Eif2s1 cDNA ORF clone, Mus musculus(house mouse)

FGF21-induced by carbon monoxide mediates metabolic homeostasis
Joe Y, Kim S, Kim HJ, Park J, Chen Y, Park HJ, Jekal SJ, Ryter SW, Kim UH, Chung HT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2018 Jan)

Exploring the Interaction Between eIF2? Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.
Beauvais G, Rodriguez-Losada N, Ying L, Zakirova Z, Watson JL, Readhead B, Gadue P, French DL, Ehrlich ME, Gonzalez-Alegre P
Neuroscience371455-468(2017 Dec)

Neuroprotection by eIF2?-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.
Huang H, Miao L, Liang F, Liu X, Xu L, Teng X, Wang Q, Ridder WH 3rd, Shindler KS, Sun Y, Hu Y
Cell death & disease8(7)e2936(2017 Jul)

ER stress-induced increase in ATF4 and CHOP expression is initiated by an increase in Atf4 and Chop mRNA, which is also dependent upon eIF2alpha phosphorylation.
Title: The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells.

We hypothesize that the essential role of methionine-charged initiator tRNA in forming ternary complex is responsible for the robust ability of methionine deficiency to induce ATF4 and the ISR even in the absence of GCN2 or eIF2alpha kinase activity.
Title: GCN2- and eIF2?-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells.

Endoplasmic reticulum stress suppressed CReP expression in an IRE1 alpha-dependent manner, which increased eIF2alpha phosphorylation and consequently attenuated protein synthesis.
Title: IRE1?-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2? Phosphorylation and Suppresses Protein Synthesis.

Data indicate that 5xFAD-related pathologies do not necessarily require hyperphosphorylation of eIF2alpha to emerge.
Title: Limited effects of an eIF2?S51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's disease.

eIF2alphaP acts as a molecular switch that dictates either cell survival or death by activated Akt in response to oxidative stress.
Title: Phosphorylation of the translation initiation factor eIF2? at serine 51 determines the cell fate decisions of Akt in response to oxidative stress.