Sord cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sord
Entrez Gene ID	20322
Full Name	sorbitol dehydrogenase
Synonyms	Sdh-1,Sdh1,Sodh-1
General protein information	Preferred Names sorbitol dehydrogenase Names sorbitol dehydrogenase L-iditol 2-dehydrogenase sorbitol dehydrogenase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 E5\|2 60.59 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_146126.4	NP_666238.1	sorbitol dehydrogenase

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sord	NP_058748.2
Drosophila melanogaster (fruit fly)	Sodh-1	NP_477348.1
Drosophila melanogaster (fruit fly)	Sodh-2	NP_524311.1
Saccharomyces cerevisiae (baker's yeast)	SOR2	NP_010035.1
Kluyveromyces lactis	KLLA0D05511g	XP_453306.1
Pan troglodytes (chimpanzee)	SORD	XP_003952695.1
Canis lupus familiaris (dog)	SORD	XP_544659.2
Mus musculus (house mouse)	Sord	NP_666238.1
Gallus gallus (chicken)	SORD	XP_413719.1
Schizosaccharomyces pombe (fission yeast)	tms1	NP_595120.1
Xenopus tropicalis (tropical clawed frog)	sord	NP_001011264.1
Bos taurus (cattle)	SORD	NP_001032397.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003584	XP_313338.3
Caenorhabditis elegans (roundworm)	CELE_R04B5.5	NP_505591.1
Saccharomyces cerevisiae (baker's yeast)	SOR1	NP_012693.1
Magnaporthe oryzae (rice blast fungus)	MGG_01176	XP_003714060.1
	SORD	XP_001111041.1
Eremothecium gossypii	AGOS_ABR229C	NP_983178.1
Neurospora crassa	NCU00891	XP_964807.1
Homo sapiens (human)	SORD	NP_003095.2
Danio rerio (zebrafish)	LOC570613	NP_001165890.1
Caenorhabditis elegans (roundworm)	CELE_R04B5.6	NP_505590.1
Arabidopsis thaliana (thale cress)	AT5G51970	NP_200010.1
Oryza sativa (rice)	Os08g0545200	NP_001062412.1

Gene Ontology
Bibliography

Related articles in PubMed

Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity.
Mohammad F E, Hasan WA, Mohamed EG
Journal of biochemical and molecular toxicology31(7)(2017 Jul)

Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa.
Dai J, Xu W, Zhao X, Zhang M, Zhang D, Nie D, Bao M, Wang Z, Wang L, Qiao Z
Reproduction (Cambridge, England)151(3)227-37(2016 Mar)

The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing.
Abe K, Yamamoto R, Franke V, Cao M, Suzuki Y, Suzuki MG, Vlahovicek K, Svoboda P, Schultz RM, Aoki F
The EMBO journal34(11)1523-37(2015 Jun)

Notch signaling in stomach epithelial stem cell homeostasis.
Kim TH, Shivdasani RA
The Journal of experimental medicine208(4)677-88(2011 Apr)

Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.
Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH
PloS one6(2)e17286(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

flavonoids induced marked improvement in paw licking time, paw edema %, malondialdehyde content, superoxide dismutase, and sorbitol dehydrogenase activities, with slight progress in paw interlukin-1beta. Additionally, silymarin augmented brain content of dopamine and norepinephrine.
Title: Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity.

Nicotine-induced reduced expression of Sord could be involved in impaired secretory functions of the epididymis.
Title: Protein profile screening: reduced expression of Sord in the mouse epididymis induced by nicotine inhibits tyrosine phosphorylation level in capacitated spermatozoa.

Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
Title: Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.

The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.
Title: ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.

Knockout mice had the highest sorbitol content among various genetic types including mice wwith human aldose reductase.
Title: Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency.

The following Sord gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sord cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12242	NM_146126.4 Latest version!	Mus musculus sorbitol dehydrogenase (Sord), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sord ( NM_146126.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666238.1 Mus musculus sorbitol dehydrogenase (Sord), mRNA.

Price & Availability↑

CloneID	OMu12242
Clone ID Related Accession (Same CDS sequence)	NM_146126.4
Accession Version	NM_146126.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	sorbitol dehydrogenase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL844573.4 and AL844566.8. On Oct 19, 2007 this sequence version replaced NM_146126.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK015059.1, AK152169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCTC CAGCTAAGGG CGAGAACCTG TCCCTGGTGG TGCACGGACC TGGAGACATC 
CGCCTGGAGA ACTACCCAAT ACCTGAGCTC GGCCCAAATG ATGTGTTACT AAAGATGCAC 
TCGGTGGGGA TTTGCGGCTC AGATGTTCAC TACTGGGAGC ATGGACGAAT TGGGGACTTT 
GTTGTGAAAA AGCCAATGGT GCTTGGGCAT GAGGCTGCTG GAACAGTCAC AAAAGTAGGA 
GAGTTGGTGA AACATCTGAA ACCAGGAGAT CGGGTTGCCA TCGAGCCTGG CGTTCCCCGA 
GAAGTAGATG AGTACTGCAA GATTGGCCGG TACAACCTGA CGCCGACTAT CTTCTTCTGT 
GCCACGCCCC CGGATGATGG AAACCTCTGC CGATTCTACA AGCACAATGC TGACTTCTGC 
TACAAGCTTC CTGACAGTGT CACTTTTGAA GAAGGGGCCC TGATTGAACC TCTCTCTGTG 
GGGATCTATG CCTGCCGTCG AGGTTCAGTT TCCCTGGGGA ACAAGGTCCT TGTGTGTGGC 
GCTGGGCCAG TTGGGATGGT CACTTTGCTT GTGGCCAAAG CAATGGGAGC TGCTCAAGTT 
GTGGTGACTG ACCTATCCGC TTCTCGGTTG ACCAAAGCCA AGGAAGTTGG AGCAGACTTT 
ACCATCCAGG TTGGCAAAGA GACCCCTCAG GAAATTGCCA GTAAGGTGGA AAGCCTGCTG 
GGAAGCAAGC CGGAGGTTAC CATTGAGTGC ACAGGAGCCG AGTCCTCCGT CCAGACGGGC 
ATCTATGCCA CTCACTCTGG TGGGACCTTG GTGATTGTGG GAATGGGCGC CGAGATGGTC 
AATTTACCCC TGGTGCACGC AGCCATTCGG GAAGTGGATA TCAAAGGCGT GTTTCGATAC 
TGCAACACGT GGCCGATGGC AATTTCCATG CTTGCATCGA AGACGTTGAA TGTAAAGCCC 
TTAGTTACCC ACAGATTCCC CCTGGAGAAG GCAGTTGAAG CCTTTGAAAC AGCCAAAAAG 
GGAGTGGGGC TGAAAGTTAT GATCAAGTGT GACCCCAATG ACCAAAACCC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666238.1
CDS	55..1128
Translation	MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGELVKHLKPGDRVAIEPGVPREVDEYCKIGRYNLTPTIFFCATPPDDGNLCRFYKHNADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPVGMVTLLVAKAMGAAQVVVTDLSASRLTKAKEVGADFTIQVGKETPQEIASKVESLLGSKPEVTIECTGAESSVQTGIYATHSGGTLVIVGMGAEMVNLPLVHAAIREVDIKGVFRYCNTWPMAISMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGVGLKVMIKCDPNDQNP

Target ORF information:

RefSeq Version	NM_146126.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus sorbitol dehydrogenase (Sord), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146126.4

ORF Insert Sequence:

ATGGCAGCTC CAGCTAAGGG CGAGAACCTG TCCCTGGTGG TGCACGGACC TGGAGACATC 
CGCCTGGAGA ACTACCCAAT ACCTGAGCTC GGCCCAAATG ATGTGTTACT AAAGATGCAC 
TCGGTGGGGA TTTGCGGCTC AGATGTTCAC TACTGGGAGC ATGGACGAAT TGGGGACTTT 
GTTGTGAAAA AGCCAATGGT GCTTGGGCAT GAGGCTGCTG GAACAGTCAC AAAAGTAGGA 
GAGTTGGTGA AACATCTGAA ACCAGGAGAT CGGGTTGCCA TCGAGCCTGG CGTTCCCCGA 
GAAGTAGATG AGTACTGCAA GATTGGCCGG TACAACCTGA CGCCGACTAT CTTCTTCTGT 
GCCACGCCCC CGGATGATGG AAACCTCTGC CGATTCTACA AGCACAATGC TGACTTCTGC 
TACAAGCTTC CTGACAGTGT CACTTTTGAA GAAGGGGCCC TGATTGAACC TCTCTCTGTG 
GGGATCTATG CCTGCCGTCG AGGTTCAGTT TCCCTGGGGA ACAAGGTCCT TGTGTGTGGC 
GCTGGGCCAG TTGGGATGGT CACTTTGCTT GTGGCCAAAG CAATGGGAGC TGCTCAAGTT 
GTGGTGACTG ACCTATCCGC TTCTCGGTTG ACCAAAGCCA AGGAAGTTGG AGCAGACTTT 
ACCATCCAGG TTGGCAAAGA GACCCCTCAG GAAATTGCCA GTAAGGTGGA AAGCCTGCTG 
GGAAGCAAGC CGGAGGTTAC CATTGAGTGC ACAGGAGCCG AGTCCTCCGT CCAGACGGGC 
ATCTATGCCA CTCACTCTGG TGGGACCTTG GTGATTGTGG GAATGGGCGC CGAGATGGTC 
AATTTACCCC TGGTGCACGC AGCCATTCGG GAAGTGGATA TCAAAGGCGT GTTTCGATAC 
TGCAACACGT GGCCGATGGC AATTTCCATG CTTGCATCGA AGACGTTGAA TGTAAAGCCC 
TTAGTTACCC ACAGATTCCC CCTGGAGAAG GCAGTTGAAG CCTTTGAAAC AGCCAAAAAG 
GGAGTGGGGC TGAAAGTTAT GATCAAGTGT GACCCCAATG ACCAAAACCC CTAG