NUMBL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NUMBL
Entrez Gene ID	9253
Full Name	NUMB like, endocytic adaptor protein
Synonyms	CAG3A,CTG3a,NBL,NUMB-R,NUMBLIKE,NUMBR,TNRC23
General protein information	Preferred Names NUMB like, endocytic adaptor protein Names numb-like protein numb homolog-like numb-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Disorder MIM:	604018

mRNA and Protein(s)

mRNA	Protein	Name
XM_011527490.1	XP_011525792.1	numb-like protein isoform X1
NM_001289979.1	NP_001276908.1	numb-like protein isoform b
NM_001289980.2	NP_001276909.1	numb-like protein isoform b
NM_004756.5	NP_004747.1	numb-like protein isoform a
NM_004756.4	NP_004747.1	numb-like protein isoform a
NM_001289980.1	NP_001276909.1	numb-like protein isoform b
NM_001289979.2	NP_001276908.1	numb-like protein isoform b

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NUMBL	XP_855314.2
Xenopus tropicalis (tropical clawed frog)	numbl	XP_002938862.2
Homo sapiens (human)	NUMBL	NP_004747.1
Mus musculus (house mouse)	Numbl	NP_035080.2
Pan troglodytes (chimpanzee)	NUMBL	XP_524270.4
Rattus norvegicus (Norway rat)	Numbl	NP_001029060.1
Danio rerio (zebrafish)	numbl	NP_001012375.3
Bos taurus (cattle)	NUMBL	NP_001070302.1

Gene Ontology
Bibliography

Related articles in PubMed

Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
Hirai M, Arita Y, McGlade CJ, Lee KF, Chen J, Evans SM
The Journal of clinical investigation127(2)569-582(2017 Feb)

Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.
Zhang Y, Li F, Song Y, Sheng X, Ren F, Xiong K, Chen L, Zhang H, Liu D, Lengner CJ, Xue L, Yu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3474-3488(2016 10)

Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl.
Nwaeburu CC, Bauer N, Zhao Z, Abukiwan A, Gladkich J, Benner A, Herr I
Oncotarget7(36)58367-58380(2016 09)

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.
Garc?a-Heredia JM, Verdugo Sivianes EM, Lucena-Cacace A, Molina-Pinelo S, Carnero A
Oncotarget7(39)63611-63628(2016 09)

Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.
van Lessen M, Nakayama M, Kato K, Kim JM, Kaibuchi K, Adams RH
Arteriosclerosis, thrombosis, and vascular biology35(8)1815-25(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

investigations revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endosome for degradation.
Title: Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.

These findings highlight the importance of Numb and Numbl in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis
Title: Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.

Numb/Numbl control VEGF receptor endocytosis, signaling, and recycling in endothelial cells, which promotes the angiogenic growth of blood vessels.
Title: Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.

Numbl might be involved in the inhibition of growth, proliferation, and invasion of 95-D lung cancer cells.
Title: Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell.

Numbl-Klf4 signaling is critical to maintain multiple nodes of metastatic progression, including persistence of cancer-initiating cells.
Title: Regulation of lung cancer metastasis by Klf4-Numb-like signaling.

The following NUMBL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NUMBL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21322	NM_001289979.2 Latest version!	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu21322	NM_001289980.2 Latest version!	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu21322	XM_011527490.1 Latest version!	Homo sapiens numb homolog (Drosophila)-like (NUMBL), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu21120	NM_004756.5 Latest version!	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu21120	NM_004756.4	Homo sapiens NUMB like, endocytic adaptor protein (NUMBL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OHu21322	NM_001289980.1	Homo sapiens numb homolog (Drosophila)-like (NUMBL), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu21322	NM_001289979.1	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NUMBL ( NM_001289979.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001276908.1 Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21322
Clone ID Related Accession (Same CDS sequence)	XM_011527490.1 , NM_001289979.1 , NM_001289980.2 , NM_001289980.1 , NM_001289979.2
Accession Version	NM_001289979.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	numb-like protein isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY111715.1, BC144583.1 and AC010412.9. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC144583.1, SRR1660803.244308.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276908.1
CDS	214..1920
Translation	MNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	NM_001289979.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289979.1

ORF Insert Sequence:

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUMBL ( NM_001289980.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001276909.1 Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu21322
Clone ID Related Accession (Same CDS sequence)	XM_011527490.1 , NM_001289979.1 , NM_001289980.2 , NM_001289980.1 , NM_001289979.2
Accession Version	NM_001289980.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	numb-like protein isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC374917.1, AK299484.1 and AC010412.9. On Dec 16, 2016 this sequence version replaced NM_001289980.1. Transcript Variant: This variant (3) ) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299484.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276909.1
CDS	140..1846
Translation	MNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	NM_001289980.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289980.2

ORF Insert Sequence:

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUMBL ( NM_001289980.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001276909.1 Homo sapiens numb homolog (Drosophila)-like (NUMBL), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu21322
Clone ID Related Accession (Same CDS sequence)	XM_011527490.1 , NM_001289979.1 , NM_001289980.2 , NM_001289980.1 , NM_001289979.2
Accession Version	NM_001289980.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-05-12
Organism	Homo sapiens(Human)
Product	numb-like protein isoform b
Comment

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_001276909.1

Translation

MNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	NM_001289980.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens numb homolog (Drosophila)-like (NUMBL), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289980.1

ORF Insert Sequence:

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUMBL ( NM_001289979.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001276908.1 Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21322
Clone ID Related Accession (Same CDS sequence)	XM_011527490.1 , NM_001289979.1 , NM_001289980.2 , NM_001289980.1 , NM_001289979.2
Accession Version	NM_001289979.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	numb-like protein isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY111715.1, BC144583.1 and AC010412.9. On Jun 1, 2019 this sequence version replaced NM_001289979.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC144583.1, SRR1660803.244308.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276908.1
CDS	207..1913
Translation	MNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	NM_001289979.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289979.2

ORF Insert Sequence:

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUMBL ( XM_011527490.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525792.1 Homo sapiens numb homolog (Drosophila)-like (NUMBL), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu21322
Clone ID Related Accession (Same CDS sequence)	XM_011527490.1 , NM_001289979.1 , NM_001289980.2 , NM_001289980.1 , NM_001289979.2
Accession Version	XM_011527490.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	numb-like protein isoform X1
Comment

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011525792.1

Translation

MNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	XM_011527490.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens numb homolog (Drosophila)-like (NUMBL), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527490.1

ORF Insert Sequence:

ATGAACAAGT TACGGCAGAG CCTGCGGCGG AGGAAGCCAG CCTACGTGCC CGAGGCGTCG 
CGCCCGCACC AGTGGCAGGC AGACGAGGAC GCGGTGCGGA AGGGCACGTG CAGCTTCCCG 
GTCAGGTACC TGGGTCACGT GGAGGTAGAG GAGTCCCGGG GAATGCACGT GTGTGAAGAT 
GCGGTGAAGA AGCTGAAGGC GATGGGCCGA AAGTCCGTGA AGTCTGTCCT GTGGGTGTCA 
GCCGATGGGC TCCGAGTGGT GGACGACAAA ACCAAGGATC TTCTGGTCGA CCAGACCATC 
GAAAAGGTCT CCTTTTGTGC TCCTGACCGC AACCTGGACA AGGCTTTCTC CTATATCTGT 
CGTGACGGGA CTACCCGCCG CTGGATCTGC CACTGTTTTC TGGCACTGAA GGACTCCGGC 
GAGAGGCTGA GCCACGCTGT GGGCTGTGCT TTTGCCGCCT GCCTGGAGCG AAAACAGCGA 
CGGGAGAAGG AATGTGGGGT CACGGCCGCC TTCGATGCCA GCCGCACCAG CTTCGCCCGC 
GAGGGCTCCT TCCGCCTGTC TGGGGGTGGG CGGCCTGCTG AGCGAGAGGC CCCGGACAAG 
AAGAAAGCAG AGGCAGCAGC TGCCCCCACT GTGGCTCCTG GCCCTGCCCA GCCTGGGCAC 
GTGTCCCCGA CACCAGCCAC CACATCCCCT GGTGAGAAGG GTGAGGCAGG CACCCCTGTG 
GCTGCAGGCA CCACTGCGGC CGCCATCCCC CGGCGCCATG CACCCCTGGA GCAGCTGGTT 
CGCCAGGGCT CCTTCCGTGG GTTCCCAGCA CTCAGCCAGA AGAACTCGCC TTTCAAACGG 
CAGCTGAGCC TACGGCTGAA TGAGCTGCCA TCCACGCTGC AGCGCCGCAC TGACTTCCAG 
GTGAAGGGCA CAGTGCCTGA GATGGAGCCT CCTGGTGCCG GCGACAGTGA CAGCATCAAC 
GCTCTGTGCA CACAGATCAG TTCATCTTTT GCCAGTGCTG GAGCGCCAGC ACCAGGGCCA 
CCACCTGCCA CAACAGGGAC TTCTGCCTGG GGTGAGCCCT CCGTGCCCCC TGCAGCTGCC 
TTCCAGCCTG GGCACAAGCG GACACCTTCA GAGGCTGAGC GATGGCTGGA GGAGGTGTCA 
CAGGTGGCCA AGGCCCAGCA GCAGCAGCAG CAGCAACAGC AACAGCAGCA GCAGCAGCAG 
CAGCAACAGC AGCAAGCAGC CTCAGTGGCC CCAGTGCCCA CCATGCCTCC TGCCCTGCAG 
CCTTTCCCCG CCCCCGTGGG GCCCTTTGAC GCTGCACCTG CCCAAGTGGC CGTGTTCCTG 
CCACCCCCAC ACATGCAGCC CCCTTTTGTG CCCGCCTACC CGGGCTTGGG CTACCCACCG 
ATGCCCCGGG TGCCCGTGGT GGGCATCACA CCCTCACAGA TGGTGGCAAA CGCCTTCTGC 
TCAGCCGCCC AGCTCCAGCC TCAGCCTGCC ACTCTGCTTG GGAAAGCTGG GGCCTTCCCG 
CCCCCTGCCA TACCCAGTGC CCCTGGGAGC CAGGCCCGCC CTCGCCCCAA TGGGGCCCCC 
TGGCCCCCTG AGCCAGCGCC TGCCCCAGCT CCAGAGTTGG ACCCCTTTGA GGCCCAGTGG 
GCGGCATTAG AAGGCAAAGC CACTGTAGAG AAACCCTCCA ACCCCTTTTC TGGCGACCTG 
CAAAAGACAT TCGAGATTGA ACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUMBL ( NM_004756.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004747.1 Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21120
Clone ID Related Accession (Same CDS sequence)	NM_004756.5 , NM_004756.4
Accession Version	NM_004756.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1830bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	numb-like protein isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC010412.9 and AK289398.1. On Nov 22, 2018 this sequence version replaced NM_004756.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF015041.2, SRR3476690.920880.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252891.8/ ENSP00000252891.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCCGGAGGC CTGAGCGGCA CCTGCCCCCA 
GCCCCCTGTG GGGCCCCGGG GCCCCCAGAA ACCTGCAGGA CGGAGCCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGCCTGCGG CGGAGGAAGC CAGCCTACGT GCCCGAGGCG 
TCGCGCCCGC ACCAGTGGCA GGCAGACGAG GACGCGGTGC GGAAGGGCAC GTGCAGCTTC 
CCGGTCAGGT ACCTGGGTCA CGTGGAGGTA GAGGAGTCCC GGGGAATGCA CGTGTGTGAA 
GATGCGGTGA AGAAGCTGAA GGCGATGGGC CGAAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCAGCCGATG GGCTCCGAGT GGTGGACGAC AAAACCAAGG ATCTTCTGGT CGACCAGACC 
ATCGAAAAGG TCTCCTTTTG TGCTCCTGAC CGCAACCTGG ACAAGGCTTT CTCCTATATC 
TGTCGTGACG GGACTACCCG CCGCTGGATC TGCCACTGTT TTCTGGCACT GAAGGACTCC 
GGCGAGAGGC TGAGCCACGC TGTGGGCTGT GCTTTTGCCG CCTGCCTGGA GCGAAAACAG 
CGACGGGAGA AGGAATGTGG GGTCACGGCC GCCTTCGATG CCAGCCGCAC CAGCTTCGCC 
CGCGAGGGCT CCTTCCGCCT GTCTGGGGGT GGGCGGCCTG CTGAGCGAGA GGCCCCGGAC 
AAGAAGAAAG CAGAGGCAGC AGCTGCCCCC ACTGTGGCTC CTGGCCCTGC CCAGCCTGGG 
CACGTGTCCC CGACACCAGC CACCACATCC CCTGGTGAGA AGGGTGAGGC AGGCACCCCT 
GTGGCTGCAG GCACCACTGC GGCCGCCATC CCCCGGCGCC ATGCACCCCT GGAGCAGCTG 
GTTCGCCAGG GCTCCTTCCG TGGGTTCCCA GCACTCAGCC AGAAGAACTC GCCTTTCAAA 
CGGCAGCTGA GCCTACGGCT GAATGAGCTG CCATCCACGC TGCAGCGCCG CACTGACTTC 
CAGGTGAAGG GCACAGTGCC TGAGATGGAG CCTCCTGGTG CCGGCGACAG TGACAGCATC 
AACGCTCTGT GCACACAGAT CAGTTCATCT TTTGCCAGTG CTGGAGCGCC AGCACCAGGG 
CCACCACCTG CCACAACAGG GACTTCTGCC TGGGGTGAGC CCTCCGTGCC CCCTGCAGCT 
GCCTTCCAGC CTGGGCACAA GCGGACACCT TCAGAGGCTG AGCGATGGCT GGAGGAGGTG 
TCACAGGTGG CCAAGGCCCA GCAGCAGCAG CAGCAGCAAC AGCAACAGCA GCAGCAGCAG 
CAGCAGCAAC AGCAGCAAGC AGCCTCAGTG GCCCCAGTGC CCACCATGCC TCCTGCCCTG 
CAGCCTTTCC CCGCCCCCGT GGGGCCCTTT GACGCTGCAC CTGCCCAAGT GGCCGTGTTC 
CTGCCACCCC CACACATGCA GCCCCCTTTT GTGCCCGCCT ACCCGGGCTT GGGCTACCCA 
CCGATGCCCC GGGTGCCCGT GGTGGGCATC ACACCCTCAC AGATGGTGGC AAACGCCTTC 
TGCTCAGCCG CCCAGCTCCA GCCTCAGCCT GCCACTCTGC TTGGGAAAGC TGGGGCCTTC 
CCGCCCCCTG CCATACCCAG TGCCCCTGGG AGCCAGGCCC GCCCTCGCCC CAATGGGGCC 
CCCTGGCCCC CTGAGCCAGC GCCTGCCCCA GCTCCAGAGT TGGACCCCTT TGAGGCCCAG 
TGGGCGGCAT TAGAAGGCAA AGCCACTGTA GAGAAACCCT CCAACCCCTT TTCTGGCGAC 
CTGCAAAAGA CATTCGAGAT TGAACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004747.1
CDS	169..1998
Translation	MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	NM_004756.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NUMB like endocytic adaptor protein (NUMBL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004756.5

ORF Insert Sequence:

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCCGGAGGC CTGAGCGGCA CCTGCCCCCA 
GCCCCCTGTG GGGCCCCGGG GCCCCCAGAA ACCTGCAGGA CGGAGCCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGCCTGCGG CGGAGGAAGC CAGCCTACGT GCCCGAGGCG 
TCGCGCCCGC ACCAGTGGCA GGCAGACGAG GACGCGGTGC GGAAGGGCAC GTGCAGCTTC 
CCGGTCAGGT ACCTGGGTCA CGTGGAGGTA GAGGAGTCCC GGGGAATGCA CGTGTGTGAA 
GATGCGGTGA AGAAGCTGAA GGCGATGGGC CGAAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCAGCCGATG GGCTCCGAGT GGTGGACGAC AAAACCAAGG ATCTTCTGGT CGACCAGACC 
ATCGAAAAGG TCTCCTTTTG TGCTCCTGAC CGCAACCTGG ACAAGGCTTT CTCCTATATC 
TGTCGTGACG GGACTACCCG CCGCTGGATC TGCCACTGTT TTCTGGCACT GAAGGACTCC 
GGCGAGAGGC TGAGCCACGC TGTGGGCTGT GCTTTTGCCG CCTGCCTGGA GCGAAAACAG 
CGACGGGAGA AGGAATGTGG GGTCACGGCC GCCTTCGATG CCAGCCGCAC CAGCTTCGCC 
CGCGAGGGCT CCTTCCGCCT GTCTGGGGGT GGGCGGCCTG CTGAGCGAGA GGCCCCGGAC 
AAGAAGAAAG CAGAGGCAGC AGCTGCCCCC ACTGTGGCTC CTGGCCCTGC CCAGCCTGGG 
CACGTGTCCC CGACACCAGC CACCACATCC CCTGGTGAGA AGGGTGAGGC AGGCACCCCT 
GTGGCTGCAG GCACCACTGC GGCCGCCATC CCCCGGCGCC ATGCACCCCT GGAGCAGCTG 
GTTCGCCAGG GCTCCTTCCG TGGGTTCCCA GCACTCAGCC AGAAGAACTC GCCTTTCAAA 
CGGCAGCTGA GCCTACGGCT GAATGAGCTG CCATCCACGC TGCAGCGCCG CACTGACTTC 
CAGGTGAAGG GCACAGTGCC TGAGATGGAG CCTCCTGGTG CCGGCGACAG TGACAGCATC 
AACGCTCTGT GCACACAGAT CAGTTCATCT TTTGCCAGTG CTGGAGCGCC AGCACCAGGG 
CCACCACCTG CCACAACAGG GACTTCTGCC TGGGGTGAGC CCTCCGTGCC CCCTGCAGCT 
GCCTTCCAGC CTGGGCACAA GCGGACACCT TCAGAGGCTG AGCGATGGCT GGAGGAGGTG 
TCACAGGTGG CCAAGGCCCA GCAGCAGCAG CAGCAGCAAC AGCAACAGCA GCAGCAGCAG 
CAGCAGCAAC AGCAGCAAGC AGCCTCAGTG GCCCCAGTGC CCACCATGCC TCCTGCCCTG 
CAGCCTTTCC CCGCCCCCGT GGGGCCCTTT GACGCTGCAC CTGCCCAAGT GGCCGTGTTC 
CTGCCACCCC CACACATGCA GCCCCCTTTT GTGCCCGCCT ACCCGGGCTT GGGCTACCCA 
CCGATGCCCC GGGTGCCCGT GGTGGGCATC ACACCCTCAC AGATGGTGGC AAACGCCTTC 
TGCTCAGCCG CCCAGCTCCA GCCTCAGCCT GCCACTCTGC TTGGGAAAGC TGGGGCCTTC 
CCGCCCCCTG CCATACCCAG TGCCCCTGGG AGCCAGGCCC GCCCTCGCCC CAATGGGGCC 
CCCTGGCCCC CTGAGCCAGC GCCTGCCCCA GCTCCAGAGT TGGACCCCTT TGAGGCCCAG 
TGGGCGGCAT TAGAAGGCAA AGCCACTGTA GAGAAACCCT CCAACCCCTT TTCTGGCGAC 
CTGCAAAAGA CATTCGAGAT TGAACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUMBL ( NM_004756.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004747.1 Homo sapiens NUMB like, endocytic adaptor protein (NUMBL), transcript variant 1, mRNA.

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CloneID	OHu21120
Clone ID Related Accession (Same CDS sequence)	NM_004756.5 , NM_004756.4
Accession Version	NM_004756.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1830bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	numb-like protein isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC010412.9 and AK289398.1. On Feb 18, 2014 this sequence version replaced NM_004756.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF015041.2, AK289398.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCCGGAGGC CTGAGCGGCA CCTGCCCCCA 
GCCCCCTGTG GGGCCCCGGG GCCCCCAGAA ACCTGCAGGA CGGAGCCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGCCTGCGG CGGAGGAAGC CAGCCTACGT GCCCGAGGCG 
TCGCGCCCGC ACCAGTGGCA GGCAGACGAG GACGCGGTGC GGAAGGGCAC GTGCAGCTTC 
CCGGTCAGGT ACCTGGGTCA CGTGGAGGTA GAGGAGTCCC GGGGAATGCA CGTGTGTGAA 
GATGCGGTGA AGAAGCTGAA GGCGATGGGC CGAAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCAGCCGATG GGCTCCGAGT GGTGGACGAC AAAACCAAGG ATCTTCTGGT CGACCAGACC 
ATCGAAAAGG TCTCCTTTTG TGCTCCTGAC CGCAACCTGG ACAAGGCTTT CTCCTATATC 
TGTCGTGACG GGACTACCCG CCGCTGGATC TGCCACTGTT TTCTGGCACT GAAGGACTCC 
GGCGAGAGGC TGAGCCACGC TGTGGGCTGT GCTTTTGCCG CCTGCCTGGA GCGAAAACAG 
CGACGGGAGA AGGAATGTGG GGTCACGGCC GCCTTCGATG CCAGCCGCAC CAGCTTCGCC 
CGCGAGGGCT CCTTCCGCCT GTCTGGGGGT GGGCGGCCTG CTGAGCGAGA GGCCCCGGAC 
AAGAAGAAAG CAGAGGCAGC AGCTGCCCCC ACTGTGGCTC CTGGCCCTGC CCAGCCTGGG 
CACGTGTCCC CGACACCAGC CACCACATCC CCTGGTGAGA AGGGTGAGGC AGGCACCCCT 
GTGGCTGCAG GCACCACTGC GGCCGCCATC CCCCGGCGCC ATGCACCCCT GGAGCAGCTG 
GTTCGCCAGG GCTCCTTCCG TGGGTTCCCA GCACTCAGCC AGAAGAACTC GCCTTTCAAA 
CGGCAGCTGA GCCTACGGCT GAATGAGCTG CCATCCACGC TGCAGCGCCG CACTGACTTC 
CAGGTGAAGG GCACAGTGCC TGAGATGGAG CCTCCTGGTG CCGGCGACAG TGACAGCATC 
AACGCTCTGT GCACACAGAT CAGTTCATCT TTTGCCAGTG CTGGAGCGCC AGCACCAGGG 
CCACCACCTG CCACAACAGG GACTTCTGCC TGGGGTGAGC CCTCCGTGCC CCCTGCAGCT 
GCCTTCCAGC CTGGGCACAA GCGGACACCT TCAGAGGCTG AGCGATGGCT GGAGGAGGTG 
TCACAGGTGG CCAAGGCCCA GCAGCAGCAG CAGCAGCAAC AGCAACAGCA GCAGCAGCAG 
CAGCAGCAAC AGCAGCAAGC AGCCTCAGTG GCCCCAGTGC CCACCATGCC TCCTGCCCTG 
CAGCCTTTCC CCGCCCCCGT GGGGCCCTTT GACGCTGCAC CTGCCCAAGT GGCCGTGTTC 
CTGCCACCCC CACACATGCA GCCCCCTTTT GTGCCCGCCT ACCCGGGCTT GGGCTACCCA 
CCGATGCCCC GGGTGCCCGT GGTGGGCATC ACACCCTCAC AGATGGTGGC AAACGCCTTC 
TGCTCAGCCG CCCAGCTCCA GCCTCAGCCT GCCACTCTGC TTGGGAAAGC TGGGGCCTTC 
CCGCCCCCTG CCATACCCAG TGCCCCTGGG AGCCAGGCCC GCCCTCGCCC CAATGGGGCC 
CCCTGGCCCC CTGAGCCAGC GCCTGCCCCA GCTCCAGAGT TGGACCCCTT TGAGGCCCAG 
TGGGCGGCAT TAGAAGGCAA AGCCACTGTA GAGAAACCCT CCAACCCCTT TTCTGGCGAC 
CTGCAAAAGA CATTCGAGAT TGAACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004747.1
CDS	176..2005
Translation	MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL

Target ORF information:

RefSeq Version	NM_004756.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NUMB like, endocytic adaptor protein (NUMBL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004756.4

ORF Insert Sequence:

ATGTCCCGCA GCGCGGCGGC CAGCGGCGGA CCCCGGAGGC CTGAGCGGCA CCTGCCCCCA 
GCCCCCTGTG GGGCCCCGGG GCCCCCAGAA ACCTGCAGGA CGGAGCCAGA CGGGGCGGGC 
ACCATGAACA AGTTACGGCA GAGCCTGCGG CGGAGGAAGC CAGCCTACGT GCCCGAGGCG 
TCGCGCCCGC ACCAGTGGCA GGCAGACGAG GACGCGGTGC GGAAGGGCAC GTGCAGCTTC 
CCGGTCAGGT ACCTGGGTCA CGTGGAGGTA GAGGAGTCCC GGGGAATGCA CGTGTGTGAA 
GATGCGGTGA AGAAGCTGAA GGCGATGGGC CGAAAGTCCG TGAAGTCTGT CCTGTGGGTG 
TCAGCCGATG GGCTCCGAGT GGTGGACGAC AAAACCAAGG ATCTTCTGGT CGACCAGACC 
ATCGAAAAGG TCTCCTTTTG TGCTCCTGAC CGCAACCTGG ACAAGGCTTT CTCCTATATC 
TGTCGTGACG GGACTACCCG CCGCTGGATC TGCCACTGTT TTCTGGCACT GAAGGACTCC 
GGCGAGAGGC TGAGCCACGC TGTGGGCTGT GCTTTTGCCG CCTGCCTGGA GCGAAAACAG 
CGACGGGAGA AGGAATGTGG GGTCACGGCC GCCTTCGATG CCAGCCGCAC CAGCTTCGCC 
CGCGAGGGCT CCTTCCGCCT GTCTGGGGGT GGGCGGCCTG CTGAGCGAGA GGCCCCGGAC 
AAGAAGAAAG CAGAGGCAGC AGCTGCCCCC ACTGTGGCTC CTGGCCCTGC CCAGCCTGGG 
CACGTGTCCC CGACACCAGC CACCACATCC CCTGGTGAGA AGGGTGAGGC AGGCACCCCT 
GTGGCTGCAG GCACCACTGC GGCCGCCATC CCCCGGCGCC ATGCACCCCT GGAGCAGCTG 
GTTCGCCAGG GCTCCTTCCG TGGGTTCCCA GCACTCAGCC AGAAGAACTC GCCTTTCAAA 
CGGCAGCTGA GCCTACGGCT GAATGAGCTG CCATCCACGC TGCAGCGCCG CACTGACTTC 
CAGGTGAAGG GCACAGTGCC TGAGATGGAG CCTCCTGGTG CCGGCGACAG TGACAGCATC 
AACGCTCTGT GCACACAGAT CAGTTCATCT TTTGCCAGTG CTGGAGCGCC AGCACCAGGG 
CCACCACCTG CCACAACAGG GACTTCTGCC TGGGGTGAGC CCTCCGTGCC CCCTGCAGCT 
GCCTTCCAGC CTGGGCACAA GCGGACACCT TCAGAGGCTG AGCGATGGCT GGAGGAGGTG 
TCACAGGTGG CCAAGGCCCA GCAGCAGCAG CAGCAGCAAC AGCAACAGCA GCAGCAGCAG 
CAGCAGCAAC AGCAGCAAGC AGCCTCAGTG GCCCCAGTGC CCACCATGCC TCCTGCCCTG 
CAGCCTTTCC CCGCCCCCGT GGGGCCCTTT GACGCTGCAC CTGCCCAAGT GGCCGTGTTC 
CTGCCACCCC CACACATGCA GCCCCCTTTT GTGCCCGCCT ACCCGGGCTT GGGCTACCCA 
CCGATGCCCC GGGTGCCCGT GGTGGGCATC ACACCCTCAC AGATGGTGGC AAACGCCTTC 
TGCTCAGCCG CCCAGCTCCA GCCTCAGCCT GCCACTCTGC TTGGGAAAGC TGGGGCCTTC 
CCGCCCCCTG CCATACCCAG TGCCCCTGGG AGCCAGGCCC GCCCTCGCCC CAATGGGGCC 
CCCTGGCCCC CTGAGCCAGC GCCTGCCCCA GCTCCAGAGT TGGACCCCTT TGAGGCCCAG 
TGGGCGGCAT TAGAAGGCAA AGCCACTGTA GAGAAACCCT CCAACCCCTT TTCTGGCGAC 
CTGCAAAAGA CATTCGAGAT TGAACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
The Journal of clinical investigation127(2)569-582(2017 Feb)
Hirai M,Arita Y,McGlade CJ,Lee KF,Chen J,Evans SM

Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3474-3488(2016 10)
Zhang Y,Li F,Song Y,Sheng X,Ren F,Xiong K,Chen L,Zhang H,Liu D,Lengner CJ,Xue L,Yu Z

Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl.
Oncotarget7(36)58367-58380(2016 09)
Nwaeburu CC,Bauer N,Zhao Z,Abukiwan A,Gladkich J,Benner A,Herr I

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.
Oncotarget7(39)63611-63628(2016 09)
Garc?a-Heredia JM,Verdugo Sivianes EM,Lucena-Cacace A,Molina-Pinelo S,Carnero A

Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.
Arteriosclerosis, thrombosis, and vascular biology35(8)1815-25(2015 Aug)
van Lessen M,Nakayama M,Kato K,Kim JM,Kaibuchi K,Adams RH

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NUMBL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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