Ripply3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ripply3
Entrez Gene ID	170765
Full Name	ripply transcriptional repressor 3
Synonyms	Dscr6
General protein information	Preferred Names ripply transcriptional repressor 3 Names protein ripply3 Down syndrome critical region homolog 6 down syndrome critical region protein 6 homolog of human Down syndrome critical region gene 6 DSCR6 ripply3 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C4

mRNA and Protein(s)

mRNA	Protein	Name
NM_133229.2	NP_573492.2	protein ripply3

Pathways from BioSystems

Homologies

Homo sapiens (human)	RIPPLY3	NP_061835.1
Pan troglodytes (chimpanzee)	DSCR6	XP_001169524.2
Bos taurus (cattle)	RIPPLY3	XP_003585757.2
Mus musculus (house mouse)	Ripply3	NP_573492.2
Rattus norvegicus (Norway rat)	Ripply3	NP_001099362.1
Gallus gallus (chicken)	DSCR6	XP_004934599.1
Canis lupus familiaris (dog)	DSCR6	XP_003434016.2

Gene Ontology
Bibliography

Related articles in PubMed

Reduced dosage of ?-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.
Racedo SE, Hasten E, Lin M, Devakanmalai GS, Guo T, Ozbudak EM, Cai CL, Zheng D, Morrow BE
PLoS genetics13(3)e1006687(2017 Mar)

Pharyngeal arch deficiencies affect taste bud development in the circumvallate papilla with aberrant glossopharyngeal nerve formation.
Okubo T, Takada S
Developmental dynamics : an official publication of the American Association of Anatomists244(7)874-87(2015 Jul)

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.
Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ Jr, Takada S, Magnuson MA
Development (Cambridge, England)141(15)2939-49(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 and Ripply3
Title: Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.

Ripply3-deficient mice exhibit abnormal development of pharyngeal derivatives, including ectopic formation of the thymus and the parathyroid gland, as well as cardiovascular malformation.
Title: Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice.

The following Ripply3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ripply3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09957	NM_133229.2 Latest version!	Mus musculus ripply transcriptional repressor 3 (Ripply3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ripply3 ( NM_133229.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573492.2 Mus musculus ripply transcriptional repressor 3 (Ripply3), mRNA.

Price & Availability↑

CloneID	OMu09957
Clone ID Related Accession (Same CDS sequence)	NM_133229.2
Accession Version	NM_133229.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	protein ripply3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF170896.1, AK041355.1 and AB063284.1. On Apr 4, 2008 this sequence version replaced NM_133229.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB063284.1, AK041355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGACCGG AGGCGGCCGG AGTCCGGGAG GCGCGGGGAC GCCTCTGCCA CTGTCCGGGG 
GATGATCCCG GGAGGCTACC GCTGCCACGC GGGCCCGAAA GTTCCATTCC AGCCCCGTGG 
AGACCGTGGA TGTCGCCTCC CCCCGGAGAT GCTGAACTGA CCAGAACTGA ACGTCCGTGT 
GAGTCTTGGG GAGACCAACA CACATCGGGA TCAAAGGGAG CCTTTGGATT CCAGCATCCT 
GTCAGACTTT ACTTACCCGT TTCAAAGCGT CAAGAATACC TTCAGAGTTC TGGGGAAAAA 
GTGCTGGCCA GCTTCCCAGT GCAAGCCACC ATTCATTTCT ACAACGATGA CTCTGAGTCT 
GGCTCTGAGG AGGAACAAGA GGAGGAGGCC CAGCCCAACC ACCTTCAGTG CCTGGAGGCA 
GAAGTCAGGG ATTCTGCTCA GGAGGAAAGG GCAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573492.2
CDS	76..534
Translation	MRPEAAGVREARGRLCHCPGDDPGRLPLPRGPESSIPAPWRPWMSPPPGDAELTRTERPCESWGDQHTSGSKGAFGFQHPVRLYLPVSKRQEYLQSSGEKVLASFPVQATIHFYNDDSESGSEEEQEEEAQPNHLQCLEAEVRDSAQEERAE

Target ORF information:

RefSeq Version	NM_133229.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ripply transcriptional repressor 3 (Ripply3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133229.2

ORF Insert Sequence:

ATGAGACCGG AGGCGGCCGG AGTCCGGGAG GCGCGGGGAC GCCTCTGCCA CTGTCCGGGG 
GATGATCCCG GGAGGCTACC GCTGCCACGC GGGCCCGAAA GTTCCATTCC AGCCCCGTGG 
AGACCGTGGA TGTCGCCTCC CCCCGGAGAT GCTGAACTGA CCAGAACTGA ACGTCCGTGT 
GAGTCTTGGG GAGACCAACA CACATCGGGA TCAAAGGGAG CCTTTGGATT CCAGCATCCT 
GTCAGACTTT ACTTACCCGT TTCAAAGCGT CAAGAATACC TTCAGAGTTC TGGGGAAAAA 
GTGCTGGCCA GCTTCCCAGT GCAAGCCACC ATTCATTTCT ACAACGATGA CTCTGAGTCT 
GGCTCTGAGG AGGAACAAGA GGAGGAGGCC CAGCCCAACC ACCTTCAGTG CCTGGAGGCA 
GAAGTCAGGG ATTCTGCTCA GGAGGAAAGG GCAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reduced dosage of ?-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.
PLoS genetics13(3)e1006687(2017 Mar)
Racedo SE,Hasten E,Lin M,Devakanmalai GS,Guo T,Ozbudak EM,Cai CL,Zheng D,Morrow BE

Pharyngeal arch deficiencies affect taste bud development in the circumvallate papilla with aberrant glossopharyngeal nerve formation.
Developmental dynamics : an official publication of the American Association of Anatomists244(7)874-87(2015 Jul)
Okubo T,Takada S

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.
Development (Cambridge, England)141(15)2939-49(2014 Aug)
Osipovich AB,Long Q,Manduchi E,Gangula R,Hipkens SB,Schneider J,Okubo T,Stoeckert CJ Jr,Takada S,Magnuson MA