Gpr37l1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr37l1
Entrez Gene ID	171469
Full Name	G protein-coupled receptor 37-like 1
Synonyms	AW047233,CAG-18,D0Kist8
General protein information	Preferred Names G protein-coupled receptor 37-like 1 Names prosaposin receptor GPR37L1 ETBR-LP-2 G protein-coupled receptor 37-lke 1 endothelin B receptor-like protein 2 orphan Gpr37-like protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 E4

mRNA and Protein(s)

mRNA	Protein	Name
NM_134438.3	NP_602320.2	G-protein coupled receptor 37-like 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPR37L1	NP_004758.3
Rattus norvegicus (Norway rat)	Gpr37l1	NP_665727.2
	GPR37L1	XP_001106794.1
Canis lupus familiaris (dog)	GPR37L1	XP_849000.3
Mus musculus (house mouse)	Gpr37l1	NP_602320.2
Gallus gallus (chicken)	GPR37L1	XP_419256.4
Danio rerio (zebrafish)	gpr37l1b	XP_696192.2
Xenopus tropicalis (tropical clawed frog)	gpr37l1	NP_001072523.1
Pan troglodytes (chimpanzee)	GPR37L1	XP_514100.2
Bos taurus (cattle)	GPR37L1	NP_001069367.1

Gene Ontology
Bibliography

Related articles in PubMed

G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia.
Jolly S, Bazargani N, Quiroga AC, Pringle NP, Attwell D, Richardson WD, Li H
Glia66(1)47-61(2018 Jan)

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Giddens MM, Wong JC, Schroeder JP, Farrow EG, Smith BM, Owino S, Soden SE, Meyer RC, Saunders C, LePichon JB, Weinshenker D, Escayg A, Hall RA
Neurobiology of disease106181-190(2017 Oct)

Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.
Smith BM, Giddens MM, Neil J, Owino S, Nguyen TT, Duong D, Li F, Hall RA
Neuroscience35849-57(2017 Sep)

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Meyer RC, Giddens MM, Schaefer SA, Hall RA
Proceedings of the National Academy of Sciences of the United States of America110(23)9529-34(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gpr37l1 participates in the regulation of sonic hedgehog signaling during postnatal cerebellar development.
Title: Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor.

The following Gpr37l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr37l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21226	NM_134438.3 Latest version!	Mus musculus G protein-coupled receptor 37-like 1 (Gpr37l1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr37l1 ( NM_134438.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_602320.2 Mus musculus G protein-coupled receptor 37-like 1 (Gpr37l1), mRNA.

Price & Availability↑

CloneID	OMu21226
Clone ID Related Accession (Same CDS sequence)	NM_134438.3
Accession Version	NM_134438.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	G-protein coupled receptor 37-like 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK158275.1, BY727284.1, BC127619.1 and CD774808.1. On Dec 13, 2007 this sequence version replaced NM_134438.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB016602.1, AK158275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCGGTGGC TGTGGCCCCT GGCTGTGTCT CTTGTTGTAG TGTTGACTGT GGGGCTGAGT 
GGGGTCTCTG GGGCTGCCAC CTCATCTTTA GGTGGGCATA GAGCCAAGGT CCAGGAGCAG 
CAGAGTCGAC CCCGAAGAGG CACCAAGGAC GAGGGGCCCA AGGAGGTACA GCACTATGTA 
CCCGAGGAGT GGGCTGAATA TCCCAAGCCC ATCCATCCTG CTGGCCTGCA GCCCACCAAG 
ACTTTGGAGG CCACTAGCCC CAACCCAGAC AAGGATGGGG CCACCCCAGG TAATGGACAA 
GAGCTGAGGG TCAACCTGAC CGGGACGCCA AGTCAGAGGC TGCAGATTCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGCGCC TACGCCATCA TGCTCCTGGC TCTGGTGGTG 
TTTGCTGTGG GTATCGTTGG CAATCTGTCT GTCATGTGCA TTGTGTGGCA CAGCTACTAC 
TTGAAGAGTG CCTGGAACTC TATCCTTGCC AGCCTGGCTC TCTGGGATTT CCTGGTCCTC 
TTCTTCTGCC TCCCAATTGT CATCTTCAAT GAGATTACCA AGCAAAGGCT ACTCGGGGAT 
GTTTCTTGCC GGGCAGTGCC CTTCATGGAG GTCTCCTCCC TGGGAGTCAC AACCTTCAGT 
CTCTGTGCCC TGGGCATAGA CCGATTCCAT GTGGCCACCA GCACCCTGCC AAAGGTGAGG 
CCCATTGAGC GATGTCAATC AATTCTGGCT AAACTAGCTG TCATCTGGGT GGGCTCCATG 
ATGCTGGCCG TGCCCGAACT CCTGCTATGG CAGCTGGCCC AGGAGCCGGC TCCCACCGCA 
GGAACTGTGG ACTCGTGTAT CATGAAACCT TCAGCTGACC TGCCCGAATC TGTCTATTCG 
CTGGTGATGA CCTACCAGAA TGCCCGCATG TGGTGGTATT TTGGTTGCTA CTTCTGTCTG 
CCCATCCTCT TCACCGTCAC CTGTCAGCTG GTGACGTGGC GGGTGCGGGG CCCACCAGGC 
AGGAAGCCTG AGTGTAGAGC GGGCAGGCAT GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTCGGCC TGACTGTGGT CTATGCCTTC TGTACACTCC CTGAGAACGT CTGCAATATC 
GTGGTGGCTT ACCTCTCTAC CGAGCTCACG CGGCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT TAAGGGCGCC ATCACCCCTG TGCTCCTCCT GTGCATCTGC 
AGGCCACTGG GCCAGGCCTT TCTGGATTGC TGCTGCTGCT GCTGCTGCGA GGAGTGCGGC 
GGGGCCTCAG ACTCCTCAGC CACAGTCAGC GCGGACAGCA AGCTGAAGGC GGAAGTGTCC 
TCTTCTATCT ACTTCCACAA GCCCAGGGAG TCGCCCCCAC TCCTGCCCCT GGGCACCCCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_602320.2
CDS	178..1623
Translation	MRWLWPLAVSLVVVLTVGLSGVSGAATSSLGGHRAKVQEQQSRPRRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKTLEATSPNPDKDGATPGNGQELRVNLTGTPSQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEPAPTAGTVDSCIMKPSADLPESVYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASDSSATVSADSKLKAEVSSSIYFHKPRESPPLLPLGTPC

Target ORF information:

RefSeq Version	NM_134438.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus G protein-coupled receptor 37-like 1 (Gpr37l1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134438.3

ORF Insert Sequence:

ATGCGGTGGC TGTGGCCCCT GGCTGTGTCT CTTGTTGTAG TGTTGACTGT GGGGCTGAGT 
GGGGTCTCTG GGGCTGCCAC CTCATCTTTA GGTGGGCATA GAGCCAAGGT CCAGGAGCAG 
CAGAGTCGAC CCCGAAGAGG CACCAAGGAC GAGGGGCCCA AGGAGGTACA GCACTATGTA 
CCCGAGGAGT GGGCTGAATA TCCCAAGCCC ATCCATCCTG CTGGCCTGCA GCCCACCAAG 
ACTTTGGAGG CCACTAGCCC CAACCCAGAC AAGGATGGGG CCACCCCAGG TAATGGACAA 
GAGCTGAGGG TCAACCTGAC CGGGACGCCA AGTCAGAGGC TGCAGATTCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGCGCC TACGCCATCA TGCTCCTGGC TCTGGTGGTG 
TTTGCTGTGG GTATCGTTGG CAATCTGTCT GTCATGTGCA TTGTGTGGCA CAGCTACTAC 
TTGAAGAGTG CCTGGAACTC TATCCTTGCC AGCCTGGCTC TCTGGGATTT CCTGGTCCTC 
TTCTTCTGCC TCCCAATTGT CATCTTCAAT GAGATTACCA AGCAAAGGCT ACTCGGGGAT 
GTTTCTTGCC GGGCAGTGCC CTTCATGGAG GTCTCCTCCC TGGGAGTCAC AACCTTCAGT 
CTCTGTGCCC TGGGCATAGA CCGATTCCAT GTGGCCACCA GCACCCTGCC AAAGGTGAGG 
CCCATTGAGC GATGTCAATC AATTCTGGCT AAACTAGCTG TCATCTGGGT GGGCTCCATG 
ATGCTGGCCG TGCCCGAACT CCTGCTATGG CAGCTGGCCC AGGAGCCGGC TCCCACCGCA 
GGAACTGTGG ACTCGTGTAT CATGAAACCT TCAGCTGACC TGCCCGAATC TGTCTATTCG 
CTGGTGATGA CCTACCAGAA TGCCCGCATG TGGTGGTATT TTGGTTGCTA CTTCTGTCTG 
CCCATCCTCT TCACCGTCAC CTGTCAGCTG GTGACGTGGC GGGTGCGGGG CCCACCAGGC 
AGGAAGCCTG AGTGTAGAGC GGGCAGGCAT GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTCGGCC TGACTGTGGT CTATGCCTTC TGTACACTCC CTGAGAACGT CTGCAATATC 
GTGGTGGCTT ACCTCTCTAC CGAGCTCACG CGGCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT TAAGGGCGCC ATCACCCCTG TGCTCCTCCT GTGCATCTGC 
AGGCCACTGG GCCAGGCCTT TCTGGATTGC TGCTGCTGCT GCTGCTGCGA GGAGTGCGGC 
GGGGCCTCAG ACTCCTCAGC CACAGTCAGC GCGGACAGCA AGCTGAAGGC GGAAGTGTCC 
TCTTCTATCT ACTTCCACAA GCCCAGGGAG TCGCCCCCAC TCCTGCCCCT GGGCACCCCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia.
Glia66(1)47-61(2018 Jan)
Jolly S,Bazargani N,Quiroga AC,Pringle NP,Attwell D,Richardson WD,Li H

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Neurobiology of disease106181-190(2017 Oct)
Giddens MM,Wong JC,Schroeder JP,Farrow EG,Smith BM,Owino S,Soden SE,Meyer RC,Saunders C,LePichon JB,Weinshenker D,Escayg A,Hall RA

Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.
Neuroscience35849-57(2017 Sep)
Smith BM,Giddens MM,Neil J,Owino S,Nguyen TT,Duong D,Li F,Hall RA

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Proceedings of the National Academy of Sciences of the United States of America110(23)9529-34(2013 Jun)
Meyer RC,Giddens MM,Schaefer SA,Hall RA