| Gene Symbol | TNFRSF4 |
| Entrez Gene ID | 7293 |
| Full Name | TNF receptor superfamily member 4 |
| Synonyms | ACT35,CD134,IMD16,OX40,TXGP1L |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | ?Immunodeficiency 16, 615593 (3) |









































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