Klrb1c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klrb1c
Entrez Gene ID	17059
Full Name	killer cell lectin-like receptor subfamily B member 1C
Synonyms	AI462337,CD161,Klrb1b,Ly-59,Ly55c,Ly59,NK-RP1,NK1.1,NKR-P1.9,NKRP1,NKRP140,Nk-1,Nk-1.2,Nk1,Nk1.2,Nkrp1b,Nkrp1c,ly-55c
General protein information	Preferred Names killer cell lectin-like receptor subfamily B member 1C Names killer cell lectin-like receptor subfamily B member 1C CD161 antigen-like family member C NKR-P1 40 NKR-P1B killer cell lectin-like receptor subfamily A member 1C lymphocyte antigen 55 complex, locus C lymphocyte antigen 55c lymphocyte antigen 59 natural killer cell receptor protein NKR-P1C natural killer cell receptor-P1 natural killer cell surface protein P1-40 natural killer cell-associated antigen 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F3\|6 63.09 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001159904.1	NP_001153376.1	killer cell lectin-like receptor subfamily B member 1C isoform 1
NM_008527.2	NP_032553.2	killer cell lectin-like receptor subfamily B member 1C isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Klrb1b	NP_775414.2
Bos taurus (cattle)	KLRB1	NP_001193565.1
Homo sapiens (human)	KLRB1	NP_002249.1
Canis lupus familiaris (dog)	KLRB1	XP_005637227.1
Mus musculus (house mouse)	Klrb1b	NP_085102.4
Mus musculus (house mouse)	Klrb1c	NP_001153376.1
Mus musculus (house mouse)	Klrb1a	NP_034867.3
Rattus norvegicus (Norway rat)	Klrb1a	NP_001010964.1
Pan troglodytes (chimpanzee)	KLRB1	XP_001141049.1
	LOC100430783	XP_002798528.1
Bos taurus (cattle)	LOC100138381	XP_003586184.2

Gene Ontology
Bibliography

Related articles in PubMed

NK1.1
Qian X, Hu C, Han S, Lin Z, Xiao W, Ding Y, Zhang Y, Qian L, Jia X, Zhu G, Gong W
Journal of cellular and molecular medicine21(7)1431-1444(2017 Jul)

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.
Aguilar OA, Berry R, Rahim MMA, Reichel JJ, Popovi? B, Tanaka M, Fu Z, Balaji GR, Lau TNH, Tu MM, Kirkham CL, Mahmoud AB, Mesci A, Krmpoti? A, Allan DSJ, Makrigiannis AP, Jonji? S, Rossjohn J, Carlyle JR
Cell169(1)58-71.e14(2017 Mar)

Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.
Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD
Nature neuroscience19(2)243-52(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MCMV may encode a novel Clr-b-independent immunoevasin that functionally engages the NKR-P1B receptor.
Title: Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.

NK1.1+ CD8+ T cells have a role in TGF-beta control and contribute to early microbial pathogen response
Title: NK1.1+ CD8+ T cells escape TGF-? control and contribute to early microbial pathogen response.

5-HT3 and NK1 immunopositive macrophages and mucosal mast cells in lamina propria release 5-HT and substance P, which in turn activate their corresponding receptors on mucosal cells in autocrine and paracrine manners.
Title: Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.

Data indicate that C-type lectin-like NK receptor NKR-P1C proteins showed no affinity to the various neoglycoproteins.
Title: Re-evaluation of the involvement of NK cells and C-type lectin-like NK receptors in modulation of immune responses by multivalent GlcNAc-terminated oligosaccharides.

Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner
Title: Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance.

The following Klrb1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klrb1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07791	NM_001159904.1 Latest version!	Mus musculus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu00032	NM_008527.2 Latest version!	Mus musculus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klrb1c ( NM_001159904.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001153376.1 Mus musculus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu07791
Clone ID Related Accession (Same CDS sequence)	NM_001159904.1
Accession Version	NM_001159904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor subfamily B member 1C isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK079743.1, AC102693.9 and M77678.1. On or before Jan 5, 2014 this sequence version replaced XM_006544079.1, XM_003946192.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK079743.1, DQ237929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAAAC CCTCAGAGAC AGGAATCAGT GGGTGTGGGA ACAGAGCAGA GCATTCACAG 
AGGACTTTCT TTTGCTTATT TCACCTCAAA GGCCTTGGAG TTTGTCCCTT CTCACCACCA 
GTTAAGTGTT GCATCTCCTG TGAAATGGAC ACAGCAAGTA TCTACCTCGG TTTAAAGCCA 
CCCAGGACAC TGGGGGCTTG GCATGAGTCA CCCCCATCTC TTCCCCCAGA TGCCTGTCGG 
TGCCCACGTT CACACAGGTT GGCTCTGAAG CTCAGCTGTG CTGGGCTCAT CCTCCTTGTC 
CTGACCCTGA TTGGGATGAG TGTCTTAGTG CGAGTCTTAG TACAAAAACC ATCAAGAGAA 
AAATGCTGTG TGTTTATTCA AGAGAACCTG AATAAAACAA CAGATTGTTC AGTTAATTTA 
GAGTGCCCAC AAGACTGGCT TTTACACCGA GATAAGTGCT TTCACGTTTC TCAAGTTTCC 
AACACTTGGG AGGAAGGTCA AGCTGACTGT GGTAGAAAAG GAGCCACTTT GCTGCTCATT 
CAAGACCAAG AAGAACTGAG ATTCCTACTG GACTCAATAA AGGAAAAATA TAATTCATTT 
TGGATTGGAC TAAGGTTCAC ATTGCCAGAC ATGAACTGGA AGTGGATAAA TGGCACAACT 
TTCAATTCTG ATGTACTAAA AATCACTGGT GTCACTGAAA ATGGCAGCTG TGCCTCCATC 
TTAGGAGATA AAGTGACTCC TGAGAGCTGT GCTTCAGACA ACCGTTGGAT CTGCCAAAAG 
GAACTAAACC ATGAAACCCC GAGTAATGAC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153376.1
CDS	17..832
Translation	MEKPSETGISGCGNRAEHSQRTFFCLFHLKGLGVCPFSPPVKCCISCEMDTASIYLGLKPPRTLGAWHESPPSLPPDACRCPRSHRLALKLSCAGLILLVLTLIGMSVLVRVLVQKPSREKCCVFIQENLNKTTDCSVNLECPQDWLLHRDKCFHVSQVSNTWEEGQADCGRKGATLLLIQDQEELRFLLDSIKEKYNSFWIGLRFTLPDMNWKWINGTTFNSDVLKITGVTENGSCASILGDKVTPESCASDNRWICQKELNHETPSNDS

Target ORF information:

RefSeq Version	NM_001159904.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159904.1

ORF Insert Sequence:

ATGGAGAAAC CCTCAGAGAC AGGAATCAGT GGGTGTGGGA ACAGAGCAGA GCATTCACAG 
AGGACTTTCT TTTGCTTATT TCACCTCAAA GGCCTTGGAG TTTGTCCCTT CTCACCACCA 
GTTAAGTGTT GCATCTCCTG TGAAATGGAC ACAGCAAGTA TCTACCTCGG TTTAAAGCCA 
CCCAGGACAC TGGGGGCTTG GCATGAGTCA CCCCCATCTC TTCCCCCAGA TGCCTGTCGG 
TGCCCACGTT CACACAGGTT GGCTCTGAAG CTCAGCTGTG CTGGGCTCAT CCTCCTTGTC 
CTGACCCTGA TTGGGATGAG TGTCTTAGTG CGAGTCTTAG TACAAAAACC ATCAAGAGAA 
AAATGCTGTG TGTTTATTCA AGAGAACCTG AATAAAACAA CAGATTGTTC AGTTAATTTA 
GAGTGCCCAC AAGACTGGCT TTTACACCGA GATAAGTGCT TTCACGTTTC TCAAGTTTCC 
AACACTTGGG AGGAAGGTCA AGCTGACTGT GGTAGAAAAG GAGCCACTTT GCTGCTCATT 
CAAGACCAAG AAGAACTGAG ATTCCTACTG GACTCAATAA AGGAAAAATA TAATTCATTT 
TGGATTGGAC TAAGGTTCAC ATTGCCAGAC ATGAACTGGA AGTGGATAAA TGGCACAACT 
TTCAATTCTG ATGTACTAAA AATCACTGGT GTCACTGAAA ATGGCAGCTG TGCCTCCATC 
TTAGGAGATA AAGTGACTCC TGAGAGCTGT GCTTCAGACA ACCGTTGGAT CTGCCAAAAG 
GAACTAAACC ATGAAACCCC GAGTAATGAC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrb1c ( NM_008527.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032553.2 Mus musculus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu00032
Clone ID Related Accession (Same CDS sequence)	NM_008527.2
Accession Version	NM_008527.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor subfamily B member 1C isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK079743.1, M77678.1 and AC102693.9. On or before Jan 8, 2014 this sequence version replaced XM_006544078.1, NM_008527.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KX443618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAAAC CCTCAGAGAC AGGAATCAGT GGGTGTGGGA ACAGAGCAGA GCATTCACAG 
AGGACTTTCT TTTGCTTATT TCACCTCAAA GGCCTTGGAG TTTGTCCCTT CTCACCACCA 
GTTAAGTGTT GCATCTCCTG TGAAATGGAC ACAGCAAGTA TCTACCTCGG TTTAAAGCCA 
CCCAGGACAC TGGGGGCTTG GCATGAGTCA CCCCCATCTC TTCCCCCAGA TGCCTGTCGG 
TGCCCACGTT CACACAGGTT GGCTCTGAAG CTCAGCTGTG CTGGGCTCAT CCTCCTTGTC 
CTGACCCTGA TTGGGATGAG TGTCTTAGTG CGAGTCTTAG TACAAAAACC ATCAAGAGAA 
AAATGCTGTG TGTTTATTCA AGAGAACCTG AATAAAACAA CAGTTAATTT AGAGTGCCCA 
CAAGACTGGC TTTTACACCG AGATAAGTGC TTTCACGTTT CTCAAGTTTC CAACACTTGG 
GAGGAAGGTC AAGCTGACTG TGGTAGAAAA GGAGCCACTT TGCTGCTCAT TCAAGACCAA 
GAAGAACTGA GATTCCTACT GGACTCAATA AAGGAAAAAT ATAATTCATT TTGGATTGGA 
CTAAGGTTCA CATTGCCAGA CATGAACTGG AAGTGGATAA ATGGCACAAC TTTCAATTCT 
GATGTACTAA AAATCACTGG TGTCACTGAA AATGGCAGCT GTGCCTCCAT CTTAGGAGAT 
AAAGTGACTC CTGAGAGCTG TGCTTCAGAC AACCGTTGGA TCTGCCAAAA GGAACTAAAC 
CATGAAACCC CGAGTAATGA CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032553.2
CDS	17..823
Translation	MEKPSETGISGCGNRAEHSQRTFFCLFHLKGLGVCPFSPPVKCCISCEMDTASIYLGLKPPRTLGAWHESPPSLPPDACRCPRSHRLALKLSCAGLILLVLTLIGMSVLVRVLVQKPSREKCCVFIQENLNKTTVNLECPQDWLLHRDKCFHVSQVSNTWEEGQADCGRKGATLLLIQDQEELRFLLDSIKEKYNSFWIGLRFTLPDMNWKWINGTTFNSDVLKITGVTENGSCASILGDKVTPESCASDNRWICQKELNHETPSNDS

Target ORF information:

RefSeq Version	NM_008527.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008527.2

ORF Insert Sequence:

ATGGAGAAAC CCTCAGAGAC AGGAATCAGT GGGTGTGGGA ACAGAGCAGA GCATTCACAG 
AGGACTTTCT TTTGCTTATT TCACCTCAAA GGCCTTGGAG TTTGTCCCTT CTCACCACCA 
GTTAAGTGTT GCATCTCCTG TGAAATGGAC ACAGCAAGTA TCTACCTCGG TTTAAAGCCA 
CCCAGGACAC TGGGGGCTTG GCATGAGTCA CCCCCATCTC TTCCCCCAGA TGCCTGTCGG 
TGCCCACGTT CACACAGGTT GGCTCTGAAG CTCAGCTGTG CTGGGCTCAT CCTCCTTGTC 
CTGACCCTGA TTGGGATGAG TGTCTTAGTG CGAGTCTTAG TACAAAAACC ATCAAGAGAA 
AAATGCTGTG TGTTTATTCA AGAGAACCTG AATAAAACAA CAGTTAATTT AGAGTGCCCA 
CAAGACTGGC TTTTACACCG AGATAAGTGC TTTCACGTTT CTCAAGTTTC CAACACTTGG 
GAGGAAGGTC AAGCTGACTG TGGTAGAAAA GGAGCCACTT TGCTGCTCAT TCAAGACCAA 
GAAGAACTGA GATTCCTACT GGACTCAATA AAGGAAAAAT ATAATTCATT TTGGATTGGA 
CTAAGGTTCA CATTGCCAGA CATGAACTGG AAGTGGATAA ATGGCACAAC TTTCAATTCT 
GATGTACTAA AAATCACTGG TGTCACTGAA AATGGCAGCT GTGCCTCCAT CTTAGGAGAT 
AAAGTGACTC CTGAGAGCTG TGCTTCAGAC AACCGTTGGA TCTGCCAAAA GGAACTAAAC 
CATGAAACCC CGAGTAATGA CTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NK1.1
Journal of cellular and molecular medicine21(7)1431-1444(2017 Jul)
Qian X,Hu C,Han S,Lin Z,Xiao W,Ding Y,Zhang Y,Qian L,Jia X,Zhu G,Gong W

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.
Cell169(1)58-71.e14(2017 Mar)
Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popovi? B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpoti? A,Allan DSJ,Makrigiannis AP,Jonji? S,Rossjohn J,Carlyle JR

Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation.
Nature neuroscience19(2)243-52(2016 Feb)
Liu Q,Sanai N,Jin WN,La Cava A,Van Kaer L,Shi FD