Pawr cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pawr
Entrez Gene ID	114774
Full Name	PRKC, apoptosis, WT1, regulator
Synonyms	2310001G03Rik,PAR4,Par-4
General protein information	Preferred Names PRKC, apoptosis, WT1, regulator Names PRKC apoptosis WT1 regulator protein prostate apoptosis response 4 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_054056.2	NP_473397.1	PRKC apoptosis WT1 regulator protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	PAWR	NP_002574.2
Pan troglodytes (chimpanzee)	PAWR	XP_001163796.1
Bos taurus (cattle)	PAWR	XP_002687221.2
Danio rerio (zebrafish)	pawr	NP_001006015.1
	PAWR	XP_001085206.1
Xenopus tropicalis (tropical clawed frog)	pawr	XP_002935689.2
Mus musculus (house mouse)	Pawr	NP_473397.1
Rattus norvegicus (Norway rat)	Pawr	NP_277020.1
Canis lupus familiaris (dog)	PAWR	XP_005629237.1
Gallus gallus (chicken)	PAWR	XP_416112.4

Gene Ontology
Bibliography

Related articles in PubMed

Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.
Burikhanov R, Hebbar N, Noothi SK, Shukla N, Sledziona J, Araujo N, Kudrimoti M, Wang QJ, Watt DS, Welch DR, Maranchie J, Harada A, Rangnekar VM
Cell reports18(2)508-519(2017 01)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages.
Han JY, Lim YJ, Choi JA, Lee JH, Jo SH, Oh SM, Song CH
Scientific reports632079(2016 Aug)

Par-4/NF-?B Mediates the Apoptosis of Islet ? Cells Induced by Glucolipotoxicity.
QiNan W, XiaGuang G, XiaoTian L, WuQuan D, Ling Z, Bing C
Journal of diabetes research20164692478(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings reveal a novel role for Par-4/NF-kappaB in islet beta cell apoptosis and type 2 diabetes.
Title: Par-4/NF-?B Mediates the Apoptosis of Islet ? Cells Induced by Glucolipotoxicity.

Par4, CEBPB and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT and self-renewal
Title: The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4.

a novel mechanism of apoptosis induction by PAR-4/ceramide-enriched exosomes, which may critically contribute to Alzheimer disease.
Title: Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD).

extracellular Par-4/SAC is systemically functional in inhibition of tumor growth and metastasis progression.
Title: Systemic Par-4 inhibits non-autochthonous tumor growth.

By 6 mo of age, glomerular disease was severe in Par4-/- mice.
Title: Nephrin deficiency activates NF-kappaB and promotes glomerular injury.

The following Pawr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pawr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09530	NM_054056.2 Latest version!	Mus musculus PRKC, apoptosis, WT1, regulator (Pawr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pawr ( NM_054056.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_473397.1 Mus musculus PRKC, apoptosis, WT1, regulator (Pawr), mRNA.

Price & Availability↑

CloneID	OMu09530
Clone ID Related Accession (Same CDS sequence)	NM_054056.2
Accession Version	NM_054056.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-20
Organism	Mus musculus(house mouse)
Product	PRKC apoptosis WT1 regulator protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ363525.1, AW123400.1 and DV057979.1. On Dec 14, 2006 this sequence version replaced NM_054056.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ363525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGCGACCG GCGGCTACCG GAGCGGCGGC AGCACCACCA CGGACTTCCT GGAGGAGTGG 
AAGGCGAAGC GCGAGAAGAT GCGCGCCAAG CAGAACCCCG CGGGCCCGGG GTCGAGCGGC 
GGGGATCCAG CCGCCAAGTC CCCCGCGGGA TCGCTGACCC CGACCGCGGT CGCGGGAACC 
TCGGAGCTCA ACCACGGCCC CGCGGGCGCG GCCGCACCTG CCGCCCCCGC GCCCGGCGCC 
CTGAACTGCG CTCACGGCTC GTCCACGCTG CCCCGCGCGG CTCCCGGCTC CCGGCGGGCG 
GAGGACGAGT GCCCTAGCGC CGCTGCGGCC TCGGGAGCGC CTGGGTCCCG GGGCGATGAG 
GAGGAGCCGG ATAGCGCCCG GGAGAAGGGC CGCAGCTCGG GACCCAGCGC CAGGAAAGGC 
AAGGGGCAGA TCGAGAAGAG GAAGCTGCGG GAGAAGCGCC GCTCCACCGG CGTGGTCAAC 
ATCCCCGCGG CGGAGTGCTT AGATGAGTAC GAAGATGATG AAGCAGGACA GAAGGAACGG 
AAGCGAGAGG ATGCCATCAC CCAGCAAAAC ACCATCCAGA ATGAAGCTGC GACCCTCCCA 
GATCCAGGCA CATCCTACCT GCCCCAGGAC CCGTCGAGAA CAGTTCCAGG CAGATACAAA 
AGCACAACCA GTGCCCCAGA AGATGAAATC TCAAATAGAT ATCCCCGAAC AGACAGAAGT 
GGTTTCAGTA GACACAACAG AGATGCAAAT GCGCCGGCTA GTTTCTCCTC AAGTAGCACC 
TTGGAAAAGA GAATTGAAGA TCTTGAAAAG GAAGTTGTAA GAGAAAGGCA AGAAAACCTT 
CGACTTGTGA GGCTGATGCA AGATAAAGAA GAAATGATTG GGAAACTCAA GGAAGAGATC 
GATTTGTTAA ATAGAGACCT AGATGACATG GAAGATGAGA ACGAGCAACT AAAACAGGAA 
AATAAAACTC TTTTGAAGGT TGTTGGGCAG CTGACAAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_473397.1
CDS	190..1191
Translation	MATGGYRSGGSTTTDFLEEWKAKREKMRAKQNPAGPGSSGGDPAAKSPAGSLTPTAVAGTSELNHGPAGAAAPAAPAPGALNCAHGSSTLPRAAPGSRRAEDECPSAAAASGAPGSRGDEEEPDSAREKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAATLPDPGTSYLPQDPSRTVPGRYKSTTSAPEDEISNRYPRTDRSGFSRHNRDANAPASFSSSSTLEKRIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR

Target ORF information:

RefSeq Version	NM_054056.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus PRKC, apoptosis, WT1, regulator (Pawr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054056.2

ORF Insert Sequence:

ATGGCGACCG GCGGCTACCG GAGCGGCGGC AGCACCACCA CGGACTTCCT GGAGGAGTGG 
AAGGCGAAGC GCGAGAAGAT GCGCGCCAAG CAGAACCCCG CGGGCCCGGG GTCGAGCGGC 
GGGGATCCAG CCGCCAAGTC CCCCGCGGGA TCGCTGACCC CGACCGCGGT CGCGGGAACC 
TCGGAGCTCA ACCACGGCCC CGCGGGCGCG GCCGCACCTG CCGCCCCCGC GCCCGGCGCC 
CTGAACTGCG CTCACGGCTC GTCCACGCTG CCCCGCGCGG CTCCCGGCTC CCGGCGGGCG 
GAGGACGAGT GCCCTAGCGC CGCTGCGGCC TCGGGAGCGC CTGGGTCCCG GGGCGATGAG 
GAGGAGCCGG ATAGCGCCCG GGAGAAGGGC CGCAGCTCGG GACCCAGCGC CAGGAAAGGC 
AAGGGGCAGA TCGAGAAGAG GAAGCTGCGG GAGAAGCGCC GCTCCACCGG CGTGGTCAAC 
ATCCCCGCGG CGGAGTGCTT AGATGAGTAC GAAGATGATG AAGCAGGACA GAAGGAACGG 
AAGCGAGAGG ATGCCATCAC CCAGCAAAAC ACCATCCAGA ATGAAGCTGC GACCCTCCCA 
GATCCAGGCA CATCCTACCT GCCCCAGGAC CCGTCGAGAA CAGTTCCAGG CAGATACAAA 
AGCACAACCA GTGCCCCAGA AGATGAAATC TCAAATAGAT ATCCCCGAAC AGACAGAAGT 
GGTTTCAGTA GACACAACAG AGATGCAAAT GCGCCGGCTA GTTTCTCCTC AAGTAGCACC 
TTGGAAAAGA GAATTGAAGA TCTTGAAAAG GAAGTTGTAA GAGAAAGGCA AGAAAACCTT 
CGACTTGTGA GGCTGATGCA AGATAAAGAA GAAATGATTG GGAAACTCAA GGAAGAGATC 
GATTTGTTAA ATAGAGACCT AGATGACATG GAAGATGAGA ACGAGCAACT AAAACAGGAA 
AATAAAACTC TTTTGAAGGT TGTTGGGCAG CTGACAAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.
Cell reports18(2)508-519(2017 01)
Burikhanov R,Hebbar N,Noothi SK,Shukla N,Sledziona J,Araujo N,Kudrimoti M,Wang QJ,Watt DS,Welch DR,Maranchie J,Harada A,Rangnekar VM

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages.
Scientific reports632079(2016 Aug)
Han JY,Lim YJ,Choi JA,Lee JH,Jo SH,Oh SM,Song CH

Par-4/NF-?B Mediates the Apoptosis of Islet ? Cells Induced by Glucolipotoxicity.
Journal of diabetes research20164692478(2016)
QiNan W,XiaGuang G,XiaoTian L,WuQuan D,Ling Z,Bing C