Kcnn3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnn3
Entrez Gene ID	140493
Full Name	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Synonyms	KCa2.3,SK3,SKCA3
General protein information	Preferred Names potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Names small conductance calcium-activated potassium channel protein 3 SKCa 3 small conductance calcium-activated potassium channel 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_080466.2	NP_536714.2	small conductance calcium-activated potassium channel protein 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Kcnn3	NP_536714.2
Rattus norvegicus (Norway rat)	Kcnn3	NP_062188.2
Danio rerio (zebrafish)	kcnn3	XP_001921794.2
Pan troglodytes (chimpanzee)	KCNN3	XP_003308520.2
Canis lupus familiaris (dog)	KCNN3	XP_547563.2
Homo sapiens (human)	KCNN3	NP_002240.3
Bos taurus (cattle)	KCNN3	XP_003585876.1

Gene Ontology
Bibliography

Related articles in PubMed

Premature contractions of the bladder are suppressed by interactions between TRPV4 and SK3 channels in murine detrusor PDGFR?
Lee H, Koh BH, Peri LE, Corrigan RD, Lee HT, George NE, Bhetwal BP, Xie Y, Perrino BA, Chai TC, Sanders KM, Koh SD
Scientific reports7(1)12245(2017 Sep)

Down-regulation of K
Comerma-Steffensen S, Kun A, Hedegaard ER, Mogensen S, Aalkjaer C, K?hler R, M?nster Christensen B, Simonsen U
Scientific reports7(1)3839(2017 Jun)

Dynamic coupling between TRPV4 and Ca
Li Y, Hu H, Tian JB, Zhu MX, O'Neil RG
American journal of physiology. Renal physiology312(6)F1081-F1089(2017 Jun)

Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.
Sargin D, Oliver DK, Lambe EK
eLife5(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.
Title: Dynamic coupling between TRPV4 and Ca

Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability.
Title: Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.

These results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals' feeding behavior and energy metabolism.
Title: A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism.

SK3 signaling microdomain modulates endothelial Ca(2+) dynamics, vascular tone, and blood pressure. SK3 knockout mice are hypertensive.
Title: Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure.

The data of this study implicated the family of KCNN genes in alcohol, nicotine, and drug addiction, and identify KCNN3 as a mediator of voluntary and excessive alcohol consumption
Title: KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction.

The following Kcnn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13024	NM_080466.2 Latest version!	Mus musculus potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (Kcnn3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnn3 ( NM_080466.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_536714.2 Mus musculus potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (Kcnn3), mRNA.

Price & Availability↑

CloneID	OMu13024
Clone ID Related Accession (Same CDS sequence)	NM_080466.2
Accession Version	NM_080466.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2199bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	small conductance calcium-activated potassium channel protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK137738.1 and AC166364.2. On Oct 30, 2007 this sequence version replaced NM_080466.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK137738.1, BC106769.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGACACTT CTGGGCACTT CCATGACTCG GGGGTGGGGG ACCTGGATGA AGACCCCAAG 
TGTCCCTGTC CATCTTCTGG GGACGAGCAA CAGCAGCAGC AGCAACCGCC ACCACCGCCA 
GCGCCACCAG CAGTCCCCCA GCAGCCTCCG GGACCCTTGC TGCAGCCTCA GCCTCCGCAG 
CCTCAGCAGC AACAGTCGCA GCAGCAGCAG CAGCAGCAGT CGCAGCAGCA GCAGCAGCAG 
GCTCCACTGC ACCCCCTGCC TCAGCTTGCC CAACTCCAGA GCCAGCTTGT CCATCCTGGT 
CTGTTGCACT CTTCTCCCAC GGCGTTCAGG GCCCCCACTT CAGCCAACTC TACCGCCATC 
CTCCACCCTT CCTCCAGGCA AGGCAGCCAG CTAAATCTCA ATGACCACTT GCTTGGCCAC 
TCTCCAAGTT CCACAGCCAC AAGTGGGCCC GGTGGAGGCA GCCGGCACCG GCAGGCCAGC 
CCCCTGGTGC ACCGGCGGGA CAGCAATCCC TTCACGGAGA TAGCTATGAG CTCCTGCAAA 
TACAGCGGTG GGGTCATGAA GCCCCTCAGC CGCCTCAGCG CCTCTCGGAG AAACCTTATC 
GAGGCTGAGC CTGAGGGCCA ACCCCTCCAG CTCTTCAGTC CCAGCAACCC CCCAGAGATT 
ATCATCTCCT CCAGGGAGGA TAACCATGCC CACCAGACTC TGCTCCATCA CCCCAACGCT 
ACCCACAACC ACCAGCATGC CGGCACCACG GCCGGCAGCA CCACCTTCCC CAAAGCCAAC 
AAGCGGAAAA ACCAAAACAT TGGCTATAAG CTGGGACACA GGAGGGCCCT GTTTGAAAAG 
AGAAAGCGAC TGAGTGACTA TGCTCTGATT TTTGGGATGT TTGGAATTGT TGTTATGGTG 
ATAGAGACCG AACTGTCTTG GGGTTTGTAC TCAAAGGATT CCATGTTTTC GTTGGCCCTG 
AAATGCCTTA TCAGTTTATC CACCGTCATC CTGCTTGGTT TGATCATCGC CTATCACACA 
AGGGAAGTAC AGCTCTTTGT GATCGACAAT GGTGCAGATG ACTGGCGGAT AGCCATGACC 
TACGAGCGTA TCCTCTACAT CAGCCTGGAG ATGCTGGTGT GCGCCATCCA CCCCATCCCT 
GGAGAGTACA AGTTCTTCTG GACTGCACGC CTGGCCTTCT CCTATACCCC ATCTCGGGCA 
GAGGCTGACG TGGACATTAT TCTGTCCATC CCCATGTTCC TGCGCCTGTA CCTGATCGCC 
CGGGTCATGC TGCTCCATAG CAAACTCTTC ACTGATGCCT CCTCCCGAAG CATCGGGGCC 
CTCAACAAGA TCAACTTCAA CACCCGATTC GTCATGAAGA CGCTCATGAC CATCTGCCCT 
GGCACGGTGC TGCTGGTGTT CAGCATCTCT CTGTGGATCA TCGCTGCCTG GACTGTGCGA 
GTCTGTGAAA GGTACCATGA TCAGCAGGAT GTAACTAGTA ACTTTCTGGG TGCCATGTGG 
CTCATCTCCA TCACGTTCCT TTCCATTGGC TATGGGGACA TGGTGCCCCA CACATACTGT 
GGGAAAGGTG TCTGTCTTCT CACCGGCATC ATGGGTGCAG GCTGCACTGC CCTTGTGGTA 
GCTGTGGTTG CCCGAAAGCT CGAACTCACC AAAGCAGAGA AGCATGTGCA CAACTTCATG 
ATGGACACTC AGCTCACCAA ACGGATCAAG AATGCCGCCG CCAATGTCCT CCGGGAAACG 
TGGCTAATCT ATAAACATAC AAAGCTGCTA AAGAAGATTG ACCATGCCAA AGTCAGGAAA 
CACCAGAGGA AGTTCCTCCA AGCTATCCAC CAACTGCGGG GTGTCAAGAT GGAACAAAGG 
AAGCTGAGTG ACCAAGCCAA CACCCTGGTG GACCTTTCCA AGATGCAGAA CGTCATGTAT 
GACTTAATCA CGGAGCTCAA TGACCGGAGT GAAGATCTAG AAAAGCAGAT TGGCAGCCTG 
GAGTCCAAGC TGGAGCACCT CACAGCCAGT TTCAATTCCC TGCCCCTGCT CATCGCAGAT 
ACCCTGCGCC AGCAGCAGCA GCAGCTGCTC ACTGCCTTCG TGGAGGCCCG GGGCATCAGT 
GTGGCCGTGG GAACTAGCCA CGCCCCTCCC TCTGACAGCC CTATCGGGAT CAGCTCCACC 
TCTTTCCCAA CCCCATACAC AAGTTCAAGC AGTTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536714.2
CDS	306..2504
Translation	MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPPAPPAVPQQPPGPLLQPQPPQPQQQQSQQQQQQQSQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPTSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTVILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC

Target ORF information:

RefSeq Version	NM_080466.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (Kcnn3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080466.2

ORF Insert Sequence:

ATGGACACTT CTGGGCACTT CCATGACTCG GGGGTGGGGG ACCTGGATGA AGACCCCAAG 
TGTCCCTGTC CATCTTCTGG GGACGAGCAA CAGCAGCAGC AGCAACCGCC ACCACCGCCA 
GCGCCACCAG CAGTCCCCCA GCAGCCTCCG GGACCCTTGC TGCAGCCTCA GCCTCCGCAG 
CCTCAGCAGC AACAGTCGCA GCAGCAGCAG CAGCAGCAGT CGCAGCAGCA GCAGCAGCAG 
GCTCCACTGC ACCCCCTGCC TCAGCTTGCC CAACTCCAGA GCCAGCTTGT CCATCCTGGT 
CTGTTGCACT CTTCTCCCAC GGCGTTCAGG GCCCCCACTT CAGCCAACTC TACCGCCATC 
CTCCACCCTT CCTCCAGGCA AGGCAGCCAG CTAAATCTCA ATGACCACTT GCTTGGCCAC 
TCTCCAAGTT CCACAGCCAC AAGTGGGCCC GGTGGAGGCA GCCGGCACCG GCAGGCCAGC 
CCCCTGGTGC ACCGGCGGGA CAGCAATCCC TTCACGGAGA TAGCTATGAG CTCCTGCAAA 
TACAGCGGTG GGGTCATGAA GCCCCTCAGC CGCCTCAGCG CCTCTCGGAG AAACCTTATC 
GAGGCTGAGC CTGAGGGCCA ACCCCTCCAG CTCTTCAGTC CCAGCAACCC CCCAGAGATT 
ATCATCTCCT CCAGGGAGGA TAACCATGCC CACCAGACTC TGCTCCATCA CCCCAACGCT 
ACCCACAACC ACCAGCATGC CGGCACCACG GCCGGCAGCA CCACCTTCCC CAAAGCCAAC 
AAGCGGAAAA ACCAAAACAT TGGCTATAAG CTGGGACACA GGAGGGCCCT GTTTGAAAAG 
AGAAAGCGAC TGAGTGACTA TGCTCTGATT TTTGGGATGT TTGGAATTGT TGTTATGGTG 
ATAGAGACCG AACTGTCTTG GGGTTTGTAC TCAAAGGATT CCATGTTTTC GTTGGCCCTG 
AAATGCCTTA TCAGTTTATC CACCGTCATC CTGCTTGGTT TGATCATCGC CTATCACACA 
AGGGAAGTAC AGCTCTTTGT GATCGACAAT GGTGCAGATG ACTGGCGGAT AGCCATGACC 
TACGAGCGTA TCCTCTACAT CAGCCTGGAG ATGCTGGTGT GCGCCATCCA CCCCATCCCT 
GGAGAGTACA AGTTCTTCTG GACTGCACGC CTGGCCTTCT CCTATACCCC ATCTCGGGCA 
GAGGCTGACG TGGACATTAT TCTGTCCATC CCCATGTTCC TGCGCCTGTA CCTGATCGCC 
CGGGTCATGC TGCTCCATAG CAAACTCTTC ACTGATGCCT CCTCCCGAAG CATCGGGGCC 
CTCAACAAGA TCAACTTCAA CACCCGATTC GTCATGAAGA CGCTCATGAC CATCTGCCCT 
GGCACGGTGC TGCTGGTGTT CAGCATCTCT CTGTGGATCA TCGCTGCCTG GACTGTGCGA 
GTCTGTGAAA GGTACCATGA TCAGCAGGAT GTAACTAGTA ACTTTCTGGG TGCCATGTGG 
CTCATCTCCA TCACGTTCCT TTCCATTGGC TATGGGGACA TGGTGCCCCA CACATACTGT 
GGGAAAGGTG TCTGTCTTCT CACCGGCATC ATGGGTGCAG GCTGCACTGC CCTTGTGGTA 
GCTGTGGTTG CCCGAAAGCT CGAACTCACC AAAGCAGAGA AGCATGTGCA CAACTTCATG 
ATGGACACTC AGCTCACCAA ACGGATCAAG AATGCCGCCG CCAATGTCCT CCGGGAAACG 
TGGCTAATCT ATAAACATAC AAAGCTGCTA AAGAAGATTG ACCATGCCAA AGTCAGGAAA 
CACCAGAGGA AGTTCCTCCA AGCTATCCAC CAACTGCGGG GTGTCAAGAT GGAACAAAGG 
AAGCTGAGTG ACCAAGCCAA CACCCTGGTG GACCTTTCCA AGATGCAGAA CGTCATGTAT 
GACTTAATCA CGGAGCTCAA TGACCGGAGT GAAGATCTAG AAAAGCAGAT TGGCAGCCTG 
GAGTCCAAGC TGGAGCACCT CACAGCCAGT TTCAATTCCC TGCCCCTGCT CATCGCAGAT 
ACCCTGCGCC AGCAGCAGCA GCAGCTGCTC ACTGCCTTCG TGGAGGCCCG GGGCATCAGT 
GTGGCCGTGG GAACTAGCCA CGCCCCTCCC TCTGACAGCC CTATCGGGAT CAGCTCCACC 
TCTTTCCCAA CCCCATACAC AAGTTCAAGC AGTTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Premature contractions of the bladder are suppressed by interactions between TRPV4 and SK3 channels in murine detrusor PDGFR?
Scientific reports7(1)12245(2017 Sep)
Lee H,Koh BH,Peri LE,Corrigan RD,Lee HT,George NE,Bhetwal BP,Xie Y,Perrino BA,Chai TC,Sanders KM,Koh SD

Down-regulation of K
Scientific reports7(1)3839(2017 Jun)
Comerma-Steffensen S,Kun A,Hedegaard ER,Mogensen S,Aalkjaer C,K?hler R,M?nster Christensen B,Simonsen U

Dynamic coupling between TRPV4 and Ca
American journal of physiology. Renal physiology312(6)F1081-F1089(2017 Jun)
Li Y,Hu H,Tian JB,Zhu MX,O'Neil RG

Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.
eLife5(2016 11)
Sargin D,Oliver DK,Lambe EK