TAT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAT
Entrez Gene ID	6898
Full Name	tyrosine aminotransferase
General protein information	Preferred Names tyrosine aminotransferase Names tyrosine aminotransferase L-tyrosine:2-oxoglutarate aminotransferase testis tissue sperm-binding protein Li 34a tyrosine aminotransferase, cytosolic
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q22.2
Summary	This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008].
Disorder MIM:	613018
Disorder Html:	Tyrosinemia, type II, 276600 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000353.2	NP_000344.1	tyrosine aminotransferase
NM_000353.3	NP_000344.1	tyrosine aminotransferase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAT	XP_511091.2
	TAT	XP_001106194.1
Canis lupus familiaris (dog)	TAT	XP_536796.2
Gallus gallus (chicken)	TAT	XP_004944414.1
Oryza sativa (rice)	Os11g0552000	NP_001068082.2
Homo sapiens (human)	TAT	NP_000344.1
Arabidopsis thaliana (thale cress)	AT5G36160	NP_198465.3
Mus musculus (house mouse)	Tat	NP_666326.1
Oryza sativa (rice)	Os02g0302400	NP_001046626.1
Oryza sativa (rice)	Os06g0345200	NP_001057579.1
Bos taurus (cattle)	TAT	NP_001029762.1
Rattus norvegicus (Norway rat)	Tat	NP_036800.1
Danio rerio (zebrafish)	tat	NP_001071022.1
Drosophila melanogaster (fruit fly)	CG1461	NP_572953.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000327	XP_310789.4
Caenorhabditis elegans (roundworm)	tatn-1	NP_510454.1
Oryza sativa (rice)	Os02g0302700	NP_001046628.1
Xenopus tropicalis (tropical clawed frog)	tat	NP_001006790.1

Gene Ontology
Bibliography

Related articles in PubMed

Tyrosinemia type II: Mutation update, 11 novel mutations and description of 5 independent subjects with a novel founder mutation.
Pe?a-Quintana L, Scherer G, Curbelo-Est?vez ML, Jim?nez-Acosta F, Hartmann B, La Roche F, Meavilla-Olivas S, P?rez-Cerd? C, Garc?a-Segarra N, Gigu?re Y, Huppke P, Mitchell GA, M?nch E, Trump D, Vianey-Saban C, Trimble ER, Vitoria-Mi?ana I, Reyes-Su?rez D, Ram?rez-Lorenzo T, Tugores A
Clinical genetics92(3)306-317(2017 Sep)

Tyrosinemia type II: Novel mutations in TAT in a boy with unusual presentation.
Gokay S, Kendirci M, Ustkoyuncu PS, Kardas F, Bayram AK, Per H, Poyrazo?lu HG
Pediatrics international : official journal of the Japan Pediatric Society58(10)1069-1072(2016 Oct)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)

Novel and recurrent mutations in the TAT gene in Tunisian families affected with Richner-Hanhart syndrome.
Bouyacoub Y, Zribi H, Azzouz H, Nasrallah F, Abdelaziz RB, Kacem M, Rekaya B, Messaoud O, Romdhane L, Charfeddine C, Bouziri M, Bouziri S, Tebib N, Mokni M, Kaabachi N, Boubaker S, Abdelhak S
Gene529(1)45-9(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sequencing of TAT indicated two new homozygous mutations p.L312P (c.935T>C) and p.T408M (c.1223C>T) for the proband and his asymptomatic sister.
Title: Tyrosinemia type II: Novel mutations in TAT in a boy with unusual presentation.

Two known mutations and one novel mutation was found in the TAT gene of Tunesian Richner-Hanhart syndrome patients. The geographical distribution of RHS mutations shows regional specificities.
Title: Novel and recurrent mutations in the TAT gene in Tunisian families affected with Richner-Hanhart syndrome.

The high potential application of Tat and its entrapment in elastic cationic niosomes for development of a transdermal gene delivery system are described.
Title: Potent enhancement of transdermal absorption and stability of human tyrosinase plasmid (pAH7/Tyr) by Tat peptide and an entrapment in elastic cationic niosomes.

A paternal inherited frameshift mutation c.1213delCinsAG at codon 405 causing a premature stop codon, and a maternally inherited deletion of 193kb encompassing the complete TAT gene yield the first complete TAT deletion in tyrosinaemia type II described.
Title: A large TAT deletion in a tyrosinaemia type II patient.

tumor suppressive mechanism of TAT was associated with its proapoptotic role in a mitochondrial-dependent manner by promoting cytochrome-c release and activating caspase-9 and PARP.
Title: Down-regulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma.

The following TAT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19528	NM_000353.3 Latest version!	Homo sapiens tyrosine aminotransferase (TAT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu19528	NM_000353.2	Homo sapiens tyrosine aminotransferase (TAT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAT ( NM_000353.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000344.1 Homo sapiens tyrosine aminotransferase (TAT), mRNA.

Price & Availability↑

CloneID	OHu19528
Clone ID Related Accession (Same CDS sequence)	NM_000353.2 , NM_000353.3
Accession Version	NM_000353.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	tyrosine aminotransferase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010547.9. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2008 this sequence version replaced NM_000353.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005657.1, X55675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCAT ACATGATTCA GATGAGCAGC AAAGGCAACC TCCCCTCAAT TCTGGACGTG 
CATGTCAACG TTGGTGGGAG AAGCTCTGTG CCGGGAAAAA TGAAAGGCAG AAAGGCCAGG 
TGGTCTGTGA GGCCCTCAGA CATGGCCAAG AAAACTTTCA ACCCCATCCG AGCCATTGTG 
GACAACATGA AGGTGAAACC AAATCCAAAC AAAACCATGA TTTCCCTGTC CATTGGGGAC 
CCTACTGTGT TTGGAAACCT GCCTACAGAC CCTGAAGTTA CCCAGGCAAT GAAAGATGCC 
CTGGACTCGG GCAAATATAA TGGCTATGCC CCATCCATCG GCTTCCTATC CAGTCGGGAG 
GAGATTGCTT CTTATTACCA CTGTCCTGAG GCACCCCTAG AAGCTAAGGA CGTCATTCTG 
ACAAGTGGCT GCAGCCAAGC TATTGACCTT TGTTTAGCTG TGTTGGCCAA CCCAGGGCAA 
AACATCCTGG TTCCAAGACC TGGTTTCTCT CTCTACAAGA CTCTGGCTGA GTCTATGGGA 
ATTGAGGTCA AACTCTACAA TTTGTTGCCA GAGAAATCTT GGGAAATTGA CCTGAAACAA 
CTGGAATATC TAATTGATGA AAAGACAGCT TGTCTCATTG TCAATAATCC ATCAAACCCC 
TGTGGGTCAG TGTTCAGCAA ACGTCATCTT CAGAAGATTC TGGCAGTGGC TGCACGGCAG 
TGTGTCCCCA TCTTAGCTGA TGAGATCTAT GGAGACATGG TGTTTTCGGA TTGCAAATAT 
GAACCACTGG CCACCCTCAG CACCGATGTC CCCATCCTGT CCTGTGGAGG GCTGGCCAAG 
CGCTGGCTGG TTCCTGGCTG GAGGTTGGGC TGGATCCTCA TTCATGACCG AAGAGACATT 
TTTGGCAATG AGATCCGAGA TGGGCTGGTG AAGCTGAGTC AGCGCATTTT GGGACCCTGT 
ACCATTGTCC AGGGAGCTCT GAAAAGCATC CTATGTCGCA CCCCGGGAGA GTTTTACCAC 
AACACTCTGA GCTTCCTCAA GTCCAATGCT GATCTCTGTT ATGGGGCGTT GGCTGCCATC 
CCTGGACTCC GGCCAGTCCG CCCTTCTGGG GCTATGTACC TCATGGTTGG AATTGAGATG 
GAACATTTCC CAGAATTTGA GAACGATGTG GAGTTCACGG AGCGGTTAGT TGCTGAGCAG 
TCTGTCCACT GCCTCCCAGC AACGTGCTTT GAGTACCCGA ATTTCATCCG AGTGGTCATC 
ACAGTCCCCG AGGTGATGAT GCTGGAGGCG TGCAGCCGGA TCCAGGAGTT CTGTGAGCAG 
CACTACCATT GTGCTGAAGG CAGCCAGGAG GAGTGTGATA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000344.1
CDS	100..1464
Translation	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

Target ORF information:

RefSeq Version	NM_000353.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosine aminotransferase (TAT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000353.2

ORF Insert Sequence:

ATGGACCCAT ACATGATTCA GATGAGCAGC AAAGGCAACC TCCCCTCAAT TCTGGACGTG 
CATGTCAACG TTGGTGGGAG AAGCTCTGTG CCGGGAAAAA TGAAAGGCAG AAAGGCCAGG 
TGGTCTGTGA GGCCCTCAGA CATGGCCAAG AAAACTTTCA ACCCCATCCG AGCCATTGTG 
GACAACATGA AGGTGAAACC AAATCCAAAC AAAACCATGA TTTCCCTGTC CATTGGGGAC 
CCTACTGTGT TTGGAAACCT GCCTACAGAC CCTGAAGTTA CCCAGGCAAT GAAAGATGCC 
CTGGACTCGG GCAAATATAA TGGCTATGCC CCATCCATCG GCTTCCTATC CAGTCGGGAG 
GAGATTGCTT CTTATTACCA CTGTCCTGAG GCACCCCTAG AAGCTAAGGA CGTCATTCTG 
ACAAGTGGCT GCAGCCAAGC TATTGACCTT TGTTTAGCTG TGTTGGCCAA CCCAGGGCAA 
AACATCCTGG TTCCAAGACC TGGTTTCTCT CTCTACAAGA CTCTGGCTGA GTCTATGGGA 
ATTGAGGTCA AACTCTACAA TTTGTTGCCA GAGAAATCTT GGGAAATTGA CCTGAAACAA 
CTGGAATATC TAATTGATGA AAAGACAGCT TGTCTCATTG TCAATAATCC ATCAAACCCC 
TGTGGGTCAG TGTTCAGCAA ACGTCATCTT CAGAAGATTC TGGCAGTGGC TGCACGGCAG 
TGTGTCCCCA TCTTAGCTGA TGAGATCTAT GGAGACATGG TGTTTTCGGA TTGCAAATAT 
GAACCACTGG CCACCCTCAG CACCGATGTC CCCATCCTGT CCTGTGGAGG GCTGGCCAAG 
CGCTGGCTGG TTCCTGGCTG GAGGTTGGGC TGGATCCTCA TTCATGACCG AAGAGACATT 
TTTGGCAATG AGATCCGAGA TGGGCTGGTG AAGCTGAGTC AGCGCATTTT GGGACCCTGT 
ACCATTGTCC AGGGAGCTCT GAAAAGCATC CTATGTCGCA CCCCGGGAGA GTTTTACCAC 
AACACTCTGA GCTTCCTCAA GTCCAATGCT GATCTCTGTT ATGGGGCGTT GGCTGCCATC 
CCTGGACTCC GGCCAGTCCG CCCTTCTGGG GCTATGTACC TCATGGTTGG AATTGAGATG 
GAACATTTCC CAGAATTTGA GAACGATGTG GAGTTCACGG AGCGGTTAGT TGCTGAGCAG 
TCTGTCCACT GCCTCCCAGC AACGTGCTTT GAGTACCCGA ATTTCATCCG AGTGGTCATC 
ACAGTCCCCG AGGTGATGAT GCTGGAGGCG TGCAGCCGGA TCCAGGAGTT CTGTGAGCAG 
CACTACCATT GTGCTGAAGG CAGCCAGGAG GAGTGTGATA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAT ( NM_000353.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000344.1 Homo sapiens tyrosine aminotransferase (TAT), mRNA.

Price & Availability↑

CloneID	OHu19528
Clone ID Related Accession (Same CDS sequence)	NM_000353.2 , NM_000353.3
Accession Version	NM_000353.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	tyrosine aminotransferase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010547.9. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000353.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X52520.1, HM005657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04284274 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000355962.5/ ENSP00000348234.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCCAT ACATGATTCA GATGAGCAGC AAAGGCAACC TCCCCTCAAT TCTGGACGTG 
CATGTCAACG TTGGTGGGAG AAGCTCTGTG CCGGGAAAAA TGAAAGGCAG AAAGGCCAGG 
TGGTCTGTGA GGCCCTCAGA CATGGCCAAG AAAACTTTCA ACCCCATCCG AGCCATTGTG 
GACAACATGA AGGTGAAACC AAATCCAAAC AAAACCATGA TTTCCCTGTC CATTGGGGAC 
CCTACTGTGT TTGGAAACCT GCCTACAGAC CCTGAAGTTA CCCAGGCAAT GAAAGATGCC 
CTGGACTCGG GCAAATATAA TGGCTATGCC CCATCCATCG GCTTCCTATC CAGTCGGGAG 
GAGATTGCTT CTTATTACCA CTGTCCTGAG GCACCCCTAG AAGCTAAGGA CGTCATTCTG 
ACAAGTGGCT GCAGCCAAGC TATTGACCTT TGTTTAGCTG TGTTGGCCAA CCCAGGGCAA 
AACATCCTGG TTCCAAGACC TGGTTTCTCT CTCTACAAGA CTCTGGCTGA GTCTATGGGA 
ATTGAGGTCA AACTCTACAA TTTGTTGCCA GAGAAATCTT GGGAAATTGA CCTGAAACAA 
CTGGAATATC TAATTGATGA AAAGACAGCT TGTCTCATTG TCAATAATCC ATCAAACCCC 
TGTGGGTCAG TGTTCAGCAA ACGTCATCTT CAGAAGATTC TGGCAGTGGC TGCACGGCAG 
TGTGTCCCCA TCTTAGCTGA TGAGATCTAT GGAGACATGG TGTTTTCGGA TTGCAAATAT 
GAACCACTGG CCACCCTCAG CACCGATGTC CCCATCCTGT CCTGTGGAGG GCTGGCCAAG 
CGCTGGCTGG TTCCTGGCTG GAGGTTGGGC TGGATCCTCA TTCATGACCG AAGAGACATT 
TTTGGCAATG AGATCCGAGA TGGGCTGGTG AAGCTGAGTC AGCGCATTTT GGGACCCTGT 
ACCATTGTCC AGGGAGCTCT GAAAAGCATC CTATGTCGCA CCCCGGGAGA GTTTTACCAC 
AACACTCTGA GCTTCCTCAA GTCCAATGCT GATCTCTGTT ATGGGGCGTT GGCTGCCATC 
CCTGGACTCC GGCCAGTCCG CCCTTCTGGG GCTATGTACC TCATGGTTGG AATTGAGATG 
GAACATTTCC CAGAATTTGA GAACGATGTG GAGTTCACGG AGCGGTTAGT TGCTGAGCAG 
TCTGTCCACT GCCTCCCAGC AACGTGCTTT GAGTACCCGA ATTTCATCCG AGTGGTCATC 
ACAGTCCCCG AGGTGATGAT GCTGGAGGCG TGCAGCCGGA TCCAGGAGTT CTGTGAGCAG 
CACTACCATT GTGCTGAAGG CAGCCAGGAG GAGTGTGATA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000344.1
CDS	97..1461
Translation	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

Target ORF information:

RefSeq Version	NM_000353.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosine aminotransferase (TAT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000353.3

ORF Insert Sequence:

ATGGACCCAT ACATGATTCA GATGAGCAGC AAAGGCAACC TCCCCTCAAT TCTGGACGTG 
CATGTCAACG TTGGTGGGAG AAGCTCTGTG CCGGGAAAAA TGAAAGGCAG AAAGGCCAGG 
TGGTCTGTGA GGCCCTCAGA CATGGCCAAG AAAACTTTCA ACCCCATCCG AGCCATTGTG 
GACAACATGA AGGTGAAACC AAATCCAAAC AAAACCATGA TTTCCCTGTC CATTGGGGAC 
CCTACTGTGT TTGGAAACCT GCCTACAGAC CCTGAAGTTA CCCAGGCAAT GAAAGATGCC 
CTGGACTCGG GCAAATATAA TGGCTATGCC CCATCCATCG GCTTCCTATC CAGTCGGGAG 
GAGATTGCTT CTTATTACCA CTGTCCTGAG GCACCCCTAG AAGCTAAGGA CGTCATTCTG 
ACAAGTGGCT GCAGCCAAGC TATTGACCTT TGTTTAGCTG TGTTGGCCAA CCCAGGGCAA 
AACATCCTGG TTCCAAGACC TGGTTTCTCT CTCTACAAGA CTCTGGCTGA GTCTATGGGA 
ATTGAGGTCA AACTCTACAA TTTGTTGCCA GAGAAATCTT GGGAAATTGA CCTGAAACAA 
CTGGAATATC TAATTGATGA AAAGACAGCT TGTCTCATTG TCAATAATCC ATCAAACCCC 
TGTGGGTCAG TGTTCAGCAA ACGTCATCTT CAGAAGATTC TGGCAGTGGC TGCACGGCAG 
TGTGTCCCCA TCTTAGCTGA TGAGATCTAT GGAGACATGG TGTTTTCGGA TTGCAAATAT 
GAACCACTGG CCACCCTCAG CACCGATGTC CCCATCCTGT CCTGTGGAGG GCTGGCCAAG 
CGCTGGCTGG TTCCTGGCTG GAGGTTGGGC TGGATCCTCA TTCATGACCG AAGAGACATT 
TTTGGCAATG AGATCCGAGA TGGGCTGGTG AAGCTGAGTC AGCGCATTTT GGGACCCTGT 
ACCATTGTCC AGGGAGCTCT GAAAAGCATC CTATGTCGCA CCCCGGGAGA GTTTTACCAC 
AACACTCTGA GCTTCCTCAA GTCCAATGCT GATCTCTGTT ATGGGGCGTT GGCTGCCATC 
CCTGGACTCC GGCCAGTCCG CCCTTCTGGG GCTATGTACC TCATGGTTGG AATTGAGATG 
GAACATTTCC CAGAATTTGA GAACGATGTG GAGTTCACGG AGCGGTTAGT TGCTGAGCAG 
TCTGTCCACT GCCTCCCAGC AACGTGCTTT GAGTACCCGA ATTTCATCCG AGTGGTCATC 
ACAGTCCCCG AGGTGATGAT GCTGGAGGCG TGCAGCCGGA TCCAGGAGTT CTGTGAGCAG 
CACTACCATT GTGCTGAAGG CAGCCAGGAG GAGTGTGATA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tyrosinemia type II: Mutation update, 11 novel mutations and description of 5 independent subjects with a novel founder mutation.
Clinical genetics92(3)306-317(2017 Sep)
Pe?a-Quintana L,Scherer G,Curbelo-Est?vez ML,Jim?nez-Acosta F,Hartmann B,La Roche F,Meavilla-Olivas S,P?rez-Cerd? C,Garc?a-Segarra N,Gigu?re Y,Huppke P,Mitchell GA,M?nch E,Trump D,Vianey-Saban C,Trimble ER,Vitoria-Mi?ana I,Reyes-Su?rez D,Ram?rez-Lorenzo T,Tugores A

Tyrosinemia type II: Novel mutations in TAT in a boy with unusual presentation.
Pediatrics international : official journal of the Japan Pediatric Society58(10)1069-1072(2016 Oct)
Gokay S,Kendirci M,Ustkoyuncu PS,Kardas F,Bayram AK,Per H,Poyrazo?lu HG

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nature communications53650(2014 Apr)
Corominas R,Yang X,Lin GN,Kang S,Shen Y,Ghamsari L,Broly M,Rodriguez M,Tam S,Trigg SA,Fan C,Yi S,Tasan M,Lemmens I,Kuang X,Zhao N,Malhotra D,Michaelson JJ,Vacic V,Calderwood MA,Roth FP,Tavernier J,Horvath S,Salehi-Ashtiani K,Korkin D,Sebat J,Hill DE,Hao T,Vidal M,Iakoucheva LM

Novel and recurrent mutations in the TAT gene in Tunisian families affected with Richner-Hanhart syndrome.
Gene529(1)45-9(2013 Oct)
Bouyacoub Y,Zribi H,Azzouz H,Nasrallah F,Abdelaziz RB,Kacem M,Rekaya B,Messaoud O,Romdhane L,Charfeddine C,Bouziri M,Bouziri S,Tebib N,Mokni M,Kaabachi N,Boubaker S,Abdelhak S

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TAT cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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