki H, Cheng J, Ikawa M, Okabe M, Morisaki T, Ichida K, Hosoya T, Shibasaki T
Nucleosides, nucleotides & nucleic acids29(4-6)314-20(2010 Jun)

Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.
Cheng X, Klaassen CD
Drug metabolism and disposition: the biological fate of chemicals37(11)2178-85(2009 Nov)

Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1, ABCG2, and URAT1. Immunostaining for GLUT9 was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.
Title: Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain.

Urat1-Uox double knockout mice are a suitable animal model for renal hypouricemia.
Title: Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury.

The cause of obesity/metabolic syndrome-associated hyperuricemia appears to be associated with the urate reabsorption transporter Urat1 protein enhanced by fat.
Title: The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice.

Although the fractional excretion of urate of knockout mice was tend to higher than that of wildtype mice, the urate reabsorption ability remained in the kidney of knockout mice, indicating a urate reabsorptive transporter other than Urat1.
Title: Establishment and analysis of SLC22A12 (URAT1) knockout mouse.

NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the brush Border membrane abundance of mURAT1.
Title: Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport.