SLA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLA2
Entrez Gene ID	84174
Full Name	Src like adaptor 2
Synonyms	C20orf156,MARS,SLAP-2,SLAP2
General protein information	Preferred Names Src like adaptor 2 Names src-like-adapter 2 Src-like adapter protein-2 modulator of antigen receptor signaling
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.23
Summary	This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	606577

mRNA and Protein(s)

mRNA	Protein	Name
XM_017028098.1	XP_016883587.1	src-like-adapter 2 isoform X1
NM_175077.3	NP_778252.1	src-like-adapter 2 isoform b
NM_032214.4	NP_115590.1	src-like-adapter 2 isoform a
NM_175077.2	NP_778252.1	src-like-adapter 2 isoform b
NM_032214.3	NP_115590.1	src-like-adapter 2 isoform a

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLA2	XP_001137186.1
Danio rerio (zebrafish)	sla2	NP_001107907.1
Canis lupus familiaris (dog)	SLA2	XP_542983.3
Bos taurus (cattle)	SLA2	NP_001030371.1
Xenopus tropicalis (tropical clawed frog)	sla2	XP_002939613.1
Homo sapiens (human)	SLA2	NP_115590.1
	SLA2	XP_001094483.1
Mus musculus (house mouse)	Sla2	NP_084259.1
Rattus norvegicus (Norway rat)	Sla2	NP_001165589.1
Gallus gallus (chicken)	SLA2	XP_003642494.2

Gene Ontology
Bibliography

Related articles in PubMed

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.
Marton N, Baricza E, ?rsek B, Buz?s EI, Nagy G
Mediators of inflammation2015952536(2015)

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Leung KK, Hause RJ Jr, Barkinge JL, Ciaccio MF, Chuu CP, Jones RB
Molecular & cellular proteomics : MCP13(7)1705-23(2014 Jul)

Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through ?-sheet formation.
Wybenga-Groot LE, McGlade CJ
Cellular signalling25(12)2702-8(2013 Dec)

Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI-mediated platelet activation SLAP-2 and GPVI signaling.
Sugihara S, Katsutani S, Deckmyn H, Fujimura K, Kimura A
Thrombosis research126(4)e276-85(2010 Oct)

A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones RB, Gordus A, Krall JA, MacBeath G
Nature439(7073)168-74(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SLAP2 SH3 and SH2 domains are separated by a short SH3-SH2 connector sequence.
Title: Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through ?-sheet formation.

In platelets, SLAP-2 may have function as a negative regulator of GPVI-mediated signaling by interacting with c-Cbl.
Title: Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI-mediated platelet activation SLAP-2 and GPVI signaling.

Observational study of gene-disease association. (HuGE Navigator)
Title: An integrative method for scoring candidate genes from association studies: application to warfarin dosing.

The human SLAP-2 gene is located on chromosome 20q, and the SLAP-2 coding region consists of seven exons, a unique cDNA encoding an alternatively spliced SLAP-2 isoform has been identified
Title: Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v.

negatively regulates T cell receptor signaling
Title: A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.

The following SLA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20345	NM_032214.4 Latest version!	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07404	NM_175077.3 Latest version!	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu93135	XM_017028098.1 Latest version!	Homo sapiens Src like adaptor 2 (SLA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu07404	NM_175077.2	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu20345	NM_032214.3	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLA2 ( NM_032214.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115590.1 Homo sapiens Src like adaptor 2 (SLA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20345
Clone ID Related Accession (Same CDS sequence)	NM_032214.4 , NM_032214.3
Accession Version	NM_032214.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	src-like-adapter 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA983348.1, BC042041.1, BF510664.1 and AL050318.13. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_032214.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK291513.1, BC042041.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262866.9/ ENSP00000262866.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGCTGGCG 
GATGACATCT GCTGCCTACT CAAGGAGCCC TGTGTCCTGC AGAGGGCTGG CCCGCTCCCT 
GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG GAAAGAGCTG 
GACAGCTCCC TCCTGTTTTC TGAAGCTGCC ACAGGGGAGG AGTCTCTTCT CAGTGAGGGT 
CTCCGGGAGT CCCTCAGCTT CTACATCAGC CTGAATGACG AGGCTGTCTC TTTGGATGAT 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115590.1
CDS	404..1189
Translation	MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEGLRESLSFYISLNDEAVSLDDA

Target ORF information:

RefSeq Version	NM_032214.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032214.4

ORF Insert Sequence:

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGCTGGCG 
GATGACATCT GCTGCCTACT CAAGGAGCCC TGTGTCCTGC AGAGGGCTGG CCCGCTCCCT 
GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG GAAAGAGCTG 
GACAGCTCCC TCCTGTTTTC TGAAGCTGCC ACAGGGGAGG AGTCTCTTCT CAGTGAGGGT 
CTCCGGGAGT CCCTCAGCTT CTACATCAGC CTGAATGACG AGGCTGTCTC TTTGGATGAT 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLA2 ( NM_032214.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115590.1 Homo sapiens Src like adaptor 2 (SLA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20345
Clone ID Related Accession (Same CDS sequence)	NM_032214.4 , NM_032214.3
Accession Version	NM_032214.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	src-like-adapter 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA983348.1, BC042041.1 and BF510664.1. This sequence is a reference standard in the RefSeqGene project. On Dec 1, 2011 this sequence version replaced NM_032214.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC042041.1, AK291513.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGCTGGCG 
GATGACATCT GCTGCCTACT CAAGGAGCCC TGTGTCCTGC AGAGGGCTGG CCCGCTCCCT 
GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG GAAAGAGCTG 
GACAGCTCCC TCCTGTTTTC TGAAGCTGCC ACAGGGGAGG AGTCTCTTCT CAGTGAGGGT 
CTCCGGGAGT CCCTCAGCTT CTACATCAGC CTGAATGACG AGGCTGTCTC TTTGGATGAT 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115590.1
CDS	424..1209
Translation	MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEGLRESLSFYISLNDEAVSLDDA

Target ORF information:

RefSeq Version	NM_032214.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032214.3

ORF Insert Sequence:

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGCTGGCG 
GATGACATCT GCTGCCTACT CAAGGAGCCC TGTGTCCTGC AGAGGGCTGG CCCGCTCCCT 
GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG GAAAGAGCTG 
GACAGCTCCC TCCTGTTTTC TGAAGCTGCC ACAGGGGAGG AGTCTCTTCT CAGTGAGGGT 
CTCCGGGAGT CCCTCAGCTT CTACATCAGC CTGAATGACG AGGCTGTCTC TTTGGATGAT 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLA2 ( NM_175077.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_778252.1 Homo sapiens Src like adaptor 2 (SLA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07404
Clone ID Related Accession (Same CDS sequence)	NM_175077.3 , NM_175077.2
Accession Version	NM_175077.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	src-like-adapter 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA983348.1, BQ052468.1, AF290986.1, BC042041.1, BF510664.1 and AL050318.13. On May 31, 2019 this sequence version replaced NM_175077.2. Transcript Variant: This variant (2, also known as SLAP-2-v) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: BQ052468.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGGGCTGG 
CCCGCTCCCT GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG 
GAAAGAGCTG GACAGCTCCC TCCTGTTTTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778252.1
CDS	404..1036
Translation	MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGWPAPWQGYTPTCDCAEDTTQLERAGQLPPVF

Target ORF information:

RefSeq Version	NM_175077.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175077.3

ORF Insert Sequence:

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGGGCTGG 
CCCGCTCCCT GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG 
GAAAGAGCTG GACAGCTCCC TCCTGTTTTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLA2 ( NM_175077.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_778252.1 Homo sapiens Src like adaptor 2 (SLA2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07404
Clone ID Related Accession (Same CDS sequence)	NM_175077.3 , NM_175077.2
Accession Version	NM_175077.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	src-like-adapter 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA983348.1, BQ052468.1, AF290986.1, BC042041.1 and BF510664.1. On Dec 1, 2011 this sequence version replaced NM_175077.1. Transcript Variant: This variant (2, also known as SLAP-2-v) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: BQ052468.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGGGCTGG 
CCCGCTCCCT GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG 
GAAAGAGCTG GACAGCTCCC TCCTGTTTTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_778252.1
CDS	424..1056
Translation	MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGWPAPWQGYTPTCDCAEDTTQLERAGQLPPVF

Target ORF information:

RefSeq Version	NM_175077.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Src like adaptor 2 (SLA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175077.2

ORF Insert Sequence:

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGAGGGCTGG 
CCCGCTCCCT GGCAAGGATA TACCCCTACC TGTGACTGTG CAGAGGACAC CACTCAACTG 
GAAAGAGCTG GACAGCTCCC TCCTGTTTTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLA2 ( XM_017028098.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883587.1 Homo sapiens Src like adaptor 2 (SLA2), transcript variant X1, mRNA.

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CloneID	OHu93135
Clone ID Related Accession (Same CDS sequence)	XM_017028098.1
Accession Version	XM_017028098.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	src-like-adapter 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGACAGACAG 
AAGAGCGGCC TCCCCTATTT TCACGCCAGT CCCTATGCCA AGAAATGCAG GCTGGGAGCC 
CTGTCTTCAC CTCGTGCCCT GGCAGAAAAG CCACAGACCT CCTGTGTAGG CTCAGGTCAG 
TACCTTGCCT ACCACTCTGG TTCTGACTCA GAGCCCCTGG CAGCAGGCAG AGTTCTCTCC 
ACAGGAACCG GGCACAGAGC TGCTGCTGTG TGGGATTCAA TCCTGACTCT CCTTAGTACT 
TCCTGGTGCC TGTCCTTCAA CAGACACTGG AAGATGCAGT CACTGGGCAC AGCGTCAGGG 
GGCAGAGAGG GAAGAGCACT CTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883587.1
CDS	415..1281
Translation	MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSDRQKSGLPYFHASPYAKKCRLGALSSPRALAEKPQTSCVGSGQYLAYHSGSDSEPLAAGRVLSTGTGHRAAAVWDSILTLLSTSWCLSFNRHWKMQSLGTASGGREGRALL

Target ORF information:

RefSeq Version	XM_017028098.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Src like adaptor 2 (SLA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028098.1

ORF Insert Sequence:

ATGGGAAGTC TGCCCAGCAG AAGAAAATCT CTGCCAAGCC CAAGCTTGAG TTCCTCTGTC 
CAAGGCCAGG GACCTGTGAC CATGGAAGCA GAGAGAAGCA AGGCCACAGC CGTGGCCCTG 
GGCAGTTTCC CGGCAGGTGG CCCGGCCGAG CTGTCGCTGA GACTCGGGGA GCCATTGACC 
ATCGTCTCTG AGGATGGAGA CTGGTGGACG GTGCTGTCTG AAGTCTCAGG CAGAGAGTAT 
AACATCCCCA GCGTCCACGT GGCCAAAGTC TCCCATGGGT GGCTGTATGA GGGCCTGAGC 
AGGGAGAAAG CAGAGGAACT GCTGTTGTTA CCTGGGAACC CTGGAGGGGC CTTCCTCATC 
CGGGAGAGCC AGACCAGGAG AGGCTCTTAC TCTCTGTCAG TCCGCCTCAG CCGCCCTGCA 
TCCTGGGACC GGATCAGACA CTACAGGATC CACTGCCTTG ACAATGGCTG GCTGTACATC 
TCACCGCGCC TCACCTTCCC CTCACTCCAG GCCCTGGTGG ACCATTACTC TGACAGACAG 
AAGAGCGGCC TCCCCTATTT TCACGCCAGT CCCTATGCCA AGAAATGCAG GCTGGGAGCC 
CTGTCTTCAC CTCGTGCCCT GGCAGAAAAG CCACAGACCT CCTGTGTAGG CTCAGGTCAG 
TACCTTGCCT ACCACTCTGG TTCTGACTCA GAGCCCCTGG CAGCAGGCAG AGTTCTCTCC 
ACAGGAACCG GGCACAGAGC TGCTGCTGTG TGGGATTCAA TCCTGACTCT CCTTAGTACT 
TCCTGGTGCC TGTCCTTCAA CAGACACTGG AAGATGCAGT CACTGGGCAC AGCGTCAGGG 
GGCAGAGAGG GAAGAGCACT CTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.
Mediators of inflammation2015952536(2015)
Marton N,Baricza E,?rsek B,Buz?s EI,Nagy G

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Molecular & cellular proteomics : MCP13(7)1705-23(2014 Jul)
Leung KK,Hause RJ Jr,Barkinge JL,Ciaccio MF,Chuu CP,Jones RB

Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through ?-sheet formation.
Cellular signalling25(12)2702-8(2013 Dec)
Wybenga-Groot LE,McGlade CJ

Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI-mediated platelet activation SLAP-2 and GPVI signaling.
Thrombosis research126(4)e276-85(2010 Oct)
Sugihara S,Katsutani S,Deckmyn H,Fujimura K,Kimura A

A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Nature439(7073)168-74(2006 Jan)
Jones RB,Gordus A,Krall JA,MacBeath G