MSMP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSMP
Entrez Gene ID	692094
Full Name	microseminoprotein, prostate associated
Synonyms	PSMP
General protein information	Preferred Names microseminoprotein, prostate associated Names prostate-associated microseminoprotein PC3 prostate cancer cell-secreted microprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p13.3
Summary	This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancer tumorigenesis. [provided by RefSeq, Jan 2011].
Disorder MIM:	612191

mRNA and Protein(s)

mRNA	Protein	Name
NM_001044264.3	NP_001037729.1	prostate-associated microseminoprotein precursor
NM_001044264.2	NP_001037729.1	prostate-associated microseminoprotein precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MSMP	XP_868663.2
Rattus norvegicus (Norway rat)	LOC100365008	NP_001258251.1
Homo sapiens (human)	MSMP	NP_001037729.1
Bos taurus (cattle)	MSMP	XP_002689727.1
Gallus gallus (chicken)	MSMP	XP_001233141.1
Danio rerio (zebrafish)	LOC101884672	XP_005172388.1
Pan troglodytes (chimpanzee)	MSMP	XP_001168039.1
	MSMP	XP_001085913.1
Mus musculus (house mouse)	Msmp	NP_001092784.1

Gene Ontology
Bibliography

Related articles in PubMed

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).
Mitamura T, Pradeep S, McGuire M, Wu SY, Ma S, Hatakeyama H, Lyons YA, Hisamatsu T, Noh K, Villar-Prados A, Chen X, Ivan C, Rodriguez-Aguayo C, Hu W, Lopez-Berestein G, Coleman RL, Sood AK
Oncogene(2017 Oct)

PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2.
Pei X, Sun Q, Zhang Y, Wang P, Peng X, Guo C, Xu E, Zheng Y, Mo X, Ma J, Chen D, Zhang Y, Zhang Y, Song Q, Guo S, Shi T, Zhang Z, Ma D, Wang Y
Journal of immunology (Baltimore, Md. : 1950)192(4)1878-86(2014 Feb)

A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue.
Valtonen-Andr? C, Bjartell A, Hellsten R, Lilja H, H?rk?nen P, Lundwall A
Biological chemistry388(3)289-95(2007 Mar)

Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones.
Gonzalez P, Epstein DL, Borr?s T
Investigative ophthalmology & visual science41(12)3678-93(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these data collectively suggest that PSMP is a chemoattractant protein acting as a novel CCR2 ligand that may influence inflammation and cancer development.
Title: PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2.

The following MSMP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSMP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16861	NM_001044264.3 Latest version!	Homo sapiens microseminoprotein, prostate associated (MSMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16861	NM_001044264.2	Homo sapiens microseminoprotein, prostate associated (MSMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSMP ( NM_001044264.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001037729.1 Homo sapiens microseminoprotein, prostate associated (MSMP), mRNA.

Price & Availability↑

CloneID	OHu16861
Clone ID Related Accession (Same CDS sequence)	NM_001044264.3 , NM_001044264.2
Accession Version	NM_001044264.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	prostate-associated microseminoprotein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC071800.1, DQ012170.1 and BE439525.1. On Nov 23, 2018 this sequence version replaced NM_001044264.2. ##Evidence-Data-START## Transcript exon combination :: BE439730.1, BC105274.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000436428.3/ ENSP00000419194.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCTAA GGATGCTCTG GGCTGGACAG GCCAAGGGGA TCCTAGGAGG CTGGGGGATC 
ATCTGCTTGG TGATGTCTCT ACTCCTCCAG CACCCAGGAG TCTACAGCAA GTGCTACTTC 
CAAGCTCAAG CCCCCTGTCA CTATGAGGGG AAATATTTTA CCCTGGGTGA GTCTTGGCTC 
CGCAAGGACT GTTTCCATTG CACCTGTCTG CATCCTGTTG GCGTGGGCTG CTGTGACACG 
TCCCAGCATC CCATCGACTT CCCGGCTGGG TGTGAGGTAC GTCAGGAGGC AGGAACCTGC 
CAGTTCTCCT TGGTGCAAAA ATCTGACCCT CGGCTGCCCT GCAAAGGGGG AGGGCCTGAC 
CCAGAATGGG GCTCAGCCAA CACCCCTGTT CCTGGGGCTC CTGCTCCCCA CTCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001037729.1
CDS	148..567
Translation	MALRMLWAGQAKGILGGWGIICLVMSLLLQHPGVYSKCYFQAQAPCHYEGKYFTLGESWLRKDCFHCTCLHPVGVGCCDTSQHPIDFPAGCEVRQEAGTCQFSLVQKSDPRLPCKGGGPDPEWGSANTPVPGAPAPHSS

Target ORF information:

RefSeq Version	NM_001044264.3
Organism	Homo sapiens(human)
Definition	Homo sapiens microseminoprotein, prostate associated (MSMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001044264.3

ORF Insert Sequence:

ATGGCCCTAA GGATGCTCTG GGCTGGACAG GCCAAGGGGA TCCTAGGAGG CTGGGGGATC 
ATCTGCTTGG TGATGTCTCT ACTCCTCCAG CACCCAGGAG TCTACAGCAA GTGCTACTTC 
CAAGCTCAAG CCCCCTGTCA CTATGAGGGG AAATATTTTA CCCTGGGTGA GTCTTGGCTC 
CGCAAGGACT GTTTCCATTG CACCTGTCTG CATCCTGTTG GCGTGGGCTG CTGTGACACG 
TCCCAGCATC CCATCGACTT CCCGGCTGGG TGTGAGGTAC GTCAGGAGGC AGGAACCTGC 
CAGTTCTCCT TGGTGCAAAA ATCTGACCCT CGGCTGCCCT GCAAAGGGGG AGGGCCTGAC 
CCAGAATGGG GCTCAGCCAA CACCCCTGTT CCTGGGGCTC CTGCTCCCCA CTCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSMP ( NM_001044264.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001037729.1 Homo sapiens microseminoprotein, prostate associated (MSMP), mRNA.

Price & Availability↑

CloneID	OHu16861
Clone ID Related Accession (Same CDS sequence)	NM_001044264.3 , NM_001044264.2
Accession Version	NM_001044264.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-25
Organism	Homo sapiens(human)
Product	prostate-associated microseminoprotein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC071800.1, DQ012170.1 and BE439525.1. On Jan 7, 2011 this sequence version replaced NM_001044264.1. ##Evidence-Data-START## Transcript exon combination :: BC071800.1, BC105274.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCTAA GGATGCTCTG GGCTGGACAG GCCAAGGGGA TCCTAGGAGG CTGGGGGATC 
ATCTGCTTGG TGATGTCTCT ACTCCTCCAG CACCCAGGAG TCTACAGCAA GTGCTACTTC 
CAAGCTCAAG CCCCCTGTCA CTATGAGGGG AAATATTTTA CCCTGGGTGA GTCTTGGCTC 
CGCAAGGACT GTTTCCATTG CACCTGTCTG CATCCTGTTG GCGTGGGCTG CTGTGACACG 
TCCCAGCATC CCATCGACTT CCCGGCTGGG TGTGAGGTAC GTCAGGAGGC AGGAACCTGC 
CAGTTCTCCT TGGTGCAAAA ATCTGACCCT CGGCTGCCCT GCAAAGGGGG AGGGCCTGAC 
CCAGAATGGG GCTCAGCCAA CACCCCTGTT CCTGGGGCTC CTGCTCCCCA CTCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001037729.1
CDS	149..568
Translation	MALRMLWAGQAKGILGGWGIICLVMSLLLQHPGVYSKCYFQAQAPCHYEGKYFTLGESWLRKDCFHCTCLHPVGVGCCDTSQHPIDFPAGCEVRQEAGTCQFSLVQKSDPRLPCKGGGPDPEWGSANTPVPGAPAPHSS

Target ORF information:

RefSeq Version	NM_001044264.2
Organism	Homo sapiens(human)
Definition	Homo sapiens microseminoprotein, prostate associated (MSMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001044264.2

ORF Insert Sequence:

ATGGCCCTAA GGATGCTCTG GGCTGGACAG GCCAAGGGGA TCCTAGGAGG CTGGGGGATC 
ATCTGCTTGG TGATGTCTCT ACTCCTCCAG CACCCAGGAG TCTACAGCAA GTGCTACTTC 
CAAGCTCAAG CCCCCTGTCA CTATGAGGGG AAATATTTTA CCCTGGGTGA GTCTTGGCTC 
CGCAAGGACT GTTTCCATTG CACCTGTCTG CATCCTGTTG GCGTGGGCTG CTGTGACACG 
TCCCAGCATC CCATCGACTT CCCGGCTGGG TGTGAGGTAC GTCAGGAGGC AGGAACCTGC 
CAGTTCTCCT TGGTGCAAAA ATCTGACCCT CGGCTGCCCT GCAAAGGGGG AGGGCCTGAC 
CCAGAATGGG GCTCAGCCAA CACCCCTGTT CCTGGGGCTC CTGCTCCCCA CTCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).
Oncogene(2017 Oct)
Mitamura T,Pradeep S,McGuire M,Wu SY,Ma S,Hatakeyama H,Lyons YA,Hisamatsu T,Noh K,Villar-Prados A,Chen X,Ivan C,Rodriguez-Aguayo C,Hu W,Lopez-Berestein G,Coleman RL,Sood AK

PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2.
Journal of immunology (Baltimore, Md. : 1950)192(4)1878-86(2014 Feb)
Pei X,Sun Q,Zhang Y,Wang P,Peng X,Guo C,Xu E,Zheng Y,Mo X,Ma J,Chen D,Zhang Y,Zhang Y,Song Q,Guo S,Shi T,Zhang Z,Ma D,Wang Y

A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue.
Biological chemistry388(3)289-95(2007 Mar)
Valtonen-Andr? C,Bjartell A,Hellsten R,Lilja H,H?rk?nen P,Lundwall A

Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones.
Investigative ophthalmology & visual science41(12)3678-93(2000 Nov)
Gonzalez P,Epstein DL,Borr?s T