Bloc1s6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bloc1s6
Entrez Gene ID	18457
Full Name	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Synonyms	BLOC-1,Pldn,Stx13bp1,pa
General protein information	Preferred Names biogenesis of lysosomal organelles complex-1, subunit 6, pallidin Names biogenesis of lysosome-related organelles complex 1 subunit 6 BLOC-1 subunit 6 biogenesis of organelles complex-1, subunit 6, pallidin pallid protein pallidin syntaxin 13 binding protein 1 syntaxin 13-interacting protein pallid
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 E5\|2 60.66 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019788.3	NP_062762.1	biogenesis of lysosome-related organelles complex 1 subunit 6

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Bloc1s6	NP_001020885.1
Gallus gallus (chicken)	PLDN	NP_001007826.1
Pan troglodytes (chimpanzee)	BLOC1S6	XP_003314757.1
Canis lupus familiaris (dog)	LOC478288	XP_535463.3
	PLDN	XP_001111943.1
Bos taurus (cattle)	BLOC1S6	NP_001069793.1
Mus musculus (house mouse)	Bloc1s6	NP_062762.1
Homo sapiens (human)	BLOC1S6	NP_036520.1
Xenopus tropicalis (tropical clawed frog)	bloc1s6	NP_001016502.1
Danio rerio (zebrafish)	bloc1s6	NP_001074166.1

Gene Ontology
Bibliography

Related articles in PubMed

Ferritin is secreted via 2 distinct nonclassical vesicular pathways.
Truman-Rosentsvit M, Berenbaum D, Spektor L, Cohen LA, Belizowsky-Moshe S, Lifshitz L, Ma J, Li W, Kesselman E, Abutbul-Ionita I, Danino D, Gutierrez L, Li H, Li K, Lou H, Regoni M, Poli M, Glaser F, Rouault TA, Meyron-Holtz EG
Blood131(3)342-352(2018 Jan)

BLOC-1 deficiency causes alterations in amino acid profile and in phospholipid and adenosine metabolism in the postnatal mouse hippocampus.
van Liempd SM, Cabrera D, Lee FY, Gonz?lez E, Dell'Angelica EC, Ghiani CA, Falcon-Perez JM
Scientific reports7(1)5231(2017 Jul)

Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model.
Pedroza M, Welschhans RL, Agarwal SK
PloS one12(11)e0187109(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Polycystin-2 requires IFT20-GMAP210, the exocyst, and BLOC-1 for trafficking from endosomes to primary cilia.
Title: BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia.

We found 491 proteins sensitive to dysbindin and BLOC-1 loss of function
Title: The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse.

VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, illuminate SNARE recycling from melanosomes as a critical BLOC-3-dependent step.
Title: BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers.

Mecp2 regulates the expression of components belonging to the dysbindin interactome
Title: MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.

Data suggest functional links between OCA2 and the BLOC-1, BLOC-2, and AP-3 protein complexes involved in melanosome biogenesis.
Title: Functional interactions between OCA2 and the protein complexes BLOC-1, BLOC-2, and AP-3 inferred from epistatic analyses of mouse coat pigmentation.

The following Bloc1s6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bloc1s6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12993	NM_019788.3 Latest version!	Mus musculus biogenesis of lysosomal organelles complex-1, subunit 6, pallidin (Bloc1s6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bloc1s6 ( NM_019788.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062762.1 Mus musculus biogenesis of lysosomal organelles complex-1, subunit 6, pallidin (Bloc1s6), mRNA.

Price & Availability↑

CloneID	OMu12993
Clone ID Related Accession (Same CDS sequence)	NM_019788.3
Accession Version	NM_019788.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	biogenesis of lysosome-related organelles complex 1 subunit 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY015259.1, AK147116.1, AI596295.1 and CJ304271.1. On Jul 20, 2006 this sequence version replaced NM_019788.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147116.1, AK077720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGTTC CTGAGCCACC GCCTCCAGAC GGGGTCCTTA CGGGGCCTTC CGACAGCCTG 
GAGGCCGGCG AGCCCACGCC GGGCTTAAGC GACACGTCTC CAGATGAAGG ACTGATAGAG 
GACTTCCCTG TGGACGATAG AGCTGTAGAG CACTTGGTGG GAGGCCTGCT GTCCCACTAC 
TTACCAGATC TGCAGAGGTC CAAGCGAGCA CTCCAGGAAC TCACACAGAA CCAAGTTGTG 
TTACTAGATA CACTGGAACA AGAGATTTCA AAATTTAAAG AATGCCACTC CATGTTGGAC 
ATCAATGCTT TGTTCACAGA GGCGAAGCAC TATCACGCCA AGCTGGTGAC TATAAGGAAG 
GAGATGCTGC TGCTCCATGA GAAAACGTCC AAGTTGAAAA AAAGAGCACT GAAGCTGCAG 
CAGAAGCGGC AGAGAGAAGA GCTGGAGAGG GAGCAGCAAC GCGAAAAGGA ATTTGAAAGA 
GAAAAGCAGC TGACAGCCAA GCCAGCCAAG AGGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062762.1
CDS	119..637
Translation	MSVPEPPPPDGVLTGPSDSLEAGEPTPGLSDTSPDEGLIEDFPVDDRAVEHLVGGLLSHYLPDLQRSKRALQELTQNQVVLLDTLEQEISKFKECHSMLDINALFTEAKHYHAKLVTIRKEMLLLHEKTSKLKKRALKLQQKRQREELEREQQREKEFEREKQLTAKPAKRT

Target ORF information:

RefSeq Version	NM_019788.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus biogenesis of lysosomal organelles complex-1, subunit 6, pallidin (Bloc1s6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019788.3

ORF Insert Sequence:

ATGAGTGTTC CTGAGCCACC GCCTCCAGAC GGGGTCCTTA CGGGGCCTTC CGACAGCCTG 
GAGGCCGGCG AGCCCACGCC GGGCTTAAGC GACACGTCTC CAGATGAAGG ACTGATAGAG 
GACTTCCCTG TGGACGATAG AGCTGTAGAG CACTTGGTGG GAGGCCTGCT GTCCCACTAC 
TTACCAGATC TGCAGAGGTC CAAGCGAGCA CTCCAGGAAC TCACACAGAA CCAAGTTGTG 
TTACTAGATA CACTGGAACA AGAGATTTCA AAATTTAAAG AATGCCACTC CATGTTGGAC 
ATCAATGCTT TGTTCACAGA GGCGAAGCAC TATCACGCCA AGCTGGTGAC TATAAGGAAG 
GAGATGCTGC TGCTCCATGA GAAAACGTCC AAGTTGAAAA AAAGAGCACT GAAGCTGCAG 
CAGAAGCGGC AGAGAGAAGA GCTGGAGAGG GAGCAGCAAC GCGAAAAGGA ATTTGAAAGA 
GAAAAGCAGC TGACAGCCAA GCCAGCCAAG AGGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ferritin is secreted via 2 distinct nonclassical vesicular pathways.
Blood131(3)342-352(2018 Jan)
Truman-Rosentsvit M,Berenbaum D,Spektor L,Cohen LA,Belizowsky-Moshe S,Lifshitz L,Ma J,Li W,Kesselman E,Abutbul-Ionita I,Danino D,Gutierrez L,Li H,Li K,Lou H,Regoni M,Poli M,Glaser F,Rouault TA,Meyron-Holtz EG

BLOC-1 deficiency causes alterations in amino acid profile and in phospholipid and adenosine metabolism in the postnatal mouse hippocampus.
Scientific reports7(1)5231(2017 Jul)
van Liempd SM,Cabrera D,Lee FY,Gonz?lez E,Dell'Angelica EC,Ghiani CA,Falcon-Perez JM

Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model.
PloS one12(11)e0187109(2017)
Pedroza M,Welschhans RL,Agarwal SK