Kcnk5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnk5
Entrez Gene ID	16529
Full Name	potassium channel, subfamily K, member 5
Synonyms	KCNK5b,TASK-2
General protein information	Preferred Names potassium channel, subfamily K, member 5 Names potassium channel subfamily K member 5 potassium channel, subfamily, member 5 (KCNK5) potassium inwardly-rectifying channel, subfamily K, member 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_021542.4	NP_067517.1	potassium channel subfamily K member 5
XM_006518590.3	XP_006518653.1	potassium channel subfamily K member 5 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KCNK5	XP_518449.2
Canis lupus familiaris (dog)	KCNK5	XP_538901.2
Gallus gallus (chicken)	KCNK5	XP_419478.2
Homo sapiens (human)	KCNK5	NP_003731.1
	KCNK5	XP_001117117.1
Rattus norvegicus (Norway rat)	Kcnk5	NP_001034605.1
Bos taurus (cattle)	KCNK5	NP_001178073.1
Mus musculus (house mouse)	Kcnk5	NP_067517.1
Danio rerio (zebrafish)	kcnk5a	NP_001032478.1
Xenopus tropicalis (tropical clawed frog)	kcnk5	XP_002942651.2

Gene Ontology
Bibliography

Related articles in PubMed

Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K
Niemeyer MI, Cid LP, Paulais M, Teulon J, Sep?lveda FV
Scientific reports745407(2017 Mar)

Identification of potassium and chloride channels in eccrine sweat glands.
Cui CY, Sima J, Yin M, Michel M, Kunisada M, Schlessinger D
Journal of dermatological science81(2)129-31(2016 Feb)

KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
Cazals Y, B?vengut M, Zanella S, Brocard F, Barhanin J, Gestreau C
Nature communications68780(2015 Nov)

PHYSIOLOGY. Regulation of breathing by CO? requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA
Science (New York, N.Y.)348(6240)1255-60(2015 Jun)

Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model.
Nakakura S, Matsui M, Sato A, Ishii M, Endo K, Muragishi S, Murase M, Kito H, Niguma H, Kurokawa N, Fujii M, Araki M, Araki K, Ohya S
Frontiers in physiology6299(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KCNK5 channels are indispensable for the maintenance of hearing. KCNK5 is mainly found in outer sulcus Claudius', Boettcher's and root cells.
Title: KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.

The data identify GPR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.
Title: PHYSIOLOGY. Regulation of breathing by CO? requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.

TASK-2 is upregulated under hypoxia in a HIF-1alpha-dependent manner in B cells.
Title: HIF-1?-mediated upregulation of TASK-2 K? channels augments Ca?? signaling in mouse B cells under hypoxia.

alkaline-activated TASK-2 channels contribute to pH sensitivity in retrotrapezoid nucleus neurons
Title: TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons.

The strong physiological impairment of KCNK5 in Ehrlich cells after long-term hypotonic stimulation is predominantly due to down-regulation of the KCNK5 protein synthesis.
Title: KCNK5 is functionally down-regulated upon long-term hypotonicity in Ehrlich ascites tumor cells.

The following Kcnk5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnk5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12467	NM_021542.4 Latest version!	Mus musculus potassium channel, subfamily K, member 5 (Kcnk5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$293.30 $419.00
OMu49687	XM_006518590.3 Latest version!	Mus musculus potassium channel, subfamily K, member 5 (Kcnk5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnk5 ( NM_021542.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067517.1 Mus musculus potassium channel, subfamily K, member 5 (Kcnk5), mRNA.

Price & Availability↑

CloneID	OMu12467
Clone ID Related Accession (Same CDS sequence)	NM_021542.4
Accession Version	NM_021542.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	potassium channel subfamily K member 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC126275.3. On Apr 29, 2007 this sequence version replaced NM_021542.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK085330.1, AK132172.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGGTGGACC GGGGTCCTTT ACTCACCTCG GCCATCATAT TCTACCTGGC CATCGGGGCA 
GCGATCTTCG AAGTGCTGGA GGAGCCACAC TGGAAGGAGG CCAAGAAAAA CTACTATACA 
CAGAAACTGC ATCTACTCAA GGAGTTTCCG TGCCTGAGTC AGGAGGGACT GGACAAGATC 
CTACAGGTGG TGTCTGATGC TGCGGATCAG GGTGTGGCCA TCACCGGGAA CCAGACTTTC 
AACAACTGGA ACTGGCCCAA TGCAATGATT TTTGCTGCCA CAGTCATCAC CACCATCGGT 
TATGGCAATG TGGCTCCCAA GACCCCAGCT GGGCGCCTCT TCTGTGTCTT CTACGGCCTC 
TTCGGGGTGC CGCTGTGCCT GACATGGATC AGTGCCCTGG GCAAGTTCTT CGGGGGACGT 
GCAAAGAGGT TGGGCCAGTT TCTTACCAGG AGAGGAGTGA GCCTGAGGAA GGCTCAGATC 
ACGTGTACAG CCATCTTCAT CGTGTGGGGT GTCCTGGTCC ATCTGGTGAT CCCGCCCTTT 
GTGTTCATGG TGACAGAAGA ATGGAACTAC ATTGAGGGCC TCTACTATTC CTTCATCACC 
ATCTCCACCA TTGGCTTTGG GGACTTTGTG GCCGGTGTGA ACCCCAGTGC CAACTACCAC 
GCCCTATACC GATACTTTGT GGAGCTTTGG ATCTACCTGG GGCTGGCTTG GCTGTCCCTC 
TTTGTCAACT GGAAGGTGAG CATGTTTGTG GAAGTACACA AAGCCATTAA AAAGAGGCGG 
CGGCGGCGCA AGGAATCCTT TGAGAGCTCT CCACACTCCC GGAAGGCCCT ACAGATGGCT 
GGAAGTACAG CATCCAAGGA CGTCAACATC TTCAGCTTCC TATCCAAAAA GGAGGAGACC 
TACAATGACC TCATCAAACA GATTGGGAAG AAGGCAATGA AAACAAGTGG GGGAGGGGAG 
AGGGTCCCAG GACCTGGACA CGGGCTGGGA CCTCAAGGGG ATAGACTACC CACCATCCCT 
GCATCCCTGG CACCTTTGGT GGTCTATTCC AAGAATCGGG TGCCCAGCTT GGAAGAGGTA 
TCTCAGACTC TAAAAAACAA GGGACATGTG TCAAGGCCAC TTGGTGAGGA GGCTGGGGCA 
CAGGCCCCCA AGGATAGTTA CCAAACCTCT GAAGTGTTTA TTAACCAACT GGACCGTATC 
AGTGAGGAGG GAGAGCCGTG GGAAGCCCTG GACTACCACC CGCTCATCTT CCAAAATGCC 
AACATTACCT TTGAAAATGA AGAAACCGGC CTCTCAGACG AGGAGACCTC TAAGTCTTCT 
GTGGAGGACA ACCTGACCTC AAAGGAGCAG CCTGAACAGG GACCCATGGC TGAGGCACCC 
TTGAGCAGCA CGGGTGAATT CCCTTCATCC GATGAGTCCA CCTTCACCAG CACCGAGTCA 
GAGCTCTCCG TGCCTTACGA GCAGCTGATG AACGAATACA ACAAGGCAGA TAACCCCAGG 
GGCACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067517.1
CDS	331..1839
Translation	MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLSQEGLDKILQVVSDAADQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTRRGVSLRKAQITCTAIFIVWGVLVHLVIPPFVFMVTEEWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQMAGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGERVPGPGHGLGPQGDRLPTIPASLAPLVVYSKNRVPSLEEVSQTLKNKGHVSRPLGEEAGAQAPKDSYQTSEVFINQLDRISEEGEPWEALDYHPLIFQNANITFENEETGLSDEETSKSSVEDNLTSKEQPEQGPMAEAPLSSTGEFPSSDESTFTSTESELSVPYEQLMNEYNKADNPRGT

Target ORF information:

RefSeq Version	NM_021542.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium channel, subfamily K, member 5 (Kcnk5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021542.4

ORF Insert Sequence:

ATGGTGGACC GGGGTCCTTT ACTCACCTCG GCCATCATAT TCTACCTGGC CATCGGGGCA 
GCGATCTTCG AAGTGCTGGA GGAGCCACAC TGGAAGGAGG CCAAGAAAAA CTACTATACA 
CAGAAACTGC ATCTACTCAA GGAGTTTCCG TGCCTGAGTC AGGAGGGACT GGACAAGATC 
CTACAGGTGG TGTCTGATGC TGCGGATCAG GGTGTGGCCA TCACCGGGAA CCAGACTTTC 
AACAACTGGA ACTGGCCCAA TGCAATGATT TTTGCTGCCA CAGTCATCAC CACCATCGGT 
TATGGCAATG TGGCTCCCAA GACCCCAGCT GGGCGCCTCT TCTGTGTCTT CTACGGCCTC 
TTCGGGGTGC CGCTGTGCCT GACATGGATC AGTGCCCTGG GCAAGTTCTT CGGGGGACGT 
GCAAAGAGGT TGGGCCAGTT TCTTACCAGG AGAGGAGTGA GCCTGAGGAA GGCTCAGATC 
ACGTGTACAG CCATCTTCAT CGTGTGGGGT GTCCTGGTCC ATCTGGTGAT CCCGCCCTTT 
GTGTTCATGG TGACAGAAGA ATGGAACTAC ATTGAGGGCC TCTACTATTC CTTCATCACC 
ATCTCCACCA TTGGCTTTGG GGACTTTGTG GCCGGTGTGA ACCCCAGTGC CAACTACCAC 
GCCCTATACC GATACTTTGT GGAGCTTTGG ATCTACCTGG GGCTGGCTTG GCTGTCCCTC 
TTTGTCAACT GGAAGGTGAG CATGTTTGTG GAAGTACACA AAGCCATTAA AAAGAGGCGG 
CGGCGGCGCA AGGAATCCTT TGAGAGCTCT CCACACTCCC GGAAGGCCCT ACAGATGGCT 
GGAAGTACAG CATCCAAGGA CGTCAACATC TTCAGCTTCC TATCCAAAAA GGAGGAGACC 
TACAATGACC TCATCAAACA GATTGGGAAG AAGGCAATGA AAACAAGTGG GGGAGGGGAG 
AGGGTCCCAG GACCTGGACA CGGGCTGGGA CCTCAAGGGG ATAGACTACC CACCATCCCT 
GCATCCCTGG CACCTTTGGT GGTCTATTCC AAGAATCGGG TGCCCAGCTT GGAAGAGGTA 
TCTCAGACTC TAAAAAACAA GGGACATGTG TCAAGGCCAC TTGGTGAGGA GGCTGGGGCA 
CAGGCCCCCA AGGATAGTTA CCAAACCTCT GAAGTGTTTA TTAACCAACT GGACCGTATC 
AGTGAGGAGG GAGAGCCGTG GGAAGCCCTG GACTACCACC CGCTCATCTT CCAAAATGCC 
AACATTACCT TTGAAAATGA AGAAACCGGC CTCTCAGACG AGGAGACCTC TAAGTCTTCT 
GTGGAGGACA ACCTGACCTC AAAGGAGCAG CCTGAACAGG GACCCATGGC TGAGGCACCC 
TTGAGCAGCA CGGGTGAATT CCCTTCATCC GATGAGTCCA CCTTCACCAG CACCGAGTCA 
GAGCTCTCCG TGCCTTACGA GCAGCTGATG AACGAATACA ACAAGGCAGA TAACCCCAGG 
GGCACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnk5 ( XM_006518590.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006518653.1 Mus musculus potassium channel, subfamily K, member 5 (Kcnk5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu49687
Clone ID Related Accession (Same CDS sequence)	XM_006518590.3
Accession Version	XM_006518590.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	potassium channel subfamily K member 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006518590.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGACAG AAGAATGGAA CTACATTGAG GGCCTCTACT ATTCCTTCAT CACCATCTCC 
ACCATTGGCT TTGGGGACTT TGTGGCCGGT GTGAACCCCA GTGCCAACTA CCACGCCCTA 
TACCGATACT TTGTGGAGCT TTGGATCTAC CTGGGGCTGG CTTGGCTGTC CCTCTTTGTC 
AACTGGAAGG TGAGCATGTT TGTGGAAGTA CACAAAGCCA TTAAAAAGAG GCGGCGGCGG 
CGCAAGGAAT CCTTTGAGAG CTCTCCACAC TCCCGGAAGG CCCTACAGAT GGCTGGAAGT 
ACAGCATCCA AGGACGTCAA CATCTTCAGC TTCCTATCCA AAAAGGAGGA GACCTACAAT 
GACCTCATCA AACAGATTGG GAAGAAGGCA ATGAAAACAA GTGGGGGAGG GGAGAGGGTC 
CCAGGACCTG GACACGGGCT GGGACCTCAA GGGGATAGAC TACCCACCAT CCCTGCATCC 
CTGGCACCTT TGGTGGTCTA TTCCAAGAAT CGGGTGCCCA GCTTGGAAGA GGTATCTCAG 
ACTCTAAAAA ACAAGGGACA TGTGTCAAGG CCACTTGGTG AGGAGGCTGG GGCACAGGCC 
CCCAAGGATA GTTACCAAAC CTCTGAAGTG TTTATTAACC AACTGGACCG TATCAGTGAG 
GAGGGAGAGC CGTGGGAAGC CCTGGACTAC CACCCGCTCA TCTTCCAAAA TGCCAACATT 
ACCTTTGAAA ATGAAGAAAC CGGCCTCTCA GACGAGGAGA CCTCTAAGTC TTCTGTGGAG 
GACAACCTGA CCTCAAAGGA GCAGCCTGAA CAGGGACCCA TGGCTGAGGC ACCCTTGAGC 
AGCACGGGTG AATTCCCTTC ATCCGATGAG TCCACCTTCA CCAGCACCGA GTCAGAGCTC 
TCCGTGCCTT ACGAGCAGCT GATGAACGAA TACAACAAGG CAGATAACCC CAGGGGCACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006518653.1
CDS	1237..2199
Translation	MVTEEWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQMAGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGERVPGPGHGLGPQGDRLPTIPASLAPLVVYSKNRVPSLEEVSQTLKNKGHVSRPLGEEAGAQAPKDSYQTSEVFINQLDRISEEGEPWEALDYHPLIFQNANITFENEETGLSDEETSKSSVEDNLTSKEQPEQGPMAEAPLSSTGEFPSSDESTFTSTESELSVPYEQLMNEYNKADNPRGT

Target ORF information:

RefSeq Version	XM_006518590.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium channel, subfamily K, member 5 (Kcnk5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006518590.3

ORF Insert Sequence:

ATGGTGACAG AAGAATGGAA CTACATTGAG GGCCTCTACT ATTCCTTCAT CACCATCTCC 
ACCATTGGCT TTGGGGACTT TGTGGCCGGT GTGAACCCCA GTGCCAACTA CCACGCCCTA 
TACCGATACT TTGTGGAGCT TTGGATCTAC CTGGGGCTGG CTTGGCTGTC CCTCTTTGTC 
AACTGGAAGG TGAGCATGTT TGTGGAAGTA CACAAAGCCA TTAAAAAGAG GCGGCGGCGG 
CGCAAGGAAT CCTTTGAGAG CTCTCCACAC TCCCGGAAGG CCCTACAGAT GGCTGGAAGT 
ACAGCATCCA AGGACGTCAA CATCTTCAGC TTCCTATCCA AAAAGGAGGA GACCTACAAT 
GACCTCATCA AACAGATTGG GAAGAAGGCA ATGAAAACAA GTGGGGGAGG GGAGAGGGTC 
CCAGGACCTG GACACGGGCT GGGACCTCAA GGGGATAGAC TACCCACCAT CCCTGCATCC 
CTGGCACCTT TGGTGGTCTA TTCCAAGAAT CGGGTGCCCA GCTTGGAAGA GGTATCTCAG 
ACTCTAAAAA ACAAGGGACA TGTGTCAAGG CCACTTGGTG AGGAGGCTGG GGCACAGGCC 
CCCAAGGATA GTTACCAAAC CTCTGAAGTG TTTATTAACC AACTGGACCG TATCAGTGAG 
GAGGGAGAGC CGTGGGAAGC CCTGGACTAC CACCCGCTCA TCTTCCAAAA TGCCAACATT 
ACCTTTGAAA ATGAAGAAAC CGGCCTCTCA GACGAGGAGA CCTCTAAGTC TTCTGTGGAG 
GACAACCTGA CCTCAAAGGA GCAGCCTGAA CAGGGACCCA TGGCTGAGGC ACCCTTGAGC 
AGCACGGGTG AATTCCCTTC ATCCGATGAG TCCACCTTCA CCAGCACCGA GTCAGAGCTC 
TCCGTGCCTT ACGAGCAGCT GATGAACGAA TACAACAAGG CAGATAACCC CAGGGGCACG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K
Scientific reports745407(2017 Mar)
Niemeyer MI,Cid LP,Paulais M,Teulon J,Sep?lveda FV

Identification of potassium and chloride channels in eccrine sweat glands.
Journal of dermatological science81(2)129-31(2016 Feb)
Cui CY,Sima J,Yin M,Michel M,Kunisada M,Schlessinger D

KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
Nature communications68780(2015 Nov)
Cazals Y,B?vengut M,Zanella S,Brocard F,Barhanin J,Gestreau C

PHYSIOLOGY. Regulation of breathing by CO? requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
Science (New York, N.Y.)348(6240)1255-60(2015 Jun)
Kumar NN,Velic A,Soliz J,Shi Y,Li K,Wang S,Weaver JL,Sen J,Abbott SB,Lazarenko RM,Ludwig MG,Perez-Reyes E,Mohebbi N,Bettoni C,Gassmann M,Suply T,Seuwen K,Guyenet PG,Wagner CA,Bayliss DA

Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model.
Frontiers in physiology6299(2015)
Nakakura S,Matsui M,Sato A,Ishii M,Endo K,Muragishi S,Murase M,Kito H,Niguma H,Kurokawa N,Fujii M,Araki M,Araki K,Ohya S