SCRN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCRN1
Entrez Gene ID	9805
Full Name	secernin 1
Synonyms	SES1
General protein information	Preferred Names secernin 1 Names secernin-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.3
Summary	This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009].
Disorder MIM:	614965

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145515.1	NP_001138987.1	secernin-1 isoform c
NM_001145513.1	NP_001138985.1	secernin-1 isoform a
NM_014766.4	NP_055581.3	secernin-1 isoform a
XM_024447007.1	XP_024302775.1	secernin-1 isoform X1
NM_001145514.1	NP_001138986.1	secernin-1 isoform b
NM_014766.5	NP_055581.3	secernin-1 isoform a
NM_001145515.2	NP_001138987.1	secernin-1 isoform c

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SCRN1	XP_539497.2
Bos taurus (cattle)	SCRN1	NP_001104273.1
Mus musculus (house mouse)	Scrn1	NP_081544.1
Rattus norvegicus (Norway rat)	Scrn1	NP_001020234.1
Xenopus tropicalis (tropical clawed frog)	scrn1	XP_002933425.1
Homo sapiens (human)	SCRN1	NP_001138986.1
Gallus gallus (chicken)	SCRN1	XP_418734.4
Pan troglodytes (chimpanzee)	SCRN1	XP_003318279.1

Gene Ontology
Bibliography

Related articles in PubMed

Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.
Kim N, Cho A, Watanabe H, Choi YL, Aziz M, Kassner M, Joung JG, Park AK, Francis JM, Bae JS, Ahn SM, Kim KM, Park JO, Park WY, Ahn MJ, Park K, Koo J, Yin HH, Cho J
Oncotarget7(12)13797-809(2016 Mar)

A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer.
Song P, Zhu H, Zhang D, Chu H, Wu D, Kang M, Wang M, Gong W, Zhou J, Zhang Z, Zhao Q
Scientific reports47080(2014 Nov)

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S
Journal of proteome research11(4)2533-43(2012 Apr)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics.
Suehara Y, Tochigi N, Kubota D, Kikuta K, Nakayama R, Seki K, Yoshida A, Ichikawa H, Hasegawa T, Kaneko K, Chuman H, Beppu Y, Kawai A, Kondo T
Journal of proteomics74(6)829-42(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Upregulation of SCRN1 is associated with acquired resistance to erlotinib in non-small cell lung cancer.
Title: Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.

Luciferase report assay showed that the rs6976789 variant T allele influenced the binding ability of miR-148a. Our results suggested that the SCRN1 rs6976789 polymorphism may play an important role in the GC development and progression
Title: A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer.

A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.

in synovial sarcoma, metastasis-free survival was significantly higher in the group with high secernin-1 expression compared to low expression; results indicate secernin-1 may be used as a biomarker to predict overall and metastasis-free survival
Title: Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics.

This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Title: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.

The following SCRN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCRN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02684	NM_001145514.1 Latest version!	Homo sapiens secernin 1 (SCRN1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu02686	NM_001145515.2 Latest version!	Homo sapiens secernin 1 (SCRN1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu13636	NM_014766.5 Latest version!	Homo sapiens secernin 1 (SCRN1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu13636	NM_001145513.1 Latest version!	Homo sapiens secernin 1 (SCRN1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu13636	XM_024447007.1 Latest version!	Homo sapiens secernin 1 (SCRN1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu13636	NM_014766.4	Homo sapiens secernin 1 (SCRN1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu02686	NM_001145515.1	Homo sapiens secernin 1 (SCRN1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCRN1 ( NM_001145514.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138986.1 Homo sapiens secernin 1 (SCRN1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu02684
Clone ID Related Accession (Same CDS sequence)	NM_001145514.1
Accession Version	NM_001145514.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	secernin-1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK295172.1, AB071705.1 and AA910381.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK295172.1, SRR1803615.5160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTACAGG ACGGCACTTT TAAAACCAGG GACTCGACTT GGACGTGCGA GTCAACAAGG 
ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138986.1
CDS	50..1354
Translation	MVQDGTFKTRDSTWTCESTRMAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Target ORF information:

RefSeq Version	NM_001145514.1
Organism	Homo sapiens(human)
Definition	Homo sapiens secernin 1 (SCRN1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145514.1

ORF Insert Sequence:

ATGGTACAGG ACGGCACTTT TAAAACCAGG GACTCGACTT GGACGTGCGA GTCAACAAGG 
ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCRN1 ( NM_001145515.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138987.1 Homo sapiens secernin 1 (SCRN1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu02686
Clone ID Related Accession (Same CDS sequence)	NM_001145515.1 , NM_001145515.2
Accession Version	NM_001145515.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	secernin-1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC370097.1, AK295713.1, AB071705.1 and AA910381.1. Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.226376.1, SRR1803614.172233.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATAAGCA GACCCGCCTG GCTCTGGGGA GCAGAAATGG GAGCCAATGA ACATGGAGTG 
TGCATAGCCA ATGAAGCCAT CAACACCAGA GAGCCAGCTG CCGAGATAGA AGCCTTGCTG 
GGGATGGATC TGGTCAGGCT TGGTTTAGAA AGAGGGGAAA CAGCTAAAGA AGCCTTAGAT 
GTCATTGTCT CCTTGTTGGA AGAACATGGA CAAGGTGGGA ATTACTTTGA AGATGCAAAC 
TCCTGCCACA GCTTCCAAAG TGCATATCTG ATTGTGGATC GTGATGAAGC CTGGGTGCTC 
GAGACCATAG GGAAGTACTG GGCTGCCGAG AAAGTCACAG AGGGAGTGAG GTGCATTTGC 
AGTCAGCTTT CGCTCACCAC TAAGATGGAT GCAGAGCATC CGGAACTCAG GAGTTACGCT 
CAGAGCCAAG GTTGGTGGAC GGGAGAGGGC GAGTTCAATT TTTCCGAAGT CTTTTCTCCA 
GTTGAGGATC ATCTAGACTG CGGTGCTGGC AAAGACAGCT TAGAAAAACA AGAAGAAAGC 
ATCACAGTGC AGACTATGAT GAACACCTTA CGGGACAAAG CCAGCGGAGT GTGCATAGAC 
TCTGAGTTTT TCCTCACCAC AGCCAGTGGA GTGTCTGTCC TGCCGCAGAA TAGAAGCTCT 
CCGTGCATTC ACTACTTCAC TGGAACCCCT GATCCTTCCA GGTCCATATT CAAGCCTTTC 
ATCTTTGTTG ATGACGTAAA ACTTGTCCCC AAAACACAGT CTCCCTGTTT TGGGGATGAC 
GACCCTGCCA AAAAGGAGCC TCGGTTCCAG GAGAAACCAG ACCGCCGGCA TGAGCTGTAC 
AAAGCCCACG AGTGGGCACG TGCCATCATC GAAAGTGACC AGGAGCAAGG TCGCAAGCTG 
AGGAGCACCA TGCTGGAGCT GGAGAAGCAA GGCCTGGAAG CCATGGAAGA AATCCTGACC 
AGCTCCGAGC CACTGGACCC TGCGGAAGTG GGGGACCTTT TCTATGACTG TGTTGACACG 
GAGATTAAGT TCTTTAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138987.1
CDS	214..1254
Translation	MISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Target ORF information:

RefSeq Version	NM_001145515.1
Organism	Homo sapiens(human)
Definition	Homo sapiens secernin 1 (SCRN1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145515.1

ORF Insert Sequence:

ATGATAAGCA GACCCGCCTG GCTCTGGGGA GCAGAAATGG GAGCCAATGA ACATGGAGTG 
TGCATAGCCA ATGAAGCCAT CAACACCAGA GAGCCAGCTG CCGAGATAGA AGCCTTGCTG 
GGGATGGATC TGGTCAGGCT TGGTTTAGAA AGAGGGGAAA CAGCTAAAGA AGCCTTAGAT 
GTCATTGTCT CCTTGTTGGA AGAACATGGA CAAGGTGGGA ATTACTTTGA AGATGCAAAC 
TCCTGCCACA GCTTCCAAAG TGCATATCTG ATTGTGGATC GTGATGAAGC CTGGGTGCTC 
GAGACCATAG GGAAGTACTG GGCTGCCGAG AAAGTCACAG AGGGAGTGAG GTGCATTTGC 
AGTCAGCTTT CGCTCACCAC TAAGATGGAT GCAGAGCATC CGGAACTCAG GAGTTACGCT 
CAGAGCCAAG GTTGGTGGAC GGGAGAGGGC GAGTTCAATT TTTCCGAAGT CTTTTCTCCA 
GTTGAGGATC ATCTAGACTG CGGTGCTGGC AAAGACAGCT TAGAAAAACA AGAAGAAAGC 
ATCACAGTGC AGACTATGAT GAACACCTTA CGGGACAAAG CCAGCGGAGT GTGCATAGAC 
TCTGAGTTTT TCCTCACCAC AGCCAGTGGA GTGTCTGTCC TGCCGCAGAA TAGAAGCTCT 
CCGTGCATTC ACTACTTCAC TGGAACCCCT GATCCTTCCA GGTCCATATT CAAGCCTTTC 
ATCTTTGTTG ATGACGTAAA ACTTGTCCCC AAAACACAGT CTCCCTGTTT TGGGGATGAC 
GACCCTGCCA AAAAGGAGCC TCGGTTCCAG GAGAAACCAG ACCGCCGGCA TGAGCTGTAC 
AAAGCCCACG AGTGGGCACG TGCCATCATC GAAAGTGACC AGGAGCAAGG TCGCAAGCTG 
AGGAGCACCA TGCTGGAGCT GGAGAAGCAA GGCCTGGAAG CCATGGAAGA AATCCTGACC 
AGCTCCGAGC CACTGGACCC TGCGGAAGTG GGGGACCTTT TCTATGACTG TGTTGACACG 
GAGATTAAGT TCTTTAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCRN1 ( NM_001145515.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138987.1 Homo sapiens secernin 1 (SCRN1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu02686
Clone ID Related Accession (Same CDS sequence)	NM_001145515.1 , NM_001145515.2
Accession Version	NM_001145515.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	secernin-1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC370097.1, AK295713.1, AB071705.1 and AA910381.1. On May 31, 2019 this sequence version replaced NM_001145515.1. Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.93824.1, SRR1803613.277710.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATAAGCA GACCCGCCTG GCTCTGGGGA GCAGAAATGG GAGCCAATGA ACATGGAGTG 
TGCATAGCCA ATGAAGCCAT CAACACCAGA GAGCCAGCTG CCGAGATAGA AGCCTTGCTG 
GGGATGGATC TGGTCAGGCT TGGTTTAGAA AGAGGGGAAA CAGCTAAAGA AGCCTTAGAT 
GTCATTGTCT CCTTGTTGGA AGAACATGGA CAAGGTGGGA ATTACTTTGA AGATGCAAAC 
TCCTGCCACA GCTTCCAAAG TGCATATCTG ATTGTGGATC GTGATGAAGC CTGGGTGCTC 
GAGACCATAG GGAAGTACTG GGCTGCCGAG AAAGTCACAG AGGGAGTGAG GTGCATTTGC 
AGTCAGCTTT CGCTCACCAC TAAGATGGAT GCAGAGCATC CGGAACTCAG GAGTTACGCT 
CAGAGCCAAG GTTGGTGGAC GGGAGAGGGC GAGTTCAATT TTTCCGAAGT CTTTTCTCCA 
GTTGAGGATC ATCTAGACTG CGGTGCTGGC AAAGACAGCT TAGAAAAACA AGAAGAAAGC 
ATCACAGTGC AGACTATGAT GAACACCTTA CGGGACAAAG CCAGCGGAGT GTGCATAGAC 
TCTGAGTTTT TCCTCACCAC AGCCAGTGGA GTGTCTGTCC TGCCGCAGAA TAGAAGCTCT 
CCGTGCATTC ACTACTTCAC TGGAACCCCT GATCCTTCCA GGTCCATATT CAAGCCTTTC 
ATCTTTGTTG ATGACGTAAA ACTTGTCCCC AAAACACAGT CTCCCTGTTT TGGGGATGAC 
GACCCTGCCA AAAAGGAGCC TCGGTTCCAG GAGAAACCAG ACCGCCGGCA TGAGCTGTAC 
AAAGCCCACG AGTGGGCACG TGCCATCATC GAAAGTGACC AGGAGCAAGG TCGCAAGCTG 
AGGAGCACCA TGCTGGAGCT GGAGAAGCAA GGCCTGGAAG CCATGGAAGA AATCCTGACC 
AGCTCCGAGC CACTGGACCC TGCGGAAGTG GGGGACCTTT TCTATGACTG TGTTGACACG 
GAGATTAAGT TCTTTAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138987.1
CDS	206..1246
Translation	MISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Target ORF information:

RefSeq Version	NM_001145515.2
Organism	Homo sapiens(human)
Definition	Homo sapiens secernin 1 (SCRN1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145515.2

ORF Insert Sequence:

ATGATAAGCA GACCCGCCTG GCTCTGGGGA GCAGAAATGG GAGCCAATGA ACATGGAGTG 
TGCATAGCCA ATGAAGCCAT CAACACCAGA GAGCCAGCTG CCGAGATAGA AGCCTTGCTG 
GGGATGGATC TGGTCAGGCT TGGTTTAGAA AGAGGGGAAA CAGCTAAAGA AGCCTTAGAT 
GTCATTGTCT CCTTGTTGGA AGAACATGGA CAAGGTGGGA ATTACTTTGA AGATGCAAAC 
TCCTGCCACA GCTTCCAAAG TGCATATCTG ATTGTGGATC GTGATGAAGC CTGGGTGCTC 
GAGACCATAG GGAAGTACTG GGCTGCCGAG AAAGTCACAG AGGGAGTGAG GTGCATTTGC 
AGTCAGCTTT CGCTCACCAC TAAGATGGAT GCAGAGCATC CGGAACTCAG GAGTTACGCT 
CAGAGCCAAG GTTGGTGGAC GGGAGAGGGC GAGTTCAATT TTTCCGAAGT CTTTTCTCCA 
GTTGAGGATC ATCTAGACTG CGGTGCTGGC AAAGACAGCT TAGAAAAACA AGAAGAAAGC 
ATCACAGTGC AGACTATGAT GAACACCTTA CGGGACAAAG CCAGCGGAGT GTGCATAGAC 
TCTGAGTTTT TCCTCACCAC AGCCAGTGGA GTGTCTGTCC TGCCGCAGAA TAGAAGCTCT 
CCGTGCATTC ACTACTTCAC TGGAACCCCT GATCCTTCCA GGTCCATATT CAAGCCTTTC 
ATCTTTGTTG ATGACGTAAA ACTTGTCCCC AAAACACAGT CTCCCTGTTT TGGGGATGAC 
GACCCTGCCA AAAAGGAGCC TCGGTTCCAG GAGAAACCAG ACCGCCGGCA TGAGCTGTAC 
AAAGCCCACG AGTGGGCACG TGCCATCATC GAAAGTGACC AGGAGCAAGG TCGCAAGCTG 
AGGAGCACCA TGCTGGAGCT GGAGAAGCAA GGCCTGGAAG CCATGGAAGA AATCCTGACC 
AGCTCCGAGC CACTGGACCC TGCGGAAGTG GGGGACCTTT TCTATGACTG TGTTGACACG 
GAGATTAAGT TCTTTAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCRN1 ( NM_001145513.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138985.1 Homo sapiens secernin 1 (SCRN1), transcript variant 1, mRNA.

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CloneID	OHu13636
Clone ID Related Accession (Same CDS sequence)	NM_001145513.1 , NM_014766.4 , XM_024447007.1 , NM_014766.5
Accession Version	NM_001145513.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	secernin-1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC307846.1, AB071705.1, BC040492.1 and AA910381.1. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform a). ##Evidence-Data-START## Transcript exon combination :: SRR1803615.222684.1, SRR1803612.216312.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138985.1
CDS	178..1422
Translation	MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Target ORF information:

RefSeq Version	NM_001145513.1
Organism	Homo sapiens(human)
Definition	Homo sapiens secernin 1 (SCRN1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145513.1

ORF Insert Sequence:

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCRN1 ( NM_014766.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055581.3 Homo sapiens secernin 1 (SCRN1), transcript variant 2, mRNA.

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CloneID	OHu13636
Clone ID Related Accession (Same CDS sequence)	NM_001145513.1 , NM_014766.4 , XM_024447007.1 , NM_014766.5
Accession Version	NM_014766.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	secernin-1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC370097.1, AB071705.1 and AA910381.1. On Mar 3, 2009 this sequence version replaced NM_014766.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform a). ##Evidence-Data-START## Transcript exon combination :: SRR1803612.60893.1, SRR1803615.120058.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055581.3
CDS	170..1414
Translation	MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Target ORF information:

RefSeq Version	NM_014766.4
Organism	Homo sapiens(human)
Definition	Homo sapiens secernin 1 (SCRN1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014766.4

ORF Insert Sequence:

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCRN1 ( NM_014766.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055581.3 Homo sapiens secernin 1 (SCRN1), transcript variant 2, mRNA.

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CloneID	OHu13636
Clone ID Related Accession (Same CDS sequence)	NM_001145513.1 , NM_014766.4 , XM_024447007.1 , NM_014766.5
Accession Version	NM_014766.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	secernin-1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC370097.1, AB071705.1 and AA910381.1. On Nov 22, 2018 this sequence version replaced NM_014766.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform a). ##Evidence-Data-START## Transcript exon combination :: SRR1803612.49661.1, SRR1803615.120058.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000242059.10/ ENSP00000242059.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055581.3
CDS	162..1406
Translation	MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Target ORF information:

RefSeq Version	NM_014766.5
Organism	Homo sapiens(human)
Definition	Homo sapiens secernin 1 (SCRN1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014766.5

ORF Insert Sequence:

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCRN1 ( XM_024447007.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302775.1 Homo sapiens secernin 1 (SCRN1), transcript variant X1, mRNA.

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CloneID	OHu13636
Clone ID Related Accession (Same CDS sequence)	NM_001145513.1 , NM_014766.4 , XM_024447007.1 , NM_014766.5
Accession Version	XM_024447007.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	secernin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302775.1
CDS	554..1798
Translation	MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Target ORF information:

RefSeq Version	XM_024447007.1
Organism	Homo sapiens(human)
Definition	Homo sapiens secernin 1 (SCRN1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447007.1

ORF Insert Sequence:

ATGGCTGCAG CTCCTCCAAG TTACTGTTTT GTTGCCTTCC CTCCACGTGC TAAGGATGGT 
CTGGTGGTAT TTGGGAAAAA TTCAGCCCGG CCCAGAGATG AAGTGCAAGA GGTTGTGTAT 
TTCTCGGCTG CTGATCACGA ACCGGAGAGC AAGGTTGAGT GCACTTACAT TTCAATCGAC 
CAAGTTCCAA GGACCTATGC CATAATGATA AGCAGACCCG CCTGGCTCTG GGGAGCAGAA 
ATGGGAGCCA ATGAACATGG AGTGTGCATA GCCAATGAAG CCATCAACAC CAGAGAGCCA 
GCTGCCGAGA TAGAAGCCTT GCTGGGGATG GATCTGGTCA GGCTTGGTTT AGAAAGAGGG 
GAAACAGCTA AAGAAGCCTT AGATGTCATT GTCTCCTTGT TGGAAGAACA TGGACAAGGT 
GGGAATTACT TTGAAGATGC AAACTCCTGC CACAGCTTCC AAAGTGCATA TCTGATTGTG 
GATCGTGATG AAGCCTGGGT GCTCGAGACC ATAGGGAAGT ACTGGGCTGC CGAGAAAGTC 
ACAGAGGGAG TGAGGTGCAT TTGCAGTCAG CTTTCGCTCA CCACTAAGAT GGATGCAGAG 
CATCCGGAAC TCAGGAGTTA CGCTCAGAGC CAAGGTTGGT GGACGGGAGA GGGCGAGTTC 
AATTTTTCCG AAGTCTTTTC TCCAGTTGAG GATCATCTAG ACTGCGGTGC TGGCAAAGAC 
AGCTTAGAAA AACAAGAAGA AAGCATCACA GTGCAGACTA TGATGAACAC CTTACGGGAC 
AAAGCCAGCG GAGTGTGCAT AGACTCTGAG TTTTTCCTCA CCACAGCCAG TGGAGTGTCT 
GTCCTGCCGC AGAATAGAAG CTCTCCGTGC ATTCACTACT TCACTGGAAC CCCTGATCCT 
TCCAGGTCCA TATTCAAGCC TTTCATCTTT GTTGATGACG TAAAACTTGT CCCCAAAACA 
CAGTCTCCCT GTTTTGGGGA TGACGACCCT GCCAAAAAGG AGCCTCGGTT CCAGGAGAAA 
CCAGACCGCC GGCATGAGCT GTACAAAGCC CACGAGTGGG CACGTGCCAT CATCGAAAGT 
GACCAGGAGC AAGGTCGCAA GCTGAGGAGC ACCATGCTGG AGCTGGAGAA GCAAGGCCTG 
GAAGCCATGG AAGAAATCCT GACCAGCTCC GAGCCACTGG ACCCTGCGGA AGTGGGGGAC 
CTTTTCTATG ACTGTGTTGA CACGGAGATT AAGTTCTTTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.
Oncotarget7(12)13797-809(2016 Mar)
Kim N,Cho A,Watanabe H,Choi YL,Aziz M,Kassner M,Joung JG,Park AK,Francis JM,Bae JS,Ahn SM,Kim KM,Park JO,Park WY,Ahn MJ,Park K,Koo J,Yin HH,Cho J

A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer.
Scientific reports47080(2014 Nov)
Song P,Zhu H,Zhang D,Chu H,Wu D,Kang M,Wang M,Gong W,Zhou J,Zhang Z,Zhao Q

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Journal of proteome research11(4)2533-43(2012 Apr)
Martins-de-Souza D,Guest PC,Mann DM,Roeber S,Rahmoune H,Bauder C,Kretzschmar H,Volk B,Baborie A,Bahn S

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics.
Journal of proteomics74(6)829-42(2011 May)
Suehara Y,Tochigi N,Kubota D,Kikuta K,Nakayama R,Seki K,Yoshida A,Ichikawa H,Hasegawa T,Kaneko K,Chuman H,Beppu Y,Kawai A,Kondo T

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SCRN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

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電話

FAX

オンラインフォーム