Pigr cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pigr
Entrez Gene ID	18703
Full Name	polymeric immunoglobulin receptor
General protein information	Preferred Names polymeric immunoglobulin receptor Names polymeric immunoglobulin receptor phosphatidylinositol glycan, class R poly-Ig receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 E4\|1 56.89 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011082.3	NP_035212.2	polymeric immunoglobulin receptor precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PIGR	XP_537133.3
Bos taurus (cattle)	PIGR	NP_776568.1
Rattus norvegicus (Norway rat)	Pigr	NP_036855.3
Homo sapiens (human)	PIGR	NP_002635.2
Pan troglodytes (chimpanzee)	PIGR	XP_003308758.1
Gallus gallus (chicken)	PIGR	NP_001038109.1
	PIGR	XP_001083307.2
Mus musculus (house mouse)	Pigr	NP_035212.2
Xenopus tropicalis (tropical clawed frog)	LOC100495453	XP_002932180.1

Gene Ontology
Bibliography

Related articles in PubMed

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M
Nature551(7680)340-345(2017 Nov)

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.
Iovino F, Engelen-Lee JY, Brouwer M, van de Beek D, van der Ende A, Valls Seron M, Mellroth P, Muschiol S, Bergstrand J, Widengren J, Henriques-Normark B
The Journal of experimental medicine214(6)1619-1630(2017 Jun)

Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV
Nature communications711240(2016 Apr)

Enhanced differentiation of intraepithelial lymphocytes in the intestine of polymeric immunoglobulin receptor-deficient mice.
Kato-Nagaoka N, Shimada S, Yamakawa Y, Tsujibe S, Naito T, Setoyama H, Watanabe Y, Shida K, Matsumoto S, Nanno M
Immunology146(1)59-69(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RrgA, binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR
Title: pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.

pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.
Title: Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.

the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 pathway activation.
Title: Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease.

Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
Title: Increased autoimmune diabetes in pIgR-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.

pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.
Title: Streptococcus pneumoniae Interacts with pIgR expressed by the brain microvascular endothelium but does not co-localize with PAF receptor.

The following Pigr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pigr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19391	NM_011082.3 Latest version!	Mus musculus polymeric immunoglobulin receptor (Pigr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pigr ( NM_011082.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035212.2 Mus musculus polymeric immunoglobulin receptor (Pigr), mRNA.

Price & Availability↑

CloneID	OMu19391
Clone ID Related Accession (Same CDS sequence)	NM_011082.3
Accession Version	NM_011082.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2316bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	polymeric immunoglobulin receptor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK142656.1 and AC165322.12. On Aug 12, 2009 this sequence version replaced NM_011082.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128944.1, AK142656.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTCT ACTTGTTCAC GCTCTTGGTA ACTGTCTTTT CAGGGGTCTC CACAAAAAGC 
CCCATATTTG GTCCCCAGGA GGTGAGTAGT ATAGAAGGCG ACTCTGTTTC CATCACGTGC 
TACTACCCAG ACACCTCTGT CAACCGGCAC ACCCGGAAAT ACTGGTGCCG ACAAGGAGCC 
AGCGGCATGT GCACAACGCT CATCTCTTCA AATGGCTACC TCTCCAAGGA GTATTCAGGC 
AGAGCCAACC TCATCAACTT CCCAGAGAAC AACACATTTG TGATTAACAT TGAGCAGCTC 
ACCCAGGACG ACACTGGGAG CTACAAGTGT GGCCTGGGTA CCAGTAACCG AGGCCTGTCC 
TTCGATGTCA GCCTGGAGGT CAGCCAGGTT CCTGAGTTGC CGAGTGACAC CCACGTCTAC 
ACAAAGGACA TAGGCAGAAA TGTGACCATT GAATGCCCTT TCAAAAGGGA GAATGCTCCC 
AGCAAGAAAT CCCTGTGTAA GAAGACAAAC CAGTCCTGCG AACTTGTCAT TGACTCTACT 
GAGAAGGTGA ACCCCAGCTA TATAGGCAGA GCAAAACTTT TTATGAAAGG GACCGACCTA 
ACTGTATTCT ATGTCAACAT TAGTCACCTA ACGCACAATG ATGCTGGGCT GTACATCTGC 
CAAGCTGGAG AAGGTCCTAG TGCTGATAAG AAGAATGTTG ACCTCCAGGT GCTAGCGCCT 
GAGCCAGAGC TGCTTTATAA AGACCTGAGG TCCTCAGTGA CTTTTGAATG TGACCTGGGC 
CGTGAGGTGG CAAACGAGGC CAAATATCTG TGCCGGATGA ATAAGGAAAC CTGTGATGTG 
ATCATTAACA CCCTGGGGAA GAGGGATCCA GACTTTGAGG GCAGGATCCT GATAACCCCC 
AAGGATGACA ATGGCCGCTT CAGTGTGTTG ATCACAGGCC TGAGGAAGGA GGATGCAGGG 
CACTACCAGT GTGGAGCCCA CAGTTCTGGT TTGCCTCAAG AAGGCTGGCC CATCCAGACT 
TGGCAACTCT TTGTCAATGA AGAGTCTACC ATTCCCAATC GTCGCTCTGT TGTGAAGGGA 
GTCACAGGAG GCTCTGTGGC CATCGCCTGT CCCTATAACC CCAAGGAAAG CAGCAGCCTC 
AAGTACTGGT GTCGCTGGGA AGGGGACGGA AATGGACATT GCCCCGTGCT TGTGGGGACC 
CAGGCCCAGG TGCAAGAAGA GTATGAAGGC CGACTGGCAC TGTTTGATCA GCCAGGCAAT 
GGTACTTACA CTGTCATCCT CAACCAGCTC ACCACCGAGG ATGCTGGCTT CTATTGGTGT 
CTTACCAATG GTGACTCTCG CTGGAGAACC ACAATAGAAC TCCAGGTTGC CGAAGCTACA 
AGGGAGCCAA ACCTTGAGGT GACGCCACAG AACGCAACAG CAGTACTAGG AGAGACCTTC 
ACCGTTTCCT GCCACTATCC GTGCAAATTC TACTCCCAGG AGAAATACTG GTGCAAGTGG 
AGCAACAAGG GTTGCCACAT CCTGCCAAGC CATGACGAAG GTGCCCGCCA ATCTTCTGTG 
AGCTGCGACC AGAGCAGCCA GCTGGTCTCC ATGACCCTGA ACCCGGTCAG TAAGGAAGAT 
GAAGGCTGGT ACTGGTGTGG GGTAAAGCAA GGCCAGACCT ATGGAGAAAC TACCGCCATC 
TATATAGCAG TTGAAGAGAG GACCAGAGGG TCATCCCATG TCAACCCAAC AGATGCAAAT 
GCACGTGCCA AAGTCGCTCT GGAAGAAGAG GTAGTGGACT CCTCCATCAG TGAAAAAGAG 
AACAAAGCCA TTCCAAATCC CGGGCCTTTT GCCAACGAAA GAGAGATACA GAATGTGGGA 
GACCAAGCTC AGGAGAACAG AGCATCTGGG GATGCTGGCA GTGCTGATGG ACAAAGCAGG 
AGCTCCAGCT CCAAAGTGCT GTTCTCCACC CTGGTGCCCC TGGGTCTGGT GCTGGCAGTG 
GGTGCTATAG CTGTGTGGGT GGCCAGAGTC CGACATCGGA AGAATGTAGA CCGCATGTCA 
ATCAGCAGCT ACAGGACAGA CATTAGCATG GCAGACTTCA AGAACTCCAG AGATTTGGGA 
GGCAATGACA ACATGGGGGC CTCTCCAGAC ACACAGCAAA CAGTCATCGA AGGAAAAGAT 
GAAATCGTGA CTACCACGGA GTGCACCGCT GAGCCAGAAG AATCCAAGAA AGCAAAAAGG 
TCATCCAAGG AGGAAGCTGA CATGGCCTAC TCGGCATTCC TGCTTCAGTC CAGCACCATA 
GCTGCACAGG TCCACGATGG TCCCCAGGAA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035212.2
CDS	181..2496
Translation	MRLYLFTLLVTVFSGVSTKSPIFGPQEVSSIEGDSVSITCYYPDTSVNRHTRKYWCRQGASGMCTTLISSNGYLSKEYSGRANLINFPENNTFVINIEQLTQDDTGSYKCGLGTSNRGLSFDVSLEVSQVPELPSDTHVYTKDIGRNVTIECPFKRENAPSKKSLCKKTNQSCELVIDSTEKVNPSYIGRAKLFMKGTDLTVFYVNISHLTHNDAGLYICQAGEGPSADKKNVDLQVLAPEPELLYKDLRSSVTFECDLGREVANEAKYLCRMNKETCDVIINTLGKRDPDFEGRILITPKDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPIQTWQLFVNEESTIPNRRSVVKGVTGGSVAIACPYNPKESSSLKYWCRWEGDGNGHCPVLVGTQAQVQEEYEGRLALFDQPGNGTYTVILNQLTTEDAGFYWCLTNGDSRWRTTIELQVAEATREPNLEVTPQNATAVLGETFTVSCHYPCKFYSQEKYWCKWSNKGCHILPSHDEGARQSSVSCDQSSQLVSMTLNPVSKEDEGWYWCGVKQGQTYGETTAIYIAVEERTRGSSHVNPTDANARAKVALEEEVVDSSISEKENKAIPNPGPFANEREIQNVGDQAQENRASGDAGSADGQSRSSSSKVLFSTLVPLGLVLAVGAIAVWVARVRHRKNVDRMSISSYRTDISMADFKNSRDLGGNDNMGASPDTQQTVIEGKDEIVTTTECTAEPEESKKAKRSSKEEADMAYSAFLLQSSTIAAQVHDGPQEA

Target ORF information:

RefSeq Version	NM_011082.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus polymeric immunoglobulin receptor (Pigr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011082.3

ORF Insert Sequence:

ATGAGGCTCT ACTTGTTCAC GCTCTTGGTA ACTGTCTTTT CAGGGGTCTC CACAAAAAGC 
CCCATATTTG GTCCCCAGGA GGTGAGTAGT ATAGAAGGCG ACTCTGTTTC CATCACGTGC 
TACTACCCAG ACACCTCTGT CAACCGGCAC ACCCGGAAAT ACTGGTGCCG ACAAGGAGCC 
AGCGGCATGT GCACAACGCT CATCTCTTCA AATGGCTACC TCTCCAAGGA GTATTCAGGC 
AGAGCCAACC TCATCAACTT CCCAGAGAAC AACACATTTG TGATTAACAT TGAGCAGCTC 
ACCCAGGACG ACACTGGGAG CTACAAGTGT GGCCTGGGTA CCAGTAACCG AGGCCTGTCC 
TTCGATGTCA GCCTGGAGGT CAGCCAGGTT CCTGAGTTGC CGAGTGACAC CCACGTCTAC 
ACAAAGGACA TAGGCAGAAA TGTGACCATT GAATGCCCTT TCAAAAGGGA GAATGCTCCC 
AGCAAGAAAT CCCTGTGTAA GAAGACAAAC CAGTCCTGCG AACTTGTCAT TGACTCTACT 
GAGAAGGTGA ACCCCAGCTA TATAGGCAGA GCAAAACTTT TTATGAAAGG GACCGACCTA 
ACTGTATTCT ATGTCAACAT TAGTCACCTA ACGCACAATG ATGCTGGGCT GTACATCTGC 
CAAGCTGGAG AAGGTCCTAG TGCTGATAAG AAGAATGTTG ACCTCCAGGT GCTAGCGCCT 
GAGCCAGAGC TGCTTTATAA AGACCTGAGG TCCTCAGTGA CTTTTGAATG TGACCTGGGC 
CGTGAGGTGG CAAACGAGGC CAAATATCTG TGCCGGATGA ATAAGGAAAC CTGTGATGTG 
ATCATTAACA CCCTGGGGAA GAGGGATCCA GACTTTGAGG GCAGGATCCT GATAACCCCC 
AAGGATGACA ATGGCCGCTT CAGTGTGTTG ATCACAGGCC TGAGGAAGGA GGATGCAGGG 
CACTACCAGT GTGGAGCCCA CAGTTCTGGT TTGCCTCAAG AAGGCTGGCC CATCCAGACT 
TGGCAACTCT TTGTCAATGA AGAGTCTACC ATTCCCAATC GTCGCTCTGT TGTGAAGGGA 
GTCACAGGAG GCTCTGTGGC CATCGCCTGT CCCTATAACC CCAAGGAAAG CAGCAGCCTC 
AAGTACTGGT GTCGCTGGGA AGGGGACGGA AATGGACATT GCCCCGTGCT TGTGGGGACC 
CAGGCCCAGG TGCAAGAAGA GTATGAAGGC CGACTGGCAC TGTTTGATCA GCCAGGCAAT 
GGTACTTACA CTGTCATCCT CAACCAGCTC ACCACCGAGG ATGCTGGCTT CTATTGGTGT 
CTTACCAATG GTGACTCTCG CTGGAGAACC ACAATAGAAC TCCAGGTTGC CGAAGCTACA 
AGGGAGCCAA ACCTTGAGGT GACGCCACAG AACGCAACAG CAGTACTAGG AGAGACCTTC 
ACCGTTTCCT GCCACTATCC GTGCAAATTC TACTCCCAGG AGAAATACTG GTGCAAGTGG 
AGCAACAAGG GTTGCCACAT CCTGCCAAGC CATGACGAAG GTGCCCGCCA ATCTTCTGTG 
AGCTGCGACC AGAGCAGCCA GCTGGTCTCC ATGACCCTGA ACCCGGTCAG TAAGGAAGAT 
GAAGGCTGGT ACTGGTGTGG GGTAAAGCAA GGCCAGACCT ATGGAGAAAC TACCGCCATC 
TATATAGCAG TTGAAGAGAG GACCAGAGGG TCATCCCATG TCAACCCAAC AGATGCAAAT 
GCACGTGCCA AAGTCGCTCT GGAAGAAGAG GTAGTGGACT CCTCCATCAG TGAAAAAGAG 
AACAAAGCCA TTCCAAATCC CGGGCCTTTT GCCAACGAAA GAGAGATACA GAATGTGGGA 
GACCAAGCTC AGGAGAACAG AGCATCTGGG GATGCTGGCA GTGCTGATGG ACAAAGCAGG 
AGCTCCAGCT CCAAAGTGCT GTTCTCCACC CTGGTGCCCC TGGGTCTGGT GCTGGCAGTG 
GGTGCTATAG CTGTGTGGGT GGCCAGAGTC CGACATCGGA AGAATGTAGA CCGCATGTCA 
ATCAGCAGCT ACAGGACAGA CATTAGCATG GCAGACTTCA AGAACTCCAG AGATTTGGGA 
GGCAATGACA ACATGGGGGC CTCTCCAGAC ACACAGCAAA CAGTCATCGA AGGAAAAGAT 
GAAATCGTGA CTACCACGGA GTGCACCGCT GAGCCAGAAG AATCCAAGAA AGCAAAAAGG 
TCATCCAAGG AGGAAGCTGA CATGGCCTAC TCGGCATTCC TGCTTCAGTC CAGCACCATA 
GCTGCACAGG TCCACGATGG TCCCCAGGAA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Nature551(7680)340-345(2017 Nov)
Shalapour S,Lin XJ,Bastian IN,Brain J,Burt AD,Aksenov AA,Vrbanac AF,Li W,Perkins A,Matsutani T,Zhong Z,Dhar D,Navas-Molina JA,Xu J,Loomba R,Downes M,Yu RT,Evans RM,Dorrestein PC,Knight R,Benner C,Anstee QM,Karin M

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.
The Journal of experimental medicine214(6)1619-1630(2017 Jun)
Iovino F,Engelen-Lee JY,Brouwer M,van de Beek D,van der Ende A,Valls Seron M,Mellroth P,Muschiol S,Bergstrand J,Widengren J,Henriques-Normark B

Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Nature communications711240(2016 Apr)
Richmond BW,Brucker RM,Han W,Du RH,Zhang Y,Cheng DS,Gleaves L,Abdolrasulnia R,Polosukhina D,Clark PE,Bordenstein SR,Blackwell TS,Polosukhin VV

Enhanced differentiation of intraepithelial lymphocytes in the intestine of polymeric immunoglobulin receptor-deficient mice.
Immunology146(1)59-69(2015 Sep)
Kato-Nagaoka N,Shimada S,Yamakawa Y,Tsujibe S,Naito T,Setoyama H,Watanabe Y,Shida K,Matsumoto S,Nanno M

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Pigr cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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