Klrc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klrc1
Entrez Gene ID	16641
Full Name	killer cell lectin-like receptor subfamily C, member 1
Synonyms	CD159a,NKG2A,NKG2B
General protein information	Preferred Names killer cell lectin-like receptor subfamily C, member 1 Names NKG2-A/NKG2-B type II integral membrane protein Cluster of Differentiation 159a
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F3

mRNA and Protein(s)

mRNA	Protein	Name
XM_011241236.1	XP_011239538.1	NKG2-A/NKG2-B type II integral membrane protein isoform X1
XM_017321418.1	XP_017176907.1	NKG2-A/NKG2-B type II integral membrane protein isoform X3
NM_010652.2	NP_034782.1	NKG2-A/NKG2-B type II integral membrane protein isoform 2
NM_001136068.2	NP_001129540.1	NKG2-A/NKG2-B type II integral membrane protein isoform 1
XM_011241237.1	XP_011239539.1	NKG2-A/NKG2-B type II integral membrane protein isoform X2
NM_001288664.1	NP_001275593.1	NKG2-A/NKG2-B type II integral membrane protein isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	KLRC1	NP_002250.1
	KLRC1	NP_001028001.1
Bos taurus (cattle)	LOC101904048	XP_005207090.1
Bos taurus (cattle)	LOC100140174	XP_003586165.1
Pan troglodytes (chimpanzee)	KLRC1	NP_001009048.2
Bos taurus (cattle)	LOC513869	XP_002687840.1
Bos taurus (cattle)	LOC100139049	XP_003586167.1
Rattus norvegicus (Norway rat)	LOC100910089	XP_006237173.1
Bos taurus (cattle)	NKG2C	NP_001091632.1
Bos taurus (cattle)	LOC100847738	XP_003586171.1
Mus musculus (house mouse)	Klrc1	NP_001129540.1
Rattus norvegicus (Norway rat)	Klrc1	NP_001032518.1
Bos taurus (cattle)	LOC100336869	XP_002687846.1
Bos taurus (cattle)	LOC788694	XP_003586164.1
Bos taurus (cattle)	KLRC1	NP_001162059.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement.
Meyer CE, Key PN, Zhu T, Shabsovich M, Ni A, Tripathy SK
Immunity, inflammation and disease5(2)177-189(2017 Jun)

The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.
Zou Z, Zuo D, Yang J, Fan H
Biochemical and biophysical research communications478(1)213-220(2016 09)

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8? T Cells in Response to a Lethal Poxvirus Infection.
Rapaport AS, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel BF, Wang Y, Le Friec G, Gao J, Cella M, Pircher H, Yokoyama WM, Buller RM, Colonna M
Immunity43(6)1112-24(2015 Dec)

Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.
Ely KH, Matsuoka M, DeBerge MP, Ruby JA, Liu J, Schneider MJ, Wang Y, Hahn YS, Enelow RI
PloS one9(9)e108385(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.
Title: The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.

NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection.
Title: The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8? T Cells in Response to a Lethal Poxvirus Infection.

Results demonstrate the immunoregulatory role of CD8(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance.
Title: Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.

role in NK cell-mediated protection from DSS-induced colitis
Title: Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor.

Endogenous NKG2A contributes to the rejection of cells lacking human HLA-Cw3.
Title: HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model.

The following Klrc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klrc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu16642	NM_001136068.2 Latest version!	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu16642	XM_011241236.1 Latest version!	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu16663	NM_001288664.1 Latest version!	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu16759	NM_010652.2 Latest version!	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu16663	XM_017321418.1 Latest version!	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu16759	XM_011241237.1 Latest version!	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klrc1 ( NM_001136068.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001129540.1 Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16642
Clone ID Related Accession (Same CDS sequence)	XM_011241236.1 , NM_001136068.2
Accession Version	NM_001136068.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Mus musculus(house mouse)
Product	NKG2-A/NKG2-B type II integral membrane protein isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC171002.2 and AF106008.1. On Dec 27, 2013 this sequence version replaced NM_001136068.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF106008.1, AK138801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TACCGAAGCA 
AAGGCACAGA TCAATTCCTC AATGACTAGA ACCCACAGAG ATATAAACTA CACTCTATCT 
TCAGCACAGC CTTGTCCTCA TTGTCCAAAG GAGTGGATAT CATATTCTCA CAATTGTTAT 
TTCATTGGTA TGGAGAGAAA ATCTTGGAAT GACAGTTTGG TGTCCTGCAT TTCCAAAAAC 
TGTAGTCTGC TTTACATAGA TAGTGAAGAG GAGCAGGATT TTCTGCAATC TCTTTCACTG 
ATCTCATGGA CTGGAATCCT TCGGAAGGGC AGAGGTCAGC CCTGGGTCTG GAAAGAAGAC 
TCAATTTTCA AACCAAAGAT AGCAGAGATT CTCCATGATG AATGTAACTG TGCCATGATG 
TCAGCTTCTG GTCTCACAGC AGACAACTGT ACAACTTTAC ATCCATATCT TTGTAAGTGT 
AAATTCCCCA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129540.1
CDS	64..798
Translation	MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKGFPSPPEKLIAGTLGLICFVLIVAVVVITTVATPYTEAKAQINSSMTRTHRDINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLISWTGILRKGRGQPWVWKEDSIFKPKIAEILHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI

Target ORF information:

RefSeq Version	NM_001136068.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136068.2

ORF Insert Sequence:

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TACCGAAGCA 
AAGGCACAGA TCAATTCCTC AATGACTAGA ACCCACAGAG ATATAAACTA CACTCTATCT 
TCAGCACAGC CTTGTCCTCA TTGTCCAAAG GAGTGGATAT CATATTCTCA CAATTGTTAT 
TTCATTGGTA TGGAGAGAAA ATCTTGGAAT GACAGTTTGG TGTCCTGCAT TTCCAAAAAC 
TGTAGTCTGC TTTACATAGA TAGTGAAGAG GAGCAGGATT TTCTGCAATC TCTTTCACTG 
ATCTCATGGA CTGGAATCCT TCGGAAGGGC AGAGGTCAGC CCTGGGTCTG GAAAGAAGAC 
TCAATTTTCA AACCAAAGAT AGCAGAGATT CTCCATGATG AATGTAACTG TGCCATGATG 
TCAGCTTCTG GTCTCACAGC AGACAACTGT ACAACTTTAC ATCCATATCT TTGTAAGTGT 
AAATTCCCCA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrc1 ( XM_011241236.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239538.1 Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu16642
Clone ID Related Accession (Same CDS sequence)	XM_011241236.1 , NM_001136068.2
Accession Version	XM_011241236.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	NKG2-A/NKG2-B type II integral membrane protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TACCGAAGCA 
AAGGCACAGA TCAATTCCTC AATGACTAGA ACCCACAGAG ATATAAACTA CACTCTATCT 
TCAGCACAGC CTTGTCCTCA TTGTCCAAAG GAGTGGATAT CATATTCTCA CAATTGTTAT 
TTCATTGGTA TGGAGAGAAA ATCTTGGAAT GACAGTTTGG TGTCCTGCAT TTCCAAAAAC 
TGTAGTCTGC TTTACATAGA TAGTGAAGAG GAGCAGGATT TTCTGCAATC TCTTTCACTG 
ATCTCATGGA CTGGAATCCT TCGGAAGGGC AGAGGTCAGC CCTGGGTCTG GAAAGAAGAC 
TCAATTTTCA AACCAAAGAT AGCAGAGATT CTCCATGATG AATGTAACTG TGCCATGATG 
TCAGCTTCTG GTCTCACAGC AGACAACTGT ACAACTTTAC ATCCATATCT TTGTAAGTGT 
AAATTCCCCA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239538.1
CDS	88..822
Translation	MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKGFPSPPEKLIAGTLGLICFVLIVAVVVITTVATPYTEAKAQINSSMTRTHRDINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLISWTGILRKGRGQPWVWKEDSIFKPKIAEILHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI

Target ORF information:

RefSeq Version	XM_011241236.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011241236.1

ORF Insert Sequence:

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TACCGAAGCA 
AAGGCACAGA TCAATTCCTC AATGACTAGA ACCCACAGAG ATATAAACTA CACTCTATCT 
TCAGCACAGC CTTGTCCTCA TTGTCCAAAG GAGTGGATAT CATATTCTCA CAATTGTTAT 
TTCATTGGTA TGGAGAGAAA ATCTTGGAAT GACAGTTTGG TGTCCTGCAT TTCCAAAAAC 
TGTAGTCTGC TTTACATAGA TAGTGAAGAG GAGCAGGATT TTCTGCAATC TCTTTCACTG 
ATCTCATGGA CTGGAATCCT TCGGAAGGGC AGAGGTCAGC CCTGGGTCTG GAAAGAAGAC 
TCAATTTTCA AACCAAAGAT AGCAGAGATT CTCCATGATG AATGTAACTG TGCCATGATG 
TCAGCTTCTG GTCTCACAGC AGACAACTGT ACAACTTTAC ATCCATATCT TTGTAAGTGT 
AAATTCCCCA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrc1 ( NM_001288664.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001275593.1 Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu16663
Clone ID Related Accession (Same CDS sequence)	XM_017321418.1 , NM_001288664.1
Accession Version	NM_001288664.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Mus musculus(house mouse)
Product	NKG2-A/NKG2-B type II integral membrane protein isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC171002.2, AF106009.1 and AF106008.1. On Jul 31, 2015 this sequence version replaced XM_011241238.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF106009.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849388, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGATA CCGAAGCAAA GGCACAGATC AATTCCTCAA TGACTAGAAC CCACAGAGAT 
ATAAACTACA CTCTATCTTC AGCACAGCCT TGTCCTCATT GTCCAAAGGA GTGGATATCA 
TATTCTCACA ATTGTTATTT CATTGGTATG GAGAGAAAAT CTTGGAATGA CAGTTTGGTG 
TCCTGCATTT CCAAAAACTG TAGTCTGCTT TACATAGATA GTGAAGAGGA GCAGGATTTT 
CTGCAATCTC TTTCACTGAT CTCATGGACT GGAATCCTTC GGAAGGGCAG AGGTCAGCCC 
TGGGTCTGGA AAGAAGACTC AATTTTCAAA CCAAAGATAG CAGAGATTCT CCATGATGAA 
TGTAACTGTG CCATGATGTC AGCTTCTGGT CTCACAGCAG ACAACTGTAC AACTTTACAT 
CCATATCTTT GTAAGTGTAA ATTCCCCATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001275593.1
CDS	64..696
Translation	MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKDTEAKAQINSSMTRTHRDINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLISWTGILRKGRGQPWVWKEDSIFKPKIAEILHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI

Target ORF information:

RefSeq Version	NM_001288664.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001288664.1

ORF Insert Sequence:

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGATA CCGAAGCAAA GGCACAGATC AATTCCTCAA TGACTAGAAC CCACAGAGAT 
ATAAACTACA CTCTATCTTC AGCACAGCCT TGTCCTCATT GTCCAAAGGA GTGGATATCA 
TATTCTCACA ATTGTTATTT CATTGGTATG GAGAGAAAAT CTTGGAATGA CAGTTTGGTG 
TCCTGCATTT CCAAAAACTG TAGTCTGCTT TACATAGATA GTGAAGAGGA GCAGGATTTT 
CTGCAATCTC TTTCACTGAT CTCATGGACT GGAATCCTTC GGAAGGGCAG AGGTCAGCCC 
TGGGTCTGGA AAGAAGACTC AATTTTCAAA CCAAAGATAG CAGAGATTCT CCATGATGAA 
TGTAACTGTG CCATGATGTC AGCTTCTGGT CTCACAGCAG ACAACTGTAC AACTTTACAT 
CCATATCTTT GTAAGTGTAA ATTCCCCATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrc1 ( NM_010652.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034782.1 Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu16759
Clone ID Related Accession (Same CDS sequence)	NM_010652.2 , XM_011241237.1
Accession Version	NM_010652.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Mus musculus(house mouse)
Product	NKG2-A/NKG2-B type II integral membrane protein isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC171002.2, AF109784.1 and AF106008.1. On Dec 27, 2013 this sequence version replaced NM_010652.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF109784.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TATAAACTAC 
ACTCTATCTT CAGCACAGCC TTGTCCTCAT TGTCCAAAGG AGTGGATATC ATATTCTCAC 
AATTGTTATT TCATTGGTAT GGAGAGAAAA TCTTGGAATG ACAGTTTGGT GTCCTGCATT 
TCCAAAAACT GTAGTCTGCT TTACATAGAT AGTGAAGAGG AGCAGGATTT TCTGCAATCT 
CTTTCACTGA TCTCATGGAC TGGAATCCTT CGGAAGGGCA GAGGTCAGCC CTGGGTCTGG 
AAAGAAGACT CAATTTTCAA ACCAAAGATA GCAGAGATTC TCCATGATGA ATGTAACTGT 
GCCATGATGT CAGCTTCTGG TCTCACAGCA GACAACTGTA CAACTTTACA TCCATATCTT 
TGTAAGTGTA AATTCCCCAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034782.1
CDS	64..747
Translation	MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKGFPSPPEKLIAGTLGLICFVLIVAVVVITTVATPYINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLISWTGILRKGRGQPWVWKEDSIFKPKIAEILHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI

Target ORF information:

RefSeq Version	NM_010652.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010652.2

ORF Insert Sequence:

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TATAAACTAC 
ACTCTATCTT CAGCACAGCC TTGTCCTCAT TGTCCAAAGG AGTGGATATC ATATTCTCAC 
AATTGTTATT TCATTGGTAT GGAGAGAAAA TCTTGGAATG ACAGTTTGGT GTCCTGCATT 
TCCAAAAACT GTAGTCTGCT TTACATAGAT AGTGAAGAGG AGCAGGATTT TCTGCAATCT 
CTTTCACTGA TCTCATGGAC TGGAATCCTT CGGAAGGGCA GAGGTCAGCC CTGGGTCTGG 
AAAGAAGACT CAATTTTCAA ACCAAAGATA GCAGAGATTC TCCATGATGA ATGTAACTGT 
GCCATGATGT CAGCTTCTGG TCTCACAGCA GACAACTGTA CAACTTTACA TCCATATCTT 
TGTAAGTGTA AATTCCCCAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrc1 ( XM_017321418.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017176907.1 Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X3, mRNA.

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CloneID	OMu16663
Clone ID Related Accession (Same CDS sequence)	XM_017321418.1 , NM_001288664.1
Accession Version	XM_017321418.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	NKG2-A/NKG2-B type II integral membrane protein isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGATA CCGAAGCAAA GGCACAGATC AATTCCTCAA TGACTAGAAC CCACAGAGAT 
ATAAACTACA CTCTATCTTC AGCACAGCCT TGTCCTCATT GTCCAAAGGA GTGGATATCA 
TATTCTCACA ATTGTTATTT CATTGGTATG GAGAGAAAAT CTTGGAATGA CAGTTTGGTG 
TCCTGCATTT CCAAAAACTG TAGTCTGCTT TACATAGATA GTGAAGAGGA GCAGGATTTT 
CTGCAATCTC TTTCACTGAT CTCATGGACT GGAATCCTTC GGAAGGGCAG AGGTCAGCCC 
TGGGTCTGGA AAGAAGACTC AATTTTCAAA CCAAAGATAG CAGAGATTCT CCATGATGAA 
TGTAACTGTG CCATGATGTC AGCTTCTGGT CTCACAGCAG ACAACTGTAC AACTTTACAT 
CCATATCTTT GTAAGTGTAA ATTCCCCATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017176907.1
CDS	88..720
Translation	MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKDTEAKAQINSSMTRTHRDINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLISWTGILRKGRGQPWVWKEDSIFKPKIAEILHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI

Target ORF information:

RefSeq Version	XM_017321418.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017321418.1

ORF Insert Sequence:

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGATA CCGAAGCAAA GGCACAGATC AATTCCTCAA TGACTAGAAC CCACAGAGAT 
ATAAACTACA CTCTATCTTC AGCACAGCCT TGTCCTCATT GTCCAAAGGA GTGGATATCA 
TATTCTCACA ATTGTTATTT CATTGGTATG GAGAGAAAAT CTTGGAATGA CAGTTTGGTG 
TCCTGCATTT CCAAAAACTG TAGTCTGCTT TACATAGATA GTGAAGAGGA GCAGGATTTT 
CTGCAATCTC TTTCACTGAT CTCATGGACT GGAATCCTTC GGAAGGGCAG AGGTCAGCCC 
TGGGTCTGGA AAGAAGACTC AATTTTCAAA CCAAAGATAG CAGAGATTCT CCATGATGAA 
TGTAACTGTG CCATGATGTC AGCTTCTGGT CTCACAGCAG ACAACTGTAC AACTTTACAT 
CCATATCTTT GTAAGTGTAA ATTCCCCATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrc1 ( XM_011241237.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239539.1 Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu16759
Clone ID Related Accession (Same CDS sequence)	NM_010652.2 , XM_011241237.1
Accession Version	XM_011241237.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	NKG2-A/NKG2-B type II integral membrane protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TATAAACTAC 
ACTCTATCTT CAGCACAGCC TTGTCCTCAT TGTCCAAAGG AGTGGATATC ATATTCTCAC 
AATTGTTATT TCATTGGTAT GGAGAGAAAA TCTTGGAATG ACAGTTTGGT GTCCTGCATT 
TCCAAAAACT GTAGTCTGCT TTACATAGAT AGTGAAGAGG AGCAGGATTT TCTGCAATCT 
CTTTCACTGA TCTCATGGAC TGGAATCCTT CGGAAGGGCA GAGGTCAGCC CTGGGTCTGG 
AAAGAAGACT CAATTTTCAA ACCAAAGATA GCAGAGATTC TCCATGATGA ATGTAACTGT 
GCCATGATGT CAGCTTCTGG TCTCACAGCA GACAACTGTA CAACTTTACA TCCATATCTT 
TGTAAGTGTA AATTCCCCAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239539.1
CDS	88..771
Translation	MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKGFPSPPEKLIAGTLGLICFVLIVAVVVITTVATPYINYTLSSAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLISWTGILRKGRGQPWVWKEDSIFKPKIAEILHDECNCAMMSASGLTADNCTTLHPYLCKCKFPI

Target ORF information:

RefSeq Version	XM_011241237.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011241237.1

ORF Insert Sequence:

ATGAGTAATG AACGCGTCAC CTATGCAGAA CTGAAGGTGG CAAAGAACTC AAGGAACCAG 
CACAGGAAAC CAAGGGGTCC TCGCAGCTCC ATTTCAGTCA TCGAGCAGGA AATCATCTAT 
TCGGACTTCA GCTTTCAAAA TCCTTCTCAG GAGCATCCCT GGATCTGCAG GAATTGCCCC 
TGCAAAGGTT TTCCATCTCC TCCAGAGAAA CTCATTGCTG GTACCCTGGG CCTCATCTGT 
TTTGTCTTAA TTGTCGCTGT GGTTGTAATT ACTACAGTTG CCACACCATA TATAAACTAC 
ACTCTATCTT CAGCACAGCC TTGTCCTCAT TGTCCAAAGG AGTGGATATC ATATTCTCAC 
AATTGTTATT TCATTGGTAT GGAGAGAAAA TCTTGGAATG ACAGTTTGGT GTCCTGCATT 
TCCAAAAACT GTAGTCTGCT TTACATAGAT AGTGAAGAGG AGCAGGATTT TCTGCAATCT 
CTTTCACTGA TCTCATGGAC TGGAATCCTT CGGAAGGGCA GAGGTCAGCC CTGGGTCTGG 
AAAGAAGACT CAATTTTCAA ACCAAAGATA GCAGAGATTC TCCATGATGA ATGTAACTGT 
GCCATGATGT CAGCTTCTGG TCTCACAGCA GACAACTGTA CAACTTTACA TCCATATCTT 
TGTAAGTGTA AATTCCCCAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement.
Immunity, inflammation and disease5(2)177-189(2017 Jun)
Meyer CE,Key PN,Zhu T,Shabsovich M,Ni A,Tripathy SK

The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.
Biochemical and biophysical research communications478(1)213-220(2016 09)
Zou Z,Zuo D,Yang J,Fan H

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8? T Cells in Response to a Lethal Poxvirus Infection.
Immunity43(6)1112-24(2015 Dec)
Rapaport AS,Schriewer J,Gilfillan S,Hembrador E,Crump R,Plougastel BF,Wang Y,Le Friec G,Gao J,Cella M,Pircher H,Yokoyama WM,Buller RM,Colonna M

Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.
PloS one9(9)e108385(2014)
Ely KH,Matsuoka M,DeBerge MP,Ruby JA,Liu J,Schneider MJ,Wang Y,Hahn YS,Enelow RI

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Klrc1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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