RAB6C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB6C
Entrez Gene ID	84084
Full Name	RAB6C, member RAS oncogene family
Synonyms	WTH3
General protein information	Preferred Names RAB6C, member RAS oncogene family Names ras-related protein Rab-6C rab6-like protein WTH3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q21.1
Disorder MIM:	612909

mRNA and Protein(s)

mRNA	Protein	Name
NM_032144.3	NP_115520.2	ras-related protein Rab-6C
NM_032144.2	NP_115520.2	ras-related protein Rab-6C

Pathways from BioSystems

Homologies

Homo sapiens (human)	RAB6C	NP_115520.2
Homo sapiens (human)	WTH3DI	NP_001071105.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue.
Bhat S, Kabekkodu SP, Jayaprakash C, Radhakrishnan R, Ray S, Satyamoorthy K
Virchows Archiv : an international journal of pathology470(4)445-454(2017 Apr)

Genome-wide association study of chronic periodontitis in a general German population.
Teumer A, Holtfreter B, V?lker U, Petersmann A, Nauck M, Biffar R, V?lzke H, Kroemer HK, Meisel P, Homuth G, Kocher T
Journal of clinical periodontology40(11)977-85(2013 Nov)

Crystallization and preliminary X-ray crystallographic studies of Rab6A'(Q72L): a GTP-locked form.
Shin YC, Jang TH, Yoon JH, Jeon JH, Park HH
Acta crystallographica. Section F, Structural biology and crystallization communications68(Pt 9)1077-80(2012 Sep)

Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
International journal of molecular medicine25(4)649-56(2010 Apr)

RAB6C is a retrogene that encodes a centrosomal protein involved in cell cycle progression.
Young J, M?n?trey J, Goud B
Journal of molecular biology397(1)69-88(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the first study to report hypermethylation of LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue
Title: Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue.

Rab6A'(Q72L) was then purified to homogeneity and crystallized at 293 K. X-ray diffraction data were collected to a resolution of 1.9 A from a crystal belonging to space group P22(1)2(1) with unit-cell parameters a = 36.84, b = 96.78, c = 109.99 A
Title: Crystallization and preliminary X-ray crystallographic studies of Rab6A'(Q72L): a GTP-locked form.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.

RAB6C is a rare example of a recently emerged retrogene that has acquired the status of a new gene, encoding a functional protein with altered characteristics compared to Rab6A'.
Title: RAB6C is a retrogene that encodes a centrosomal protein involved in cell cycle progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

The following RAB6C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB6C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24231	NM_032144.3 Latest version!	Homo sapiens RAB6C, member RAS oncogene family (RAB6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24231	NM_032144.2	Homo sapiens RAB6C, member RAS oncogene family (RAB6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB6C ( NM_032144.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115520.2 Homo sapiens RAB6C, member RAS oncogene family (RAB6C), mRNA.

Price & Availability↑

CloneID	OHu24231
Clone ID Related Accession (Same CDS sequence)	NM_032144.3 , NM_032144.2
Accession Version	NM_032144.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079776.5. On May 17, 2019 this sequence version replaced NM_032144.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AL136727.1, SRR1803611.68708.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000410061.4/ ENSP00000387307.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCCGCGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGCAAAGAC ATCTTTGATC ACCAGATTCA GGTATGACAG TTTTGACAAC 
ACCTATCAGG CAATAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATGGA 
ACAATCGGGC TTCGGCTGTG GGATACGGCG GGTCAGGAAC GTCTCCGTAG CCTCATTCCC 
AGGTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCACGCTAG TAGGAAATAG AACAGATCTT GCTGACAAGA GGCAAGTGTC AGTTGAGGAG 
GGAGAGAGGA AAGCCAAAGG GCTGAATGTT ACGTTTATTG AAACTAGGGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACGGAA GCAGAGAAGA CATGAGTGAC ATAAAACTGG AAAAGCCTCA GGAGCAAACA 
GTCAGCGAAG GGGGTTGTTC CTGCTACTCT CCCATGTCAT CTTCAACCCT TCCTCAGAAG 
CCCCCTTACT CTTTCATTGA CTGCAGTGTG AATATTGGCT TGAACCTTTT CCCTTCATTA 
ATAACGTTTT GCAATTCATC ATTGCTGCCT GTCTCGTGGA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115520.2
CDS	451..1215
Translation	MSAGGDFGNPLRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIITLVGNRTDLADKRQVSVEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSDIKLEKPQEQTVSEGGCSCYSPMSSSTLPQKPPYSFIDCSVNIGLNLFPSLITFCNSSLLPVSWR

Target ORF information:

RefSeq Version	NM_032144.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6C, member RAS oncogene family (RAB6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032144.3

ORF Insert Sequence:

ATGTCCGCGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGCAAAGAC ATCTTTGATC ACCAGATTCA GGTATGACAG TTTTGACAAC 
ACCTATCAGG CAATAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATGGA 
ACAATCGGGC TTCGGCTGTG GGATACGGCG GGTCAGGAAC GTCTCCGTAG CCTCATTCCC 
AGGTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCACGCTAG TAGGAAATAG AACAGATCTT GCTGACAAGA GGCAAGTGTC AGTTGAGGAG 
GGAGAGAGGA AAGCCAAAGG GCTGAATGTT ACGTTTATTG AAACTAGGGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACGGAA GCAGAGAAGA CATGAGTGAC ATAAAACTGG AAAAGCCTCA GGAGCAAACA 
GTCAGCGAAG GGGGTTGTTC CTGCTACTCT CCCATGTCAT CTTCAACCCT TCCTCAGAAG 
CCCCCTTACT CTTTCATTGA CTGCAGTGTG AATATTGGCT TGAACCTTTT CCCTTCATTA 
ATAACGTTTT GCAATTCATC ATTGCTGCCT GTCTCGTGGA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB6C ( NM_032144.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115520.2 Homo sapiens RAB6C, member RAS oncogene family (RAB6C), mRNA.

Price & Availability↑

CloneID	OHu24231
Clone ID Related Accession (Same CDS sequence)	NM_032144.3 , NM_032144.2
Accession Version	NM_032144.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	ras-related protein Rab-6C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079776.5. On Oct 31, 2006 this sequence version replaced NM_032144.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AL136727.1 [ECO:0000345] ##Evidence-Data-END##

ATGTCCGCGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGCAAAGAC ATCTTTGATC ACCAGATTCA GGTATGACAG TTTTGACAAC 
ACCTATCAGG CAATAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATGGA 
ACAATCGGGC TTCGGCTGTG GGATACGGCG GGTCAGGAAC GTCTCCGTAG CCTCATTCCC 
AGGTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCACGCTAG TAGGAAATAG AACAGATCTT GCTGACAAGA GGCAAGTGTC AGTTGAGGAG 
GGAGAGAGGA AAGCCAAAGG GCTGAATGTT ACGTTTATTG AAACTAGGGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACGGAA GCAGAGAAGA CATGAGTGAC ATAAAACTGG AAAAGCCTCA GGAGCAAACA 
GTCAGCGAAG GGGGTTGTTC CTGCTACTCT CCCATGTCAT CTTCAACCCT TCCTCAGAAG 
CCCCCTTACT CTTTCATTGA CTGCAGTGTG AATATTGGCT TGAACCTTTT CCCTTCATTA 
ATAACGTTTT GCAATTCATC ATTGCTGCCT GTCTCGTGGA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115520.2
CDS	455..1219
Translation	MSAGGDFGNPLRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIITLVGNRTDLADKRQVSVEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSDIKLEKPQEQTVSEGGCSCYSPMSSSTLPQKPPYSFIDCSVNIGLNLFPSLITFCNSSLLPVSWR

Target ORF information:

RefSeq Version	NM_032144.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB6C, member RAS oncogene family (RAB6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032144.2

ORF Insert Sequence:

ATGTCCGCGG GCGGAGACTT CGGGAATCCG CTGAGGAAAT TCAAGCTGGT GTTCCTGGGG 
GAGCAAAGCG TTGCAAAGAC ATCTTTGATC ACCAGATTCA GGTATGACAG TTTTGACAAC 
ACCTATCAGG CAATAATTGG CATTGACTTT TTATCAAAAA CTATGTACTT GGAGGATGGA 
ACAATCGGGC TTCGGCTGTG GGATACGGCG GGTCAGGAAC GTCTCCGTAG CCTCATTCCC 
AGGTACATCC GTGATTCTGC TGCAGCTGTA GTAGTTTACG ATATCACAAA TGTTAACTCA 
TTCCAGCAAA CTACAAAGTG GATTGATGAT GTCAGAACAG AAAGAGGAAG TGATGTTATC 
ATCACGCTAG TAGGAAATAG AACAGATCTT GCTGACAAGA GGCAAGTGTC AGTTGAGGAG 
GGAGAGAGGA AAGCCAAAGG GCTGAATGTT ACGTTTATTG AAACTAGGGC AAAAGCTGGA 
TACAATGTAA AGCAGCTCTT TCGACGTGTA GCAGCAGCTT TGCCGGGAAT GGAAAGCACA 
CAGGACGGAA GCAGAGAAGA CATGAGTGAC ATAAAACTGG AAAAGCCTCA GGAGCAAACA 
GTCAGCGAAG GGGGTTGTTC CTGCTACTCT CCCATGTCAT CTTCAACCCT TCCTCAGAAG 
CCCCCTTACT CTTTCATTGA CTGCAGTGTG AATATTGGCT TGAACCTTTT CCCTTCATTA 
ATAACGTTTT GCAATTCATC ATTGCTGCCT GTCTCGTGGA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue.
Virchows Archiv : an international journal of pathology470(4)445-454(2017 Apr)
Bhat S,Kabekkodu SP,Jayaprakash C,Radhakrishnan R,Ray S,Satyamoorthy K

Genome-wide association study of chronic periodontitis in a general German population.
Journal of clinical periodontology40(11)977-85(2013 Nov)
Teumer A,Holtfreter B,V?lker U,Petersmann A,Nauck M,Biffar R,V?lzke H,Kroemer HK,Meisel P,Homuth G,Kocher T

Crystallization and preliminary X-ray crystallographic studies of Rab6A'(Q72L): a GTP-locked form.
Acta crystallographica. Section F, Structural biology and crystallization communications68(Pt 9)1077-80(2012 Sep)
Shin YC,Jang TH,Yoon JH,Jeon JH,Park HH

Association of genetic variants with hemorrhagic stroke in Japanese individuals.
International journal of molecular medicine25(4)649-56(2010 Apr)
Yoshida T,Kato K,Yokoi K,Oguri M,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nozawa Y,Yamada Y

RAB6C is a retrogene that encodes a centrosomal protein involved in cell cycle progression.
Journal of molecular biology397(1)69-88(2010 Mar)
Young J,M?n?trey J,Goud B