Klra7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klra7
Entrez Gene ID	16638
Full Name	killer cell lectin-like receptor, subfamily A, member 7
Synonyms	LGL-1,Ly-49G.1,Ly-49G.2,Ly-49G.3,Ly49G.4,Ly49g,Ly49g1,Ly49g2
General protein information	Preferred Names killer cell lectin-like receptor, subfamily A, member 7 Names killer cell lectin-like receptor 7 T-cell surface glycoprotein Ly-49G ly-49g lymphocyte antigen 49g
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 F3\|6 63.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_014194.5	NP_055009.5	killer cell lectin-like receptor 7 isoform 2
NM_001110323.1	NP_001103793.1	killer cell lectin-like receptor 7 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klra9	NP_034781.2
Mus musculus (house mouse)	Klra21	NP_444381.1
Mus musculus (house mouse)	Klra3	NP_034778.2
Mus musculus (house mouse)	Klra1	NP_057868.2
Mus musculus (house mouse)	Klra4	NP_034779.1
Mus musculus (house mouse)	Gm15854	XP_003688868.1
Mus musculus (house mouse)	Klra6	NP_032490.1
Mus musculus (house mouse)	Klra10	NP_032485.2
Mus musculus (house mouse)	Klra7	NP_001103793.1
Mus musculus (house mouse)	Klra5	NP_032489.1
Mus musculus (house mouse)	Klra8	NP_034780.1
Rattus norvegicus (Norway rat)	Klra2	NP_001009718.1

Gene Ontology
Bibliography

Related articles in PubMed

The distal upstream promoter in Ly49 genes, Pro1, is active in mature NK cells and T cells, does not require TATA boxes, and displays enhancer activity.
Gays F, Taha S, Brooks CG
Journal of immunology (Baltimore, Md. : 1950)194(12)6068-81(2015 Jun)

The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.
Ma BJ, Craveiro Salvado CM, Kane KP
Immunogenetics66(7-8)467-77(2014 Aug)

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Schenkel AR, Kingry LC, Slayden RA
Frontiers in immunology490(2013)

Loss of aPKC? in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.
Yamanaka T, Tosaki A, Kurosawa M, Akimoto K, Hirose T, Ohno S, Hattori N, Nukina N
PloS one8(12)e84036(2013)

Comprehensive analysis of transcript start sites in ly49 genes reveals an unexpected relationship with gene function and a lack of upstream promoters.
Gays F, Koh AS, Mickiewicz KM, Aust JG, Brooks CG
PloS one6(3)e18475(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The ectodomain of inhibitory Ly49G of the BALB/c mouse strain is highly similar to the Ly49W activating receptor in the nonobese diabetic (NOD) mouse.
Title: The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.

High levels of Ly49G2 have a dominant inhibitory effect on Ly49D expressed at low levels on immature bone marrow and mature B cells, resulting in inhibition of interferon-gamma secretion.
Title: Tight regulation of IFN-gamma transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2.

Glycosylation of Ly-49G2 at amino acid residues NTT221-23 reduces receptor binding to H-2Dd tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands.
Title: Receptor glycosylation regulates Ly-49 binding to MHC class I.

Allelic variation in Ly-49G2 extracellular domains has functional significance by altering Ly-49 receptor specificity for class I MHC and xenogeneic ligands.
Title: Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands.

The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.

The following Klra7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klra7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04621	NM_001110323.1 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 7 (Klra7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu09634	NM_014194.5 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 7 (Klra7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klra7 ( NM_001110323.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103793.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 7 (Klra7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu04621
Clone ID Related Accession (Same CDS sequence)	NM_001110323.1
Accession Version	NM_001110323.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 7 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U10093.1 and AC161448.4. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U10093.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849381 [ECO:0000350] ##Evidence-Data-END##

ATGAGTGAGC AGGAGGTCAC TTACTCAACT GTGAGATTTC ATGAGTCTTC AAGGTTGCAG 
AAACTAGTGA GGACTGAGGA GCCTCAAAGG CCCAGAGAAG CTTGCTACAG AGAGTATTCA 
GTCCCCTGGA AGCTCATTGT GATAGCTTGT GGAATCCTCT GTTTCCTTCT CCTGGTAACT 
GTTGCATTGT TGGCAATAAC GATTTTTCAG CATAGTCAAC AAAAACATGA ACTACAGGAA 
ACTCTAAATT GCCACGATAA CTGCAGCCCC ACGCAAAGTG ACGTCAACTT GAAGGATGAA 
CTGCTGAGAA ATAAGTCTAT AGAGTGTAGG CCAGGCAATG ATCTTCTGGA ATCCCTCAGC 
AGGGATCAGA ACAGATGGTA CAGTGAAACC AAGACTTTTT CAGATTCCTC ACAGCACACA 
GGTGTTCACA AAAGACCCAT CTCCAAGGCA GAGGGGAAGG GTAGAGGTTT TGAAAAATAT 
TGGTTCTGTT ATGGTATAAA ATGTTATTAT TTCAACATGG ACAGAAAAAC GTGGAGTGGA 
TGTAAACAGA CCTGCCAGAT TTCCAGCTTA TCCCTTCTGA AGATAGACAA TGAGGATGAA 
CTGAAGTTCC TTCAGAACCT GGCTCCTTCA GACATTTCCT GGATTGGATT GTCATATGAC 
AATAAGAAAA AAGATTGGGT ATGGATTGAC AATGGCCCAT CTAAACTTGC CTTGAACACA 
ACGAAATATA ATATAAGAGA TGGATTATGT ATGTCGTTAT CTAAAACAAG ACTAGACAAT 
GGGGACTGTG ATAAATCATA CATCTGTATT TGTGGTAAGA GACTGGATAA ATTTCCTCAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103793.1
CDS	131..973
Translation	MSEQEVTYSTVRFHESSRLQKLVRTEEPQRPREACYREYSVPWKLIVIACGILCFLLLVTVALLAITIFQHSQQKHELQETLNCHDNCSPTQSDVNLKDELLRNKSIECRPGNDLLESLSRDQNRWYSETKTFSDSSQHTGVHKRPISKAEGKGRGFEKYWFCYGIKCYYFNMDRKTWSGCKQTCQISSLSLLKIDNEDELKFLQNLAPSDISWIGLSYDNKKKDWVWIDNGPSKLALNTTKYNIRDGLCMSLSKTRLDNGDCDKSYICICGKRLDKFPH

Target ORF information:

RefSeq Version	NM_001110323.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 7 (Klra7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110323.1

ORF Insert Sequence:

ATGAGTGAGC AGGAGGTCAC TTACTCAACT GTGAGATTTC ATGAGTCTTC AAGGTTGCAG 
AAACTAGTGA GGACTGAGGA GCCTCAAAGG CCCAGAGAAG CTTGCTACAG AGAGTATTCA 
GTCCCCTGGA AGCTCATTGT GATAGCTTGT GGAATCCTCT GTTTCCTTCT CCTGGTAACT 
GTTGCATTGT TGGCAATAAC GATTTTTCAG CATAGTCAAC AAAAACATGA ACTACAGGAA 
ACTCTAAATT GCCACGATAA CTGCAGCCCC ACGCAAAGTG ACGTCAACTT GAAGGATGAA 
CTGCTGAGAA ATAAGTCTAT AGAGTGTAGG CCAGGCAATG ATCTTCTGGA ATCCCTCAGC 
AGGGATCAGA ACAGATGGTA CAGTGAAACC AAGACTTTTT CAGATTCCTC ACAGCACACA 
GGTGTTCACA AAAGACCCAT CTCCAAGGCA GAGGGGAAGG GTAGAGGTTT TGAAAAATAT 
TGGTTCTGTT ATGGTATAAA ATGTTATTAT TTCAACATGG ACAGAAAAAC GTGGAGTGGA 
TGTAAACAGA CCTGCCAGAT TTCCAGCTTA TCCCTTCTGA AGATAGACAA TGAGGATGAA 
CTGAAGTTCC TTCAGAACCT GGCTCCTTCA GACATTTCCT GGATTGGATT GTCATATGAC 
AATAAGAAAA AAGATTGGGT ATGGATTGAC AATGGCCCAT CTAAACTTGC CTTGAACACA 
ACGAAATATA ATATAAGAGA TGGATTATGT ATGTCGTTAT CTAAAACAAG ACTAGACAAT 
GGGGACTGTG ATAAATCATA CATCTGTATT TGTGGTAAGA GACTGGATAA ATTTCCTCAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klra7 ( NM_014194.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_055009.5 Mus musculus killer cell lectin-like receptor, subfamily A, member 7 (Klra7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu09634
Clone ID Related Accession (Same CDS sequence)	NM_014194.5
Accession Version	NM_014194.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor 7 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U10094.1. On Nov 15, 2007 this sequence version replaced NM_014194.4. Transcript Variant: This variant (2) differs in the 5' and 3' UTR and lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U10094.1, AK143240.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849381 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGC AGGAGGTCAC TTACTCAACT GTGAGATTTC ATGAGTCTTC AAGGTTGCAG 
AAACTAGTGA GGACTGAGGA GCCTCAAAGG CCCAGAGAAG CTTGCTACAG AGAGTATTCA 
GTCCCCTGGA AGCTCATTGT GATAGCTTGT GGAATCCTCT GTTTCCTTCT CCTGGTAACT 
GTTGCATTGT TGGCAATAAC GATTTTTCAG CATAGTCAAC AAAAACATGA ACTACAGGAA 
ACTCTAAATT GCCACGATAA CTGCAGCCCC ACGCAAAGTG ACGTCAACTT GAAGGATGAA 
CTGCTGAGAA ATAAGTCTAT AGAGTGTAGG CCAGGCAATG ATCTTCTGGA ATCCCTCAGC 
AGGGATCAGA ACAGATGGTA CAGTGAAACC AAGACTTTTT CAGATTCCTC ACAGCACACA 
GGTAGAGGTT TTGAAAAATA TTGGTTCTGT TATGGTATAA AATGTTATTA TTTCAACATG 
GACAGAAAAA CGTGGAGTGG ATGTAAACAG ACCTGCCAGA TTTCCAGCTT ATCCCTTCTG 
AAGATAGACA ATGAGGATGA ACTGAAGTTC CTTCAGAACC TGGCTCCTTC AGACATTTCC 
TGGATTGGAT TGTCATATGA CAATAAGAAA AAAGATTGGG TATGGATTGA CAATGGCCCA 
TCTAAACTTG CCTTGAACAC AACGAAATAT AATATAAGAG ATGGATTATG TATGTCGTTA 
TCTAAAACAA GACTAGACAA TGGGGACTGT GATAAATCAT ACATCTGTAT TTGTGGTAAG 
AGACTGGATA AATTTCCTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055009.5
CDS	71..874
Translation	MSEQEVTYSTVRFHESSRLQKLVRTEEPQRPREACYREYSVPWKLIVIACGILCFLLLVTVALLAITIFQHSQQKHELQETLNCHDNCSPTQSDVNLKDELLRNKSIECRPGNDLLESLSRDQNRWYSETKTFSDSSQHTGRGFEKYWFCYGIKCYYFNMDRKTWSGCKQTCQISSLSLLKIDNEDELKFLQNLAPSDISWIGLSYDNKKKDWVWIDNGPSKLALNTTKYNIRDGLCMSLSKTRLDNGDCDKSYICICGKRLDKFPH

Target ORF information:

RefSeq Version	NM_014194.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 7 (Klra7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014194.5

ORF Insert Sequence:

ATGAGTGAGC AGGAGGTCAC TTACTCAACT GTGAGATTTC ATGAGTCTTC AAGGTTGCAG 
AAACTAGTGA GGACTGAGGA GCCTCAAAGG CCCAGAGAAG CTTGCTACAG AGAGTATTCA 
GTCCCCTGGA AGCTCATTGT GATAGCTTGT GGAATCCTCT GTTTCCTTCT CCTGGTAACT 
GTTGCATTGT TGGCAATAAC GATTTTTCAG CATAGTCAAC AAAAACATGA ACTACAGGAA 
ACTCTAAATT GCCACGATAA CTGCAGCCCC ACGCAAAGTG ACGTCAACTT GAAGGATGAA 
CTGCTGAGAA ATAAGTCTAT AGAGTGTAGG CCAGGCAATG ATCTTCTGGA ATCCCTCAGC 
AGGGATCAGA ACAGATGGTA CAGTGAAACC AAGACTTTTT CAGATTCCTC ACAGCACACA 
GGTAGAGGTT TTGAAAAATA TTGGTTCTGT TATGGTATAA AATGTTATTA TTTCAACATG 
GACAGAAAAA CGTGGAGTGG ATGTAAACAG ACCTGCCAGA TTTCCAGCTT ATCCCTTCTG 
AAGATAGACA ATGAGGATGA ACTGAAGTTC CTTCAGAACC TGGCTCCTTC AGACATTTCC 
TGGATTGGAT TGTCATATGA CAATAAGAAA AAAGATTGGG TATGGATTGA CAATGGCCCA 
TCTAAACTTG CCTTGAACAC AACGAAATAT AATATAAGAG ATGGATTATG TATGTCGTTA 
TCTAAAACAA GACTAGACAA TGGGGACTGT GATAAATCAT ACATCTGTAT TTGTGGTAAG 
AGACTGGATA AATTTCCTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The distal upstream promoter in Ly49 genes, Pro1, is active in mature NK cells and T cells, does not require TATA boxes, and displays enhancer activity.
Journal of immunology (Baltimore, Md. : 1950)194(12)6068-81(2015 Jun)
Gays F,Taha S,Brooks CG

The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.
Immunogenetics66(7-8)467-77(2014 Aug)
Ma BJ,Craveiro Salvado CM,Kane KP

The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.
Frontiers in immunology490(2013)
Schenkel AR,Kingry LC,Slayden RA

Loss of aPKC? in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.
PloS one8(12)e84036(2013)
Yamanaka T,Tosaki A,Kurosawa M,Akimoto K,Hirose T,Ohno S,Hattori N,Nukina N

Comprehensive analysis of transcript start sites in ly49 genes reveals an unexpected relationship with gene function and a lack of upstream promoters.
PloS one6(3)e18475(2011 Mar)
Gays F,Koh AS,Mickiewicz KM,Aust JG,Brooks CG