WRN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WRN
Entrez Gene ID	7486
Full Name	Werner syndrome RecQ like helicase
Synonyms	RECQ3,RECQL2,RECQL3
General protein information	Preferred Names Werner syndrome RecQ like helicase Names Werner syndrome ATP-dependent helicase DNA helicase, RecQ-like type 3 Werner syndrome, RecQ helicase-like exonuclease WRN recQ protein-like 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p12
Summary	This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017].
Disorder MIM:	604611
Disorder Html:	Werner syndrome, 277700 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024447265.1	XP_024303033.1	Werner syndrome ATP-dependent helicase isoform X2
XM_011544640.1	XP_011542942.1	Werner syndrome ATP-dependent helicase isoform X3
NM_000553.4	NP_000544.2	Werner syndrome ATP-dependent helicase
XM_011544639.3	XP_011542941.1	Werner syndrome ATP-dependent helicase isoform X1
NM_000553.5	NP_000544.2	Werner syndrome ATP-dependent helicase
XM_011544639.2	XP_011542941.1	Werner syndrome ATP-dependent helicase isoform X1
NM_000553.6	NP_000544.2	Werner syndrome ATP-dependent helicase

Pathways from BioSystems

Homologies

Homo sapiens (human)	WRN	NP_000544.2
Mus musculus (house mouse)	Wrn	NP_035851.3
Bos taurus (cattle)	WRN	NP_001137329.2
Caenorhabditis elegans (roundworm)	wrn-1	NP_495324.2
Canis lupus familiaris (dog)	WRN	XP_539984.4
Gallus gallus (chicken)	WRN	XP_001235033.2
Xenopus tropicalis (tropical clawed frog)	wrn	XP_002939304.1
Pan troglodytes (chimpanzee)	WRN	XP_528104.2
	WRN	XP_001085031.1
Rattus norvegicus (Norway rat)	RGD1564788	XP_006253317.1
Danio rerio (zebrafish)	wrn	XP_697980.5
Oryza sativa (rice)	Os07g0681600	NP_001060655.1

Gene Ontology

The following WRN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WRN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu61340	XM_011544640.1 Latest version!	Homo sapiens WRN RecQ like helicase (WRN), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu18809	NM_000553.6 Latest version!	Homo sapiens WRN RecQ like helicase (WRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$727.30 $1039.00
OHu106056	XM_024447265.1 Latest version!	Homo sapiens WRN RecQ like helicase (WRN), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$727.30 $1039.00
OHu61339	XM_011544639.3 Latest version!	Homo sapiens WRN RecQ like helicase (WRN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
View Old Accession Versions >>
OHu18809	NM_000553.4	Homo sapiens Werner syndrome RecQ like helicase (WRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00
OHu61339	XM_011544639.2	Homo sapiens Werner syndrome RecQ like helicase (WRN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00
OHu18809	NM_000553.5	Homo sapiens WRN RecQ like helicase (WRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WRN ( XM_011544640.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542942.1 Homo sapiens WRN RecQ like helicase (WRN), transcript variant X6, mRNA.

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CloneID	OHu61340
Clone ID Related Accession (Same CDS sequence)	XM_011544640.1
Accession Version	XM_011544640.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2700bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	Werner syndrome ATP-dependent helicase isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT TTGTGGCCAG 
CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC AGTTTTAAAC 
CGATATGGAA AGAGTTTGTG CTTCCAGTAT CCACCTGTTT ATGTAGGCAA GATTGGCCTT 
GTTATCTCTC CCCTTATTTC TCTGATGGAA GACCAAGTGC TACAGCTTAA AATGTCCAAC 
ATCCCAGCTT GCTTCCTTGG ATCAGCACAG TCAGAAAATG TTCTAACAGA TATTAAATTA 
GGTAAATACC GGATTGTATA CGTAACTCCA GAATACTGTT CAGGTAACAT GGGCCTGCTC 
CAGCAACTTG AGGCTGATAT TGGTATCACG CTCATTGCTG TGGATGAGGC TCACTGTATT 
TCTGAGTGGG GGCATGATTT TAGGGATTCA TTCAGGAAGT TGGGCTCCCT AAAGACAGCA 
CTGCCAATGG TTCCAATCGT TGCACTTACT GCTACTGCAA GTTCTTCAAT CCGGGAAGAC 
ATTGTACGTT GCTTAAATCT GAGAAATCCT CAGATCACCT GTACTGGTTT TGATCGACCA 
AACCTGTATT TAGAAGTTAG GCGAAAAACA GGGAATATCC TTCAGGATCT GCAGCCATTT 
CTTGTCAAAA CAAGTTCCCA CTGGGAATTT GAAGGTCCAA CAATCATCTA CTGTCCTTCT 
AGAAAAATGA CACAACAAGT TACAGGTGAA CTTAGGAAAC TGAATCTATC CTGTGGAACA 
TACCATGCGG GCATGAGTTT TAGCACAAGG AAAGACATTC ATCATAGGTT TGTAAGAGAT 
GAAATTCAGT GTGTCATAGC TACCATAGCT TTTGGAATGG GCATTAATAA AGCTGACATT 
CGCCAAGTCA TTCATTACGG TGCTCCTAAG GACATGGAAT CATATTATCA GGAGATTGGT 
AGAGCTGGTC GTGATGGACT TCAAAGTTCT TGTCACGTCC TCTGGGCTCC TGCAGACATT 
AACTTAAATA GGCACCTTCT TACTGAGATA CGTAATGAGA AGTTTCGATT ATACAAATTA 
AAGATGATGG CAAAGATGGA AAAATATCTT CATTCTAGCA GATGTAGGAG ACAAATCATC 
TTGTCTCATT TTGAGGACAA ACAAGTACAA AAAGCCTCCT TGGGAATTAT GGGAACTGAA 
AAATGCTGTG ATAATTGCAG GTCCAGATTG GATCATTGCT ATTCCATGGA TGACTCAGAG 
GATACATCCT GGGACTTTGG TCCACAAGCA TTTAAGCTTT TGTCTGCTGT GGACATCTTA 
GGCGAAAAAT TTGGAATTGG GCTTCCAATT TTATTTCTCC GAGGATCTAA TTCTCAGCGT 
CTTGCCGATC AATATCGCAG GCACAGTTTA TTTGGCACTG GCAAGGATCA AACAGAGAGT 
TGGTGGAAGG CTTTTTCCCG TCAGCTGATC ACTGAGGGAT TCTTGGTAGA AGTTTCTCGG 
TATAACAAAT TTATGAAGAT TTGCGCCCTT ACGAAAAAGG GTAGAAATTG GCTTCATAAA 
GCTAATACAG AATCTCAGAG CCTCATCCTT CAAGCTAATG AAGAATTGTG TCCAAAGAAG 
TTGCTTCTGC CTAGTTCGAA AACTGTATCT TCGGGCACCA AAGAGCATTG TTATAATCAA 
GTACCAGTTG AATTAAGTAC AGAGAAGAAG TCTAACTTGG AGAAGTTATA TTCTTATAAA 
CCATGTGATA AGATTTCTTC TGGGAGTAAC ATTTCTAAAA AAAGTATCAT GGTACAGTCA 
CCAGAAAAAG CTTACAGTTC CTCACAGCCT GTTATTTCGG CACAAGAGCA GGAGACTCAG 
ATTGTGTTAT ATGGCAAATT GGTAGAAGCT AGGCAGAAAC ATGCCAATAA AATGGATGTT 
CCCCCAGCTA TTCTGGCAAC AAACAAGATA CTGGTGGATA TGGCCAAAAT GAGACCAACT 
ACGGTTGAAA ACGTAAAAAG GATTGATGGT GTTTCTGAAG GCAAAGCTGC CATGTTGGCC 
CCTCTGTTGG AAGTCATCAA ACATTTCTGC CAAACAAATA GTGTTCAGAC AGACCTCTTT 
TCAAGTACAA AACCTCAAGA AGAACAGAAG ACGAGTCTGG TAGCAAAAAA TAAAATATGC 
ACACTTTCAC AGTCTATGGC CATCACATAC TCTTTATTCC AAGAAAAGAA GATGCCTTTG 
AAGAGCATAG CTGAGAGCAG GATTCTGCCT CTCATGACAA TTGGCATGCA CTTATCCCAA 
GCGGTGAAAG CTGGCTGCCC CCTTGATTTG GAGCGAGCAG GCCTGACTCC AGAGGTTCAG 
AAGATTATTG CTGATGTTAT CCGAAACCCT CCCGTCAACT CAGATATGAG TAAAATTAGC 
CTAATCAGAA TGTTAGTTCC TGAAAACATT GACACGTACC TTATCCACAT GGCAATTGAG 
ATCCTTAAAC ATGGTCCTGA CAGCGGACTT CAACCTTCAT GTGATGTCAA CAAAAGGAGA 
TGTTTTCCCG GTTCTGAAGA GATCTGTTCA AGTTCTAAGA GAAGCAAGGA AGAAGTAGGC 
ATCAATACTG AGACTTCATC TGCAGAGAGA AAGAGACGAT TACCTGTGTG GTTTGCCAAA 
GGAAGTGATA CCAGCAAGAA ATTAATGGAC AAAACGAAAA GGGGAGGTCT TTTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542942.1
CDS	101..2800
Translation	MMKMKLMKGKKMMIRTFCGQHPMKSKLLASRCTLAIPVLNRYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Target ORF information:

RefSeq Version	XM_011544640.1
Organism	Homo sapiens(human)
Definition	Homo sapiens WRN RecQ like helicase (WRN), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544640.1

ORF Insert Sequence:

ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT TTGTGGCCAG 
CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC AGTTTTAAAC 
CGATATGGAA AGAGTTTGTG CTTCCAGTAT CCACCTGTTT ATGTAGGCAA GATTGGCCTT 
GTTATCTCTC CCCTTATTTC TCTGATGGAA GACCAAGTGC TACAGCTTAA AATGTCCAAC 
ATCCCAGCTT GCTTCCTTGG ATCAGCACAG TCAGAAAATG TTCTAACAGA TATTAAATTA 
GGTAAATACC GGATTGTATA CGTAACTCCA GAATACTGTT CAGGTAACAT GGGCCTGCTC 
CAGCAACTTG AGGCTGATAT TGGTATCACG CTCATTGCTG TGGATGAGGC TCACTGTATT 
TCTGAGTGGG GGCATGATTT TAGGGATTCA TTCAGGAAGT TGGGCTCCCT AAAGACAGCA 
CTGCCAATGG TTCCAATCGT TGCACTTACT GCTACTGCAA GTTCTTCAAT CCGGGAAGAC 
ATTGTACGTT GCTTAAATCT GAGAAATCCT CAGATCACCT GTACTGGTTT TGATCGACCA 
AACCTGTATT TAGAAGTTAG GCGAAAAACA GGGAATATCC TTCAGGATCT GCAGCCATTT 
CTTGTCAAAA CAAGTTCCCA CTGGGAATTT GAAGGTCCAA CAATCATCTA CTGTCCTTCT 
AGAAAAATGA CACAACAAGT TACAGGTGAA CTTAGGAAAC TGAATCTATC CTGTGGAACA 
TACCATGCGG GCATGAGTTT TAGCACAAGG AAAGACATTC ATCATAGGTT TGTAAGAGAT 
GAAATTCAGT GTGTCATAGC TACCATAGCT TTTGGAATGG GCATTAATAA AGCTGACATT 
CGCCAAGTCA TTCATTACGG TGCTCCTAAG GACATGGAAT CATATTATCA GGAGATTGGT 
AGAGCTGGTC GTGATGGACT TCAAAGTTCT TGTCACGTCC TCTGGGCTCC TGCAGACATT 
AACTTAAATA GGCACCTTCT TACTGAGATA CGTAATGAGA AGTTTCGATT ATACAAATTA 
AAGATGATGG CAAAGATGGA AAAATATCTT CATTCTAGCA GATGTAGGAG ACAAATCATC 
TTGTCTCATT TTGAGGACAA ACAAGTACAA AAAGCCTCCT TGGGAATTAT GGGAACTGAA 
AAATGCTGTG ATAATTGCAG GTCCAGATTG GATCATTGCT ATTCCATGGA TGACTCAGAG 
GATACATCCT GGGACTTTGG TCCACAAGCA TTTAAGCTTT TGTCTGCTGT GGACATCTTA 
GGCGAAAAAT TTGGAATTGG GCTTCCAATT TTATTTCTCC GAGGATCTAA TTCTCAGCGT 
CTTGCCGATC AATATCGCAG GCACAGTTTA TTTGGCACTG GCAAGGATCA AACAGAGAGT 
TGGTGGAAGG CTTTTTCCCG TCAGCTGATC ACTGAGGGAT TCTTGGTAGA AGTTTCTCGG 
TATAACAAAT TTATGAAGAT TTGCGCCCTT ACGAAAAAGG GTAGAAATTG GCTTCATAAA 
GCTAATACAG AATCTCAGAG CCTCATCCTT CAAGCTAATG AAGAATTGTG TCCAAAGAAG 
TTGCTTCTGC CTAGTTCGAA AACTGTATCT TCGGGCACCA AAGAGCATTG TTATAATCAA 
GTACCAGTTG AATTAAGTAC AGAGAAGAAG TCTAACTTGG AGAAGTTATA TTCTTATAAA 
CCATGTGATA AGATTTCTTC TGGGAGTAAC ATTTCTAAAA AAAGTATCAT GGTACAGTCA 
CCAGAAAAAG CTTACAGTTC CTCACAGCCT GTTATTTCGG CACAAGAGCA GGAGACTCAG 
ATTGTGTTAT ATGGCAAATT GGTAGAAGCT AGGCAGAAAC ATGCCAATAA AATGGATGTT 
CCCCCAGCTA TTCTGGCAAC AAACAAGATA CTGGTGGATA TGGCCAAAAT GAGACCAACT 
ACGGTTGAAA ACGTAAAAAG GATTGATGGT GTTTCTGAAG GCAAAGCTGC CATGTTGGCC 
CCTCTGTTGG AAGTCATCAA ACATTTCTGC CAAACAAATA GTGTTCAGAC AGACCTCTTT 
TCAAGTACAA AACCTCAAGA AGAACAGAAG ACGAGTCTGG TAGCAAAAAA TAAAATATGC 
ACACTTTCAC AGTCTATGGC CATCACATAC TCTTTATTCC AAGAAAAGAA GATGCCTTTG 
AAGAGCATAG CTGAGAGCAG GATTCTGCCT CTCATGACAA TTGGCATGCA CTTATCCCAA 
GCGGTGAAAG CTGGCTGCCC CCTTGATTTG GAGCGAGCAG GCCTGACTCC AGAGGTTCAG 
AAGATTATTG CTGATGTTAT CCGAAACCCT CCCGTCAACT CAGATATGAG TAAAATTAGC 
CTAATCAGAA TGTTAGTTCC TGAAAACATT GACACGTACC TTATCCACAT GGCAATTGAG 
ATCCTTAAAC ATGGTCCTGA CAGCGGACTT CAACCTTCAT GTGATGTCAA CAAAAGGAGA 
TGTTTTCCCG GTTCTGAAGA GATCTGTTCA AGTTCTAAGA GAAGCAAGGA AGAAGTAGGC 
ATCAATACTG AGACTTCATC TGCAGAGAGA AAGAGACGAT TACCTGTGTG GTTTGCCAAA 
GGAAGTGATA CCAGCAAGAA ATTAATGGAC AAAACGAAAA GGGGAGGTCT TTTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WRN ( NM_000553.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000544.2 Homo sapiens WRN RecQ like helicase (WRN), mRNA.

Price & Availability↑

CloneID	OHu18809
Clone ID Related Accession (Same CDS sequence)	NM_000553.4 , NM_000553.5 , NM_000553.6
Accession Version	NM_000553.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	Werner syndrome ATP-dependent helicase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084736.5 and AC009563.12. On Jul 25, 2019 this sequence version replaced NM_000553.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.266899.1, AF091214.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG CATTTATCTC CCAATGATAA TGAAAACGAT 
ACGTCCTATG TAATTGAGAG TGATGAAGAT TTAGAAATGG AGATGCTTAA GTCTTTAGAA 
AACCTCAATA GTGGCACGGT AGAACCAACT CATTCTAAAT GCTTAAAAAT GGAAAGAAAT 
CTGGGTCTTC CTACTAAAGA AGAAGAAGAA GATGATGAAA ATGAAGCTAA TGAAGGGGAA 
GAAGATGATG ATAAGGACTT TTTGTGGCCA GCACCCAATG AAGAGCAAGT TACTTGCCTC 
AAGATGTACT TTGGCCATTC CAGTTTTAAA CCAGTTCAGT GGAAAGTGAT TCATTCAGTA 
TTAGAAGAAA GAAGAGATAA TGTTGCTGTC ATGGCAACTG GATATGGAAA GAGTTTGTGC 
TTCCAGTATC CACCTGTTTA TGTAGGCAAG ATTGGCCTTG TTATCTCTCC CCTTATTTCT 
CTGATGGAAG ACCAAGTGCT ACAGCTTAAA ATGTCCAACA TCCCAGCTTG CTTCCTTGGA 
TCAGCACAGT CAGAAAATGT TCTAACAGAT ATTAAATTAG GTAAATACCG GATTGTATAC 
GTAACTCCAG AATACTGTTC AGGTAACATG GGCCTGCTCC AGCAACTTGA GGCTGATATT 
GGTATCACGC TCATTGCTGT GGATGAGGCT CACTGTATTT CTGAGTGGGG GCATGATTTT 
AGGGATTCAT TCAGGAAGTT GGGCTCCCTA AAGACAGCAC TGCCAATGGT TCCAATCGTT 
GCACTTACTG CTACTGCAAG TTCTTCAATC CGGGAAGACA TTGTACGTTG CTTAAATCTG 
AGAAATCCTC AGATCACCTG TACTGGTTTT GATCGACCAA ACCTGTATTT AGAAGTTAGG 
CGAAAAACAG GGAATATCCT TCAGGATCTG CAGCCATTTC TTGTCAAAAC AAGTTCCCAC 
TGGGAATTTG AAGGTCCAAC AATCATCTAC TGTCCTTCTA GAAAAATGAC ACAACAAGTT 
ACAGGTGAAC TTAGGAAACT GAATCTATCC TGTGGAACAT ACCATGCGGG CATGAGTTTT 
AGCACAAGGA AAGACATTCA TCATAGGTTT GTAAGAGATG AAATTCAGTG TGTCATAGCT 
ACCATAGCTT TTGGAATGGG CATTAATAAA GCTGACATTC GCCAAGTCAT TCATTACGGT 
GCTCCTAAGG ACATGGAATC ATATTATCAG GAGATTGGTA GAGCTGGTCG TGATGGACTT 
CAAAGTTCTT GTCACGTCCT CTGGGCTCCT GCAGACATTA ACTTAAATAG GCACCTTCTT 
ACTGAGATAC GTAATGAGAA GTTTCGATTA TACAAATTAA AGATGATGGC AAAGATGGAA 
AAATATCTTC ATTCTAGCAG ATGTAGGAGA CAAATCATCT TGTCTCATTT TGAGGACAAA 
CAAGTACAAA AAGCCTCCTT GGGAATTATG GGAACTGAAA AATGCTGTGA TAATTGCAGG 
TCCAGATTGG ATCATTGCTA TTCCATGGAT GACTCAGAGG ATACATCCTG GGACTTTGGT 
CCACAAGCAT TTAAGCTTTT GTCTGCTGTG GACATCTTAG GCGAAAAATT TGGAATTGGG 
CTTCCAATTT TATTTCTCCG AGGATCTAAT TCTCAGCGTC TTGCCGATCA ATATCGCAGG 
CACAGTTTAT TTGGCACTGG CAAGGATCAA ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT 
CAGCTGATCA CTGAGGGATT CTTGGTAGAA GTTTCTCGGT ATAACAAATT TATGAAGATT 
TGCGCCCTTA CGAAAAAGGG TAGAAATTGG CTTCATAAAG CTAATACAGA ATCTCAGAGC 
CTCATCCTTC AAGCTAATGA AGAATTGTGT CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA 
ACTGTATCTT CGGGCACCAA AGAGCATTGT TATAATCAAG TACCAGTTGA ATTAAGTACA 
GAGAAGAAGT CTAACTTGGA GAAGTTATAT TCTTATAAAC CATGTGATAA GATTTCTTCT 
GGGAGTAACA TTTCTAAAAA AAGTATCATG GTACAGTCAC CAGAAAAAGC TTACAGTTCC 
TCACAGCCTG TTATTTCGGC ACAAGAGCAG GAGACTCAGA TTGTGTTATA TGGCAAATTG 
GTAGAAGCTA GGCAGAAACA TGCCAATAAA ATGGATGTTC CCCCAGCTAT TCTGGCAACA 
AACAAGATAC TGGTGGATAT GGCCAAAATG AGACCAACTA CGGTTGAAAA CGTAAAAAGG 
ATTGATGGTG TTTCTGAAGG CAAAGCTGCC ATGTTGGCCC CTCTGTTGGA AGTCATCAAA 
CATTTCTGCC AAACAAATAG TGTTCAGACA GACCTCTTTT CAAGTACAAA ACCTCAAGAA 
GAACAGAAGA CGAGTCTGGT AGCAAAAAAT AAAATATGCA CACTTTCACA GTCTATGGCC 
ATCACATACT CTTTATTCCA AGAAAAGAAG ATGCCTTTGA AGAGCATAGC TGAGAGCAGG 
ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TGGCTGCCCC 
CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TGATGTTATC 
CGAAACCCTC CCGTCAACTC AGATATGAGT AAAATTAGCC TAATCAGAAT GTTAGTTCCT 
GAAAACATTG ACACGTACCT TATCCACATG GCAATTGAGA TCCTTAAACA TGGTCCTGAC 
AGCGGACTTC AACCTTCATG TGATGTCAAC AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG 
ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA GAAGTAGGCA TCAATACTGA GACTTCATCT 
GCAGAGAGAA AGAGACGATT ACCTGTGTGG TTTGCCAAAG GAAGTGATAC CAGCAAGAAA 
TTAATGGACA AAACGAAAAG GGGAGGTCTT TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000544.2
CDS	241..4539
Translation	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Target ORF information:

RefSeq Version	NM_000553.6
Organism	Homo sapiens(human)
Definition	Homo sapiens WRN RecQ like helicase (WRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000553.6

ORF Insert Sequence:

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG CATTTATCTC CCAATGATAA TGAAAACGAT 
ACGTCCTATG TAATTGAGAG TGATGAAGAT TTAGAAATGG AGATGCTTAA GTCTTTAGAA 
AACCTCAATA GTGGCACGGT AGAACCAACT CATTCTAAAT GCTTAAAAAT GGAAAGAAAT 
CTGGGTCTTC CTACTAAAGA AGAAGAAGAA GATGATGAAA ATGAAGCTAA TGAAGGGGAA 
GAAGATGATG ATAAGGACTT TTTGTGGCCA GCACCCAATG AAGAGCAAGT TACTTGCCTC 
AAGATGTACT TTGGCCATTC CAGTTTTAAA CCAGTTCAGT GGAAAGTGAT TCATTCAGTA 
TTAGAAGAAA GAAGAGATAA TGTTGCTGTC ATGGCAACTG GATATGGAAA GAGTTTGTGC 
TTCCAGTATC CACCTGTTTA TGTAGGCAAG ATTGGCCTTG TTATCTCTCC CCTTATTTCT 
CTGATGGAAG ACCAAGTGCT ACAGCTTAAA ATGTCCAACA TCCCAGCTTG CTTCCTTGGA 
TCAGCACAGT CAGAAAATGT TCTAACAGAT ATTAAATTAG GTAAATACCG GATTGTATAC 
GTAACTCCAG AATACTGTTC AGGTAACATG GGCCTGCTCC AGCAACTTGA GGCTGATATT 
GGTATCACGC TCATTGCTGT GGATGAGGCT CACTGTATTT CTGAGTGGGG GCATGATTTT 
AGGGATTCAT TCAGGAAGTT GGGCTCCCTA AAGACAGCAC TGCCAATGGT TCCAATCGTT 
GCACTTACTG CTACTGCAAG TTCTTCAATC CGGGAAGACA TTGTACGTTG CTTAAATCTG 
AGAAATCCTC AGATCACCTG TACTGGTTTT GATCGACCAA ACCTGTATTT AGAAGTTAGG 
CGAAAAACAG GGAATATCCT TCAGGATCTG CAGCCATTTC TTGTCAAAAC AAGTTCCCAC 
TGGGAATTTG AAGGTCCAAC AATCATCTAC TGTCCTTCTA GAAAAATGAC ACAACAAGTT 
ACAGGTGAAC TTAGGAAACT GAATCTATCC TGTGGAACAT ACCATGCGGG CATGAGTTTT 
AGCACAAGGA AAGACATTCA TCATAGGTTT GTAAGAGATG AAATTCAGTG TGTCATAGCT 
ACCATAGCTT TTGGAATGGG CATTAATAAA GCTGACATTC GCCAAGTCAT TCATTACGGT 
GCTCCTAAGG ACATGGAATC ATATTATCAG GAGATTGGTA GAGCTGGTCG TGATGGACTT 
CAAAGTTCTT GTCACGTCCT CTGGGCTCCT GCAGACATTA ACTTAAATAG GCACCTTCTT 
ACTGAGATAC GTAATGAGAA GTTTCGATTA TACAAATTAA AGATGATGGC AAAGATGGAA 
AAATATCTTC ATTCTAGCAG ATGTAGGAGA CAAATCATCT TGTCTCATTT TGAGGACAAA 
CAAGTACAAA AAGCCTCCTT GGGAATTATG GGAACTGAAA AATGCTGTGA TAATTGCAGG 
TCCAGATTGG ATCATTGCTA TTCCATGGAT GACTCAGAGG ATACATCCTG GGACTTTGGT 
CCACAAGCAT TTAAGCTTTT GTCTGCTGTG GACATCTTAG GCGAAAAATT TGGAATTGGG 
CTTCCAATTT TATTTCTCCG AGGATCTAAT TCTCAGCGTC TTGCCGATCA ATATCGCAGG 
CACAGTTTAT TTGGCACTGG CAAGGATCAA ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT 
CAGCTGATCA CTGAGGGATT CTTGGTAGAA GTTTCTCGGT ATAACAAATT TATGAAGATT 
TGCGCCCTTA CGAAAAAGGG TAGAAATTGG CTTCATAAAG CTAATACAGA ATCTCAGAGC 
CTCATCCTTC AAGCTAATGA AGAATTGTGT CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA 
ACTGTATCTT CGGGCACCAA AGAGCATTGT TATAATCAAG TACCAGTTGA ATTAAGTACA 
GAGAAGAAGT CTAACTTGGA GAAGTTATAT TCTTATAAAC CATGTGATAA GATTTCTTCT 
GGGAGTAACA TTTCTAAAAA AAGTATCATG GTACAGTCAC CAGAAAAAGC TTACAGTTCC 
TCACAGCCTG TTATTTCGGC ACAAGAGCAG GAGACTCAGA TTGTGTTATA TGGCAAATTG 
GTAGAAGCTA GGCAGAAACA TGCCAATAAA ATGGATGTTC CCCCAGCTAT TCTGGCAACA 
AACAAGATAC TGGTGGATAT GGCCAAAATG AGACCAACTA CGGTTGAAAA CGTAAAAAGG 
ATTGATGGTG TTTCTGAAGG CAAAGCTGCC ATGTTGGCCC CTCTGTTGGA AGTCATCAAA 
CATTTCTGCC AAACAAATAG TGTTCAGACA GACCTCTTTT CAAGTACAAA ACCTCAAGAA 
GAACAGAAGA CGAGTCTGGT AGCAAAAAAT AAAATATGCA CACTTTCACA GTCTATGGCC 
ATCACATACT CTTTATTCCA AGAAAAGAAG ATGCCTTTGA AGAGCATAGC TGAGAGCAGG 
ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TGGCTGCCCC 
CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TGATGTTATC 
CGAAACCCTC CCGTCAACTC AGATATGAGT AAAATTAGCC TAATCAGAAT GTTAGTTCCT 
GAAAACATTG ACACGTACCT TATCCACATG GCAATTGAGA TCCTTAAACA TGGTCCTGAC 
AGCGGACTTC AACCTTCATG TGATGTCAAC AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG 
ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA GAAGTAGGCA TCAATACTGA GACTTCATCT 
GCAGAGAGAA AGAGACGATT ACCTGTGTGG TTTGCCAAAG GAAGTGATAC CAGCAAGAAA 
TTAATGGACA AAACGAAAAG GGGAGGTCTT TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WRN ( XM_024447265.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303033.1 Homo sapiens WRN RecQ like helicase (WRN), transcript variant X2, mRNA.

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CloneID	OHu106056
Clone ID Related Accession (Same CDS sequence)	XM_024447265.1
Accession Version	XM_024447265.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	Werner syndrome ATP-dependent helicase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCTAT CAGATGGGGA TGTGGTGGGA TTTGACATGG AGTGGCCACC ATTATACAAT 
AGAGGGAAAC TTGGCAAAGT TGCACTAATT CAGTTGTGTG TTTCTGAGAG CAAATGTTAC 
TTGTTCCACG TTTCTTCCAT GTCAGTTTTT CCCCAGGGAT TAAAAATGTT GCTTGAAAAT 
AAAGCAGTTA AAAAGGCAGG TGTAGGAATT GAAGGAGATC AGTGGAAACT TCTACGTGAC 
TTTGATATCA AATTGAAGAA TTTTGTGGAG TTGACAGATG TTGCCAATAA AAAGCTGAAA 
TGCACAGAGA CCTGGAGCCT TAACAGTCTG GTTAAACACC TCTTAGGTAA ACAGCTCCTG 
AAAGACAAGT CTATCCGCTG TAGCAATTGG AGTAAATTTC CTCTCACTGA GGACCAGAAA 
CTGTATGCAG CCACTGATGC TTATGCTGGT TTTATTATTT ACCGAAATTT AGAGATTTTG 
GATGATACTG TGCAAAGGTT TGCTATAAAT AAAGAGGAAG AAATCCTACT TAGCGACATG 
AACAAACAGT TGACTTCAAT CTCTGAGGAA GTGATGGATC TGGCTAAGCA TCTTCCTCAT 
GCTTTCAGTA AATTGGAAAA CCCACGGAGG GTTTCTATCT TACTAAAGGA TATTTCAGAA 
AATCTATATT CACTGAGGAG GATGATAATT GGGTCTACTA ACATTGAGAC TGAACTGAGG 
CCCAGCAATA ATTTAAACTT ATTATCCTTT GAAGATTCAA CTACTGGGGG AGTACAACAG 
AAACAAATTA GAGAACATGA AGTTTTAATT CACGTTGAAG ATGAAACATG GGACCCAACA 
CTTGATCATT TAGCTAAACA TGATGGAGAA GATGTACTTG GAAATAAAGT GGAACGAAAA 
GAAGATGGAT TTGAAGATGG AGTAGAAGAC AACAAATTGA AAGAGAATAT GGAAAGAGCT 
TGTTTGATGT CGTTAGATAT TACAGAACAT GAACTCCAAA TTTTGGAACA GCAGTCTCAG 
GAAGAATATC TTAGTGATAT TGCTTATAAA TCTACTGAGC ATTTATCTCC CAATGATAAT 
GAAAACGATA CGTCCTATGT AATTGAGAGT GATGAAGATT TAGAAATGGA GATGCTTAAG 
CATTTATCTC CCAATGATAA TGAAAACGAT ACGTCCTATG TAATTGAGAG TGATGAAGAT 
TTAGAAATGG AGATGCTTAA GTCTTTAGAA AACCTCAATA GTGGCACGGT AGAACCAACT 
CATTCTAAAT GCTTAAAAAT GGAAAGAAAT CTGGGTCTTC CTACTAAAGA AGAAGAAGAA 
GATGATGAAA ATGAAGCTAA TGAAGGGGAA GAAGATGATG ATAAGGACTT TTTGTGGCCA 
GCACCCAATG AAGAGCAAGT TACTTGCCTC AAGATGTACT TTGGCCATTC CAGTTTTAAA 
CCAGTTCAGT GGAAAGTGAT TCATTCAGTA TTAGAAGAAA GAAGAGATAA TGTTGCTGTC 
ATGGCAACTG GATATGGAAA GAGTTTGTGC TTCCAGTATC CACCTGTTTA TGTAGGCAAG 
ATTGGCCTTG TTATCTCTCC CCTTATTTCT CTGATGGAAG ACCAAGTGCT ACAGCTTAAA 
ATGTCCAACA TCCCAGCTTG CTTCCTTGGA TCAGCACAGT CAGAAAATGT TCTAACAGAT 
ATTAAATTAG GTAAATACCG GATTGTATAC GTAACTCCAG AATACTGTTC AGGTAACATG 
GGCCTGCTCC AGCAACTTGA GGCTGATATT GGTATCACGC TCATTGCTGT GGATGAGGCT 
CACTGTATTT CTGAGTGGGG GCATGATTTT AGGGATTCAT TCAGGAAGTT GGGCTCCCTA 
AAGACAGCAC TGCCAATGGT TCCAATCGTT GCACTTACTG CTACTGCAAG TTCTTCAATC 
CGGGAAGACA TTGTACGTTG CTTAAATCTG AGAAATCCTC AGATCACCTG TACTGGTTTT 
GATCGACCAA ACCTGTATTT AGAAGTTAGG CGAAAAACAG GGAATATCCT TCAGGATCTG 
CAGCCATTTC TTGTCAAAAC AAGTTCCCAC TGGGAATTTG AAGGTCCAAC AATCATCTAC 
TGTCCTTCTA GAAAAATGAC ACAACAAGTT ACAGGTGAAC TTAGGAAACT GAATCTATCC 
TGTGGAACAT ACCATGCGGG CATGAGTTTT AGCACAAGGA AAGACATTCA TCATAGGTTT 
GTAAGAGATG AAATTCAGTG TGTCATAGCT ACCATAGCTT TTGGAATGGG CATTAATAAA 
GCTGACATTC GCCAAGTCAT TCATTACGGT GCTCCTAAGG ACATGGAATC ATATTATCAG 
GAGATTGGTA GAGCTGGTCG TGATGGACTT CAAAGTTCTT GTCACGTCCT CTGGGCTCCT 
GCAGACATTA ACTTAAATAG GCACCTTCTT ACTGAGATAC GTAATGAGAA GTTTCGATTA 
TACAAATTAA AGATGATGGC AAAGATGGAA AAATATCTTC ATTCTAGCAG ATGTAGGAGA 
CAAATCATCT TGTCTCATTT TGAGGACAAA CAAGTACAAA AAGCCTCCTT GGGAATTATG 
GGAACTGAAA AATGCTGTGA TAATTGCAGG TCCAGATTGG ATCATTGCTA TTCCATGGAT 
GACTCAGAGG ATACATCCTG GGACTTTGGT CCACAAGCAT TTAAGCTTTT GTCTGCTGTG 
GACATCTTAG GCGAAAAATT TGGAATTGGG CTTCCAATTT TATTTCTCCG AGGATCTAAT 
TCTCAGCGTC TTGCCGATCA ATATCGCAGG CACAGTTTAT TTGGCACTGG CAAGGATCAA 
ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT CAGCTGATCA CTGAGGGATT CTTGGTAGAA 
GTTTCTCGGT ATAACAAATT TATGAAGATT TGCGCCCTTA CGAAAAAGGG TAGAAATTGG 
CTTCATAAAG CTAATACAGA ATCTCAGAGC CTCATCCTTC AAGCTAATGA AGAATTGTGT 
CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA ACTGTATCTT CGGGCACCAA AGAGCATTGT 
TATAATCAAG TACCAGTTGA ATTAAGTACA GAGAAGAAGT CTAACTTGGA GAAGTTATAT 
TCTTATAAAC CATGTGATAA GATTTCTTCT GGGAGTAACA TTTCTAAAAA AAGTATCATG 
GTACAGTCAC CAGAAAAAGC TTACAGTTCC TCACAGCCTG TTATTTCGGC ACAAGAGCAG 
GAGACTCAGA TTGTGTTATA TGGCAAATTG GTAGAAGCTA GGCAGAAACA TGCCAATAAA 
ATGGATGTTC CCCCAGCTAT TCTGGCAACA AACAAGATAC TGGTGGATAT GGCCAAAATG 
AGACCAACTA CGGTTGAAAA CGTAAAAAGG ATTGATGGTG TTTCTGAAGG CAAAGCTGCC 
ATGTTGGCCC CTCTGTTGGA AGTCATCAAA CATTTCTGCC AAACAAATAG TGTTCAGACA 
GACCTCTTTT CAAGTACAAA ACCTCAAGAA GAACAGAAGA CGAGTCTGGT AGCAAAAAAT 
AAAATATGCA CACTTTCACA GTCTATGGCC ATCACATACT CTTTATTCCA AGAAAAGAAG 
ATGCCTTTGA AGAGCATAGC TGAGAGCAGG ATTCTGCCTC TCATGACAAT TGGCATGCAC 
TTATCCCAAG CGGTGAAAGC TGGCTGCCCC CTTGATTTGG AGCGAGCAGG CCTGACTCCA 
GAGGTTCAGA AGATTATTGC TGATGTTATC CGAAACCCTC CCGTCAACTC AGATATGAGT 
AAAATTAGCC TAATCAGAAT GTTAGTTCCT GAAAACATTG ACACGTACCT TATCCACATG 
GCAATTGAGA TCCTTAAACA TGGTCCTGAC AGCGGACTTC AACCTTCATG TGATGTCAAC 
AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA 
GAAGTAGGCA TCAATACTGA GACTTCATCT GCAGAGAGAA AGAGACGATT ACCTGTGTGG 
TTTGCCAAAG GAAGTGATAC CAGCAAGAAA TTAATGGACA AAACGAAAAG GGGAGGTCTT 
TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303033.1
CDS	605..4693
Translation	MSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Target ORF information:

RefSeq Version	XM_024447265.1
Organism	Homo sapiens(human)
Definition	Homo sapiens WRN RecQ like helicase (WRN), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447265.1

ORF Insert Sequence:

ATGAGTCTAT CAGATGGGGA TGTGGTGGGA TTTGACATGG AGTGGCCACC ATTATACAAT 
AGAGGGAAAC TTGGCAAAGT TGCACTAATT CAGTTGTGTG TTTCTGAGAG CAAATGTTAC 
TTGTTCCACG TTTCTTCCAT GTCAGTTTTT CCCCAGGGAT TAAAAATGTT GCTTGAAAAT 
AAAGCAGTTA AAAAGGCAGG TGTAGGAATT GAAGGAGATC AGTGGAAACT TCTACGTGAC 
TTTGATATCA AATTGAAGAA TTTTGTGGAG TTGACAGATG TTGCCAATAA AAAGCTGAAA 
TGCACAGAGA CCTGGAGCCT TAACAGTCTG GTTAAACACC TCTTAGGTAA ACAGCTCCTG 
AAAGACAAGT CTATCCGCTG TAGCAATTGG AGTAAATTTC CTCTCACTGA GGACCAGAAA 
CTGTATGCAG CCACTGATGC TTATGCTGGT TTTATTATTT ACCGAAATTT AGAGATTTTG 
GATGATACTG TGCAAAGGTT TGCTATAAAT AAAGAGGAAG AAATCCTACT TAGCGACATG 
AACAAACAGT TGACTTCAAT CTCTGAGGAA GTGATGGATC TGGCTAAGCA TCTTCCTCAT 
GCTTTCAGTA AATTGGAAAA CCCACGGAGG GTTTCTATCT TACTAAAGGA TATTTCAGAA 
AATCTATATT CACTGAGGAG GATGATAATT GGGTCTACTA ACATTGAGAC TGAACTGAGG 
CCCAGCAATA ATTTAAACTT ATTATCCTTT GAAGATTCAA CTACTGGGGG AGTACAACAG 
AAACAAATTA GAGAACATGA AGTTTTAATT CACGTTGAAG ATGAAACATG GGACCCAACA 
CTTGATCATT TAGCTAAACA TGATGGAGAA GATGTACTTG GAAATAAAGT GGAACGAAAA 
GAAGATGGAT TTGAAGATGG AGTAGAAGAC AACAAATTGA AAGAGAATAT GGAAAGAGCT 
TGTTTGATGT CGTTAGATAT TACAGAACAT GAACTCCAAA TTTTGGAACA GCAGTCTCAG 
GAAGAATATC TTAGTGATAT TGCTTATAAA TCTACTGAGC ATTTATCTCC CAATGATAAT 
GAAAACGATA CGTCCTATGT AATTGAGAGT GATGAAGATT TAGAAATGGA GATGCTTAAG 
CATTTATCTC CCAATGATAA TGAAAACGAT ACGTCCTATG TAATTGAGAG TGATGAAGAT 
TTAGAAATGG AGATGCTTAA GTCTTTAGAA AACCTCAATA GTGGCACGGT AGAACCAACT 
CATTCTAAAT GCTTAAAAAT GGAAAGAAAT CTGGGTCTTC CTACTAAAGA AGAAGAAGAA 
GATGATGAAA ATGAAGCTAA TGAAGGGGAA GAAGATGATG ATAAGGACTT TTTGTGGCCA 
GCACCCAATG AAGAGCAAGT TACTTGCCTC AAGATGTACT TTGGCCATTC CAGTTTTAAA 
CCAGTTCAGT GGAAAGTGAT TCATTCAGTA TTAGAAGAAA GAAGAGATAA TGTTGCTGTC 
ATGGCAACTG GATATGGAAA GAGTTTGTGC TTCCAGTATC CACCTGTTTA TGTAGGCAAG 
ATTGGCCTTG TTATCTCTCC CCTTATTTCT CTGATGGAAG ACCAAGTGCT ACAGCTTAAA 
ATGTCCAACA TCCCAGCTTG CTTCCTTGGA TCAGCACAGT CAGAAAATGT TCTAACAGAT 
ATTAAATTAG GTAAATACCG GATTGTATAC GTAACTCCAG AATACTGTTC AGGTAACATG 
GGCCTGCTCC AGCAACTTGA GGCTGATATT GGTATCACGC TCATTGCTGT GGATGAGGCT 
CACTGTATTT CTGAGTGGGG GCATGATTTT AGGGATTCAT TCAGGAAGTT GGGCTCCCTA 
AAGACAGCAC TGCCAATGGT TCCAATCGTT GCACTTACTG CTACTGCAAG TTCTTCAATC 
CGGGAAGACA TTGTACGTTG CTTAAATCTG AGAAATCCTC AGATCACCTG TACTGGTTTT 
GATCGACCAA ACCTGTATTT AGAAGTTAGG CGAAAAACAG GGAATATCCT TCAGGATCTG 
CAGCCATTTC TTGTCAAAAC AAGTTCCCAC TGGGAATTTG AAGGTCCAAC AATCATCTAC 
TGTCCTTCTA GAAAAATGAC ACAACAAGTT ACAGGTGAAC TTAGGAAACT GAATCTATCC 
TGTGGAACAT ACCATGCGGG CATGAGTTTT AGCACAAGGA AAGACATTCA TCATAGGTTT 
GTAAGAGATG AAATTCAGTG TGTCATAGCT ACCATAGCTT TTGGAATGGG CATTAATAAA 
GCTGACATTC GCCAAGTCAT TCATTACGGT GCTCCTAAGG ACATGGAATC ATATTATCAG 
GAGATTGGTA GAGCTGGTCG TGATGGACTT CAAAGTTCTT GTCACGTCCT CTGGGCTCCT 
GCAGACATTA ACTTAAATAG GCACCTTCTT ACTGAGATAC GTAATGAGAA GTTTCGATTA 
TACAAATTAA AGATGATGGC AAAGATGGAA AAATATCTTC ATTCTAGCAG ATGTAGGAGA 
CAAATCATCT TGTCTCATTT TGAGGACAAA CAAGTACAAA AAGCCTCCTT GGGAATTATG 
GGAACTGAAA AATGCTGTGA TAATTGCAGG TCCAGATTGG ATCATTGCTA TTCCATGGAT 
GACTCAGAGG ATACATCCTG GGACTTTGGT CCACAAGCAT TTAAGCTTTT GTCTGCTGTG 
GACATCTTAG GCGAAAAATT TGGAATTGGG CTTCCAATTT TATTTCTCCG AGGATCTAAT 
TCTCAGCGTC TTGCCGATCA ATATCGCAGG CACAGTTTAT TTGGCACTGG CAAGGATCAA 
ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT CAGCTGATCA CTGAGGGATT CTTGGTAGAA 
GTTTCTCGGT ATAACAAATT TATGAAGATT TGCGCCCTTA CGAAAAAGGG TAGAAATTGG 
CTTCATAAAG CTAATACAGA ATCTCAGAGC CTCATCCTTC AAGCTAATGA AGAATTGTGT 
CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA ACTGTATCTT CGGGCACCAA AGAGCATTGT 
TATAATCAAG TACCAGTTGA ATTAAGTACA GAGAAGAAGT CTAACTTGGA GAAGTTATAT 
TCTTATAAAC CATGTGATAA GATTTCTTCT GGGAGTAACA TTTCTAAAAA AAGTATCATG 
GTACAGTCAC CAGAAAAAGC TTACAGTTCC TCACAGCCTG TTATTTCGGC ACAAGAGCAG 
GAGACTCAGA TTGTGTTATA TGGCAAATTG GTAGAAGCTA GGCAGAAACA TGCCAATAAA 
ATGGATGTTC CCCCAGCTAT TCTGGCAACA AACAAGATAC TGGTGGATAT GGCCAAAATG 
AGACCAACTA CGGTTGAAAA CGTAAAAAGG ATTGATGGTG TTTCTGAAGG CAAAGCTGCC 
ATGTTGGCCC CTCTGTTGGA AGTCATCAAA CATTTCTGCC AAACAAATAG TGTTCAGACA 
GACCTCTTTT CAAGTACAAA ACCTCAAGAA GAACAGAAGA CGAGTCTGGT AGCAAAAAAT 
AAAATATGCA CACTTTCACA GTCTATGGCC ATCACATACT CTTTATTCCA AGAAAAGAAG 
ATGCCTTTGA AGAGCATAGC TGAGAGCAGG ATTCTGCCTC TCATGACAAT TGGCATGCAC 
TTATCCCAAG CGGTGAAAGC TGGCTGCCCC CTTGATTTGG AGCGAGCAGG CCTGACTCCA 
GAGGTTCAGA AGATTATTGC TGATGTTATC CGAAACCCTC CCGTCAACTC AGATATGAGT 
AAAATTAGCC TAATCAGAAT GTTAGTTCCT GAAAACATTG ACACGTACCT TATCCACATG 
GCAATTGAGA TCCTTAAACA TGGTCCTGAC AGCGGACTTC AACCTTCATG TGATGTCAAC 
AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA 
GAAGTAGGCA TCAATACTGA GACTTCATCT GCAGAGAGAA AGAGACGATT ACCTGTGTGG 
TTTGCCAAAG GAAGTGATAC CAGCAAGAAA TTAATGGACA AAACGAAAAG GGGAGGTCTT 
TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WRN ( XM_011544639.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542941.1 Homo sapiens WRN RecQ like helicase (WRN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu61339
Clone ID Related Accession (Same CDS sequence)	XM_011544639.3 , XM_011544639.2
Accession Version	XM_011544639.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	Werner syndrome ATP-dependent helicase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011544639.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG TCTTTAGAAA ACCTCAATAG TGGCACGGTA 
GAACCAACTC ATTCTAAATG CTTAAAAATG GAAAGAAATC TGGGTCTTCC TACTAAAGAA 
GAAGAAGAAG ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT 
TTGTGGCCAG CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC 
AGTTTTAAAC CAGTTCAGTG GAAAGTGATT CATTCAGTAT TAGAAGAAAG AAGAGATAAT 
GTTGCTGTCA TGGCAACTGG ATATGGAAAG AGTTTGTGCT TCCAGTATCC ACCTGTTTAT 
GTAGGCAAGA TTGGCCTTGT TATCTCTCCC CTTATTTCTC TGATGGAAGA CCAAGTGCTA 
CAGCTTAAAA TGTCCAACAT CCCAGCTTGC TTCCTTGGAT CAGCACAGTC AGAAAATGTT 
CTAACAGATA TTAAATTAGG TAAATACCGG ATTGTATACG TAACTCCAGA ATACTGTTCA 
GGTAACATGG GCCTGCTCCA GCAACTTGAG GCTGATATTG GTATCACGCT CATTGCTGTG 
GATGAGGCTC ACTGTATTTC TGAGTGGGGG CATGATTTTA GGGATTCATT CAGGAAGTTG 
GGCTCCCTAA AGACAGCACT GCCAATGGTT CCAATCGTTG CACTTACTGC TACTGCAAGT 
TCTTCAATCC GGGAAGACAT TGTACGTTGC TTAAATCTGA GAAATCCTCA GATCACCTGT 
ACTGGTTTTG ATCGACCAAA CCTGTATTTA GAAGTTAGGC GAAAAACAGG GAATATCCTT 
CAGGATCTGC AGCCATTTCT TGTCAAAACA AGTTCCCACT GGGAATTTGA AGGTCCAACA 
ATCATCTACT GTCCTTCTAG AAAAATGACA CAACAAGTTA CAGGTGAACT TAGGAAACTG 
AATCTATCCT GTGGAACATA CCATGCGGGC ATGAGTTTTA GCACAAGGAA AGACATTCAT 
CATAGGTTTG TAAGAGATGA AATTCAGTGT GTCATAGCTA CCATAGCTTT TGGAATGGGC 
ATTAATAAAG CTGACATTCG CCAAGTCATT CATTACGGTG CTCCTAAGGA CATGGAATCA 
TATTATCAGG AGATTGGTAG AGCTGGTCGT GATGGACTTC AAAGTTCTTG TCACGTCCTC 
TGGGCTCCTG CAGACATTAA CTTAAATAGG CACCTTCTTA CTGAGATACG TAATGAGAAG 
TTTCGATTAT ACAAATTAAA GATGATGGCA AAGATGGAAA AATATCTTCA TTCTAGCAGA 
TGTAGGAGAC AAATCATCTT GTCTCATTTT GAGGACAAAC AAGTACAAAA AGCCTCCTTG 
GGAATTATGG GAACTGAAAA ATGCTGTGAT AATTGCAGGT CCAGATTGGA TCATTGCTAT 
TCCATGGATG ACTCAGAGGA TACATCCTGG GACTTTGGTC CACAAGCATT TAAGCTTTTG 
TCTGCTGTGG ACATCTTAGG CGAAAAATTT GGAATTGGGC TTCCAATTTT ATTTCTCCGA 
GGATCTAATT CTCAGCGTCT TGCCGATCAA TATCGCAGGC ACAGTTTATT TGGCACTGGC 
AAGGATCAAA CAGAGAGTTG GTGGAAGGCT TTTTCCCGTC AGCTGATCAC TGAGGGATTC 
TTGGTAGAAG TTTCTCGGTA TAACAAATTT ATGAAGATTT GCGCCCTTAC GAAAAAGGGT 
AGAAATTGGC TTCATAAAGC TAATACAGAA TCTCAGAGCC TCATCCTTCA AGCTAATGAA 
GAATTGTGTC CAAAGAAGTT GCTTCTGCCT AGTTCGAAAA CTGTATCTTC GGGCACCAAA 
GAGCATTGTT ATAATCAAGT ACCAGTTGAA TTAAGTACAG AGAAGAAGTC TAACTTGGAG 
AAGTTATATT CTTATAAACC ATGTGATAAG ATTTCTTCTG GGAGTAACAT TTCTAAAAAA 
AGTATCATGG TACAGTCACC AGAAAAAGCT TACAGTTCCT CACAGCCTGT TATTTCGGCA 
CAAGAGCAGG AGACTCAGAT TGTGTTATAT GGCAAATTGG TAGAAGCTAG GCAGAAACAT 
GCCAATAAAA TGGATGTTCC CCCAGCTATT CTGGCAACAA ACAAGATACT GGTGGATATG 
GCCAAAATGA GACCAACTAC GGTTGAAAAC GTAAAAAGGA TTGATGGTGT TTCTGAAGGC 
AAAGCTGCCA TGTTGGCCCC TCTGTTGGAA GTCATCAAAC ATTTCTGCCA AACAAATAGT 
GTTCAGACAG ACCTCTTTTC AAGTACAAAA CCTCAAGAAG AACAGAAGAC GAGTCTGGTA 
GCAAAAAATA AAATATGCAC ACTTTCACAG TCTATGGCCA TCACATACTC TTTATTCCAA 
GAAAAGAAGA TGCCTTTGAA GAGCATAGCT GAGAGCAGGA TTCTGCCTCT CATGACAATT 
GGCATGCACT TATCCCAAGC GGTGAAAGCT GGCTGCCCCC TTGATTTGGA GCGAGCAGGC 
CTGACTCCAG AGGTTCAGAA GATTATTGCT GATGTTATCC GAAACCCTCC CGTCAACTCA 
GATATGAGTA AAATTAGCCT AATCAGAATG TTAGTTCCTG AAAACATTGA CACGTACCTT 
ATCCACATGG CAATTGAGAT CCTTAAACAT GGTCCTGACA GCGGACTTCA ACCTTCATGT 
GATGTCAACA AAAGGAGATG TTTTCCCGGT TCTGAAGAGA TCTGTTCAAG TTCTAAGAGA 
AGCAAGGAAG AAGTAGGCAT CAATACTGAG ACTTCATCTG CAGAGAGAAA GAGACGATTA 
CCTGTGTGGT TTGCCAAAGG AAGTGATACC AGCAAGAAAT TAATGGACAA AACGAAAAGG 
GGAGGTCTTT TTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542941.1
CDS	302..4519
Translation	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Target ORF information:

RefSeq Version	XM_011544639.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WRN RecQ like helicase (WRN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544639.3

ORF Insert Sequence:

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG TCTTTAGAAA ACCTCAATAG TGGCACGGTA 
GAACCAACTC ATTCTAAATG CTTAAAAATG GAAAGAAATC TGGGTCTTCC TACTAAAGAA 
GAAGAAGAAG ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT 
TTGTGGCCAG CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC 
AGTTTTAAAC CAGTTCAGTG GAAAGTGATT CATTCAGTAT TAGAAGAAAG AAGAGATAAT 
GTTGCTGTCA TGGCAACTGG ATATGGAAAG AGTTTGTGCT TCCAGTATCC ACCTGTTTAT 
GTAGGCAAGA TTGGCCTTGT TATCTCTCCC CTTATTTCTC TGATGGAAGA CCAAGTGCTA 
CAGCTTAAAA TGTCCAACAT CCCAGCTTGC TTCCTTGGAT CAGCACAGTC AGAAAATGTT 
CTAACAGATA TTAAATTAGG TAAATACCGG ATTGTATACG TAACTCCAGA ATACTGTTCA 
GGTAACATGG GCCTGCTCCA GCAACTTGAG GCTGATATTG GTATCACGCT CATTGCTGTG 
GATGAGGCTC ACTGTATTTC TGAGTGGGGG CATGATTTTA GGGATTCATT CAGGAAGTTG 
GGCTCCCTAA AGACAGCACT GCCAATGGTT CCAATCGTTG CACTTACTGC TACTGCAAGT 
TCTTCAATCC GGGAAGACAT TGTACGTTGC TTAAATCTGA GAAATCCTCA GATCACCTGT 
ACTGGTTTTG ATCGACCAAA CCTGTATTTA GAAGTTAGGC GAAAAACAGG GAATATCCTT 
CAGGATCTGC AGCCATTTCT TGTCAAAACA AGTTCCCACT GGGAATTTGA AGGTCCAACA 
ATCATCTACT GTCCTTCTAG AAAAATGACA CAACAAGTTA CAGGTGAACT TAGGAAACTG 
AATCTATCCT GTGGAACATA CCATGCGGGC ATGAGTTTTA GCACAAGGAA AGACATTCAT 
CATAGGTTTG TAAGAGATGA AATTCAGTGT GTCATAGCTA CCATAGCTTT TGGAATGGGC 
ATTAATAAAG CTGACATTCG CCAAGTCATT CATTACGGTG CTCCTAAGGA CATGGAATCA 
TATTATCAGG AGATTGGTAG AGCTGGTCGT GATGGACTTC AAAGTTCTTG TCACGTCCTC 
TGGGCTCCTG CAGACATTAA CTTAAATAGG CACCTTCTTA CTGAGATACG TAATGAGAAG 
TTTCGATTAT ACAAATTAAA GATGATGGCA AAGATGGAAA AATATCTTCA TTCTAGCAGA 
TGTAGGAGAC AAATCATCTT GTCTCATTTT GAGGACAAAC AAGTACAAAA AGCCTCCTTG 
GGAATTATGG GAACTGAAAA ATGCTGTGAT AATTGCAGGT CCAGATTGGA TCATTGCTAT 
TCCATGGATG ACTCAGAGGA TACATCCTGG GACTTTGGTC CACAAGCATT TAAGCTTTTG 
TCTGCTGTGG ACATCTTAGG CGAAAAATTT GGAATTGGGC TTCCAATTTT ATTTCTCCGA 
GGATCTAATT CTCAGCGTCT TGCCGATCAA TATCGCAGGC ACAGTTTATT TGGCACTGGC 
AAGGATCAAA CAGAGAGTTG GTGGAAGGCT TTTTCCCGTC AGCTGATCAC TGAGGGATTC 
TTGGTAGAAG TTTCTCGGTA TAACAAATTT ATGAAGATTT GCGCCCTTAC GAAAAAGGGT 
AGAAATTGGC TTCATAAAGC TAATACAGAA TCTCAGAGCC TCATCCTTCA AGCTAATGAA 
GAATTGTGTC CAAAGAAGTT GCTTCTGCCT AGTTCGAAAA CTGTATCTTC GGGCACCAAA 
GAGCATTGTT ATAATCAAGT ACCAGTTGAA TTAAGTACAG AGAAGAAGTC TAACTTGGAG 
AAGTTATATT CTTATAAACC ATGTGATAAG ATTTCTTCTG GGAGTAACAT TTCTAAAAAA 
AGTATCATGG TACAGTCACC AGAAAAAGCT TACAGTTCCT CACAGCCTGT TATTTCGGCA 
CAAGAGCAGG AGACTCAGAT TGTGTTATAT GGCAAATTGG TAGAAGCTAG GCAGAAACAT 
GCCAATAAAA TGGATGTTCC CCCAGCTATT CTGGCAACAA ACAAGATACT GGTGGATATG 
GCCAAAATGA GACCAACTAC GGTTGAAAAC GTAAAAAGGA TTGATGGTGT TTCTGAAGGC 
AAAGCTGCCA TGTTGGCCCC TCTGTTGGAA GTCATCAAAC ATTTCTGCCA AACAAATAGT 
GTTCAGACAG ACCTCTTTTC AAGTACAAAA CCTCAAGAAG AACAGAAGAC GAGTCTGGTA 
GCAAAAAATA AAATATGCAC ACTTTCACAG TCTATGGCCA TCACATACTC TTTATTCCAA 
GAAAAGAAGA TGCCTTTGAA GAGCATAGCT GAGAGCAGGA TTCTGCCTCT CATGACAATT 
GGCATGCACT TATCCCAAGC GGTGAAAGCT GGCTGCCCCC TTGATTTGGA GCGAGCAGGC 
CTGACTCCAG AGGTTCAGAA GATTATTGCT GATGTTATCC GAAACCCTCC CGTCAACTCA 
GATATGAGTA AAATTAGCCT AATCAGAATG TTAGTTCCTG AAAACATTGA CACGTACCTT 
ATCCACATGG CAATTGAGAT CCTTAAACAT GGTCCTGACA GCGGACTTCA ACCTTCATGT 
GATGTCAACA AAAGGAGATG TTTTCCCGGT TCTGAAGAGA TCTGTTCAAG TTCTAAGAGA 
AGCAAGGAAG AAGTAGGCAT CAATACTGAG ACTTCATCTG CAGAGAGAAA GAGACGATTA 
CCTGTGTGGT TTGCCAAAGG AAGTGATACC AGCAAGAAAT TAATGGACAA AACGAAAAGG 
GGAGGTCTTT TTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WRN ( XM_011544639.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542941.1 Homo sapiens Werner syndrome RecQ like helicase (WRN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu61339
Clone ID Related Accession (Same CDS sequence)	XM_011544639.3 , XM_011544639.2
Accession Version	XM_011544639.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	Werner syndrome ATP-dependent helicase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544639.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG TCTTTAGAAA ACCTCAATAG TGGCACGGTA 
GAACCAACTC ATTCTAAATG CTTAAAAATG GAAAGAAATC TGGGTCTTCC TACTAAAGAA 
GAAGAAGAAG ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT 
TTGTGGCCAG CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC 
AGTTTTAAAC CAGTTCAGTG GAAAGTGATT CATTCAGTAT TAGAAGAAAG AAGAGATAAT 
GTTGCTGTCA TGGCAACTGG ATATGGAAAG AGTTTGTGCT TCCAGTATCC ACCTGTTTAT 
GTAGGCAAGA TTGGCCTTGT TATCTCTCCC CTTATTTCTC TGATGGAAGA CCAAGTGCTA 
CAGCTTAAAA TGTCCAACAT CCCAGCTTGC TTCCTTGGAT CAGCACAGTC AGAAAATGTT 
CTAACAGATA TTAAATTAGG TAAATACCGG ATTGTATACG TAACTCCAGA ATACTGTTCA 
GGTAACATGG GCCTGCTCCA GCAACTTGAG GCTGATATTG GTATCACGCT CATTGCTGTG 
GATGAGGCTC ACTGTATTTC TGAGTGGGGG CATGATTTTA GGGATTCATT CAGGAAGTTG 
GGCTCCCTAA AGACAGCACT GCCAATGGTT CCAATCGTTG CACTTACTGC TACTGCAAGT 
TCTTCAATCC GGGAAGACAT TGTACGTTGC TTAAATCTGA GAAATCCTCA GATCACCTGT 
ACTGGTTTTG ATCGACCAAA CCTGTATTTA GAAGTTAGGC GAAAAACAGG GAATATCCTT 
CAGGATCTGC AGCCATTTCT TGTCAAAACA AGTTCCCACT GGGAATTTGA AGGTCCAACA 
ATCATCTACT GTCCTTCTAG AAAAATGACA CAACAAGTTA CAGGTGAACT TAGGAAACTG 
AATCTATCCT GTGGAACATA CCATGCGGGC ATGAGTTTTA GCACAAGGAA AGACATTCAT 
CATAGGTTTG TAAGAGATGA AATTCAGTGT GTCATAGCTA CCATAGCTTT TGGAATGGGC 
ATTAATAAAG CTGACATTCG CCAAGTCATT CATTACGGTG CTCCTAAGGA CATGGAATCA 
TATTATCAGG AGATTGGTAG AGCTGGTCGT GATGGACTTC AAAGTTCTTG TCACGTCCTC 
TGGGCTCCTG CAGACATTAA CTTAAATAGG CACCTTCTTA CTGAGATACG TAATGAGAAG 
TTTCGATTAT ACAAATTAAA GATGATGGCA AAGATGGAAA AATATCTTCA TTCTAGCAGA 
TGTAGGAGAC AAATCATCTT GTCTCATTTT GAGGACAAAC AAGTACAAAA AGCCTCCTTG 
GGAATTATGG GAACTGAAAA ATGCTGTGAT AATTGCAGGT CCAGATTGGA TCATTGCTAT 
TCCATGGATG ACTCAGAGGA TACATCCTGG GACTTTGGTC CACAAGCATT TAAGCTTTTG 
TCTGCTGTGG ACATCTTAGG CGAAAAATTT GGAATTGGGC TTCCAATTTT ATTTCTCCGA 
GGATCTAATT CTCAGCGTCT TGCCGATCAA TATCGCAGGC ACAGTTTATT TGGCACTGGC 
AAGGATCAAA CAGAGAGTTG GTGGAAGGCT TTTTCCCGTC AGCTGATCAC TGAGGGATTC 
TTGGTAGAAG TTTCTCGGTA TAACAAATTT ATGAAGATTT GCGCCCTTAC GAAAAAGGGT 
AGAAATTGGC TTCATAAAGC TAATACAGAA TCTCAGAGCC TCATCCTTCA AGCTAATGAA 
GAATTGTGTC CAAAGAAGTT GCTTCTGCCT AGTTCGAAAA CTGTATCTTC GGGCACCAAA 
GAGCATTGTT ATAATCAAGT ACCAGTTGAA TTAAGTACAG AGAAGAAGTC TAACTTGGAG 
AAGTTATATT CTTATAAACC ATGTGATAAG ATTTCTTCTG GGAGTAACAT TTCTAAAAAA 
AGTATCATGG TACAGTCACC AGAAAAAGCT TACAGTTCCT CACAGCCTGT TATTTCGGCA 
CAAGAGCAGG AGACTCAGAT TGTGTTATAT GGCAAATTGG TAGAAGCTAG GCAGAAACAT 
GCCAATAAAA TGGATGTTCC CCCAGCTATT CTGGCAACAA ACAAGATACT GGTGGATATG 
GCCAAAATGA GACCAACTAC GGTTGAAAAC GTAAAAAGGA TTGATGGTGT TTCTGAAGGC 
AAAGCTGCCA TGTTGGCCCC TCTGTTGGAA GTCATCAAAC ATTTCTGCCA AACAAATAGT 
GTTCAGACAG ACCTCTTTTC AAGTACAAAA CCTCAAGAAG AACAGAAGAC GAGTCTGGTA 
GCAAAAAATA AAATATGCAC ACTTTCACAG TCTATGGCCA TCACATACTC TTTATTCCAA 
GAAAAGAAGA TGCCTTTGAA GAGCATAGCT GAGAGCAGGA TTCTGCCTCT CATGACAATT 
GGCATGCACT TATCCCAAGC GGTGAAAGCT GGCTGCCCCC TTGATTTGGA GCGAGCAGGC 
CTGACTCCAG AGGTTCAGAA GATTATTGCT GATGTTATCC GAAACCCTCC CGTCAACTCA 
GATATGAGTA AAATTAGCCT AATCAGAATG TTAGTTCCTG AAAACATTGA CACGTACCTT 
ATCCACATGG CAATTGAGAT CCTTAAACAT GGTCCTGACA GCGGACTTCA ACCTTCATGT 
GATGTCAACA AAAGGAGATG TTTTCCCGGT TCTGAAGAGA TCTGTTCAAG TTCTAAGAGA 
AGCAAGGAAG AAGTAGGCAT CAATACTGAG ACTTCATCTG CAGAGAGAAA GAGACGATTA 
CCTGTGTGGT TTGCCAAAGG AAGTGATACC AGCAAGAAAT TAATGGACAA AACGAAAAGG 
GGAGGTCTTT TTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542941.1
CDS	271..4488
Translation	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Target ORF information:

RefSeq Version	XM_011544639.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Werner syndrome RecQ like helicase (WRN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544639.2

ORF Insert Sequence:

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG TCTTTAGAAA ACCTCAATAG TGGCACGGTA 
GAACCAACTC ATTCTAAATG CTTAAAAATG GAAAGAAATC TGGGTCTTCC TACTAAAGAA 
GAAGAAGAAG ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT 
TTGTGGCCAG CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC 
AGTTTTAAAC CAGTTCAGTG GAAAGTGATT CATTCAGTAT TAGAAGAAAG AAGAGATAAT 
GTTGCTGTCA TGGCAACTGG ATATGGAAAG AGTTTGTGCT TCCAGTATCC ACCTGTTTAT 
GTAGGCAAGA TTGGCCTTGT TATCTCTCCC CTTATTTCTC TGATGGAAGA CCAAGTGCTA 
CAGCTTAAAA TGTCCAACAT CCCAGCTTGC TTCCTTGGAT CAGCACAGTC AGAAAATGTT 
CTAACAGATA TTAAATTAGG TAAATACCGG ATTGTATACG TAACTCCAGA ATACTGTTCA 
GGTAACATGG GCCTGCTCCA GCAACTTGAG GCTGATATTG GTATCACGCT CATTGCTGTG 
GATGAGGCTC ACTGTATTTC TGAGTGGGGG CATGATTTTA GGGATTCATT CAGGAAGTTG 
GGCTCCCTAA AGACAGCACT GCCAATGGTT CCAATCGTTG CACTTACTGC TACTGCAAGT 
TCTTCAATCC GGGAAGACAT TGTACGTTGC TTAAATCTGA GAAATCCTCA GATCACCTGT 
ACTGGTTTTG ATCGACCAAA CCTGTATTTA GAAGTTAGGC GAAAAACAGG GAATATCCTT 
CAGGATCTGC AGCCATTTCT TGTCAAAACA AGTTCCCACT GGGAATTTGA AGGTCCAACA 
ATCATCTACT GTCCTTCTAG AAAAATGACA CAACAAGTTA CAGGTGAACT TAGGAAACTG 
AATCTATCCT GTGGAACATA CCATGCGGGC ATGAGTTTTA GCACAAGGAA AGACATTCAT 
CATAGGTTTG TAAGAGATGA AATTCAGTGT GTCATAGCTA CCATAGCTTT TGGAATGGGC 
ATTAATAAAG CTGACATTCG CCAAGTCATT CATTACGGTG CTCCTAAGGA CATGGAATCA 
TATTATCAGG AGATTGGTAG AGCTGGTCGT GATGGACTTC AAAGTTCTTG TCACGTCCTC 
TGGGCTCCTG CAGACATTAA CTTAAATAGG CACCTTCTTA CTGAGATACG TAATGAGAAG 
TTTCGATTAT ACAAATTAAA GATGATGGCA AAGATGGAAA AATATCTTCA TTCTAGCAGA 
TGTAGGAGAC AAATCATCTT GTCTCATTTT GAGGACAAAC AAGTACAAAA AGCCTCCTTG 
GGAATTATGG GAACTGAAAA ATGCTGTGAT AATTGCAGGT CCAGATTGGA TCATTGCTAT 
TCCATGGATG ACTCAGAGGA TACATCCTGG GACTTTGGTC CACAAGCATT TAAGCTTTTG 
TCTGCTGTGG ACATCTTAGG CGAAAAATTT GGAATTGGGC TTCCAATTTT ATTTCTCCGA 
GGATCTAATT CTCAGCGTCT TGCCGATCAA TATCGCAGGC ACAGTTTATT TGGCACTGGC 
AAGGATCAAA CAGAGAGTTG GTGGAAGGCT TTTTCCCGTC AGCTGATCAC TGAGGGATTC 
TTGGTAGAAG TTTCTCGGTA TAACAAATTT ATGAAGATTT GCGCCCTTAC GAAAAAGGGT 
AGAAATTGGC TTCATAAAGC TAATACAGAA TCTCAGAGCC TCATCCTTCA AGCTAATGAA 
GAATTGTGTC CAAAGAAGTT GCTTCTGCCT AGTTCGAAAA CTGTATCTTC GGGCACCAAA 
GAGCATTGTT ATAATCAAGT ACCAGTTGAA TTAAGTACAG AGAAGAAGTC TAACTTGGAG 
AAGTTATATT CTTATAAACC ATGTGATAAG ATTTCTTCTG GGAGTAACAT TTCTAAAAAA 
AGTATCATGG TACAGTCACC AGAAAAAGCT TACAGTTCCT CACAGCCTGT TATTTCGGCA 
CAAGAGCAGG AGACTCAGAT TGTGTTATAT GGCAAATTGG TAGAAGCTAG GCAGAAACAT 
GCCAATAAAA TGGATGTTCC CCCAGCTATT CTGGCAACAA ACAAGATACT GGTGGATATG 
GCCAAAATGA GACCAACTAC GGTTGAAAAC GTAAAAAGGA TTGATGGTGT TTCTGAAGGC 
AAAGCTGCCA TGTTGGCCCC TCTGTTGGAA GTCATCAAAC ATTTCTGCCA AACAAATAGT 
GTTCAGACAG ACCTCTTTTC AAGTACAAAA CCTCAAGAAG AACAGAAGAC GAGTCTGGTA 
GCAAAAAATA AAATATGCAC ACTTTCACAG TCTATGGCCA TCACATACTC TTTATTCCAA 
GAAAAGAAGA TGCCTTTGAA GAGCATAGCT GAGAGCAGGA TTCTGCCTCT CATGACAATT 
GGCATGCACT TATCCCAAGC GGTGAAAGCT GGCTGCCCCC TTGATTTGGA GCGAGCAGGC 
CTGACTCCAG AGGTTCAGAA GATTATTGCT GATGTTATCC GAAACCCTCC CGTCAACTCA 
GATATGAGTA AAATTAGCCT AATCAGAATG TTAGTTCCTG AAAACATTGA CACGTACCTT 
ATCCACATGG CAATTGAGAT CCTTAAACAT GGTCCTGACA GCGGACTTCA ACCTTCATGT 
GATGTCAACA AAAGGAGATG TTTTCCCGGT TCTGAAGAGA TCTGTTCAAG TTCTAAGAGA 
AGCAAGGAAG AAGTAGGCAT CAATACTGAG ACTTCATCTG CAGAGAGAAA GAGACGATTA 
CCTGTGTGGT TTGCCAAAGG AAGTGATACC AGCAAGAAAT TAATGGACAA AACGAAAAGG 
GGAGGTCTTT TTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WRN ( NM_000553.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000544.2 Homo sapiens Werner syndrome RecQ like helicase (WRN), mRNA.

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CloneID	OHu18809
Clone ID Related Accession (Same CDS sequence)	NM_000553.4 , NM_000553.5 , NM_000553.6
Accession Version	NM_000553.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-05-06
Organism	Homo sapiens(Human)
Product	Werner syndrome ATP-dependent helicase
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084736.5, BP279291.1, AF091214.1 and AB209652.1. This sequence is a reference standard in the RefSeqGene project. On Apr 11, 2008 this sequence version replaced NM_000553.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF091214.1, SRR1803614.266899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG CATTTATCTC CCAATGATAA TGAAAACGAT 
ACGTCCTATG TAATTGAGAG TGATGAAGAT TTAGAAATGG AGATGCTTAA GTCTTTAGAA 
AACCTCAATA GTGGCACGGT AGAACCAACT CATTCTAAAT GCTTAAAAAT GGAAAGAAAT 
CTGGGTCTTC CTACTAAAGA AGAAGAAGAA GATGATGAAA ATGAAGCTAA TGAAGGGGAA 
GAAGATGATG ATAAGGACTT TTTGTGGCCA GCACCCAATG AAGAGCAAGT TACTTGCCTC 
AAGATGTACT TTGGCCATTC CAGTTTTAAA CCAGTTCAGT GGAAAGTGAT TCATTCAGTA 
TTAGAAGAAA GAAGAGATAA TGTTGCTGTC ATGGCAACTG GATATGGAAA GAGTTTGTGC 
TTCCAGTATC CACCTGTTTA TGTAGGCAAG ATTGGCCTTG TTATCTCTCC CCTTATTTCT 
CTGATGGAAG ACCAAGTGCT ACAGCTTAAA ATGTCCAACA TCCCAGCTTG CTTCCTTGGA 
TCAGCACAGT CAGAAAATGT TCTAACAGAT ATTAAATTAG GTAAATACCG GATTGTATAC 
GTAACTCCAG AATACTGTTC AGGTAACATG GGCCTGCTCC AGCAACTTGA GGCTGATATT 
GGTATCACGC TCATTGCTGT GGATGAGGCT CACTGTATTT CTGAGTGGGG GCATGATTTT 
AGGGATTCAT TCAGGAAGTT GGGCTCCCTA AAGACAGCAC TGCCAATGGT TCCAATCGTT 
GCACTTACTG CTACTGCAAG TTCTTCAATC CGGGAAGACA TTGTACGTTG CTTAAATCTG 
AGAAATCCTC AGATCACCTG TACTGGTTTT GATCGACCAA ACCTGTATTT AGAAGTTAGG 
CGAAAAACAG GGAATATCCT TCAGGATCTG CAGCCATTTC TTGTCAAAAC AAGTTCCCAC 
TGGGAATTTG AAGGTCCAAC AATCATCTAC TGTCCTTCTA GAAAAATGAC ACAACAAGTT 
ACAGGTGAAC TTAGGAAACT GAATCTATCC TGTGGAACAT ACCATGCGGG CATGAGTTTT 
AGCACAAGGA AAGACATTCA TCATAGGTTT GTAAGAGATG AAATTCAGTG TGTCATAGCT 
ACCATAGCTT TTGGAATGGG CATTAATAAA GCTGACATTC GCCAAGTCAT TCATTACGGT 
GCTCCTAAGG ACATGGAATC ATATTATCAG GAGATTGGTA GAGCTGGTCG TGATGGACTT 
CAAAGTTCTT GTCACGTCCT CTGGGCTCCT GCAGACATTA ACTTAAATAG GCACCTTCTT 
ACTGAGATAC GTAATGAGAA GTTTCGATTA TACAAATTAA AGATGATGGC AAAGATGGAA 
AAATATCTTC ATTCTAGCAG ATGTAGGAGA CAAATCATCT TGTCTCATTT TGAGGACAAA 
CAAGTACAAA AAGCCTCCTT GGGAATTATG GGAACTGAAA AATGCTGTGA TAATTGCAGG 
TCCAGATTGG ATCATTGCTA TTCCATGGAT GACTCAGAGG ATACATCCTG GGACTTTGGT 
CCACAAGCAT TTAAGCTTTT GTCTGCTGTG GACATCTTAG GCGAAAAATT TGGAATTGGG 
CTTCCAATTT TATTTCTCCG AGGATCTAAT TCTCAGCGTC TTGCCGATCA ATATCGCAGG 
CACAGTTTAT TTGGCACTGG CAAGGATCAA ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT 
CAGCTGATCA CTGAGGGATT CTTGGTAGAA GTTTCTCGGT ATAACAAATT TATGAAGATT 
TGCGCCCTTA CGAAAAAGGG TAGAAATTGG CTTCATAAAG CTAATACAGA ATCTCAGAGC 
CTCATCCTTC AAGCTAATGA AGAATTGTGT CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA 
ACTGTATCTT CGGGCACCAA AGAGCATTGT TATAATCAAG TACCAGTTGA ATTAAGTACA 
GAGAAGAAGT CTAACTTGGA GAAGTTATAT TCTTATAAAC CATGTGATAA GATTTCTTCT 
GGGAGTAACA TTTCTAAAAA AAGTATCATG GTACAGTCAC CAGAAAAAGC TTACAGTTCC 
TCACAGCCTG TTATTTCGGC ACAAGAGCAG GAGACTCAGA TTGTGTTATA TGGCAAATTG 
GTAGAAGCTA GGCAGAAACA TGCCAATAAA ATGGATGTTC CCCCAGCTAT TCTGGCAACA 
AACAAGATAC TGGTGGATAT GGCCAAAATG AGACCAACTA CGGTTGAAAA CGTAAAAAGG 
ATTGATGGTG TTTCTGAAGG CAAAGCTGCC ATGTTGGCCC CTCTGTTGGA AGTCATCAAA 
CATTTCTGCC AAACAAATAG TGTTCAGACA GACCTCTTTT CAAGTACAAA ACCTCAAGAA 
GAACAGAAGA CGAGTCTGGT AGCAAAAAAT AAAATATGCA CACTTTCACA GTCTATGGCC 
ATCACATACT CTTTATTCCA AGAAAAGAAG ATGCCTTTGA AGAGCATAGC TGAGAGCAGG 
ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TGGCTGCCCC 
CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TGATGTTATC 
CGAAACCCTC CCGTCAACTC AGATATGAGT AAAATTAGCC TAATCAGAAT GTTAGTTCCT 
GAAAACATTG ACACGTACCT TATCCACATG GCAATTGAGA TCCTTAAACA TGGTCCTGAC 
AGCGGACTTC AACCTTCATG TGATGTCAAC AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG 
ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA GAAGTAGGCA TCAATACTGA GACTTCATCT 
GCAGAGAGAA AGAGACGATT ACCTGTGTGG TTTGCCAAAG GAAGTGATAC CAGCAAGAAA 
TTAATGGACA AAACGAAAAG GGGAGGTCTT TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000544.2
CDS	789..5087
Translation	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Target ORF information:

RefSeq Version	NM_000553.4
Organism	Homo sapiens(Human)
Definition	Homo sapiens Werner syndrome RecQ like helicase (WRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000553.4

ORF Insert Sequence:

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG CATTTATCTC CCAATGATAA TGAAAACGAT 
ACGTCCTATG TAATTGAGAG TGATGAAGAT TTAGAAATGG AGATGCTTAA GTCTTTAGAA 
AACCTCAATA GTGGCACGGT AGAACCAACT CATTCTAAAT GCTTAAAAAT GGAAAGAAAT 
CTGGGTCTTC CTACTAAAGA AGAAGAAGAA GATGATGAAA ATGAAGCTAA TGAAGGGGAA 
GAAGATGATG ATAAGGACTT TTTGTGGCCA GCACCCAATG AAGAGCAAGT TACTTGCCTC 
AAGATGTACT TTGGCCATTC CAGTTTTAAA CCAGTTCAGT GGAAAGTGAT TCATTCAGTA 
TTAGAAGAAA GAAGAGATAA TGTTGCTGTC ATGGCAACTG GATATGGAAA GAGTTTGTGC 
TTCCAGTATC CACCTGTTTA TGTAGGCAAG ATTGGCCTTG TTATCTCTCC CCTTATTTCT 
CTGATGGAAG ACCAAGTGCT ACAGCTTAAA ATGTCCAACA TCCCAGCTTG CTTCCTTGGA 
TCAGCACAGT CAGAAAATGT TCTAACAGAT ATTAAATTAG GTAAATACCG GATTGTATAC 
GTAACTCCAG AATACTGTTC AGGTAACATG GGCCTGCTCC AGCAACTTGA GGCTGATATT 
GGTATCACGC TCATTGCTGT GGATGAGGCT CACTGTATTT CTGAGTGGGG GCATGATTTT 
AGGGATTCAT TCAGGAAGTT GGGCTCCCTA AAGACAGCAC TGCCAATGGT TCCAATCGTT 
GCACTTACTG CTACTGCAAG TTCTTCAATC CGGGAAGACA TTGTACGTTG CTTAAATCTG 
AGAAATCCTC AGATCACCTG TACTGGTTTT GATCGACCAA ACCTGTATTT AGAAGTTAGG 
CGAAAAACAG GGAATATCCT TCAGGATCTG CAGCCATTTC TTGTCAAAAC AAGTTCCCAC 
TGGGAATTTG AAGGTCCAAC AATCATCTAC TGTCCTTCTA GAAAAATGAC ACAACAAGTT 
ACAGGTGAAC TTAGGAAACT GAATCTATCC TGTGGAACAT ACCATGCGGG CATGAGTTTT 
AGCACAAGGA AAGACATTCA TCATAGGTTT GTAAGAGATG AAATTCAGTG TGTCATAGCT 
ACCATAGCTT TTGGAATGGG CATTAATAAA GCTGACATTC GCCAAGTCAT TCATTACGGT 
GCTCCTAAGG ACATGGAATC ATATTATCAG GAGATTGGTA GAGCTGGTCG TGATGGACTT 
CAAAGTTCTT GTCACGTCCT CTGGGCTCCT GCAGACATTA ACTTAAATAG GCACCTTCTT 
ACTGAGATAC GTAATGAGAA GTTTCGATTA TACAAATTAA AGATGATGGC AAAGATGGAA 
AAATATCTTC ATTCTAGCAG ATGTAGGAGA CAAATCATCT TGTCTCATTT TGAGGACAAA 
CAAGTACAAA AAGCCTCCTT GGGAATTATG GGAACTGAAA AATGCTGTGA TAATTGCAGG 
TCCAGATTGG ATCATTGCTA TTCCATGGAT GACTCAGAGG ATACATCCTG GGACTTTGGT 
CCACAAGCAT TTAAGCTTTT GTCTGCTGTG GACATCTTAG GCGAAAAATT TGGAATTGGG 
CTTCCAATTT TATTTCTCCG AGGATCTAAT TCTCAGCGTC TTGCCGATCA ATATCGCAGG 
CACAGTTTAT TTGGCACTGG CAAGGATCAA ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT 
CAGCTGATCA CTGAGGGATT CTTGGTAGAA GTTTCTCGGT ATAACAAATT TATGAAGATT 
TGCGCCCTTA CGAAAAAGGG TAGAAATTGG CTTCATAAAG CTAATACAGA ATCTCAGAGC 
CTCATCCTTC AAGCTAATGA AGAATTGTGT CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA 
ACTGTATCTT CGGGCACCAA AGAGCATTGT TATAATCAAG TACCAGTTGA ATTAAGTACA 
GAGAAGAAGT CTAACTTGGA GAAGTTATAT TCTTATAAAC CATGTGATAA GATTTCTTCT 
GGGAGTAACA TTTCTAAAAA AAGTATCATG GTACAGTCAC CAGAAAAAGC TTACAGTTCC 
TCACAGCCTG TTATTTCGGC ACAAGAGCAG GAGACTCAGA TTGTGTTATA TGGCAAATTG 
GTAGAAGCTA GGCAGAAACA TGCCAATAAA ATGGATGTTC CCCCAGCTAT TCTGGCAACA 
AACAAGATAC TGGTGGATAT GGCCAAAATG AGACCAACTA CGGTTGAAAA CGTAAAAAGG 
ATTGATGGTG TTTCTGAAGG CAAAGCTGCC ATGTTGGCCC CTCTGTTGGA AGTCATCAAA 
CATTTCTGCC AAACAAATAG TGTTCAGACA GACCTCTTTT CAAGTACAAA ACCTCAAGAA 
GAACAGAAGA CGAGTCTGGT AGCAAAAAAT AAAATATGCA CACTTTCACA GTCTATGGCC 
ATCACATACT CTTTATTCCA AGAAAAGAAG ATGCCTTTGA AGAGCATAGC TGAGAGCAGG 
ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TGGCTGCCCC 
CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TGATGTTATC 
CGAAACCCTC CCGTCAACTC AGATATGAGT AAAATTAGCC TAATCAGAAT GTTAGTTCCT 
GAAAACATTG ACACGTACCT TATCCACATG GCAATTGAGA TCCTTAAACA TGGTCCTGAC 
AGCGGACTTC AACCTTCATG TGATGTCAAC AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG 
ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA GAAGTAGGCA TCAATACTGA GACTTCATCT 
GCAGAGAGAA AGAGACGATT ACCTGTGTGG TTTGCCAAAG GAAGTGATAC CAGCAAGAAA 
TTAATGGACA AAACGAAAAG GGGAGGTCTT TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WRN ( NM_000553.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000544.2 Homo sapiens WRN RecQ like helicase (WRN), mRNA.

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CloneID	OHu18809
Clone ID Related Accession (Same CDS sequence)	NM_000553.4 , NM_000553.5 , NM_000553.6
Accession Version	NM_000553.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	Werner syndrome ATP-dependent helicase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084736.5, BP279291.1, AF091214.1, AB209652.1 and AC009563.12. On Aug 29, 2017 this sequence version replaced NM_000553.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF091214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG CATTTATCTC CCAATGATAA TGAAAACGAT 
ACGTCCTATG TAATTGAGAG TGATGAAGAT TTAGAAATGG AGATGCTTAA GTCTTTAGAA 
AACCTCAATA GTGGCACGGT AGAACCAACT CATTCTAAAT GCTTAAAAAT GGAAAGAAAT 
CTGGGTCTTC CTACTAAAGA AGAAGAAGAA GATGATGAAA ATGAAGCTAA TGAAGGGGAA 
GAAGATGATG ATAAGGACTT TTTGTGGCCA GCACCCAATG AAGAGCAAGT TACTTGCCTC 
AAGATGTACT TTGGCCATTC CAGTTTTAAA CCAGTTCAGT GGAAAGTGAT TCATTCAGTA 
TTAGAAGAAA GAAGAGATAA TGTTGCTGTC ATGGCAACTG GATATGGAAA GAGTTTGTGC 
TTCCAGTATC CACCTGTTTA TGTAGGCAAG ATTGGCCTTG TTATCTCTCC CCTTATTTCT 
CTGATGGAAG ACCAAGTGCT ACAGCTTAAA ATGTCCAACA TCCCAGCTTG CTTCCTTGGA 
TCAGCACAGT CAGAAAATGT TCTAACAGAT ATTAAATTAG GTAAATACCG GATTGTATAC 
GTAACTCCAG AATACTGTTC AGGTAACATG GGCCTGCTCC AGCAACTTGA GGCTGATATT 
GGTATCACGC TCATTGCTGT GGATGAGGCT CACTGTATTT CTGAGTGGGG GCATGATTTT 
AGGGATTCAT TCAGGAAGTT GGGCTCCCTA AAGACAGCAC TGCCAATGGT TCCAATCGTT 
GCACTTACTG CTACTGCAAG TTCTTCAATC CGGGAAGACA TTGTACGTTG CTTAAATCTG 
AGAAATCCTC AGATCACCTG TACTGGTTTT GATCGACCAA ACCTGTATTT AGAAGTTAGG 
CGAAAAACAG GGAATATCCT TCAGGATCTG CAGCCATTTC TTGTCAAAAC AAGTTCCCAC 
TGGGAATTTG AAGGTCCAAC AATCATCTAC TGTCCTTCTA GAAAAATGAC ACAACAAGTT 
ACAGGTGAAC TTAGGAAACT GAATCTATCC TGTGGAACAT ACCATGCGGG CATGAGTTTT 
AGCACAAGGA AAGACATTCA TCATAGGTTT GTAAGAGATG AAATTCAGTG TGTCATAGCT 
ACCATAGCTT TTGGAATGGG CATTAATAAA GCTGACATTC GCCAAGTCAT TCATTACGGT 
GCTCCTAAGG ACATGGAATC ATATTATCAG GAGATTGGTA GAGCTGGTCG TGATGGACTT 
CAAAGTTCTT GTCACGTCCT CTGGGCTCCT GCAGACATTA ACTTAAATAG GCACCTTCTT 
ACTGAGATAC GTAATGAGAA GTTTCGATTA TACAAATTAA AGATGATGGC AAAGATGGAA 
AAATATCTTC ATTCTAGCAG ATGTAGGAGA CAAATCATCT TGTCTCATTT TGAGGACAAA 
CAAGTACAAA AAGCCTCCTT GGGAATTATG GGAACTGAAA AATGCTGTGA TAATTGCAGG 
TCCAGATTGG ATCATTGCTA TTCCATGGAT GACTCAGAGG ATACATCCTG GGACTTTGGT 
CCACAAGCAT TTAAGCTTTT GTCTGCTGTG GACATCTTAG GCGAAAAATT TGGAATTGGG 
CTTCCAATTT TATTTCTCCG AGGATCTAAT TCTCAGCGTC TTGCCGATCA ATATCGCAGG 
CACAGTTTAT TTGGCACTGG CAAGGATCAA ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT 
CAGCTGATCA CTGAGGGATT CTTGGTAGAA GTTTCTCGGT ATAACAAATT TATGAAGATT 
TGCGCCCTTA CGAAAAAGGG TAGAAATTGG CTTCATAAAG CTAATACAGA ATCTCAGAGC 
CTCATCCTTC AAGCTAATGA AGAATTGTGT CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA 
ACTGTATCTT CGGGCACCAA AGAGCATTGT TATAATCAAG TACCAGTTGA ATTAAGTACA 
GAGAAGAAGT CTAACTTGGA GAAGTTATAT TCTTATAAAC CATGTGATAA GATTTCTTCT 
GGGAGTAACA TTTCTAAAAA AAGTATCATG GTACAGTCAC CAGAAAAAGC TTACAGTTCC 
TCACAGCCTG TTATTTCGGC ACAAGAGCAG GAGACTCAGA TTGTGTTATA TGGCAAATTG 
GTAGAAGCTA GGCAGAAACA TGCCAATAAA ATGGATGTTC CCCCAGCTAT TCTGGCAACA 
AACAAGATAC TGGTGGATAT GGCCAAAATG AGACCAACTA CGGTTGAAAA CGTAAAAAGG 
ATTGATGGTG TTTCTGAAGG CAAAGCTGCC ATGTTGGCCC CTCTGTTGGA AGTCATCAAA 
CATTTCTGCC AAACAAATAG TGTTCAGACA GACCTCTTTT CAAGTACAAA ACCTCAAGAA 
GAACAGAAGA CGAGTCTGGT AGCAAAAAAT AAAATATGCA CACTTTCACA GTCTATGGCC 
ATCACATACT CTTTATTCCA AGAAAAGAAG ATGCCTTTGA AGAGCATAGC TGAGAGCAGG 
ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TGGCTGCCCC 
CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TGATGTTATC 
CGAAACCCTC CCGTCAACTC AGATATGAGT AAAATTAGCC TAATCAGAAT GTTAGTTCCT 
GAAAACATTG ACACGTACCT TATCCACATG GCAATTGAGA TCCTTAAACA TGGTCCTGAC 
AGCGGACTTC AACCTTCATG TGATGTCAAC AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG 
ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA GAAGTAGGCA TCAATACTGA GACTTCATCT 
GCAGAGAGAA AGAGACGATT ACCTGTGTGG TTTGCCAAAG GAAGTGATAC CAGCAAGAAA 
TTAATGGACA AAACGAAAAG GGGAGGTCTT TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000544.2
CDS	789..5087
Translation	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Target ORF information:

RefSeq Version	NM_000553.5
Organism	Homo sapiens(human)
Definition	Homo sapiens WRN RecQ like helicase (WRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000553.5

ORF Insert Sequence:

ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT 
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT 
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA 
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT 
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT 
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT 
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG 
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG 
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG 
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT 
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT 
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA 
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG 
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT 
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT 
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT 
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA 
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC 
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT 
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA 
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT 
GATGAAGATT TAGAAATGGA GATGCTTAAG CATTTATCTC CCAATGATAA TGAAAACGAT 
ACGTCCTATG TAATTGAGAG TGATGAAGAT TTAGAAATGG AGATGCTTAA GTCTTTAGAA 
AACCTCAATA GTGGCACGGT AGAACCAACT CATTCTAAAT GCTTAAAAAT GGAAAGAAAT 
CTGGGTCTTC CTACTAAAGA AGAAGAAGAA GATGATGAAA ATGAAGCTAA TGAAGGGGAA 
GAAGATGATG ATAAGGACTT TTTGTGGCCA GCACCCAATG AAGAGCAAGT TACTTGCCTC 
AAGATGTACT TTGGCCATTC CAGTTTTAAA CCAGTTCAGT GGAAAGTGAT TCATTCAGTA 
TTAGAAGAAA GAAGAGATAA TGTTGCTGTC ATGGCAACTG GATATGGAAA GAGTTTGTGC 
TTCCAGTATC CACCTGTTTA TGTAGGCAAG ATTGGCCTTG TTATCTCTCC CCTTATTTCT 
CTGATGGAAG ACCAAGTGCT ACAGCTTAAA ATGTCCAACA TCCCAGCTTG CTTCCTTGGA 
TCAGCACAGT CAGAAAATGT TCTAACAGAT ATTAAATTAG GTAAATACCG GATTGTATAC 
GTAACTCCAG AATACTGTTC AGGTAACATG GGCCTGCTCC AGCAACTTGA GGCTGATATT 
GGTATCACGC TCATTGCTGT GGATGAGGCT CACTGTATTT CTGAGTGGGG GCATGATTTT 
AGGGATTCAT TCAGGAAGTT GGGCTCCCTA AAGACAGCAC TGCCAATGGT TCCAATCGTT 
GCACTTACTG CTACTGCAAG TTCTTCAATC CGGGAAGACA TTGTACGTTG CTTAAATCTG 
AGAAATCCTC AGATCACCTG TACTGGTTTT GATCGACCAA ACCTGTATTT AGAAGTTAGG 
CGAAAAACAG GGAATATCCT TCAGGATCTG CAGCCATTTC TTGTCAAAAC AAGTTCCCAC 
TGGGAATTTG AAGGTCCAAC AATCATCTAC TGTCCTTCTA GAAAAATGAC ACAACAAGTT 
ACAGGTGAAC TTAGGAAACT GAATCTATCC TGTGGAACAT ACCATGCGGG CATGAGTTTT 
AGCACAAGGA AAGACATTCA TCATAGGTTT GTAAGAGATG AAATTCAGTG TGTCATAGCT 
ACCATAGCTT TTGGAATGGG CATTAATAAA GCTGACATTC GCCAAGTCAT TCATTACGGT 
GCTCCTAAGG ACATGGAATC ATATTATCAG GAGATTGGTA GAGCTGGTCG TGATGGACTT 
CAAAGTTCTT GTCACGTCCT CTGGGCTCCT GCAGACATTA ACTTAAATAG GCACCTTCTT 
ACTGAGATAC GTAATGAGAA GTTTCGATTA TACAAATTAA AGATGATGGC AAAGATGGAA 
AAATATCTTC ATTCTAGCAG ATGTAGGAGA CAAATCATCT TGTCTCATTT TGAGGACAAA 
CAAGTACAAA AAGCCTCCTT GGGAATTATG GGAACTGAAA AATGCTGTGA TAATTGCAGG 
TCCAGATTGG ATCATTGCTA TTCCATGGAT GACTCAGAGG ATACATCCTG GGACTTTGGT 
CCACAAGCAT TTAAGCTTTT GTCTGCTGTG GACATCTTAG GCGAAAAATT TGGAATTGGG 
CTTCCAATTT TATTTCTCCG AGGATCTAAT TCTCAGCGTC TTGCCGATCA ATATCGCAGG 
CACAGTTTAT TTGGCACTGG CAAGGATCAA ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT 
CAGCTGATCA CTGAGGGATT CTTGGTAGAA GTTTCTCGGT ATAACAAATT TATGAAGATT 
TGCGCCCTTA CGAAAAAGGG TAGAAATTGG CTTCATAAAG CTAATACAGA ATCTCAGAGC 
CTCATCCTTC AAGCTAATGA AGAATTGTGT CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA 
ACTGTATCTT CGGGCACCAA AGAGCATTGT TATAATCAAG TACCAGTTGA ATTAAGTACA 
GAGAAGAAGT CTAACTTGGA GAAGTTATAT TCTTATAAAC CATGTGATAA GATTTCTTCT 
GGGAGTAACA TTTCTAAAAA AAGTATCATG GTACAGTCAC CAGAAAAAGC TTACAGTTCC 
TCACAGCCTG TTATTTCGGC ACAAGAGCAG GAGACTCAGA TTGTGTTATA TGGCAAATTG 
GTAGAAGCTA GGCAGAAACA TGCCAATAAA ATGGATGTTC CCCCAGCTAT TCTGGCAACA 
AACAAGATAC TGGTGGATAT GGCCAAAATG AGACCAACTA CGGTTGAAAA CGTAAAAAGG 
ATTGATGGTG TTTCTGAAGG CAAAGCTGCC ATGTTGGCCC CTCTGTTGGA AGTCATCAAA 
CATTTCTGCC AAACAAATAG TGTTCAGACA GACCTCTTTT CAAGTACAAA ACCTCAAGAA 
GAACAGAAGA CGAGTCTGGT AGCAAAAAAT AAAATATGCA CACTTTCACA GTCTATGGCC 
ATCACATACT CTTTATTCCA AGAAAAGAAG ATGCCTTTGA AGAGCATAGC TGAGAGCAGG 
ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TGGCTGCCCC 
CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TGATGTTATC 
CGAAACCCTC CCGTCAACTC AGATATGAGT AAAATTAGCC TAATCAGAAT GTTAGTTCCT 
GAAAACATTG ACACGTACCT TATCCACATG GCAATTGAGA TCCTTAAACA TGGTCCTGAC 
AGCGGACTTC AACCTTCATG TGATGTCAAC AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG 
ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA GAAGTAGGCA TCAATACTGA GACTTCATCT 
GCAGAGAGAA AGAGACGATT ACCTGTGTGG TTTGCCAAAG GAAGTGATAC CAGCAAGAAA 
TTAATGGACA AAACGAAAAG GGGAGGTCTT TTTAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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WRN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

Eメール

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FAX

オンラインフォーム