H2-DMb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2-DMb2
Entrez Gene ID	15000
Full Name	histocompatibility 2, class II, locus Mb2
Synonyms	H-2Mb2,H2-Mb2
General protein information	Preferred Names histocompatibility 2, class II, locus Mb2 Names histocompatibility 2, class II, locus Mb2 H2-M beta2 MHC class II antigen Mb2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010388.4	NP_034518.1	histocompatibility 2, class II, locus Mb2 precursor
NM_010388.5	NP_034518.1	histocompatibility 2, class II, locus Mb2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BOLA-DMB	NP_001035571.1
Pan troglodytes (chimpanzee)	PATR-DMB	NP_001127814.1
Mus musculus (house mouse)	H2-DMb1	NP_034517.2
Homo sapiens (human)	HLA-DMB	NP_002109.2
Canis lupus familiaris (dog)	DLA-DMB	NP_001257999.1
Gallus gallus (chicken)	BMA2	NP_001128638.1
Xenopus tropicalis (tropical clawed frog)	LOC100495183	XP_002942059.1
	MAMU-DMB	XP_002803734.1
Mus musculus (house mouse)	H2-DMb2	NP_034518.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
Logunova N, Korotetskaya M, Polshakov V, Apt A
PLoS genetics11(11)e1005672(2015 Nov)

Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation.
Lankar D, Vincent-Schneider H, Briken V, Yokozeki T, Raposo G, Bonnerot C
The Journal of experimental medicine195(4)461-72(2002 Feb)

H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.
Walter W, Scheuer C, Loos M, Reichert TE, Maeurer MJ
The Journal of biological chemistry276(14)11086-91(2001 Apr)

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?
Walter W, Lingnau K, Schmitt E, Loos M, Maeurer MJ
British journal of cancer83(9)1192-201(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following H2-DMb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2-DMb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu23782	NM_010388.5 Latest version!	Mus musculus histocompatibility 2, class II, locus Mb2 (H2-DMb2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OMu23782	NM_010388.4	Mus musculus histocompatibility 2, class II, locus Mb2 (H2-DMb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2-DMb2 ( NM_010388.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034518.1 Mus musculus histocompatibility 2, class II, locus Mb2 (H2-DMb2), mRNA.

Price & Availability↑

CloneID	OMu23782
Clone ID Related Accession (Same CDS sequence)	NM_010388.4 , NM_010388.5
Accession Version	NM_010388.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-25
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II, locus Mb2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U35334.1. On Jul 25, 2007 this sequence version replaced NM_010388.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KJ650224.1, U35334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCAC TCTGGCTGCT GCTGCTGGTC CTCAGTCTGC ACTGTATGGG GGCAGGTGGC 
TTTGTGGCTC ATGTGGAAAG CACGTGCGTG CTGAATGATG CTGGGACCCC ACAGGACTTC 
ACATACTGTG TTTCCTTCAA CAAAGATCTG CTGGCCTGCT GGGATCCAGA TGTGGGAAAA 
ATAGTCCCCT GTGAATTTGG GGTGCTGTCT AGATTGGCTG AAATAATTTC AAATATCCTC 
AACGAACAGG AGAGCCTTAT TCATCGCTTG CAAAACGGGC TTCAGGACTG TGCCACCCAC 
ACCCAACCTT TCTGGGATGT GCTGACCCAC AGAACGAGAG CGCCATCTGT CCGAGTAGCC 
CAAACCACAC CTTTTAACAC AAGGGAGCCC GTGATGCTGG CCTGCTACGT CTGGGGCTTC 
TATCCAGCGG ATGTGACCAT CACATGGATG AAGAATGGGC AGCTTGTCCC TTCCCACAGC 
AACAAGGAGA AGACGGCTCA GCCCAATGGA GACTGGACAT ACCAGACAGT CTCCTACCTA 
GCCCTAACCC CTTCCTACGG GGACGTCTAC ACCTGCGTGG TTCAGCACAG CGGGACCTCT 
GAGCCCATCC GCGGGGACTG GACACCTGGG CTGTCCCCCA TCCAGACAGT GAAGGTCTCT 
GTGTCTGCAG CCACCCTGGG CCTGGGCTTC ATCATCTTCT GTGTTGGCTT CTTCAGATGG 
CGCAAGTCTC ATTCCTCCAG CTACACTCCT CTCCCCGGAT CCACCTACCC AGAAGGACGG 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034518.1
CDS	1..786
Translation	MAALWLLLLVLSLHCMGAGGFVAHVESTCVLNDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISNILNEQESLIHRLQNGLQDCATHTQPFWDVLTHRTRAPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH

Target ORF information:

RefSeq Version	NM_010388.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II, locus Mb2 (H2-DMb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010388.4

ORF Insert Sequence:

ATGGCTGCAC TCTGGCTGCT GCTGCTGGTC CTCAGTCTGC ACTGTATGGG GGCAGGTGGC 
TTTGTGGCTC ATGTGGAAAG CACGTGCGTG CTGAATGATG CTGGGACCCC ACAGGACTTC 
ACATACTGTG TTTCCTTCAA CAAAGATCTG CTGGCCTGCT GGGATCCAGA TGTGGGAAAA 
ATAGTCCCCT GTGAATTTGG GGTGCTGTCT AGATTGGCTG AAATAATTTC AAATATCCTC 
AACGAACAGG AGAGCCTTAT TCATCGCTTG CAAAACGGGC TTCAGGACTG TGCCACCCAC 
ACCCAACCTT TCTGGGATGT GCTGACCCAC AGAACGAGAG CGCCATCTGT CCGAGTAGCC 
CAAACCACAC CTTTTAACAC AAGGGAGCCC GTGATGCTGG CCTGCTACGT CTGGGGCTTC 
TATCCAGCGG ATGTGACCAT CACATGGATG AAGAATGGGC AGCTTGTCCC TTCCCACAGC 
AACAAGGAGA AGACGGCTCA GCCCAATGGA GACTGGACAT ACCAGACAGT CTCCTACCTA 
GCCCTAACCC CTTCCTACGG GGACGTCTAC ACCTGCGTGG TTCAGCACAG CGGGACCTCT 
GAGCCCATCC GCGGGGACTG GACACCTGGG CTGTCCCCCA TCCAGACAGT GAAGGTCTCT 
GTGTCTGCAG CCACCCTGGG CCTGGGCTTC ATCATCTTCT GTGTTGGCTT CTTCAGATGG 
CGCAAGTCTC ATTCCTCCAG CTACACTCCT CTCCCCGGAT CCACCTACCC AGAAGGACGG 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2-DMb2 ( NM_010388.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034518.1 Mus musculus histocompatibility 2, class II, locus Mb2 (H2-DMb2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23782
Clone ID Related Accession (Same CDS sequence)	NM_010388.4 , NM_010388.5
Accession Version	NM_010388.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II, locus Mb2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974422.14. On Feb 22, 2019 this sequence version replaced NM_010388.4. Transcript Variant: This variant (1) represents the protein-coding transcript. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154923.1, SRR6238556.750844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTGCAC TCTGGCTGCT GCTGCTGGTC CTCAGTCTGC ACTGTATGGG GGCAGGTGGC 
TTTGTGGCTC ATGTGGAAAG CACGTGCGTG CTGAATGATG CTGGGACCCC ACAGGACTTC 
ACATACTGTG TTTCCTTCAA CAAAGATCTG CTGGCCTGCT GGGATCCAGA TGTGGGAAAA 
ATAGTCCCCT GTGAATTTGG GGTGCTGTCT AGATTGGCTG AAATAATTTC AAATATCCTC 
AACGAACAGG AGAGCCTTAT TCATCGCTTG CAAAACGGGC TTCAGGACTG TGCCACCCAC 
ACCCAACCTT TCTGGGATGT GCTGACCCAC AGAACGAGAG CGCCATCTGT CCGAGTAGCC 
CAAACCACAC CTTTTAACAC AAGGGAGCCC GTGATGCTGG CCTGCTACGT CTGGGGCTTC 
TATCCAGCGG ATGTGACCAT CACATGGATG AAGAATGGGC AGCTTGTCCC TTCCCACAGC 
AACAAGGAGA AGACGGCTCA GCCCAATGGA GACTGGACAT ACCAGACAGT CTCCTACCTA 
GCCCTAACCC CTTCCTACGG GGACGTCTAC ACCTGCGTGG TTCAGCACAG CGGGACCTCT 
GAGCCCATCC GCGGGGACTG GACACCTGGG CTGTCCCCCA TCCAGACAGT GAAGGTCTCT 
GTGTCTGCAG CCACCCTGGG CCTGGGCTTC ATCATCTTCT GTGTTGGCTT CTTCAGATGG 
CGCAAGTCTC ATTCCTCCAG CTACACTCCT CTCCCCGGAT CCACCTACCC AGAAGGACGG 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034518.1
CDS	168..953
Translation	MAALWLLLLVLSLHCMGAGGFVAHVESTCVLNDAGTPQDFTYCVSFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISNILNEQESLIHRLQNGLQDCATHTQPFWDVLTHRTRAPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHSNKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVKVSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH

Target ORF information:

RefSeq Version	NM_010388.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II, locus Mb2 (H2-DMb2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010388.5

ORF Insert Sequence:

ATGGCTGCAC TCTGGCTGCT GCTGCTGGTC CTCAGTCTGC ACTGTATGGG GGCAGGTGGC 
TTTGTGGCTC ATGTGGAAAG CACGTGCGTG CTGAATGATG CTGGGACCCC ACAGGACTTC 
ACATACTGTG TTTCCTTCAA CAAAGATCTG CTGGCCTGCT GGGATCCAGA TGTGGGAAAA 
ATAGTCCCCT GTGAATTTGG GGTGCTGTCT AGATTGGCTG AAATAATTTC AAATATCCTC 
AACGAACAGG AGAGCCTTAT TCATCGCTTG CAAAACGGGC TTCAGGACTG TGCCACCCAC 
ACCCAACCTT TCTGGGATGT GCTGACCCAC AGAACGAGAG CGCCATCTGT CCGAGTAGCC 
CAAACCACAC CTTTTAACAC AAGGGAGCCC GTGATGCTGG CCTGCTACGT CTGGGGCTTC 
TATCCAGCGG ATGTGACCAT CACATGGATG AAGAATGGGC AGCTTGTCCC TTCCCACAGC 
AACAAGGAGA AGACGGCTCA GCCCAATGGA GACTGGACAT ACCAGACAGT CTCCTACCTA 
GCCCTAACCC CTTCCTACGG GGACGTCTAC ACCTGCGTGG TTCAGCACAG CGGGACCTCT 
GAGCCCATCC GCGGGGACTG GACACCTGGG CTGTCCCCCA TCCAGACAGT GAAGGTCTCT 
GTGTCTGCAG CCACCCTGGG CCTGGGCTTC ATCATCTTCT GTGTTGGCTT CTTCAGATGG 
CGCAAGTCTC ATTCCTCCAG CTACACTCCT CTCCCCGGAT CCACCTACCC AGAAGGACGG 
CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
PLoS genetics11(11)e1005672(2015 Nov)
Logunova N,Korotetskaya M,Polshakov V,Apt A

Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation.
The Journal of experimental medicine195(4)461-72(2002 Feb)
Lankar D,Vincent-Schneider H,Briken V,Yokozeki T,Raposo G,Bonnerot C

H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.
The Journal of biological chemistry276(14)11086-91(2001 Apr)
Walter W,Scheuer C,Loos M,Reichert TE,Maeurer MJ

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?
British journal of cancer83(9)1192-201(2000 Nov)
Walter W,Lingnau K,Schmitt E,Loos M,Maeurer MJ