Lnx2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lnx2
Entrez Gene ID	140887
Full Name	ligand of numb-protein X 2
Synonyms	9630046H24,AW209022
General protein information	Preferred Names ligand of numb-protein X 2 Names ligand of Numb protein X 2 numb-binding protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006504800.3	XP_006504863.1	ligand of Numb protein X 2 isoform X1
XM_006504800.4	XP_006504863.1	ligand of Numb protein X 2 isoform X1
NM_080795.4	NP_542985.4	ligand of Numb protein X 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LNX2	XP_522642.1
Canis lupus familiaris (dog)	LNX2	XP_005635567.1
Bos taurus (cattle)	LNX2	NP_001069352.1
Mus musculus (house mouse)	Lnx2	NP_542985.4
	LNX2	XP_001096316.1
Gallus gallus (chicken)	LNX2	XP_417122.2
Danio rerio (zebrafish)	lnx2a	NP_001106696.2
Xenopus tropicalis (tropical clawed frog)	lnx2	NP_001072606.1
Rattus norvegicus (Norway rat)	Lnx2	NP_001101799.1
Homo sapiens (human)	LNX2	NP_699202.1

Gene Ontology
Bibliography

Related articles in PubMed

Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases.
Sapir T, Levy T, Kozer N, Shin I, Zamor V, Haffner-Krausz R, McGlade JC, Reiner O
Cerebral cortex (New York, N.Y. : 1991)1-14(2017 Jul)

Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2.
Zhou J, Fujiwara T, Ye S, Li X, Zhao H
Calcified tissue international96(5)465-75(2015 May)

Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
Yin FT, Futagawa T, Li D, Ma YX, Lu MH, Lu L, Li S, Chen Y, Cao YJ, Yang ZZ, Oiso S, Nishida K, Kuchiiwa S, Watanabe K, Yamada K, Takeda Y, Xiao ZC, Ma QH
Stem cells and development24(5)640-52(2015 Mar)

Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis.
Mirza M, Hreinsson J, Strand ML, Hovatta O, S?der O, Philipson L, Pettersson RF, Sollerbrant K
Experimental cell research312(6)817-30(2006 Apr)

The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2).
Mirza M, Raschperger E, Philipson L, Pettersson RF, Sollerbrant K
Experimental cell research309(1)110-20(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

conclude that LNX2 regulates M-CSF/RANKL and the Notch signaling pathways during osteoclastogenesis
Title: Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2.

Caspr4 inhibits neuronal differentiation in a LNX-dependent manner.
Title: Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.

coxsackievirus and adenovirus receptor is a partner in a protein complex organized at specific subcellular sites by LNX2
Title: The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2).

The following Lnx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lnx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu21305	NM_080795.4 Latest version!	Mus musculus ligand of numb-protein X 2 (Lnx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu21305	XM_006504800.4 Latest version!	Mus musculus ligand of numb-protein X 2 (Lnx2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OMu21305	XM_006504800.3	Mus musculus ligand of numb-protein X 2 (Lnx2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lnx2 ( NM_080795.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_542985.4 Mus musculus ligand of numb-protein X 2 (Lnx2), mRNA.

Price & Availability↑

CloneID	OMu21305
Clone ID Related Accession (Same CDS sequence)	XM_006504800.3 , XM_006504800.4 , NM_080795.4
Accession Version	NM_080795.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2064bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	ligand of Numb protein X 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036218.1 and AL513345.20. On Jan 18, 2008 this sequence version replaced NM_080795.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC090665.1, AK170146.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAACAA CCAGTGACGA GATGGTGCCC GTGGAGCAGG CCTCCTCGAC CTCCTCCCTA 
GATCCCCTGT GCTTCGAGTG CGGCCAGCAG CACTGGGCGA GAGAAAACCA CCTGTATAAC 
TACCAGGGGG AGGTGGACGA CGACCTCGTG TGCCACATTT GCCTCCAGCC CCTGCTCCAG 
CCGCTCGACA CGCCCTGCGG ACACACGTTC TGCCACAAGT GCCTCAGAAA CTTCCTGCAG 
GAGAAGGATT TCTGCCCGCT GGACCGCAAG CGGCTTCATT TCAAGCTGTG TAAGAAGTCT 
AGCATCCTGG TCCACAAGCT GCTGGACAAA CTGCTGGTCC TGTGTCCGTT CTCTCCCGTG 
TGCCAAGATG TGATGCAGCG CTGTGACCTA GAGGCACATC TTAAAAACAG GTGTCCTGGA 
GCCTCTCACC GGAGAGTCGA TCTAGAGAGA AGGAAAACGA GTCAAACTCA AACACAGATT 
GAGGGTGAAA CTGGATCTAC TGTCATAGAT CCTCCAGGCA CCTTGCCCCC AGAAACGGAC 
TGCTCGGGCA CCGTGCCTGG CGAGAGGAAC TTGACACCAG CATCTCTTCC TGTGTGGACC 
GAGGAGCCTG GCCTGGACAA CCCCGCCTTC GAGGAGAGCG CTGCAGCTGA CTCTGTACAG 
CAGCCGCTTA GTTTACCAGA AGGAGAGATC ACCACCATTG AGATCCACCG CTCTAACCCG 
TACATCCAGT TAGGAATCAG CATCGTGGGC GGCAACGAGA CACCACTGAT CAACATCGTC 
ATTCAGGAAG TCTACCGGGA CGGGGTCATC GCCAGAGATG GAAGGCTCCT TGCCGGAGAC 
CAGATTCTCC AGGTCAACAA CTATGACATC AGCAACGTGT CCCACAACCA CGCCCGGGCC 
GTGCTTTCCC AGCCCTGCAG CACGCTGCAG CTGACAGTGC TGCGGGAGAG GCGCTTTGGC 
AGCCGTGCCA ACAGCCACGC GGACGGCAGC GCGCCACGGG ACGAGGTCTT CCAGGTGCTG 
CTCCACAAGC GAGACTCGAC AGAGCAGCTC GGCATTAAAC TAGTCCGAAG GACAGATGAG 
CCGGGCGTTT TCATTCTTGA CCTCCTGGAA GGGGGGCTGG CAGCACAGGA CGGCAGGCTC 
AACAGCAATG ACCGGGTGCT GGCCATCAAC GGGCATGACC TGAAGCATGG GACCCCAGAG 
CTCGCTGCCC AGATTATTCA GGCCAGTGGA GAGAGGGTGA ACTTAACAAT TGCCAGACCA 
GGGAAGCCCC AGCCCAGCAA TGGCAGCCGT GAGGCCGGAG CACACAGCAG CAGCAACCAC 
GCTCAGCCAC CCTCGCACAG CCGACCGGGC TCACACAAGG ACCTCACCCG GTGCGTCACG 
TGCCAGGAGA AGCACATCAC TGTAAAGAAG GAGCCGCATG AATCCCTCGG GATGACGGTT 
GCTGGGGGCA GAGGGAGCAA GAGTGGTGAG CTGCCCATCT TTGTGACCAG CGTGCCACCC 
CACGGCTGCC TCGCTCGAGA CGGCAGGATC AAGAGAGGTG ACGTGTTGCT GAACATCAAC 
GGCATTGACC TGACCAACCT AAGTCACAGC GAGGCTGTGG CCATGCTGAA AGCCAGCGCT 
GCGTCTCCGG CCGTCATCCT CAAGGCCCTG GAAGTGCAGA TCGCCGAGGA AGCAGCCCAG 
GCCACCGAGG AGCAGCCGAG CGCCTTCAGT GAGAACGAGT ACGACGCCAG CTGGTCCCCG 
TCCTGGGTCA TGTGGCTCGG GCTGCCAAGT GCCCTTCACA GTTGTCACGA CATCGTCTTA 
CGCAGAAGCT ACTTGGGAAG CTGGGGCTTC AGCATCGTGG GTGGGTACGA AGAGAACCAC 
ACCAATCAGC CCTTCTTCAT TAAGACCATC GTCTTAGGAA CCCCTGCTTA CTATGACGGA 
AGATTAAAGT GTGGAGACAT GATCGTAGCA GTAAACGGCC TGTCGACTGT GGGCATGAGT 
CACTCTGCTC TGGTGCCCAT GTTGAAAGAA CAGAGGAACA AGGTCACGCT GACGGTCATC 
TGCTGGCCAG GCAGCCTCGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542985.4
CDS	214..2277
Translation	MGTTSDEMVPVEQASSTSSLDPLCFECGQQHWARENHLYNYQGEVDDDLVCHICLQPLLQPLDTPCGHTFCHKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSPVCQDVMQRCDLEAHLKNRCPGASHRRVDLERRKTSQTQTQIEGETGSTVIDPPGTLPPETDCSGTVPGERNLTPASLPVWTEEPGLDNPAFEESAAADSVQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYDISNVSHNHARAVLSQPCSTLQLTVLRERRFGSRANSHADGSAPRDEVFQVLLHKRDSTEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLNSNDRVLAINGHDLKHGTPELAAQIIQASGERVNLTIARPGKPQPSNGSREAGAHSSSNHAQPPSHSRPGSHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVILKALEVQIAEEAAQATEEQPSAFSENEYDASWSPSWVMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV

Target ORF information:

RefSeq Version	NM_080795.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ligand of numb-protein X 2 (Lnx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080795.4

ORF Insert Sequence:

ATGGGAACAA CCAGTGACGA GATGGTGCCC GTGGAGCAGG CCTCCTCGAC CTCCTCCCTA 
GATCCCCTGT GCTTCGAGTG CGGCCAGCAG CACTGGGCGA GAGAAAACCA CCTGTATAAC 
TACCAGGGGG AGGTGGACGA CGACCTCGTG TGCCACATTT GCCTCCAGCC CCTGCTCCAG 
CCGCTCGACA CGCCCTGCGG ACACACGTTC TGCCACAAGT GCCTCAGAAA CTTCCTGCAG 
GAGAAGGATT TCTGCCCGCT GGACCGCAAG CGGCTTCATT TCAAGCTGTG TAAGAAGTCT 
AGCATCCTGG TCCACAAGCT GCTGGACAAA CTGCTGGTCC TGTGTCCGTT CTCTCCCGTG 
TGCCAAGATG TGATGCAGCG CTGTGACCTA GAGGCACATC TTAAAAACAG GTGTCCTGGA 
GCCTCTCACC GGAGAGTCGA TCTAGAGAGA AGGAAAACGA GTCAAACTCA AACACAGATT 
GAGGGTGAAA CTGGATCTAC TGTCATAGAT CCTCCAGGCA CCTTGCCCCC AGAAACGGAC 
TGCTCGGGCA CCGTGCCTGG CGAGAGGAAC TTGACACCAG CATCTCTTCC TGTGTGGACC 
GAGGAGCCTG GCCTGGACAA CCCCGCCTTC GAGGAGAGCG CTGCAGCTGA CTCTGTACAG 
CAGCCGCTTA GTTTACCAGA AGGAGAGATC ACCACCATTG AGATCCACCG CTCTAACCCG 
TACATCCAGT TAGGAATCAG CATCGTGGGC GGCAACGAGA CACCACTGAT CAACATCGTC 
ATTCAGGAAG TCTACCGGGA CGGGGTCATC GCCAGAGATG GAAGGCTCCT TGCCGGAGAC 
CAGATTCTCC AGGTCAACAA CTATGACATC AGCAACGTGT CCCACAACCA CGCCCGGGCC 
GTGCTTTCCC AGCCCTGCAG CACGCTGCAG CTGACAGTGC TGCGGGAGAG GCGCTTTGGC 
AGCCGTGCCA ACAGCCACGC GGACGGCAGC GCGCCACGGG ACGAGGTCTT CCAGGTGCTG 
CTCCACAAGC GAGACTCGAC AGAGCAGCTC GGCATTAAAC TAGTCCGAAG GACAGATGAG 
CCGGGCGTTT TCATTCTTGA CCTCCTGGAA GGGGGGCTGG CAGCACAGGA CGGCAGGCTC 
AACAGCAATG ACCGGGTGCT GGCCATCAAC GGGCATGACC TGAAGCATGG GACCCCAGAG 
CTCGCTGCCC AGATTATTCA GGCCAGTGGA GAGAGGGTGA ACTTAACAAT TGCCAGACCA 
GGGAAGCCCC AGCCCAGCAA TGGCAGCCGT GAGGCCGGAG CACACAGCAG CAGCAACCAC 
GCTCAGCCAC CCTCGCACAG CCGACCGGGC TCACACAAGG ACCTCACCCG GTGCGTCACG 
TGCCAGGAGA AGCACATCAC TGTAAAGAAG GAGCCGCATG AATCCCTCGG GATGACGGTT 
GCTGGGGGCA GAGGGAGCAA GAGTGGTGAG CTGCCCATCT TTGTGACCAG CGTGCCACCC 
CACGGCTGCC TCGCTCGAGA CGGCAGGATC AAGAGAGGTG ACGTGTTGCT GAACATCAAC 
GGCATTGACC TGACCAACCT AAGTCACAGC GAGGCTGTGG CCATGCTGAA AGCCAGCGCT 
GCGTCTCCGG CCGTCATCCT CAAGGCCCTG GAAGTGCAGA TCGCCGAGGA AGCAGCCCAG 
GCCACCGAGG AGCAGCCGAG CGCCTTCAGT GAGAACGAGT ACGACGCCAG CTGGTCCCCG 
TCCTGGGTCA TGTGGCTCGG GCTGCCAAGT GCCCTTCACA GTTGTCACGA CATCGTCTTA 
CGCAGAAGCT ACTTGGGAAG CTGGGGCTTC AGCATCGTGG GTGGGTACGA AGAGAACCAC 
ACCAATCAGC CCTTCTTCAT TAAGACCATC GTCTTAGGAA CCCCTGCTTA CTATGACGGA 
AGATTAAAGT GTGGAGACAT GATCGTAGCA GTAAACGGCC TGTCGACTGT GGGCATGAGT 
CACTCTGCTC TGGTGCCCAT GTTGAAAGAA CAGAGGAACA AGGTCACGCT GACGGTCATC 
TGCTGGCCAG GCAGCCTCGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lnx2 ( XM_006504800.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006504863.1 Mus musculus ligand of numb-protein X 2 (Lnx2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu21305
Clone ID Related Accession (Same CDS sequence)	XM_006504800.3 , XM_006504800.4 , NM_080795.4
Accession Version	XM_006504800.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2064bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	ligand of Numb protein X 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006504800.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAACAA CCAGTGACGA GATGGTGCCC GTGGAGCAGG CCTCCTCGAC CTCCTCCCTA 
GATCCCCTGT GCTTCGAGTG CGGCCAGCAG CACTGGGCGA GAGAAAACCA CCTGTATAAC 
TACCAGGGGG AGGTGGACGA CGACCTCGTG TGCCACATTT GCCTCCAGCC CCTGCTCCAG 
CCGCTCGACA CGCCCTGCGG ACACACGTTC TGCCACAAGT GCCTCAGAAA CTTCCTGCAG 
GAGAAGGATT TCTGCCCGCT GGACCGCAAG CGGCTTCATT TCAAGCTGTG TAAGAAGTCT 
AGCATCCTGG TCCACAAGCT GCTGGACAAA CTGCTGGTCC TGTGTCCGTT CTCTCCCGTG 
TGCCAAGATG TGATGCAGCG CTGTGACCTA GAGGCACATC TTAAAAACAG GTGTCCTGGA 
GCCTCTCACC GGAGAGTCGA TCTAGAGAGA AGGAAAACGA GTCAAACTCA AACACAGATT 
GAGGGTGAAA CTGGATCTAC TGTCATAGAT CCTCCAGGCA CCTTGCCCCC AGAAACGGAC 
TGCTCGGGCA CCGTGCCTGG CGAGAGGAAC TTGACACCAG CATCTCTTCC TGTGTGGACC 
GAGGAGCCTG GCCTGGACAA CCCCGCCTTC GAGGAGAGCG CTGCAGCTGA CTCTGTACAG 
CAGCCGCTTA GTTTACCAGA AGGAGAGATC ACCACCATTG AGATCCACCG CTCTAACCCG 
TACATCCAGT TAGGAATCAG CATCGTGGGC GGCAACGAGA CACCACTGAT CAACATCGTC 
ATTCAGGAAG TCTACCGGGA CGGGGTCATC GCCAGAGATG GAAGGCTCCT TGCCGGAGAC 
CAGATTCTCC AGGTCAACAA CTATGACATC AGCAACGTGT CCCACAACCA CGCCCGGGCC 
GTGCTTTCCC AGCCCTGCAG CACGCTGCAG CTGACAGTGC TGCGGGAGAG GCGCTTTGGC 
AGCCGTGCCA ACAGCCACGC GGACGGCAGC GCGCCACGGG ACGAGGTCTT CCAGGTGCTG 
CTCCACAAGC GAGACTCGAC AGAGCAGCTC GGCATTAAAC TAGTCCGAAG GACAGATGAG 
CCGGGCGTTT TCATTCTTGA CCTCCTGGAA GGGGGGCTGG CAGCACAGGA CGGCAGGCTC 
AACAGCAATG ACCGGGTGCT GGCCATCAAC GGGCATGACC TGAAGCATGG GACCCCAGAG 
CTCGCTGCCC AGATTATTCA GGCCAGTGGA GAGAGGGTGA ACTTAACAAT TGCCAGACCA 
GGGAAGCCCC AGCCCAGCAA TGGCAGCCGT GAGGCCGGAG CACACAGCAG CAGCAACCAC 
GCTCAGCCAC CCTCGCACAG CCGACCGGGC TCACACAAGG ACCTCACCCG GTGCGTCACG 
TGCCAGGAGA AGCACATCAC TGTAAAGAAG GAGCCGCATG AATCCCTCGG GATGACGGTT 
GCTGGGGGCA GAGGGAGCAA GAGTGGTGAG CTGCCCATCT TTGTGACCAG CGTGCCACCC 
CACGGCTGCC TCGCTCGAGA CGGCAGGATC AAGAGAGGTG ACGTGTTGCT GAACATCAAC 
GGCATTGACC TGACCAACCT AAGTCACAGC GAGGCTGTGG CCATGCTGAA AGCCAGCGCT 
GCGTCTCCGG CCGTCATCCT CAAGGCCCTG GAAGTGCAGA TCGCCGAGGA AGCAGCCCAG 
GCCACCGAGG AGCAGCCGAG CGCCTTCAGT GAGAACGAGT ACGACGCCAG CTGGTCCCCG 
TCCTGGGTCA TGTGGCTCGG GCTGCCAAGT GCCCTTCACA GTTGTCACGA CATCGTCTTA 
CGCAGAAGCT ACTTGGGAAG CTGGGGCTTC AGCATCGTGG GTGGGTACGA AGAGAACCAC 
ACCAATCAGC CCTTCTTCAT TAAGACCATC GTCTTAGGAA CCCCTGCTTA CTATGACGGA 
AGATTAAAGT GTGGAGACAT GATCGTAGCA GTAAACGGCC TGTCGACTGT GGGCATGAGT 
CACTCTGCTC TGGTGCCCAT GTTGAAAGAA CAGAGGAACA AGGTCACGCT GACGGTCATC 
TGCTGGCCAG GCAGCCTCGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006504863.1
CDS	136..2199
Translation	MGTTSDEMVPVEQASSTSSLDPLCFECGQQHWARENHLYNYQGEVDDDLVCHICLQPLLQPLDTPCGHTFCHKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSPVCQDVMQRCDLEAHLKNRCPGASHRRVDLERRKTSQTQTQIEGETGSTVIDPPGTLPPETDCSGTVPGERNLTPASLPVWTEEPGLDNPAFEESAAADSVQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYDISNVSHNHARAVLSQPCSTLQLTVLRERRFGSRANSHADGSAPRDEVFQVLLHKRDSTEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLNSNDRVLAINGHDLKHGTPELAAQIIQASGERVNLTIARPGKPQPSNGSREAGAHSSSNHAQPPSHSRPGSHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVILKALEVQIAEEAAQATEEQPSAFSENEYDASWSPSWVMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV

Target ORF information:

RefSeq Version	XM_006504800.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ligand of numb-protein X 2 (Lnx2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504800.3

ORF Insert Sequence:

ATGGGAACAA CCAGTGACGA GATGGTGCCC GTGGAGCAGG CCTCCTCGAC CTCCTCCCTA 
GATCCCCTGT GCTTCGAGTG CGGCCAGCAG CACTGGGCGA GAGAAAACCA CCTGTATAAC 
TACCAGGGGG AGGTGGACGA CGACCTCGTG TGCCACATTT GCCTCCAGCC CCTGCTCCAG 
CCGCTCGACA CGCCCTGCGG ACACACGTTC TGCCACAAGT GCCTCAGAAA CTTCCTGCAG 
GAGAAGGATT TCTGCCCGCT GGACCGCAAG CGGCTTCATT TCAAGCTGTG TAAGAAGTCT 
AGCATCCTGG TCCACAAGCT GCTGGACAAA CTGCTGGTCC TGTGTCCGTT CTCTCCCGTG 
TGCCAAGATG TGATGCAGCG CTGTGACCTA GAGGCACATC TTAAAAACAG GTGTCCTGGA 
GCCTCTCACC GGAGAGTCGA TCTAGAGAGA AGGAAAACGA GTCAAACTCA AACACAGATT 
GAGGGTGAAA CTGGATCTAC TGTCATAGAT CCTCCAGGCA CCTTGCCCCC AGAAACGGAC 
TGCTCGGGCA CCGTGCCTGG CGAGAGGAAC TTGACACCAG CATCTCTTCC TGTGTGGACC 
GAGGAGCCTG GCCTGGACAA CCCCGCCTTC GAGGAGAGCG CTGCAGCTGA CTCTGTACAG 
CAGCCGCTTA GTTTACCAGA AGGAGAGATC ACCACCATTG AGATCCACCG CTCTAACCCG 
TACATCCAGT TAGGAATCAG CATCGTGGGC GGCAACGAGA CACCACTGAT CAACATCGTC 
ATTCAGGAAG TCTACCGGGA CGGGGTCATC GCCAGAGATG GAAGGCTCCT TGCCGGAGAC 
CAGATTCTCC AGGTCAACAA CTATGACATC AGCAACGTGT CCCACAACCA CGCCCGGGCC 
GTGCTTTCCC AGCCCTGCAG CACGCTGCAG CTGACAGTGC TGCGGGAGAG GCGCTTTGGC 
AGCCGTGCCA ACAGCCACGC GGACGGCAGC GCGCCACGGG ACGAGGTCTT CCAGGTGCTG 
CTCCACAAGC GAGACTCGAC AGAGCAGCTC GGCATTAAAC TAGTCCGAAG GACAGATGAG 
CCGGGCGTTT TCATTCTTGA CCTCCTGGAA GGGGGGCTGG CAGCACAGGA CGGCAGGCTC 
AACAGCAATG ACCGGGTGCT GGCCATCAAC GGGCATGACC TGAAGCATGG GACCCCAGAG 
CTCGCTGCCC AGATTATTCA GGCCAGTGGA GAGAGGGTGA ACTTAACAAT TGCCAGACCA 
GGGAAGCCCC AGCCCAGCAA TGGCAGCCGT GAGGCCGGAG CACACAGCAG CAGCAACCAC 
GCTCAGCCAC CCTCGCACAG CCGACCGGGC TCACACAAGG ACCTCACCCG GTGCGTCACG 
TGCCAGGAGA AGCACATCAC TGTAAAGAAG GAGCCGCATG AATCCCTCGG GATGACGGTT 
GCTGGGGGCA GAGGGAGCAA GAGTGGTGAG CTGCCCATCT TTGTGACCAG CGTGCCACCC 
CACGGCTGCC TCGCTCGAGA CGGCAGGATC AAGAGAGGTG ACGTGTTGCT GAACATCAAC 
GGCATTGACC TGACCAACCT AAGTCACAGC GAGGCTGTGG CCATGCTGAA AGCCAGCGCT 
GCGTCTCCGG CCGTCATCCT CAAGGCCCTG GAAGTGCAGA TCGCCGAGGA AGCAGCCCAG 
GCCACCGAGG AGCAGCCGAG CGCCTTCAGT GAGAACGAGT ACGACGCCAG CTGGTCCCCG 
TCCTGGGTCA TGTGGCTCGG GCTGCCAAGT GCCCTTCACA GTTGTCACGA CATCGTCTTA 
CGCAGAAGCT ACTTGGGAAG CTGGGGCTTC AGCATCGTGG GTGGGTACGA AGAGAACCAC 
ACCAATCAGC CCTTCTTCAT TAAGACCATC GTCTTAGGAA CCCCTGCTTA CTATGACGGA 
AGATTAAAGT GTGGAGACAT GATCGTAGCA GTAAACGGCC TGTCGACTGT GGGCATGAGT 
CACTCTGCTC TGGTGCCCAT GTTGAAAGAA CAGAGGAACA AGGTCACGCT GACGGTCATC 
TGCTGGCCAG GCAGCCTCGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lnx2 ( XM_006504800.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006504863.1 Mus musculus ligand of numb-protein X 2 (Lnx2), transcript variant X1, mRNA.

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CloneID	OMu21305
Clone ID Related Accession (Same CDS sequence)	XM_006504800.3 , XM_006504800.4 , NM_080795.4
Accession Version	XM_006504800.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2064bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	ligand of Numb protein X 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006504800.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAACAA CCAGTGACGA GATGGTGCCC GTGGAGCAGG CCTCCTCGAC CTCCTCCCTA 
GATCCCCTGT GCTTCGAGTG CGGCCAGCAG CACTGGGCGA GAGAAAACCA CCTGTATAAC 
TACCAGGGGG AGGTGGACGA CGACCTCGTG TGCCACATTT GCCTCCAGCC CCTGCTCCAG 
CCGCTCGACA CGCCCTGCGG ACACACGTTC TGCCACAAGT GCCTCAGAAA CTTCCTGCAG 
GAGAAGGATT TCTGCCCGCT GGACCGCAAG CGGCTTCATT TCAAGCTGTG TAAGAAGTCT 
AGCATCCTGG TCCACAAGCT GCTGGACAAA CTGCTGGTCC TGTGTCCGTT CTCTCCCGTG 
TGCCAAGATG TGATGCAGCG CTGTGACCTA GAGGCACATC TTAAAAACAG GTGTCCTGGA 
GCCTCTCACC GGAGAGTCGA TCTAGAGAGA AGGAAAACGA GTCAAACTCA AACACAGATT 
GAGGGTGAAA CTGGATCTAC TGTCATAGAT CCTCCAGGCA CCTTGCCCCC AGAAACGGAC 
TGCTCGGGCA CCGTGCCTGG CGAGAGGAAC TTGACACCAG CATCTCTTCC TGTGTGGACC 
GAGGAGCCTG GCCTGGACAA CCCCGCCTTC GAGGAGAGCG CTGCAGCTGA CTCTGTACAG 
CAGCCGCTTA GTTTACCAGA AGGAGAGATC ACCACCATTG AGATCCACCG CTCTAACCCG 
TACATCCAGT TAGGAATCAG CATCGTGGGC GGCAACGAGA CACCACTGAT CAACATCGTC 
ATTCAGGAAG TCTACCGGGA CGGGGTCATC GCCAGAGATG GAAGGCTCCT TGCCGGAGAC 
CAGATTCTCC AGGTCAACAA CTATGACATC AGCAACGTGT CCCACAACCA CGCCCGGGCC 
GTGCTTTCCC AGCCCTGCAG CACGCTGCAG CTGACAGTGC TGCGGGAGAG GCGCTTTGGC 
AGCCGTGCCA ACAGCCACGC GGACGGCAGC GCGCCACGGG ACGAGGTCTT CCAGGTGCTG 
CTCCACAAGC GAGACTCGAC AGAGCAGCTC GGCATTAAAC TAGTCCGAAG GACAGATGAG 
CCGGGCGTTT TCATTCTTGA CCTCCTGGAA GGGGGGCTGG CAGCACAGGA CGGCAGGCTC 
AACAGCAATG ACCGGGTGCT GGCCATCAAC GGGCATGACC TGAAGCATGG GACCCCAGAG 
CTCGCTGCCC AGATTATTCA GGCCAGTGGA GAGAGGGTGA ACTTAACAAT TGCCAGACCA 
GGGAAGCCCC AGCCCAGCAA TGGCAGCCGT GAGGCCGGAG CACACAGCAG CAGCAACCAC 
GCTCAGCCAC CCTCGCACAG CCGACCGGGC TCACACAAGG ACCTCACCCG GTGCGTCACG 
TGCCAGGAGA AGCACATCAC TGTAAAGAAG GAGCCGCATG AATCCCTCGG GATGACGGTT 
GCTGGGGGCA GAGGGAGCAA GAGTGGTGAG CTGCCCATCT TTGTGACCAG CGTGCCACCC 
CACGGCTGCC TCGCTCGAGA CGGCAGGATC AAGAGAGGTG ACGTGTTGCT GAACATCAAC 
GGCATTGACC TGACCAACCT AAGTCACAGC GAGGCTGTGG CCATGCTGAA AGCCAGCGCT 
GCGTCTCCGG CCGTCATCCT CAAGGCCCTG GAAGTGCAGA TCGCCGAGGA AGCAGCCCAG 
GCCACCGAGG AGCAGCCGAG CGCCTTCAGT GAGAACGAGT ACGACGCCAG CTGGTCCCCG 
TCCTGGGTCA TGTGGCTCGG GCTGCCAAGT GCCCTTCACA GTTGTCACGA CATCGTCTTA 
CGCAGAAGCT ACTTGGGAAG CTGGGGCTTC AGCATCGTGG GTGGGTACGA AGAGAACCAC 
ACCAATCAGC CCTTCTTCAT TAAGACCATC GTCTTAGGAA CCCCTGCTTA CTATGACGGA 
AGATTAAAGT GTGGAGACAT GATCGTAGCA GTAAACGGCC TGTCGACTGT GGGCATGAGT 
CACTCTGCTC TGGTGCCCAT GTTGAAAGAA CAGAGGAACA AGGTCACGCT GACGGTCATC 
TGCTGGCCAG GCAGCCTCGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006504863.1
CDS	140..2203
Translation	MGTTSDEMVPVEQASSTSSLDPLCFECGQQHWARENHLYNYQGEVDDDLVCHICLQPLLQPLDTPCGHTFCHKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSPVCQDVMQRCDLEAHLKNRCPGASHRRVDLERRKTSQTQTQIEGETGSTVIDPPGTLPPETDCSGTVPGERNLTPASLPVWTEEPGLDNPAFEESAAADSVQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYDISNVSHNHARAVLSQPCSTLQLTVLRERRFGSRANSHADGSAPRDEVFQVLLHKRDSTEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLNSNDRVLAINGHDLKHGTPELAAQIIQASGERVNLTIARPGKPQPSNGSREAGAHSSSNHAQPPSHSRPGSHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVILKALEVQIAEEAAQATEEQPSAFSENEYDASWSPSWVMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV

Target ORF information:

RefSeq Version	XM_006504800.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ligand of numb-protein X 2 (Lnx2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504800.4

ORF Insert Sequence:

ATGGGAACAA CCAGTGACGA GATGGTGCCC GTGGAGCAGG CCTCCTCGAC CTCCTCCCTA 
GATCCCCTGT GCTTCGAGTG CGGCCAGCAG CACTGGGCGA GAGAAAACCA CCTGTATAAC 
TACCAGGGGG AGGTGGACGA CGACCTCGTG TGCCACATTT GCCTCCAGCC CCTGCTCCAG 
CCGCTCGACA CGCCCTGCGG ACACACGTTC TGCCACAAGT GCCTCAGAAA CTTCCTGCAG 
GAGAAGGATT TCTGCCCGCT GGACCGCAAG CGGCTTCATT TCAAGCTGTG TAAGAAGTCT 
AGCATCCTGG TCCACAAGCT GCTGGACAAA CTGCTGGTCC TGTGTCCGTT CTCTCCCGTG 
TGCCAAGATG TGATGCAGCG CTGTGACCTA GAGGCACATC TTAAAAACAG GTGTCCTGGA 
GCCTCTCACC GGAGAGTCGA TCTAGAGAGA AGGAAAACGA GTCAAACTCA AACACAGATT 
GAGGGTGAAA CTGGATCTAC TGTCATAGAT CCTCCAGGCA CCTTGCCCCC AGAAACGGAC 
TGCTCGGGCA CCGTGCCTGG CGAGAGGAAC TTGACACCAG CATCTCTTCC TGTGTGGACC 
GAGGAGCCTG GCCTGGACAA CCCCGCCTTC GAGGAGAGCG CTGCAGCTGA CTCTGTACAG 
CAGCCGCTTA GTTTACCAGA AGGAGAGATC ACCACCATTG AGATCCACCG CTCTAACCCG 
TACATCCAGT TAGGAATCAG CATCGTGGGC GGCAACGAGA CACCACTGAT CAACATCGTC 
ATTCAGGAAG TCTACCGGGA CGGGGTCATC GCCAGAGATG GAAGGCTCCT TGCCGGAGAC 
CAGATTCTCC AGGTCAACAA CTATGACATC AGCAACGTGT CCCACAACCA CGCCCGGGCC 
GTGCTTTCCC AGCCCTGCAG CACGCTGCAG CTGACAGTGC TGCGGGAGAG GCGCTTTGGC 
AGCCGTGCCA ACAGCCACGC GGACGGCAGC GCGCCACGGG ACGAGGTCTT CCAGGTGCTG 
CTCCACAAGC GAGACTCGAC AGAGCAGCTC GGCATTAAAC TAGTCCGAAG GACAGATGAG 
CCGGGCGTTT TCATTCTTGA CCTCCTGGAA GGGGGGCTGG CAGCACAGGA CGGCAGGCTC 
AACAGCAATG ACCGGGTGCT GGCCATCAAC GGGCATGACC TGAAGCATGG GACCCCAGAG 
CTCGCTGCCC AGATTATTCA GGCCAGTGGA GAGAGGGTGA ACTTAACAAT TGCCAGACCA 
GGGAAGCCCC AGCCCAGCAA TGGCAGCCGT GAGGCCGGAG CACACAGCAG CAGCAACCAC 
GCTCAGCCAC CCTCGCACAG CCGACCGGGC TCACACAAGG ACCTCACCCG GTGCGTCACG 
TGCCAGGAGA AGCACATCAC TGTAAAGAAG GAGCCGCATG AATCCCTCGG GATGACGGTT 
GCTGGGGGCA GAGGGAGCAA GAGTGGTGAG CTGCCCATCT TTGTGACCAG CGTGCCACCC 
CACGGCTGCC TCGCTCGAGA CGGCAGGATC AAGAGAGGTG ACGTGTTGCT GAACATCAAC 
GGCATTGACC TGACCAACCT AAGTCACAGC GAGGCTGTGG CCATGCTGAA AGCCAGCGCT 
GCGTCTCCGG CCGTCATCCT CAAGGCCCTG GAAGTGCAGA TCGCCGAGGA AGCAGCCCAG 
GCCACCGAGG AGCAGCCGAG CGCCTTCAGT GAGAACGAGT ACGACGCCAG CTGGTCCCCG 
TCCTGGGTCA TGTGGCTCGG GCTGCCAAGT GCCCTTCACA GTTGTCACGA CATCGTCTTA 
CGCAGAAGCT ACTTGGGAAG CTGGGGCTTC AGCATCGTGG GTGGGTACGA AGAGAACCAC 
ACCAATCAGC CCTTCTTCAT TAAGACCATC GTCTTAGGAA CCCCTGCTTA CTATGACGGA 
AGATTAAAGT GTGGAGACAT GATCGTAGCA GTAAACGGCC TGTCGACTGT GGGCATGAGT 
CACTCTGCTC TGGTGCCCAT GTTGAAAGAA CAGAGGAACA AGGTCACGCT GACGGTCATC 
TGCTGGCCAG GCAGCCTCGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases.
Cerebral cortex (New York, N.Y. : 1991)1-14(2017 Jul)
Sapir T,Levy T,Kozer N,Shin I,Zamor V,Haffner-Krausz R,McGlade JC,Reiner O

Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2.
Calcified tissue international96(5)465-75(2015 May)
Zhou J,Fujiwara T,Ye S,Li X,Zhao H

Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
Stem cells and development24(5)640-52(2015 Mar)
Yin FT,Futagawa T,Li D,Ma YX,Lu MH,Lu L,Li S,Chen Y,Cao YJ,Yang ZZ,Oiso S,Nishida K,Kuchiiwa S,Watanabe K,Yamada K,Takeda Y,Xiao ZC,Ma QH

Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis.
Experimental cell research312(6)817-30(2006 Apr)
Mirza M,Hreinsson J,Strand ML,Hovatta O,S?der O,Philipson L,Pettersson RF,Sollerbrant K

The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2).
Experimental cell research309(1)110-20(2005 Sep)
Mirza M,Raschperger E,Philipson L,Pettersson RF,Sollerbrant K