Acat1 cDNA ORF clone, Mus musculus(house mouse)

Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant.
Hai Q, Ritchey B, Robinet P, Alzayed AM, Brubaker G, Zhang J, Smith JD
Arteriosclerosis, thrombosis, and vascular biology38(1)83-91(2018 Jan)

miR-467b regulates the cholesterol ester formation via targeting ACAT1 gene in RAW 264.7 macrophages.
Wang B, He PP, Zeng GF, Zhang T, Ou Yang XP
Biochimie13238-44(2017 Jan)

Data show that microRNA miR-467b regulates the acetyl-CoA acetyltransferase 1 (ACAT1) expression via targeting ACAT1 3' untranslated regions (3'UTR).
Title: miR-467b regulates the cholesterol ester formation via targeting ACAT1 gene in RAW 264.7 macrophages.

In a mouse model, targeting ACAT1 specifically in a myeloid lineage may benefit atherosclerosis progression by reducing the infiltration of foamy macrophages.
Title: Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.

Its blockage enhances autophagy of and reduces human p301L-tau content in brain neurons of pre-symptomatic stage of Alzheimer disease.
Title: Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.

Oxidized low-density lipoprotein activated the TLR4/MyD88/NF-kappaB inflammatory signaling pathway in vascular smooth muscle cell, which upregulates the ACAT1 expression and promotes VSMC foam cell formation.
Title: TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression.

Exacerbation of liver fibrosis by ACAT1 deficiency was dependent on free cholesterol accumulation-induced enhancement of TLR4 signaling.
Title: Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.