Klf11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klf11
Entrez Gene ID	194655
Full Name	Kruppel-like factor 11
Synonyms	9830142A17,D12Ertd427e,Tieg2,Tieg2b,Tieg3
General protein information	Preferred Names Kruppel-like factor 11 Names Krueppel-like factor 11 TGFB inducible early growth response 2 TGFB inducible early growth response 3 TGFB-inducible early growth response protein 2b TGFB-inducible early growth response protein 3 TIEG-3 klf11 transforming growth factor-beta-inducible early growth response protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 A1.3\|12 8.49 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_178357.3	NP_848134.1	Krueppel-like factor 11

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KLF11	NP_001006417.1
Pan troglodytes (chimpanzee)	KLF11	XP_515296.3
Xenopus tropicalis (tropical clawed frog)	klf11	NP_001073037.1
Homo sapiens (human)	KLF11	NP_003588.1
Canis lupus familiaris (dog)	KLF11	XP_005630171.1
Danio rerio (zebrafish)	klf11a	NP_001038406.1
	KLF11	XP_001090608.2
Mus musculus (house mouse)	Klf11	NP_848134.1
Danio rerio (zebrafish)	klf11b	NP_001071072.1
Bos taurus (cattle)	KLF11	NP_001177230.1
Rattus norvegicus (Norway rat)	Klf11	NP_001032431.1

Gene Ontology
Bibliography

Related articles in PubMed

Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response.
Shenoy CC, Khan Z, Zheng Y, Jones TL, Khazaie K, Daftary GS
Endocrinology158(10)3605-3619(2017 Oct)

KLF11 is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis.
Richards EG, Zheng Y, Shenoy CC, Ainsworth AJ, Delaney AA, Jones TL, Khan Z, Daftary GS
Reproductive sciences (Thousand Oaks, Calif.)24(8)1129-1138(2017 Aug)

Genetic Deletion of Kr?ppel-Like Factor 11 Aggravates Ischemic Brain Injury.
Tang X, Liu K, Hamblin MH, Xu Y, Yin KJ
Molecular neurobiology(2017 Apr)

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice.
Hayashi S, Manabe I, Suzuki Y, Relaix F, Oishi Y
eLife5(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Using a sterile peritonitis model, fibrosis selectively developed in Klf11-/- females. Fibrosis in these animals was almost completely abrogated by ovariectomy. Ovariectomized animals were selectively supplemented with estradiol, medroxyprogesterone acetate (MPA), or dihydrotestosterone; fibrosis was only observed in mice exposed to MPA.
Title: Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response.

TGFbeta and KLF11 mediate critical, translationally relevant host and lesion-driven responses that enable establishment and progression of endometriosis.
Title: TGF-? Induces Endometriotic Progression via a Noncanonical, KLF11-Mediated Mechanism.

Data show that the major phenotype given by the whole-body deletion of Kruppel-like factor 11 (Klf11) is not diabetes but increased insulin sensitivity.
Title: Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.

Results suggest a role for KLF11 in upregulating MAO-A in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses
Title: Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders.

Loss of KLF11 expression is associated with hyperglycemia in Type 2 diabetes.
Title: Involvement of KLF11 in hepatic glucose metabolism in mice via suppressing of PEPCK-C expression.

The following Klf11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klf11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18171	NM_178357.3 Latest version!	Mus musculus Kruppel-like factor 11 (Klf11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$293.30 $419.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klf11 ( NM_178357.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848134.1 Mus musculus Kruppel-like factor 11 (Klf11), mRNA.

Price & Availability↑

CloneID	OMu18171
Clone ID Related Accession (Same CDS sequence)	NM_178357.3
Accession Version	NM_178357.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	Krueppel-like factor 11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK038397.1 and DV654709.1. On Jul 18, 2009 this sequence version replaced NM_178357.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC060642.1, AK050156.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCACTCGC CGGGCTCCAC CGGCCCCGGC GACGGGCGCG CGGCTGACAT CATGGACATT 
TGTGAGTCGA TCCTGGAGAG GAAGCGGCAT GACAGCGAAA GGTCCACATG CAGCGTCCTG 
GAGCAGACGG ACATCGAAGC TGTGGAAGCT CTTGTCTGCA TGAGCTCTTG GGGTCAGAGG 
TCCCAGATGA GACCCCTCAC GCCTGTCTCT GACTCTGGTG ACGTCACCAC TGCTGTGCTT 
ATGGACACAG CTGCACCTGA TCTACCAAAG GACTTCCATT CTTTTTCAAC TCTGTGTATA 
ACTCCTCCTC AGAGCCCAGA GCTCACGGAG CCGTCAACAG GGACCCCTGT TCCTTCCCAA 
GTAGTTAACT CCAAAGGATG CATGGTCACT GCCCTCCCCC CATCCCCTGC TGGGGGCCCC 
AGAACACTGA GCAAGAGGGA ACCACTGGAG CCAGCCTCAG GGTCCTCCTG CAGGGCTGTG 
ATGACCAGTG TGATCCGTCA CACCGGGGAG AGTCCTGCTC CTACGCGCTT CCCAACTGGC 
CCCACTCAAG AGCAACGAGC ATCCGACAGC GGAGAAGGAC AGGAGCGTTT GCTGGACCAC 
CTCGAAGCCT TGCAGGACAC ACGCTTGGCA AATGGCTTAC TCGTCACTAA CTTGGTTTCC 
TGTCAGCCTT GCTTGCACAA GTCCGGTGGT TCGTTCCCCA CTGACAAAGG TCAACAGACA 
GGATGGCCCG CTGCTGTTCA GACCTGCTTA CCAAAGAATC CTGAAAGTGA CTTGTCAAGG 
AAAATCACCC CTCTGATTTC TGTCCCTGTA TCCAGTCCCC CTGTCCTTTG CCAGATGATC 
CCTGTGGCTG GACAGAATGG CTTGTTCTCA GCCTTTTTGA AACCTCCTAC CCAGTTGCCT 
GCAGGGACTA TCAAGCCCAT CCTACCCCAA GCTGCTTCAA TGTCTCAGCC TGTGTTCATG 
GGCCCACCTG TGCCTCAGGG AACTGTGATG CTGGTCTTGC CACAGAACAC CTTCCCCCAG 
CCTGCTGCCT GTCCATCCAG TGTCATGGCC ATTGGAAATA CCAAGCTGTT GCCCCTTGCC 
CCTGCACCAG TGTTCCTTGC CTCCAGCCAG AACTGTGCCC CTCAGGTAGA CTTTTCCCGA 
AGGAGGAACT ATGTTTGCAA CTTCCCAGGA TGCCGGAAGA CCTACTTCAA AAGTTCCCAC 
CTTAAAGCTC ATCTTCGCAC TCACACAGGG GAGAAGCCTT TTACCTGCAG CTGGGACGGC 
TGTGACAAGA AGTTCGCAAG GTCAGATGAA CTGTCTCGCC ACCGCAGGAC TCACACGGGA 
GAGAAGAAGT TTGTGTGTCC TGTGTGTGAC CGGCGCTTCA TGCGGAGTGA CCACCTGACA 
AAGCACGCTC GTCGCCACAT GACAACCAAG AAGATCCCAG GCTGGCAGGC AGAGGTGGGC 
AAGCTGAACA GAATCACTTT GGCAGAGAGC CCCGGGAGCA TCCTCGAACC CTTGCCGGCC 
TCTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848134.1
CDS	155..1663
Translation	MHSPGSTGPGDGRAADIMDICESILERKRHDSERSTCSVLEQTDIEAVEALVCMSSWGQRSQMRPLTPVSDSGDVTTAVLMDTAAPDLPKDFHSFSTLCITPPQSPELTEPSTGTPVPSQVVNSKGCMVTALPPSPAGGPRTLSKREPLEPASGSSCRAVMTSVIRHTGESPAPTRFPTGPTQEQRASDSGEGQERLLDHLEALQDTRLANGLLVTNLVSCQPCLHKSGGSFPTDKGQQTGWPAAVQTCLPKNPESDLSRKITPLISVPVSSPPVLCQMIPVAGQNGLFSAFLKPPTQLPAGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQNTFPQPAACPSSVMAIGNTKLLPLAPAPVFLASSQNCAPQVDFSRRRNYVCNFPGCRKTYFKSSHLKAHLRTHTGEKPFTCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRITLAESPGSILEPLPASG

Target ORF information:

RefSeq Version	NM_178357.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Kruppel-like factor 11 (Klf11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178357.3

ORF Insert Sequence:

ATGCACTCGC CGGGCTCCAC CGGCCCCGGC GACGGGCGCG CGGCTGACAT CATGGACATT 
TGTGAGTCGA TCCTGGAGAG GAAGCGGCAT GACAGCGAAA GGTCCACATG CAGCGTCCTG 
GAGCAGACGG ACATCGAAGC TGTGGAAGCT CTTGTCTGCA TGAGCTCTTG GGGTCAGAGG 
TCCCAGATGA GACCCCTCAC GCCTGTCTCT GACTCTGGTG ACGTCACCAC TGCTGTGCTT 
ATGGACACAG CTGCACCTGA TCTACCAAAG GACTTCCATT CTTTTTCAAC TCTGTGTATA 
ACTCCTCCTC AGAGCCCAGA GCTCACGGAG CCGTCAACAG GGACCCCTGT TCCTTCCCAA 
GTAGTTAACT CCAAAGGATG CATGGTCACT GCCCTCCCCC CATCCCCTGC TGGGGGCCCC 
AGAACACTGA GCAAGAGGGA ACCACTGGAG CCAGCCTCAG GGTCCTCCTG CAGGGCTGTG 
ATGACCAGTG TGATCCGTCA CACCGGGGAG AGTCCTGCTC CTACGCGCTT CCCAACTGGC 
CCCACTCAAG AGCAACGAGC ATCCGACAGC GGAGAAGGAC AGGAGCGTTT GCTGGACCAC 
CTCGAAGCCT TGCAGGACAC ACGCTTGGCA AATGGCTTAC TCGTCACTAA CTTGGTTTCC 
TGTCAGCCTT GCTTGCACAA GTCCGGTGGT TCGTTCCCCA CTGACAAAGG TCAACAGACA 
GGATGGCCCG CTGCTGTTCA GACCTGCTTA CCAAAGAATC CTGAAAGTGA CTTGTCAAGG 
AAAATCACCC CTCTGATTTC TGTCCCTGTA TCCAGTCCCC CTGTCCTTTG CCAGATGATC 
CCTGTGGCTG GACAGAATGG CTTGTTCTCA GCCTTTTTGA AACCTCCTAC CCAGTTGCCT 
GCAGGGACTA TCAAGCCCAT CCTACCCCAA GCTGCTTCAA TGTCTCAGCC TGTGTTCATG 
GGCCCACCTG TGCCTCAGGG AACTGTGATG CTGGTCTTGC CACAGAACAC CTTCCCCCAG 
CCTGCTGCCT GTCCATCCAG TGTCATGGCC ATTGGAAATA CCAAGCTGTT GCCCCTTGCC 
CCTGCACCAG TGTTCCTTGC CTCCAGCCAG AACTGTGCCC CTCAGGTAGA CTTTTCCCGA 
AGGAGGAACT ATGTTTGCAA CTTCCCAGGA TGCCGGAAGA CCTACTTCAA AAGTTCCCAC 
CTTAAAGCTC ATCTTCGCAC TCACACAGGG GAGAAGCCTT TTACCTGCAG CTGGGACGGC 
TGTGACAAGA AGTTCGCAAG GTCAGATGAA CTGTCTCGCC ACCGCAGGAC TCACACGGGA 
GAGAAGAAGT TTGTGTGTCC TGTGTGTGAC CGGCGCTTCA TGCGGAGTGA CCACCTGACA 
AAGCACGCTC GTCGCCACAT GACAACCAAG AAGATCCCAG GCTGGCAGGC AGAGGTGGGC 
AAGCTGAACA GAATCACTTT GGCAGAGAGC CCCGGGAGCA TCCTCGAACC CTTGCCGGCC 
TCTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response.
Endocrinology158(10)3605-3619(2017 Oct)
Shenoy CC,Khan Z,Zheng Y,Jones TL,Khazaie K,Daftary GS

KLF11 is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis.
Reproductive sciences (Thousand Oaks, Calif.)24(8)1129-1138(2017 Aug)
Richards EG,Zheng Y,Shenoy CC,Ainsworth AJ,Delaney AA,Jones TL,Khan Z,Daftary GS

Genetic Deletion of Kr?ppel-Like Factor 11 Aggravates Ischemic Brain Injury.
Molecular neurobiology(2017 Apr)
Tang X,Liu K,Hamblin MH,Xu Y,Yin KJ

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice.
eLife5(2016 10)
Hayashi S,Manabe I,Suzuki Y,Relaix F,Oishi Y