XRCC5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	XRCC5
Entrez Gene ID	7520
Full Name	X-ray repair cross complementing 5
Synonyms	KARP-1,KARP1,KU80,KUB2,Ku86,NFIV
General protein information	Preferred Names X-ray repair cross complementing 5 Names X-ray repair cross-complementing protein 5 86 kDa subunit of Ku antigen ATP-dependent DNA helicase 2 subunit 2 ATP-dependent DNA helicase II 80 kDa subunit CTC box-binding factor 85 kDa subunit CTC85 CTCBF DNA repair protein XRCC5 Ku autoantigen, 80kDa Ku86 autoantigen related protein 1 TLAA X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) lupus Ku autoantigen protein p86 nuclear factor IV thyroid-lupus autoantigen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Summary	The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
Disorder MIM:	194364

mRNA and Protein(s)

mRNA	Protein	Name
NM_021141.3	NP_066964.1	X-ray repair cross-complementing protein 5
NM_021141.4	NP_066964.1	X-ray repair cross-complementing protein 5

Pathways from BioSystems

Homologies

	XRCC5	XP_001084586.2
Bos taurus (cattle)	LOC531945	NP_001095611.1
Danio rerio (zebrafish)	LOC100331090	XP_002665537.3
Neurospora crassa	NCU00077	XP_956387.2
Canis lupus familiaris (dog)	XRCC5	XP_536061.4
Rattus norvegicus (Norway rat)	Xrcc5	NP_803154.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009910	XP_319031.4
Mus musculus (house mouse)	Xrcc5	NP_033559.2
Gallus gallus (chicken)	XRCC5	XP_422072.4
Schizosaccharomyces pombe (fission yeast)	pku80	NP_596791.1
Magnaporthe oryzae (rice blast fungus)	MGG_10157	XP_003713796.1
Homo sapiens (human)	XRCC5	NP_066964.1
Pan troglodytes (chimpanzee)	XRCC5	XP_001151873.2
Danio rerio (zebrafish)	xrcc5	NP_001017360.1
Arabidopsis thaliana (thale cress)	KU80	NP_564520.1
Xenopus tropicalis (tropical clawed frog)	xrcc5	XP_002942054.2

Gene Ontology
Bibliography

Related articles in PubMed

Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair.
Yan Q, Zhu H, Lan L, Yi J, Yang J
DNA repair6018-28(2017 Dec)

XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.
Zhang Z, Zheng F, Yu Z, Hao J, Chen M, Yu W, Guo W, Chen Y, Huang W, Duan Z, Deng W
PloS one12(10)e0186900(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ku80 can be cleaved by caspases-2 at D726 upon a transient etoposide treatment. Caspase-2-mediated Ku80 cleavage promotes Ku80/DNA-PKcs interaction as the D726A mutation diminished Ku80 interaction with DNA-PKcs
Title: Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair.

Ku80 CTR (C-terminal region) is required for interaction with DNA-PKcs on short segments of blunt ended 25bp dsDNA or 25bp dsDNA with a 15-base poly dA ssDNA extension, but this requirement is less stringent on longer dsDNA molecules (35bp blunt ended dsDNA) or 25bp duplex DNA with either a 15-base poly dT or poly dC ssDNA extension. Moreover, DNA-PKcs-Ku complex forms on 25 bp DNA with poly-pyrimidine ssDNA extension.
Title: DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

Ku80 could predict the probability of resistance to neoadjuvant chemotherapy in lung adenocarcinoma, and reduced cisplatin and pemetrexed-induced apoptosis in A549 cells
Title: Ku80 correlates with neoadjuvant chemotherapy resistance in human lung adenocarcinoma, but reduces cisplatin/pemetrexed-induced apoptosis in A549 cells.

results demonstrated that XRCC5 promoted colon cancer growth by cooperating with p300 to regulate COX-2 expression, and suggested that the XRCC5/p300/COX-2 signaling pathway was a potential target in the treatment of colon cancers
Title: XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.

Results show that DDB2 is critical for chromatin association of XRCC5/6 in the absence of DNA damage and provide evidence that XRCC5/6 are functional partners of DDB2 in its transcriptional stimulatory activity.
Title: Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.

The following XRCC5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XRCC5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26107	NM_021141.4 Latest version!	Homo sapiens X-ray repair cross complementing 5 (XRCC5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu26107	NM_021141.3	Homo sapiens X-ray repair cross complementing 5 (XRCC5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XRCC5 ( NM_021141.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066964.1 Homo sapiens X-ray repair cross complementing 5 (XRCC5), mRNA.

Price & Availability↑

CloneID	OHu26107
Clone ID Related Accession (Same CDS sequence)	NM_021141.3 , NM_021141.4
Accession Version	NM_021141.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2199bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	X-ray repair cross-complementing protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP375944.1, BG717693.1, M30938.1, X57500.1 and BU184024.1. This sequence is a reference standard in the RefSeqGene project. On Aug 8, 2008 this sequence version replaced NM_021141.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.23277.1, SRR1803617.267656.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGT CGGGGAATAA GGCAGCTGTT GTGCTGTGTA TGGACGTGGG CTTTACCATG 
AGTAACTCCA TTCCTGGTAT AGAATCCCCA TTTGAACAAG CAAAGAAGGT GATAACCATG 
TTTGTACAGC GACAGGTGTT TGCTGAGAAC AAGGATGAGA TTGCTTTAGT CCTGTTTGGT 
ACAGATGGCA CTGACAATCC CCTTTCTGGT GGGGATCAGT ATCAGAACAT CACAGTGCAC 
AGACATCTGA TGCTACCAGA TTTTGATTTG CTGGAGGACA TTGAAAGCAA AATCCAACCA 
GGTTCTCAAC AGGCTGACTT CCTGGATGCA CTAATCGTGA GCATGGATGT GATTCAACAT 
GAAACAATAG GAAAGAAGTT TGAGAAGAGG CATATTGAAA TATTCACTGA CCTCAGCAGC 
CGATTCAGCA AAAGTCAGCT GGATATTATA ATTCATAGCT TGAAGAAATG TGACATCTCC 
CTGCAATTCT TCTTGCCTTT CTCACTTGGC AAGGAAGATG GAAGTGGGGA CAGAGGAGAT 
GGCCCCTTTC GCTTAGGTGG CCATGGGCCT TCCTTTCCAC TAAAAGGAAT TACCGAACAG 
CAAAAAGAAG GTCTTGAGAT AGTGAAAATG GTGATGATAT CTTTAGAAGG TGAAGATGGG 
TTGGATGAAA TTTATTCATT CAGTGAGAGT CTGAGAAAAC TGTGCGTCTT CAAGAAAATT 
GAGAGGCATT CCATTCACTG GCCCTGCCGA CTGACCATTG GCTCCAATTT GTCTATAAGG 
ATTGCAGCCT ATAAATCGAT TCTACAGGAG AGAGTTAAAA AGACTTGGAC AGTTGTGGAT 
GCAAAAACCC TAAAAAAAGA AGATATACAA AAAGAAACAG TTTATTGCTT AAATGATGAT 
GATGAAACTG AAGTTTTAAA AGAGGATATT ATTCAAGGGT TCCGCTATGG AAGTGATATA 
GTTCCTTTCT CTAAAGTGGA TGAGGAACAA ATGAAATATA AATCGGAGGG GAAGTGCTTC 
TCTGTTTTGG GATTTTGTAA ATCTTCTCAG GTTCAGAGAA GATTCTTCAT GGGAAATCAA 
GTTCTAAAGG TCTTTGCAGC AAGAGATGAT GAGGCAGCTG CAGTTGCACT TTCCTCCCTG 
ATTCATGCTT TGGATGACTT AGACATGGTG GCCATAGTTC GATATGCTTA TGACAAAAGA 
GCTAATCCTC AAGTCGGCGT GGCTTTTCCT CATATCAAGC ATAACTATGA GTGTTTAGTG 
TATGTGCAGC TGCCTTTCAT GGAAGACTTG CGGCAATACA TGTTTTCATC CTTGAAAAAC 
AGTAAGAAAT ATGCTCCCAC CGAGGCACAG TTGAATGCTG TTGATGCTTT GATTGACTCC 
ATGAGCTTGG CAAAGAAAGA TGAGAAGACA GACACCCTTG AAGACTTGTT TCCAACCACC 
AAAATCCCAA ATCCTCGATT TCAGAGATTA TTTCAGTGTC TGCTGCACAG AGCTTTACAT 
CCCCGGGAGC CTCTACCCCC AATTCAGCAG CATATTTGGA ATATGCTGAA TCCTCCCGCT 
GAGGTGACAA CAAAAAGTCA GATTCCTCTC TCTAAAATAA AGACCCTTTT TCCTCTGATT 
GAAGCCAAGA AAAAGGATCA AGTGACTGCT CAGGAAATTT TCCAAGACAA CCATGAAGAT 
GGACCTACAG CTAAAAAATT AAAGACTGAG CAAGGGGGAG CCCACTTCAG CGTCTCCAGT 
CTGGCTGAAG GCAGTGTCAC CTCTGTTGGA AGTGTGAATC CTGCTGAAAA CTTCCGTGTT 
CTAGTGAAAC AGAAGAAGGC CAGCTTTGAG GAAGCGAGTA ACCAGCTCAT AAATCACATC 
GAACAGTTTT TGGATACTAA TGAAACACCG TATTTTATGA AGAGCATAGA CTGCATCCGA 
GCCTTCCGGG AAGAAGCCAT TAAGTTTTCA GAAGAGCAGC GCTTTAACAA CTTCCTGAAA 
GCCCTTCAAG AGAAAGTGGA AATTAAACAA TTAAATCATT TCTGGGAAAT TGTTGTCCAG 
GATGGAATTA CTCTGATCAC CAAAGAGGAA GCCTCTGGAA GTTCTGTCAC AGCTGAGGAA 
GCCAAAAAGT TTCTGGCCCC CAAAGACAAA CCAAGTGGAG ACACAGCAGC TGTATTTGAA 
GAAGGTGGTG ATGTGGACGA TTTATTGGAC ATGATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066964.1
CDS	141..2339
Translation	MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI

Target ORF information:

RefSeq Version	NM_021141.3
Organism	Homo sapiens(human)
Definition	Homo sapiens X-ray repair cross complementing 5 (XRCC5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021141.3

ORF Insert Sequence:

ATGGTGCGGT CGGGGAATAA GGCAGCTGTT GTGCTGTGTA TGGACGTGGG CTTTACCATG 
AGTAACTCCA TTCCTGGTAT AGAATCCCCA TTTGAACAAG CAAAGAAGGT GATAACCATG 
TTTGTACAGC GACAGGTGTT TGCTGAGAAC AAGGATGAGA TTGCTTTAGT CCTGTTTGGT 
ACAGATGGCA CTGACAATCC CCTTTCTGGT GGGGATCAGT ATCAGAACAT CACAGTGCAC 
AGACATCTGA TGCTACCAGA TTTTGATTTG CTGGAGGACA TTGAAAGCAA AATCCAACCA 
GGTTCTCAAC AGGCTGACTT CCTGGATGCA CTAATCGTGA GCATGGATGT GATTCAACAT 
GAAACAATAG GAAAGAAGTT TGAGAAGAGG CATATTGAAA TATTCACTGA CCTCAGCAGC 
CGATTCAGCA AAAGTCAGCT GGATATTATA ATTCATAGCT TGAAGAAATG TGACATCTCC 
CTGCAATTCT TCTTGCCTTT CTCACTTGGC AAGGAAGATG GAAGTGGGGA CAGAGGAGAT 
GGCCCCTTTC GCTTAGGTGG CCATGGGCCT TCCTTTCCAC TAAAAGGAAT TACCGAACAG 
CAAAAAGAAG GTCTTGAGAT AGTGAAAATG GTGATGATAT CTTTAGAAGG TGAAGATGGG 
TTGGATGAAA TTTATTCATT CAGTGAGAGT CTGAGAAAAC TGTGCGTCTT CAAGAAAATT 
GAGAGGCATT CCATTCACTG GCCCTGCCGA CTGACCATTG GCTCCAATTT GTCTATAAGG 
ATTGCAGCCT ATAAATCGAT TCTACAGGAG AGAGTTAAAA AGACTTGGAC AGTTGTGGAT 
GCAAAAACCC TAAAAAAAGA AGATATACAA AAAGAAACAG TTTATTGCTT AAATGATGAT 
GATGAAACTG AAGTTTTAAA AGAGGATATT ATTCAAGGGT TCCGCTATGG AAGTGATATA 
GTTCCTTTCT CTAAAGTGGA TGAGGAACAA ATGAAATATA AATCGGAGGG GAAGTGCTTC 
TCTGTTTTGG GATTTTGTAA ATCTTCTCAG GTTCAGAGAA GATTCTTCAT GGGAAATCAA 
GTTCTAAAGG TCTTTGCAGC AAGAGATGAT GAGGCAGCTG CAGTTGCACT TTCCTCCCTG 
ATTCATGCTT TGGATGACTT AGACATGGTG GCCATAGTTC GATATGCTTA TGACAAAAGA 
GCTAATCCTC AAGTCGGCGT GGCTTTTCCT CATATCAAGC ATAACTATGA GTGTTTAGTG 
TATGTGCAGC TGCCTTTCAT GGAAGACTTG CGGCAATACA TGTTTTCATC CTTGAAAAAC 
AGTAAGAAAT ATGCTCCCAC CGAGGCACAG TTGAATGCTG TTGATGCTTT GATTGACTCC 
ATGAGCTTGG CAAAGAAAGA TGAGAAGACA GACACCCTTG AAGACTTGTT TCCAACCACC 
AAAATCCCAA ATCCTCGATT TCAGAGATTA TTTCAGTGTC TGCTGCACAG AGCTTTACAT 
CCCCGGGAGC CTCTACCCCC AATTCAGCAG CATATTTGGA ATATGCTGAA TCCTCCCGCT 
GAGGTGACAA CAAAAAGTCA GATTCCTCTC TCTAAAATAA AGACCCTTTT TCCTCTGATT 
GAAGCCAAGA AAAAGGATCA AGTGACTGCT CAGGAAATTT TCCAAGACAA CCATGAAGAT 
GGACCTACAG CTAAAAAATT AAAGACTGAG CAAGGGGGAG CCCACTTCAG CGTCTCCAGT 
CTGGCTGAAG GCAGTGTCAC CTCTGTTGGA AGTGTGAATC CTGCTGAAAA CTTCCGTGTT 
CTAGTGAAAC AGAAGAAGGC CAGCTTTGAG GAAGCGAGTA ACCAGCTCAT AAATCACATC 
GAACAGTTTT TGGATACTAA TGAAACACCG TATTTTATGA AGAGCATAGA CTGCATCCGA 
GCCTTCCGGG AAGAAGCCAT TAAGTTTTCA GAAGAGCAGC GCTTTAACAA CTTCCTGAAA 
GCCCTTCAAG AGAAAGTGGA AATTAAACAA TTAAATCATT TCTGGGAAAT TGTTGTCCAG 
GATGGAATTA CTCTGATCAC CAAAGAGGAA GCCTCTGGAA GTTCTGTCAC AGCTGAGGAA 
GCCAAAAAGT TTCTGGCCCC CAAAGACAAA CCAAGTGGAG ACACAGCAGC TGTATTTGAA 
GAAGGTGGTG ATGTGGACGA TTTATTGGAC ATGATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XRCC5 ( NM_021141.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066964.1 Homo sapiens X-ray repair cross complementing 5 (XRCC5), mRNA.

Price & Availability↑

CloneID	OHu26107
Clone ID Related Accession (Same CDS sequence)	NM_021141.3 , NM_021141.4
Accession Version	NM_021141.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2199bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	X-ray repair cross-complementing protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP375944.1, BG717693.1, M30938.1, X57500.1 and BU184024.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_021141.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.196403.1, SRR1660803.94913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000392132.7/ ENSP00000375977.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGCGGT CGGGGAATAA GGCAGCTGTT GTGCTGTGTA TGGACGTGGG CTTTACCATG 
AGTAACTCCA TTCCTGGTAT AGAATCCCCA TTTGAACAAG CAAAGAAGGT GATAACCATG 
TTTGTACAGC GACAGGTGTT TGCTGAGAAC AAGGATGAGA TTGCTTTAGT CCTGTTTGGT 
ACAGATGGCA CTGACAATCC CCTTTCTGGT GGGGATCAGT ATCAGAACAT CACAGTGCAC 
AGACATCTGA TGCTACCAGA TTTTGATTTG CTGGAGGACA TTGAAAGCAA AATCCAACCA 
GGTTCTCAAC AGGCTGACTT CCTGGATGCA CTAATCGTGA GCATGGATGT GATTCAACAT 
GAAACAATAG GAAAGAAGTT TGAGAAGAGG CATATTGAAA TATTCACTGA CCTCAGCAGC 
CGATTCAGCA AAAGTCAGCT GGATATTATA ATTCATAGCT TGAAGAAATG TGACATCTCC 
CTGCAATTCT TCTTGCCTTT CTCACTTGGC AAGGAAGATG GAAGTGGGGA CAGAGGAGAT 
GGCCCCTTTC GCTTAGGTGG CCATGGGCCT TCCTTTCCAC TAAAAGGAAT TACCGAACAG 
CAAAAAGAAG GTCTTGAGAT AGTGAAAATG GTGATGATAT CTTTAGAAGG TGAAGATGGG 
TTGGATGAAA TTTATTCATT CAGTGAGAGT CTGAGAAAAC TGTGCGTCTT CAAGAAAATT 
GAGAGGCATT CCATTCACTG GCCCTGCCGA CTGACCATTG GCTCCAATTT GTCTATAAGG 
ATTGCAGCCT ATAAATCGAT TCTACAGGAG AGAGTTAAAA AGACTTGGAC AGTTGTGGAT 
GCAAAAACCC TAAAAAAAGA AGATATACAA AAAGAAACAG TTTATTGCTT AAATGATGAT 
GATGAAACTG AAGTTTTAAA AGAGGATATT ATTCAAGGGT TCCGCTATGG AAGTGATATA 
GTTCCTTTCT CTAAAGTGGA TGAGGAACAA ATGAAATATA AATCGGAGGG GAAGTGCTTC 
TCTGTTTTGG GATTTTGTAA ATCTTCTCAG GTTCAGAGAA GATTCTTCAT GGGAAATCAA 
GTTCTAAAGG TCTTTGCAGC AAGAGATGAT GAGGCAGCTG CAGTTGCACT TTCCTCCCTG 
ATTCATGCTT TGGATGACTT AGACATGGTG GCCATAGTTC GATATGCTTA TGACAAAAGA 
GCTAATCCTC AAGTCGGCGT GGCTTTTCCT CATATCAAGC ATAACTATGA GTGTTTAGTG 
TATGTGCAGC TGCCTTTCAT GGAAGACTTG CGGCAATACA TGTTTTCATC CTTGAAAAAC 
AGTAAGAAAT ATGCTCCCAC CGAGGCACAG TTGAATGCTG TTGATGCTTT GATTGACTCC 
ATGAGCTTGG CAAAGAAAGA TGAGAAGACA GACACCCTTG AAGACTTGTT TCCAACCACC 
AAAATCCCAA ATCCTCGATT TCAGAGATTA TTTCAGTGTC TGCTGCACAG AGCTTTACAT 
CCCCGGGAGC CTCTACCCCC AATTCAGCAG CATATTTGGA ATATGCTGAA TCCTCCCGCT 
GAGGTGACAA CAAAAAGTCA GATTCCTCTC TCTAAAATAA AGACCCTTTT TCCTCTGATT 
GAAGCCAAGA AAAAGGATCA AGTGACTGCT CAGGAAATTT TCCAAGACAA CCATGAAGAT 
GGACCTACAG CTAAAAAATT AAAGACTGAG CAAGGGGGAG CCCACTTCAG CGTCTCCAGT 
CTGGCTGAAG GCAGTGTCAC CTCTGTTGGA AGTGTGAATC CTGCTGAAAA CTTCCGTGTT 
CTAGTGAAAC AGAAGAAGGC CAGCTTTGAG GAAGCGAGTA ACCAGCTCAT AAATCACATC 
GAACAGTTTT TGGATACTAA TGAAACACCG TATTTTATGA AGAGCATAGA CTGCATCCGA 
GCCTTCCGGG AAGAAGCCAT TAAGTTTTCA GAAGAGCAGC GCTTTAACAA CTTCCTGAAA 
GCCCTTCAAG AGAAAGTGGA AATTAAACAA TTAAATCATT TCTGGGAAAT TGTTGTCCAG 
GATGGAATTA CTCTGATCAC CAAAGAGGAA GCCTCTGGAA GTTCTGTCAC AGCTGAGGAA 
GCCAAAAAGT TTCTGGCCCC CAAAGACAAA CCAAGTGGAG ACACAGCAGC TGTATTTGAA 
GAAGGTGGTG ATGTGGACGA TTTATTGGAC ATGATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066964.1
CDS	90..2288
Translation	MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI

Target ORF information:

RefSeq Version	NM_021141.4
Organism	Homo sapiens(human)
Definition	Homo sapiens X-ray repair cross complementing 5 (XRCC5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021141.4

ORF Insert Sequence:

ATGGTGCGGT CGGGGAATAA GGCAGCTGTT GTGCTGTGTA TGGACGTGGG CTTTACCATG 
AGTAACTCCA TTCCTGGTAT AGAATCCCCA TTTGAACAAG CAAAGAAGGT GATAACCATG 
TTTGTACAGC GACAGGTGTT TGCTGAGAAC AAGGATGAGA TTGCTTTAGT CCTGTTTGGT 
ACAGATGGCA CTGACAATCC CCTTTCTGGT GGGGATCAGT ATCAGAACAT CACAGTGCAC 
AGACATCTGA TGCTACCAGA TTTTGATTTG CTGGAGGACA TTGAAAGCAA AATCCAACCA 
GGTTCTCAAC AGGCTGACTT CCTGGATGCA CTAATCGTGA GCATGGATGT GATTCAACAT 
GAAACAATAG GAAAGAAGTT TGAGAAGAGG CATATTGAAA TATTCACTGA CCTCAGCAGC 
CGATTCAGCA AAAGTCAGCT GGATATTATA ATTCATAGCT TGAAGAAATG TGACATCTCC 
CTGCAATTCT TCTTGCCTTT CTCACTTGGC AAGGAAGATG GAAGTGGGGA CAGAGGAGAT 
GGCCCCTTTC GCTTAGGTGG CCATGGGCCT TCCTTTCCAC TAAAAGGAAT TACCGAACAG 
CAAAAAGAAG GTCTTGAGAT AGTGAAAATG GTGATGATAT CTTTAGAAGG TGAAGATGGG 
TTGGATGAAA TTTATTCATT CAGTGAGAGT CTGAGAAAAC TGTGCGTCTT CAAGAAAATT 
GAGAGGCATT CCATTCACTG GCCCTGCCGA CTGACCATTG GCTCCAATTT GTCTATAAGG 
ATTGCAGCCT ATAAATCGAT TCTACAGGAG AGAGTTAAAA AGACTTGGAC AGTTGTGGAT 
GCAAAAACCC TAAAAAAAGA AGATATACAA AAAGAAACAG TTTATTGCTT AAATGATGAT 
GATGAAACTG AAGTTTTAAA AGAGGATATT ATTCAAGGGT TCCGCTATGG AAGTGATATA 
GTTCCTTTCT CTAAAGTGGA TGAGGAACAA ATGAAATATA AATCGGAGGG GAAGTGCTTC 
TCTGTTTTGG GATTTTGTAA ATCTTCTCAG GTTCAGAGAA GATTCTTCAT GGGAAATCAA 
GTTCTAAAGG TCTTTGCAGC AAGAGATGAT GAGGCAGCTG CAGTTGCACT TTCCTCCCTG 
ATTCATGCTT TGGATGACTT AGACATGGTG GCCATAGTTC GATATGCTTA TGACAAAAGA 
GCTAATCCTC AAGTCGGCGT GGCTTTTCCT CATATCAAGC ATAACTATGA GTGTTTAGTG 
TATGTGCAGC TGCCTTTCAT GGAAGACTTG CGGCAATACA TGTTTTCATC CTTGAAAAAC 
AGTAAGAAAT ATGCTCCCAC CGAGGCACAG TTGAATGCTG TTGATGCTTT GATTGACTCC 
ATGAGCTTGG CAAAGAAAGA TGAGAAGACA GACACCCTTG AAGACTTGTT TCCAACCACC 
AAAATCCCAA ATCCTCGATT TCAGAGATTA TTTCAGTGTC TGCTGCACAG AGCTTTACAT 
CCCCGGGAGC CTCTACCCCC AATTCAGCAG CATATTTGGA ATATGCTGAA TCCTCCCGCT 
GAGGTGACAA CAAAAAGTCA GATTCCTCTC TCTAAAATAA AGACCCTTTT TCCTCTGATT 
GAAGCCAAGA AAAAGGATCA AGTGACTGCT CAGGAAATTT TCCAAGACAA CCATGAAGAT 
GGACCTACAG CTAAAAAATT AAAGACTGAG CAAGGGGGAG CCCACTTCAG CGTCTCCAGT 
CTGGCTGAAG GCAGTGTCAC CTCTGTTGGA AGTGTGAATC CTGCTGAAAA CTTCCGTGTT 
CTAGTGAAAC AGAAGAAGGC CAGCTTTGAG GAAGCGAGTA ACCAGCTCAT AAATCACATC 
GAACAGTTTT TGGATACTAA TGAAACACCG TATTTTATGA AGAGCATAGA CTGCATCCGA 
GCCTTCCGGG AAGAAGCCAT TAAGTTTTCA GAAGAGCAGC GCTTTAACAA CTTCCTGAAA 
GCCCTTCAAG AGAAAGTGGA AATTAAACAA TTAAATCATT TCTGGGAAAT TGTTGTCCAG 
GATGGAATTA CTCTGATCAC CAAAGAGGAA GCCTCTGGAA GTTCTGTCAC AGCTGAGGAA 
GCCAAAAAGT TTCTGGCCCC CAAAGACAAA CCAAGTGGAG ACACAGCAGC TGTATTTGAA 
GAAGGTGGTG ATGTGGACGA TTTATTGGAC ATGATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair.
DNA repair6018-28(2017 Dec)
Yan Q,Zhu H,Lan L,Yi J,Yang J

XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.
PloS one12(10)e0186900(2017)
Zhang Z,Zheng F,Yu Z,Hao J,Chen M,Yu W,Guo W,Chen Y,Huang W,Duan Z,Deng W

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XRCC5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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