XCL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	XCL2
Entrez Gene ID	6846
Full Name	X-C motif chemokine ligand 2
Synonyms	SCM-1b,SCM1B,SCYC2
General protein information	Preferred Names X-C motif chemokine ligand 2 Names cytokine SCM-1 beta XC chemokine ligand 2 c motif chemokine 2 chemokine (C motif) ligand 2 small inducible cytokine subfamily C, member 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.2
Disorder MIM:	604828

mRNA and Protein(s)

mRNA	Protein	Name
NM_003175.4	NP_003166.1	cytokine SCM-1 beta precursor
NM_003175.3	NP_003166.1	cytokine SCM-1 beta precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	XCL2	NP_003166.1
Pan troglodytes (chimpanzee)	XCL2	XP_001134638.1

Gene Ontology
Bibliography

Related articles in PubMed

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, D?ring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C
Science translational medicine9(384)(2017 Apr)

Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer.
Zhou B, Xu H, Ni K, Ni X, Shen J
Medical science monitor : international medical journal of experimental and clinical research221560-5(2016 May)

Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.
Fox JC, Nakayama T, Tyler RC, Sander TL, Yoshie O, Volkman BF
Cytokine71(2)302-11(2015 Feb)

Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.
Suviolahti E, Ge S, Nast CC, Mirocha J, Karasyov A, White M, Jordan SC, Toyoda M
Transplant immunology32(1)9-17(2015 Jan)

Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.
Li MH, Harel M, Hla T, Ferrer F
Journal of pediatric surgery49(8)1286-91(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

XCL2 and CX3CL1 expression in lung cancers and adjacent non-cancerous tissues was detected by quantitative PCR and ELISA. The expression of XCL2 and CX3CL1 increases with increasing degree of malignancy, indicating that both chemokines might be important targets in gene therapy for lung cancer.
Title: Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer.

analysis of XCL1 and XCL2, members of the C-chemokine subfamily, in the immune system
Title: Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.

identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies
Title: Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.

S1P induced the macrophage-recruiting factor CCL2 expression in NB cells via S1P2, providing new insights into the complicated functions of S1P2 in cancer.
Title: Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.

Wag31 was found to specifically stimulate XCL2 expression in macrophages
Title: Mycobacterium tuberculosis antigen Wag31 induces expression of C-chemokine XCL2 in macrophages.

The following XCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32077	NM_003175.4 Latest version!	Homo sapiens X-C motif chemokine ligand 2 (XCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu32077	NM_003175.3	Homo sapiens X-C motif chemokine ligand 2 (XCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XCL2 ( NM_003175.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003166.1 Homo sapiens X-C motif chemokine ligand 2 (XCL2), mRNA.

Price & Availability↑

CloneID	OHu32077
Clone ID Related Accession (Same CDS sequence)	NM_003175.4 , NM_003175.3
Accession Version	NM_003175.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	cytokine SCM-1 beta precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC070308.1 and BE218461.1. On Nov 23, 2018 this sequence version replaced NM_003175.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070308.1, BE218461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367819.3/ ENSP00000356793.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGACTTC TCATCCTGGC CCTCCTTGGC ATCTGCTCTC TCACTGCATA CATTGTGGAA 
GGTGTAGGGA GTGAAGTCTC ACATAGGAGG ACCTGTGTGA GCCTCACTAC CCAGCGACTG 
CCAGTTAGCA GAATCAAGAC CTACACCATC ACGGAAGGCT CCTTGAGAGC AGTAATTTTT 
ATTACCAAAC GTGGCCTAAA AGTCTGTGCT GATCCACAAG CCACGTGGGT GAGAGACGTG 
GTCAGGAGCA TGGACAGGAA ATCCAACACC AGAAATAACA TGATCCAGAC CAAGCCAACA 
GGAACCCAGC AATCGACCAA TACAGCTGTG ACCCTGACTG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003166.1
CDS	34..378
Translation	MRLLILALLGICSLTAYIVEGVGSEVSHRRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

Target ORF information:

RefSeq Version	NM_003175.4
Organism	Homo sapiens(human)
Definition	Homo sapiens X-C motif chemokine ligand 2 (XCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003175.4

ORF Insert Sequence:

ATGAGACTTC TCATCCTGGC CCTCCTTGGC ATCTGCTCTC TCACTGCATA CATTGTGGAA 
GGTGTAGGGA GTGAAGTCTC ACATAGGAGG ACCTGTGTGA GCCTCACTAC CCAGCGACTG 
CCAGTTAGCA GAATCAAGAC CTACACCATC ACGGAAGGCT CCTTGAGAGC AGTAATTTTT 
ATTACCAAAC GTGGCCTAAA AGTCTGTGCT GATCCACAAG CCACGTGGGT GAGAGACGTG 
GTCAGGAGCA TGGACAGGAA ATCCAACACC AGAAATAACA TGATCCAGAC CAAGCCAACA 
GGAACCCAGC AATCGACCAA TACAGCTGTG ACCCTGACTG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XCL2 ( NM_003175.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003166.1 Homo sapiens X-C motif chemokine ligand 2 (XCL2), mRNA.

Price & Availability↑

CloneID	OHu32077
Clone ID Related Accession (Same CDS sequence)	NM_003175.4 , NM_003175.3
Accession Version	NM_003175.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytokine SCM-1 beta precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC070308.1 and BE218461.1. On Sep 1, 2007 this sequence version replaced NM_003175.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BE218461.1, CD521967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACTTC TCATCCTGGC CCTCCTTGGC ATCTGCTCTC TCACTGCATA CATTGTGGAA 
GGTGTAGGGA GTGAAGTCTC ACATAGGAGG ACCTGTGTGA GCCTCACTAC CCAGCGACTG 
CCAGTTAGCA GAATCAAGAC CTACACCATC ACGGAAGGCT CCTTGAGAGC AGTAATTTTT 
ATTACCAAAC GTGGCCTAAA AGTCTGTGCT GATCCACAAG CCACGTGGGT GAGAGACGTG 
GTCAGGAGCA TGGACAGGAA ATCCAACACC AGAAATAACA TGATCCAGAC CAAGCCAACA 
GGAACCCAGC AATCGACCAA TACAGCTGTG ACCCTGACTG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003166.1
CDS	34..378
Translation	MRLLILALLGICSLTAYIVEGVGSEVSHRRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

Target ORF information:

RefSeq Version	NM_003175.3
Organism	Homo sapiens(human)
Definition	Homo sapiens X-C motif chemokine ligand 2 (XCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003175.3

ORF Insert Sequence:

ATGAGACTTC TCATCCTGGC CCTCCTTGGC ATCTGCTCTC TCACTGCATA CATTGTGGAA 
GGTGTAGGGA GTGAAGTCTC ACATAGGAGG ACCTGTGTGA GCCTCACTAC CCAGCGACTG 
CCAGTTAGCA GAATCAAGAC CTACACCATC ACGGAAGGCT CCTTGAGAGC AGTAATTTTT 
ATTACCAAAC GTGGCCTAAA AGTCTGTGCT GATCCACAAG CCACGTGGGT GAGAGACGTG 
GTCAGGAGCA TGGACAGGAA ATCCAACACC AGAAATAACA TGATCCAGAC CAAGCCAACA 
GGAACCCAGC AATCGACCAA TACAGCTGTG ACCCTGACTG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Science translational medicine9(384)(2017 Apr)
von Hundelshausen P,Agten SM,Eckardt V,Blanchet X,Schmitt MM,Ippel H,Neideck C,Bidzhekov K,Leberzammer J,Wichapong K,Faussner A,Drechsler M,Grommes J,van Geffen JP,Li H,Ortega-Gomez A,Megens RT,Naumann R,Dijkgraaf I,Nicolaes GA,D?ring Y,Soehnlein O,Lutgens E,Heemskerk JW,Koenen RR,Mayo KH,Hackeng TM,Weber C

Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer.
Medical science monitor : international medical journal of experimental and clinical research221560-5(2016 May)
Zhou B,Xu H,Ni K,Ni X,Shen J

Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.
Cytokine71(2)302-11(2015 Feb)
Fox JC,Nakayama T,Tyler RC,Sander TL,Yoshie O,Volkman BF

Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.
Transplant immunology32(1)9-17(2015 Jan)
Suviolahti E,Ge S,Nast CC,Mirocha J,Karasyov A,White M,Jordan SC,Toyoda M

Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.
Journal of pediatric surgery49(8)1286-91(2014 Aug)
Li MH,Harel M,Hla T,Ferrer F