Slc22a6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc22a6
Entrez Gene ID	18399
Full Name	solute carrier family 22 (organic anion transporter), member 6
Synonyms	NKT,Oat1,Orctl1,mOat1
General protein information	Preferred Names solute carrier family 22 (organic anion transporter), member 6 Names solute carrier family 22 member 6 kidney-specific transport protein mNKT mROAT1 novel kidney transcript organic anion transporter 1 organic cationic transporter-like 1 renal organic anion transporter 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 A\|19 5.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008766.3	NP_032792.2	solute carrier family 22 member 6

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100487511	XP_002937540.1
Homo sapiens (human)	SLC22A6	NP_695008.1
Pan troglodytes (chimpanzee)	SLC22A6	XP_001160211.1
Bos taurus (cattle)	SLC22A6	NP_001001143.1
Rattus norvegicus (Norway rat)	Slc22a6	NP_058920.1
	SLC22A6	XP_001115901.1
Canis lupus familiaris (dog)	SLC22A6	XP_005631653.1
Mus musculus (house mouse)	Slc22a6	NP_032792.2
Danio rerio (zebrafish)	oatx	XP_001923128.4
Xenopus tropicalis (tropical clawed frog)	LOC100490266	XP_002937554.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
Hu S, Leblanc AF, Gibson AA, Hong KW, Kim JY, Janke LJ, Li L, Vasilyeva A, Finkelstein DB, Sprowl JA, Sweet DH, Schlatter E, Ciarimboli G, Schellens J, Baker SD, Pabla N, Sparreboom A
Clinical and translational science10(5)412-420(2017 Sep)

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.
Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush KT, Abagyan R, Palsson BO, Nigam SK
The Journal of biological chemistry291(37)19474-86(2016 09)

Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.
Espana-Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson DA, Adams DJ, Matakidou A
PloS one11(2)e0148055(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.
Title: An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.

OAT1-deficient mice showed abnormal LTP and higher spine numbers but with a much lesser maturity extent.
Title: Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity.

Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3).
Title: Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice.

At the protein level, mOat3 and mOat1 exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 is male dominant due to androgen stimulation.
Title: Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys.

acute kidney injury by HgCl(2) was found to be mediated mainly by Oat1.
Title: Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury.

The following Slc22a6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc22a6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23259	NM_008766.3 Latest version!	Mus musculus solute carrier family 22 (organic anion transporter), member 6 (Slc22a6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc22a6 ( NM_008766.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032792.2 Mus musculus solute carrier family 22 (organic anion transporter), member 6 (Slc22a6), mRNA.

Price & Availability↑

CloneID	OMu23259
Clone ID Related Accession (Same CDS sequence)	NM_008766.3
Accession Version	NM_008766.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	solute carrier family 22 member 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC025794.9 and AK035971.1. On Aug 11, 2009 this sequence version replaced NM_008766.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK035971.1, BC021647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTTCA ATGACCTCCT GAAACAGGTG GGGGGTGTCG GACGCTTCCA GCTGATCCAG 
GTCACCATGG TGGTTGCTCC CCTACTGCTG ATGGCTTCCC ACAACACCCT GCAGAACTTC 
ACTGCTGCTA TCCCCGCTCA CCACTGCCGC CCACCTGCTA ATGCCAACCT CAGCAAAGAT 
GGAGGTCTGG AGGCCTGGCT GCCCCTGGAC AAGCAAGGAC GACCCGAATC TTGCCTCCGC 
TTTCCTTTCC CGCACAATGG CACAGAGGCC AATGGCACCG GAGTCACAGA GCCCTGCCTT 
GATGGCTGGG TCTATGACAA CAGCACCTTC CCTTCAACCA TCGTGACTGA GTGGAACCTT 
GTGTGCTCTC ATCGGGCCTT CCGCCAGCTG GCCCAGTCCC TGTTCATGGT GGGAGTGTTA 
CTGGGAGCCA TGATGTTTGG CTACCTGGCG GACAGGCTGG GCCGTCGGAA GGTGCTGATC 
TTGAACTACC TGCAAACAGC TGTGTCGGGA ACCTGTGCAG CCTATGCACC CAACTATACT 
GTCTACTGCA TTTTCCGGCT CCTCTCGGGC ATGTCTTTGG CTAGCATTGC AATCAACTGC 
ATGACACTAA ACATGGAGTG GATGCCTATT CACACCCGTG CCTATGTGGG CACCTTGATT 
GGCTATGTCT ACAGCTTGGG CCAGTTCCTC CTGGCTGGTA TCGCCTATGC TGTGCCCCAC 
TGGCGCCACC TGCAGCTTGC GGTCTCTGTG CCTTTTTTCG TTGCCTTCAT CTACTCTTGG 
TTCTTCATTG AGTCAGCCCG CTGGTACTCC TCCTCTGGAA GGCTGGACCT CACCCTCCGA 
GCCCTGCAGA GAGTGGCCCG CATCAACGGG AAACAAGAAG AGGGGGCTAA GCTGAGTATA 
GAGGTGCTCC AGACCAGCCT GCAGAAGGAA CTGACTCTAA ACAAAGGCCA GGCCTCCGCC 
ATGGAGCTGC TGCGCTGCCC CACGCTTCGG CGCCTCTTCC TCTGCCTCTC TATGCTGTGG 
TTTGCCACTA GCTTTGCCTA CTACGGGCTG GTCATGGACC TGCAGGGCTT TGGGGTCAGC 
ATGTACCTTA TCCAGGTGAT TTTCGGCGCT GTGGACCTGC CTGCCAAGTT TGTGTGCTTC 
CTAGTCATCA ATTCCATGGG CCGCCGGCCT GCACAGTTGG CCTCCCTGCT GCTGGCAGGC 
ATCTGTATCC TAGTGAATGG CATAATACCG AGGGGCCATA CAATCATTCG CACATCCCTG 
GCTGTACTAG GGAAAGGCTG TCTGGCTTCC TCTTTCAACT GCATCTTCCT GTACACCGGA 
GAGCTGTACC CCACAATGAT TCGGCAGACG GGCCTGGGCA TGGGCAGCAC CATGGCCCGG 
GTGGGCAGCA TAGTGAGCCC ACTGATAAGC ATGACTGCCG AGTTCTACCC CTCCATACCT 
CTCTTCATCT TCGGCGCTGT CCCCGTGGCC GCCAGCGCTG TCACTGCCCT GCTGCCAGAG 
ACCTTGGGCC AGCCGCTGCC TGATACAGTG CAGGACCTGA AGAGCAGGAG CAGAGGAAAG 
CAGAAGCAAC AGCAGCTGGA ACAGCAGAAG CAGATGATAC CACTCCAGGT CTCAACACAA 
GAGAAGAACG GACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032792.2
CDS	301..1938
Translation	MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPLDKQGRPESCLRFPFPHNGTEANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQTSLQKELTLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQPLPDTVQDLKSRSRGKQKQQQLEQQKQMIPLQVSTQEKNGL

Target ORF information:

RefSeq Version	NM_008766.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 22 (organic anion transporter), member 6 (Slc22a6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008766.3

ORF Insert Sequence:

ATGGCCTTCA ATGACCTCCT GAAACAGGTG GGGGGTGTCG GACGCTTCCA GCTGATCCAG 
GTCACCATGG TGGTTGCTCC CCTACTGCTG ATGGCTTCCC ACAACACCCT GCAGAACTTC 
ACTGCTGCTA TCCCCGCTCA CCACTGCCGC CCACCTGCTA ATGCCAACCT CAGCAAAGAT 
GGAGGTCTGG AGGCCTGGCT GCCCCTGGAC AAGCAAGGAC GACCCGAATC TTGCCTCCGC 
TTTCCTTTCC CGCACAATGG CACAGAGGCC AATGGCACCG GAGTCACAGA GCCCTGCCTT 
GATGGCTGGG TCTATGACAA CAGCACCTTC CCTTCAACCA TCGTGACTGA GTGGAACCTT 
GTGTGCTCTC ATCGGGCCTT CCGCCAGCTG GCCCAGTCCC TGTTCATGGT GGGAGTGTTA 
CTGGGAGCCA TGATGTTTGG CTACCTGGCG GACAGGCTGG GCCGTCGGAA GGTGCTGATC 
TTGAACTACC TGCAAACAGC TGTGTCGGGA ACCTGTGCAG CCTATGCACC CAACTATACT 
GTCTACTGCA TTTTCCGGCT CCTCTCGGGC ATGTCTTTGG CTAGCATTGC AATCAACTGC 
ATGACACTAA ACATGGAGTG GATGCCTATT CACACCCGTG CCTATGTGGG CACCTTGATT 
GGCTATGTCT ACAGCTTGGG CCAGTTCCTC CTGGCTGGTA TCGCCTATGC TGTGCCCCAC 
TGGCGCCACC TGCAGCTTGC GGTCTCTGTG CCTTTTTTCG TTGCCTTCAT CTACTCTTGG 
TTCTTCATTG AGTCAGCCCG CTGGTACTCC TCCTCTGGAA GGCTGGACCT CACCCTCCGA 
GCCCTGCAGA GAGTGGCCCG CATCAACGGG AAACAAGAAG AGGGGGCTAA GCTGAGTATA 
GAGGTGCTCC AGACCAGCCT GCAGAAGGAA CTGACTCTAA ACAAAGGCCA GGCCTCCGCC 
ATGGAGCTGC TGCGCTGCCC CACGCTTCGG CGCCTCTTCC TCTGCCTCTC TATGCTGTGG 
TTTGCCACTA GCTTTGCCTA CTACGGGCTG GTCATGGACC TGCAGGGCTT TGGGGTCAGC 
ATGTACCTTA TCCAGGTGAT TTTCGGCGCT GTGGACCTGC CTGCCAAGTT TGTGTGCTTC 
CTAGTCATCA ATTCCATGGG CCGCCGGCCT GCACAGTTGG CCTCCCTGCT GCTGGCAGGC 
ATCTGTATCC TAGTGAATGG CATAATACCG AGGGGCCATA CAATCATTCG CACATCCCTG 
GCTGTACTAG GGAAAGGCTG TCTGGCTTCC TCTTTCAACT GCATCTTCCT GTACACCGGA 
GAGCTGTACC CCACAATGAT TCGGCAGACG GGCCTGGGCA TGGGCAGCAC CATGGCCCGG 
GTGGGCAGCA TAGTGAGCCC ACTGATAAGC ATGACTGCCG AGTTCTACCC CTCCATACCT 
CTCTTCATCT TCGGCGCTGT CCCCGTGGCC GCCAGCGCTG TCACTGCCCT GCTGCCAGAG 
ACCTTGGGCC AGCCGCTGCC TGATACAGTG CAGGACCTGA AGAGCAGGAG CAGAGGAAAG 
CAGAAGCAAC AGCAGCTGGA ACAGCAGAAG CAGATGATAC CACTCCAGGT CTCAACACAA 
GAGAAGAACG GACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
Clinical and translational science10(5)412-420(2017 Sep)
Hu S,Leblanc AF,Gibson AA,Hong KW,Kim JY,Janke LJ,Li L,Vasilyeva A,Finkelstein DB,Sprowl JA,Sweet DH,Schlatter E,Ciarimboli G,Schellens J,Baker SD,Pabla N,Sparreboom A

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.
The Journal of biological chemistry291(37)19474-86(2016 09)
Liu HC,Jamshidi N,Chen Y,Eraly SA,Cho SY,Bhatnagar V,Wu W,Bush KT,Abagyan R,Palsson BO,Nigam SK

Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.
PloS one11(2)e0148055(2016)
Espana-Agusti J,Zou X,Wong K,Fu B,Yang F,Tuveson DA,Adams DJ,Matakidou A