Ptf1a cDNA ORF clone, Mus musculus(house mouse)

A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.
Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, Singer RA, Caridi G, Mendelsohn C, Sussel L, Papaioannou VE, Gharavi AG
PLoS genetics9(2)e1003206(2013)

We crossed Ptf1a(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 secretion
Title: c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice.

Ptf1a is regulated by active and repressive inputs integrated through multiple sequence elements within a highly conserved sequence downstream of the Ptf1a gene.
Title: Regulating the dorsal neural tube expression of Ptf1a through a distal 3' enhancer.

the Tfap2a and Tfap2b transcription factors were identified as two major downstream effectors of Ptf1a.
Title: Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.

This study demonstrated that the transcription factor Ptf1a is capable of cell autonomously redirecting cortical pyramidal cell identity toward an inhibitory peptidergic fate.
Title: Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity.

We provide strong evidence for spatiotemporally context-dependent activity of Ptf1a as a potent gain-of-function trigger of pro-pancreatic commitment.
Title: Dominant and context-specific control of endodermal organ allocation by Ptf1a.