CRYZL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRYZL1
Entrez Gene ID	9946
Full Name	crystallin zeta like 1
Synonyms	4P11,QOH-1
General protein information	Preferred Names crystallin zeta like 1 Names quinone oxidoreductase-like protein 1 crystallin, zeta (quinone reductase)-like 1 protein 4P11 quinone oxidoreductase homolog 1 quinone reductase-like 1 zeta-crystallin homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.11
Summary	This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	603920

mRNA and Protein(s)

mRNA	Protein	Name
NM_145858.3	NP_665857.2	quinone oxidoreductase-like protein 1
NM_145858.2	NP_665857.2	quinone oxidoreductase-like protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CRYZL1	NP_665857.2
Canis lupus familiaris (dog)	CRYZL1	XP_535585.1
Gallus gallus (chicken)	CRYZL1	XP_004934579.1
Xenopus tropicalis (tropical clawed frog)	cryzl1	NP_001016084.1
Pan troglodytes (chimpanzee)	CRYZL1	XP_531441.3
Bos taurus (cattle)	CRYZL1	NP_001030209.2
	CRYZL1	XP_001090445.1
Canis lupus familiaris (dog)	LOC100856647	XP_003640128.1
Mus musculus (house mouse)	Cryzl1	NP_598440.1
Rattus norvegicus (Norway rat)	Cryzl1	NP_001013062.1
Danio rerio (zebrafish)	cryzl1	NP_001002633.1

Gene Ontology
Bibliography

Related articles in PubMed

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)

Human and yeast zeta-crystallins bind AU-rich elements in RNA.
Fern?ndez MR, Port? S, Crosas E, Barber? N, Farr?s J, Biosca JA, Par?s X
Cellular and molecular life sciences : CMLS64(11)1419-27(2007 Jun)

Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.
Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M
BMC genomics7155(2006 Jun)

Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1.
Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J
Genomics57(1)156-9(1999 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that human and yeast zeta-crystallins bind AU-rich elements in RNA.
Title: Human and yeast zeta-crystallins bind AU-rich elements in RNA.

The following CRYZL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRYZL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06593	NM_145858.3 Latest version!	Homo sapiens crystallin zeta like 1 (CRYZL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu06593	NM_145858.2	Homo sapiens crystallin zeta like 1 (CRYZL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRYZL1 ( NM_145858.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_665857.2 Homo sapiens crystallin zeta like 1 (CRYZL1), mRNA.

Price & Availability↑

CloneID	OHu06593
Clone ID Related Accession (Same CDS sequence)	NM_145858.3 , NM_145858.2
Accession Version	NM_145858.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	quinone oxidoreductase-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB037192.1, BC033023.2 and CA426424.1. On Nov 22, 2018 this sequence version replaced NM_145858.2. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.3152.1, SRR3476690.602373.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381554.8/ ENSP00000370966.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAAGGCT TATATTTCCA ACAGAGTTCC ACAGATGAAG AAATAACATT TGTATTTCAA 
GAAAAGGAAG ATCTTCCTGT TACAGAGGAT AACTTTGTGA AACTTCAAGT TAAAGCTTGT 
GCTCTGAGCC AGATAAATAC AAAGCTTCTG GCAGAAATGA AGATGAAAAA GGATTTATTT 
CCTGTTGGGA GAGAAATTGC TGGAATTGTA TTAGATGTTG GAAGCAAGGT ATCATTCTTT 
CAACCAGATG ATGAAGTAGT TGGAATTTTG CCCCTGGACT CTGAAGACCC TGGACTTTGT 
GAAGTTGTTA GAGTACATGA GCATTACTTG GTTCATAAAC CAGAAAAGGT CACATGGACG 
GAAGCAGCAG GAAGCATTCG GGATGGAGTG CGTGCCTATA CAGCTCTGCA TTATCTTTCT 
CATCTCTCTC CTGGAAAATC AGTGCTGATA ATGGATGGAG CAAGTGCATT TGGTACAATA 
GCTATTCAGT TAGCACATCA TAGAGGAGCC AAAGTGATTT CAACAGCATG CAGCCTTGAA 
GATAAGCAGT GCCTTGAAAG ATTCAGACCT CCCATAGCCC GAGTGATTGA TGTATCTAAT 
GGGAAAGTTC ATGTTGCTGA AAGCTGTTTG GAAGAAACAG GTGGCCTGGG AGTAGATATT 
GTCCTAGATG CTGGAGTGAG ATTATATAGT AAAGATGATG AACCAGCTGT AAAACTACAA 
CTACTACCAC ATAAACATGA TATCATCACA CTTCTTGGTG TTGGAGGCCA CTGGGTAACA 
ACAGAAGAAA ACCTTCAGTT GGATCCTCCA GATAGCCACT GCCTTTTCCT CAAGGGAGCA 
ACGTTAGCTT TCCTGAATGA TGAAGTTTGG AATTTGTCAA ATGTACAACA GGGAAAATAT 
CTTTGTATCT TAAAGGATGT GATGGAGAAG TTATCAACTG GTGTTTTCAG ACCTCAGTTG 
GATGAACCCA TTCCACTGTA TGAGGCAAAA GTTTCCATGG AAGCTGTTCA GAAAAATCAA 
GGAAGAAAAA AGCAAGTTGT TCAATTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665857.2
CDS	68..1117
Translation	MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF

Target ORF information:

RefSeq Version	NM_145858.3
Organism	Homo sapiens(human)
Definition	Homo sapiens crystallin zeta like 1 (CRYZL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145858.3

ORF Insert Sequence:

ATGAAAGGCT TATATTTCCA ACAGAGTTCC ACAGATGAAG AAATAACATT TGTATTTCAA 
GAAAAGGAAG ATCTTCCTGT TACAGAGGAT AACTTTGTGA AACTTCAAGT TAAAGCTTGT 
GCTCTGAGCC AGATAAATAC AAAGCTTCTG GCAGAAATGA AGATGAAAAA GGATTTATTT 
CCTGTTGGGA GAGAAATTGC TGGAATTGTA TTAGATGTTG GAAGCAAGGT ATCATTCTTT 
CAACCAGATG ATGAAGTAGT TGGAATTTTG CCCCTGGACT CTGAAGACCC TGGACTTTGT 
GAAGTTGTTA GAGTACATGA GCATTACTTG GTTCATAAAC CAGAAAAGGT CACATGGACG 
GAAGCAGCAG GAAGCATTCG GGATGGAGTG CGTGCCTATA CAGCTCTGCA TTATCTTTCT 
CATCTCTCTC CTGGAAAATC AGTGCTGATA ATGGATGGAG CAAGTGCATT TGGTACAATA 
GCTATTCAGT TAGCACATCA TAGAGGAGCC AAAGTGATTT CAACAGCATG CAGCCTTGAA 
GATAAGCAGT GCCTTGAAAG ATTCAGACCT CCCATAGCCC GAGTGATTGA TGTATCTAAT 
GGGAAAGTTC ATGTTGCTGA AAGCTGTTTG GAAGAAACAG GTGGCCTGGG AGTAGATATT 
GTCCTAGATG CTGGAGTGAG ATTATATAGT AAAGATGATG AACCAGCTGT AAAACTACAA 
CTACTACCAC ATAAACATGA TATCATCACA CTTCTTGGTG TTGGAGGCCA CTGGGTAACA 
ACAGAAGAAA ACCTTCAGTT GGATCCTCCA GATAGCCACT GCCTTTTCCT CAAGGGAGCA 
ACGTTAGCTT TCCTGAATGA TGAAGTTTGG AATTTGTCAA ATGTACAACA GGGAAAATAT 
CTTTGTATCT TAAAGGATGT GATGGAGAAG TTATCAACTG GTGTTTTCAG ACCTCAGTTG 
GATGAACCCA TTCCACTGTA TGAGGCAAAA GTTTCCATGG AAGCTGTTCA GAAAAATCAA 
GGAAGAAAAA AGCAAGTTGT TCAATTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRYZL1 ( NM_145858.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_665857.2 Homo sapiens crystallin zeta like 1 (CRYZL1), mRNA.

Price & Availability↑

CloneID	OHu06593
Clone ID Related Accession (Same CDS sequence)	NM_145858.3 , NM_145858.2
Accession Version	NM_145858.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	quinone oxidoreductase-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB037192.1, BC033023.2 and CA426424.1. On or before Mar 28, 2006 this sequence version replaced NM_005111.5, NM_145858.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.375974.1, SRR1660803.101405.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGGCT TATATTTCCA ACAGAGTTCC ACAGATGAAG AAATAACATT TGTATTTCAA 
GAAAAGGAAG ATCTTCCTGT TACAGAGGAT AACTTTGTGA AACTTCAAGT TAAAGCTTGT 
GCTCTGAGCC AGATAAATAC AAAGCTTCTG GCAGAAATGA AGATGAAAAA GGATTTATTT 
CCTGTTGGGA GAGAAATTGC TGGAATTGTA TTAGATGTTG GAAGCAAGGT ATCATTCTTT 
CAACCAGATG ATGAAGTAGT TGGAATTTTG CCCCTGGACT CTGAAGACCC TGGACTTTGT 
GAAGTTGTTA GAGTACATGA GCATTACTTG GTTCATAAAC CAGAAAAGGT CACATGGACG 
GAAGCAGCAG GAAGCATTCG GGATGGAGTG CGTGCCTATA CAGCTCTGCA TTATCTTTCT 
CATCTCTCTC CTGGAAAATC AGTGCTGATA ATGGATGGAG CAAGTGCATT TGGTACAATA 
GCTATTCAGT TAGCACATCA TAGAGGAGCC AAAGTGATTT CAACAGCATG CAGCCTTGAA 
GATAAGCAGT GCCTTGAAAG ATTCAGACCT CCCATAGCCC GAGTGATTGA TGTATCTAAT 
GGGAAAGTTC ATGTTGCTGA AAGCTGTTTG GAAGAAACAG GTGGCCTGGG AGTAGATATT 
GTCCTAGATG CTGGAGTGAG ATTATATAGT AAAGATGATG AACCAGCTGT AAAACTACAA 
CTACTACCAC ATAAACATGA TATCATCACA CTTCTTGGTG TTGGAGGCCA CTGGGTAACA 
ACAGAAGAAA ACCTTCAGTT GGATCCTCCA GATAGCCACT GCCTTTTCCT CAAGGGAGCA 
ACGTTAGCTT TCCTGAATGA TGAAGTTTGG AATTTGTCAA ATGTACAACA GGGAAAATAT 
CTTTGTATCT TAAAGGATGT GATGGAGAAG TTATCAACTG GTGTTTTCAG ACCTCAGTTG 
GATGAACCCA TTCCACTGTA TGAGGCAAAA GTTTCCATGG AAGCTGTTCA GAAAAATCAA 
GGAAGAAAAA AGCAAGTTGT TCAATTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665857.2
CDS	181..1230
Translation	MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF

Target ORF information:

RefSeq Version	NM_145858.2
Organism	Homo sapiens(human)
Definition	Homo sapiens crystallin zeta like 1 (CRYZL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145858.2

ORF Insert Sequence:

ATGAAAGGCT TATATTTCCA ACAGAGTTCC ACAGATGAAG AAATAACATT TGTATTTCAA 
GAAAAGGAAG ATCTTCCTGT TACAGAGGAT AACTTTGTGA AACTTCAAGT TAAAGCTTGT 
GCTCTGAGCC AGATAAATAC AAAGCTTCTG GCAGAAATGA AGATGAAAAA GGATTTATTT 
CCTGTTGGGA GAGAAATTGC TGGAATTGTA TTAGATGTTG GAAGCAAGGT ATCATTCTTT 
CAACCAGATG ATGAAGTAGT TGGAATTTTG CCCCTGGACT CTGAAGACCC TGGACTTTGT 
GAAGTTGTTA GAGTACATGA GCATTACTTG GTTCATAAAC CAGAAAAGGT CACATGGACG 
GAAGCAGCAG GAAGCATTCG GGATGGAGTG CGTGCCTATA CAGCTCTGCA TTATCTTTCT 
CATCTCTCTC CTGGAAAATC AGTGCTGATA ATGGATGGAG CAAGTGCATT TGGTACAATA 
GCTATTCAGT TAGCACATCA TAGAGGAGCC AAAGTGATTT CAACAGCATG CAGCCTTGAA 
GATAAGCAGT GCCTTGAAAG ATTCAGACCT CCCATAGCCC GAGTGATTGA TGTATCTAAT 
GGGAAAGTTC ATGTTGCTGA AAGCTGTTTG GAAGAAACAG GTGGCCTGGG AGTAGATATT 
GTCCTAGATG CTGGAGTGAG ATTATATAGT AAAGATGATG AACCAGCTGT AAAACTACAA 
CTACTACCAC ATAAACATGA TATCATCACA CTTCTTGGTG TTGGAGGCCA CTGGGTAACA 
ACAGAAGAAA ACCTTCAGTT GGATCCTCCA GATAGCCACT GCCTTTTCCT CAAGGGAGCA 
ACGTTAGCTT TCCTGAATGA TGAAGTTTGG AATTTGTCAA ATGTACAACA GGGAAAATAT 
CTTTGTATCT TAAAGGATGT GATGGAGAAG TTATCAACTG GTGTTTTCAG ACCTCAGTTG 
GATGAACCCA TTCCACTGTA TGAGGCAAAA GTTTCCATGG AAGCTGTTCA GAAAAATCAA 
GGAAGAAAAA AGCAAGTTGT TCAATTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Proceedings of the National Academy of Sciences of the United States of America111(38)13790-4(2014 Sep)
Rietveld CA,Esko T,Davies G,Pers TH,Turley P,Benyamin B,Chabris CF,Emilsson V,Johnson AD,Lee JJ,de Leeuw C,Marioni RE,Medland SE,Miller MB,Rostapshova O,van der Lee SJ,Vinkhuyzen AA,Amin N,Conley D,Derringer J,van Duijn CM,Fehrmann R,Franke L,Glaeser EL,Hansell NK,Hayward C,Iacono WG,Ibrahim-Verbaas C,Jaddoe V,Karjalainen J,Laibson D,Lichtenstein P,Liewald DC,Magnusson PK,Martin NG,McGue M,McMahon G,Pedersen NL,Pinker S,Porteous DJ,Posthuma D,Rivadeneira F,Smith BH,Starr JM,Tiemeier H,Timpson NJ,Trzaskowski M,Uitterlinden AG,Verhulst FC,Ward ME,Wright MJ,Davey Smith G,Deary IJ,Johannesson M,Plomin R,Visscher PM,Benjamin DJ,Cesarini D,Koellinger PD

Human and yeast zeta-crystallins bind AU-rich elements in RNA.
Cellular and molecular life sciences : CMLS64(11)1419-27(2007 Jun)
Fern?ndez MR,Port? S,Crosas E,Barber? N,Farr?s J,Biosca JA,Par?s X

Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.
BMC genomics7155(2006 Jun)
Hu YH,Warnatz HJ,Vanhecke D,Wagner F,Fiebitz A,Thamm S,Kahlem P,Lehrach H,Yaspo ML,Janitz M

Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1.
Genomics57(1)156-9(1999 Apr)
Kim MY,Lee HK,Park JS,Park SH,Kwon HB,Soh J