Gng4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gng4
Entrez Gene ID	14706
Full Name	guanine nucleotide binding protein (G protein), gamma 4
General protein information	Preferred Names guanine nucleotide binding protein (G protein), gamma 4 Names guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 A1\|13 5.29 cM
Summary	This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302997.1	NP_001289926.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor
NM_010317.3	NP_034447.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GNG4	XP_849303.2
Xenopus tropicalis (tropical clawed frog)	gng4	NP_001165066.1
Mus musculus (house mouse)	Gng4	NP_034447.1
Homo sapiens (human)	GNG4	NP_001092191.1
Pan troglodytes (chimpanzee)	GNG4	XP_001155515.1
Bos taurus (cattle)	GNG4	NP_001096794.1
Rattus norvegicus (Norway rat)	Gng4	XP_003751785.1
Gallus gallus (chicken)	GNG4	XP_004935529.1
	LOC718223	XP_001110597.2

Gene Ontology
Bibliography

Related articles in PubMed

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova D, Rocca E, Oonk AM, Schulz H, Rohde E, Bednarsch J, Feenstra I, Pennings RJ, Wende H, Garratt AN
The Journal of clinical investigation124(3)1214-27(2014 Mar)

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Tamplin OJ, Cox BJ, Rossant J
Developmental biology360(2)415-25(2011 Dec)

Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.
Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M
The Journal of cell biology159(4)563-9(2002 Nov)

Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.
Martin N, Jaubert J, Glaser P, Szatanik M, Gu?net JL
Genomics75(1-3)9-16(2001 Jul)

Structure and chromosomal localization of mouse G protein subunit gamma 4 gene.
Kalyanaraman S, Copeland NG, Gilbert DG, Jenkins NA, Gautam N
Genomics49(1)147-51(1998 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gng4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gng4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05951	NM_010317.3 Latest version!	Mus musculus guanine nucleotide binding protein (G protein), gamma 4 (Gng4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu05951	NM_001302997.1 Latest version!	Mus musculus guanine nucleotide binding protein (G protein), gamma 4 (Gng4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gng4 ( NM_001302997.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001289926.1 Mus musculus guanine nucleotide binding protein (G protein), gamma 4 (Gng4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu05951
Clone ID Related Accession (Same CDS sequence)	NM_001302997.1 , NM_010317.3
Accession Version	NM_001302997.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC171200.1. On Dec 10, 2014 this sequence version replaced XM_006516555.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.73529.1, SRR1660813.117981.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGAAG GCATGTCTAA TAACAGCACC ACCAGCATCT CCCAGGCCAG GAAAGCCGTG 
GAGCAGCTGA AGATGGAAGC CTGCATGGAC AGGGTGAAGG TCTCCCAGGC TGCCTCAGAC 
CTCCTGGCCT ACTGTGAAGC CCACGTGCGG GAGGACCCCC TCATCATCCC AGTGCCTGCC 
TCAGAAAACC CCTTCCGGGA GAAGAAGTTC TTCTGCACCA TCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289926.1
CDS	165..392
Translation	MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAASDLLAYCEAHVREDPLIIPVPASENPFREKKFFCTIL

Target ORF information:

RefSeq Version	NM_001302997.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanine nucleotide binding protein (G protein), gamma 4 (Gng4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302997.1

ORF Insert Sequence:

ATGAAGGAAG GCATGTCTAA TAACAGCACC ACCAGCATCT CCCAGGCCAG GAAAGCCGTG 
GAGCAGCTGA AGATGGAAGC CTGCATGGAC AGGGTGAAGG TCTCCCAGGC TGCCTCAGAC 
CTCCTGGCCT ACTGTGAAGC CCACGTGCGG GAGGACCCCC TCATCATCCC AGTGCCTGCC 
TCAGAAAACC CCTTCCGGGA GAAGAAGTTC TTCTGCACCA TCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gng4 ( NM_010317.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034447.1 Mus musculus guanine nucleotide binding protein (G protein), gamma 4 (Gng4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05951
Clone ID Related Accession (Same CDS sequence)	NM_001302997.1 , NM_010317.3
Accession Version	NM_010317.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC171200.1 and BC016506.1. On Dec 10, 2014 this sequence version replaced NM_010317.2. Transcript Variant: This variant (1) represents the longer transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC016506.1, AK148452.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGAAG GCATGTCTAA TAACAGCACC ACCAGCATCT CCCAGGCCAG GAAAGCCGTG 
GAGCAGCTGA AGATGGAAGC CTGCATGGAC AGGGTGAAGG TCTCCCAGGC TGCCTCAGAC 
CTCCTGGCCT ACTGTGAAGC CCACGTGCGG GAGGACCCCC TCATCATCCC AGTGCCTGCC 
TCAGAAAACC CCTTCCGGGA GAAGAAGTTC TTCTGCACCA TCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034447.1
CDS	453..680
Translation	MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAASDLLAYCEAHVREDPLIIPVPASENPFREKKFFCTIL

Target ORF information:

RefSeq Version	NM_010317.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanine nucleotide binding protein (G protein), gamma 4 (Gng4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010317.3

ORF Insert Sequence:

ATGAAGGAAG GCATGTCTAA TAACAGCACC ACCAGCATCT CCCAGGCCAG GAAAGCCGTG 
GAGCAGCTGA AGATGGAAGC CTGCATGGAC AGGGTGAAGG TCTCCCAGGC TGCCTCAGAC 
CTCCTGGCCT ACTGTGAAGC CCACGTGCGG GAGGACCCCC TCATCATCCC AGTGCCTGCC 
TCAGAAAACC CCTTCCGGGA GAAGAAGTTC TTCTGCACCA TCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
The Journal of clinical investigation124(3)1214-27(2014 Mar)
Ragancokova D,Rocca E,Oonk AM,Schulz H,Rohde E,Bednarsch J,Feenstra I,Pennings RJ,Wende H,Garratt AN

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Developmental biology360(2)415-25(2011 Dec)
Tamplin OJ,Cox BJ,Rossant J

Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.
The Journal of cell biology159(4)563-9(2002 Nov)
Bommel H,Xie G,Rossoll W,Wiese S,Jablonka S,Boehm T,Sendtner M

Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.
Genomics75(1-3)9-16(2001 Jul)
Martin N,Jaubert J,Glaser P,Szatanik M,Gu?net JL

Structure and chromosomal localization of mouse G protein subunit gamma 4 gene.
Genomics49(1)147-51(1998 Apr)
Kalyanaraman S,Copeland NG,Gilbert DG,Jenkins NA,Gautam N