STXBP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	STXBP3
Entrez Gene ID	6814
Full Name	syntaxin binding protein 3
Synonyms	MUNC18-3,MUNC18C,PSP,UNC-18C
General protein information	Preferred Names syntaxin binding protein 3 Names syntaxin-binding protein 3 platelet Sec1 protein protein unc-18 homolog 3 protein unc-18 homolog C syntaxin 4 binding protein unc18-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.3
Disorder MIM:	608339

mRNA and Protein(s)

mRNA	Protein	Name
NM_007269.2	NP_009200.2	syntaxin-binding protein 3
NM_007269.4	NP_009200.2	syntaxin-binding protein 3
NM_007269.3	NP_009200.2	syntaxin-binding protein 3

Pathways from BioSystems

Homologies

	STXBP3	XP_001087621.2
Rattus norvegicus (Norway rat)	Stxbp3	NP_446089.1
Pan troglodytes (chimpanzee)	STXBP3	XP_001145368.1
Canis lupus familiaris (dog)	STXBP3	XP_547249.2
Mus musculus (house mouse)	Stxbp3a	NP_035634.1
Danio rerio (zebrafish)	stxbp3	NP_998636.1
Xenopus tropicalis (tropical clawed frog)	stxbp3	NP_001015972.1
Homo sapiens (human)	STXBP3	NP_009200.2
Bos taurus (cattle)	STXBP3	NP_001076884.1
Gallus gallus (chicken)	STXBP3	NP_001073202.1

Gene Ontology
Bibliography

Related articles in PubMed

Munc18c depletion attenuates caerulein hyperstimulation induced pancreatitis.
Dolai S, Liang T, Orabi AI, Xie L, Holmyard D, Javed TA, Fernandez NA, Xie H, Cattral MS, Thurmond DC, Thorn P, Gaisano HY
The Journal of biological chemistry(2017 Dec)

Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.
Brasher MI, Martynowicz DM, Grafinger OR, Hucik A, Shanks-Skinner E, Uniacke J, Coppolino MG
The Journal of biological chemistry292(39)16199-16210(2017 09)

Disruption of protein complexes containing protein phosphatase?2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells.
Da Q, Shaw T, Pradhan S, Roche PA, Cruz MA, Vijayan KV
Journal of thrombosis and haemostasis : JTH15(5)1032-1039(2017 May)

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons.
Soo Hoo L, Banna CD, Radeke CM, Sharma N, Albertolle ME, Low SH, Weimbs T, Vandenberg CA
PloS one11(9)e0163671(2016)

Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet ?-cells.
Ramalingam L, Lu J, Hudmon A, Thurmond DC
The Biochemical journal464(2)251-8(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest MUNC18C is required for STX4-mediated invadopodium formation and tumor invasion of extracellular matrix; N-terminal STX4 fragment binds to MUNC18C and inhibits interactions of STX4 with synaptosome-associated protein 23 (SNAP23) and vesicle-associated membrane protein 2 (VAMP2). Fibrosarcoma/adenocarcinoma cell lines were used in these studies. (MUNC18C = syntaxin binding protein MUNC18C; STX4 = syntaxin 4)
Title: Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.

In vitro interaction assays indicated that Doc2b is required to bridge the interaction between Munc18c and Munc18-1 in the macromolecular complex; Munc18c and Munc18-1 failed to associate in the absence of Doc2b
Title: Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet ?-cells.

Munc18c gene expression in human adipose tissue is down-regulated in morbid obesity.
Title: Munc18c in adipose tissue is downregulated in obesity and is associated with insulin.

Western Blot data showed decreased expression (p < 0,05) of Munc18c and phospho-PKC Zeta in polycystic ovary-insulin resistant endometria (PCOSE-IR) with respect to the control.
Title: Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS).

The identify IR as the first known tyrosine kinase for Munc18c as part of a new insulin-signaling step in GLUT4 vesicle exocytosis.
Title: Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.

The following STXBP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STXBP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30357	NM_007269.4 Latest version!	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu30357	NM_007269.2	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu30357	NM_007269.3	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

STXBP3 ( NM_007269.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_009200.2 Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.

Price & Availability↑

CloneID	OHu30357
Clone ID Related Accession (Same CDS sequence)	NM_007269.2 , NM_007269.4 , NM_007269.3
Accession Version	NM_007269.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	syntaxin-binding protein 3
Comment

ATGGCGCCGC CGGTGGCAGA GAGGGGGCTA AAGAGCGTCG TGTGGCAGAA GATAAAAGCA 
ACAGTGTTTG ATGACTGCAA GAAAGAAGGC GAATGGAAGA TAATGCTTTT AGATGAATTT 
ACCACTAAGC TTTTGGCATC GTGTTGCAAA ATGACAGATC TTCTAGAAGA AGGTATTACT 
GTTGTAGAGA ATATTTATAA GAACCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCACTCCGA CATCAAAGTC TGTAGATTGT TTCTTACATG ATTTTGCAAG TAAATCGGAG 
AACAAGTATA AAGCAGCATA TATTTACTTC ACTGACTTTT GCCCTGATAA TCTCTTTAAC 
AAAATTAAGG CTTCTTGCTC CAAGTCAATA AGAAGATGTA AAGAAATAAA TATTTCCTTC 
ATTCCACATG AATCTCAGGT GTATACTCTT GATGTACCAG ATGCATTCTA TTACTGTTAT 
AGTCCAGACC CTGGTAATGC AAAGGGAAAA GATGCCATTA TGGAAACAAT GGCTGACCAG 
ATAGTTACAG TGTGTGCCAC CTTGGATGAA AATCCCGGAG TAAGATATAA AAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTT GTTGAAAAAA AGCTTGAAGA CTACTACAAG 
ATTGATGAAA AGAGCCTAAT AAAGGGTAAA ACTCATTCAC AGCTCTTAAT AATTGATCGT 
GGCTTTGATC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAA TATAAAACAG ATGGAAAAGA AAAGGAGGCC 
ATCCTTGAAG AAGAAGATGA CCTCTGGGTT AGAATTCGAC ATCGACATAT TGCGGTTGTG 
TTAGAGGAAA TTCCCAAGCT TATGAAAGAA ATTTCATCAA CAAAGAAAGC AACAGAAGGA 
AAGACATCAC TTAGTGCTCT TACCCAGCTG ATGAAAAAGA TGCCCCATTT CCGAAAACAG 
ATTACTAAGC AAGTTGTCCA TCTTAACTTA GCAGAAGATT GCATGAATAA GTTCAAGCTT 
AATATAGAAA AGCTCTGCAA AACTGAACAG GACCTGGCAC TTGGAACTGA TGCAGAAGGA 
CAGAAGGTGA AAGATTCCAT GCGAGTACTC CTTCCAGTTC TACTCAACAA AAATCATGAT 
AATTGTGATA AAATAAGAGC AATTCTACTT TATATCTTCA GTATTAATGG AACTACGGAA 
GAAAATTTGG ACAGGTTGAT CCAGAATGTA AAGATAGAAA ATGAGAGTGA CATGATTCGT 
AACTGGAGTT ACCTTGGTGT TCCCATTGTT CCCCAATCTC AACAAGGCAA ACCGTTAAGA 
AAGGATCGGT CTGCAGAAGA AACTTTTCAG CTCTCTCGGT GGACACCTTT TATCAAAGAT 
ATTATGGAGG ATGCTATTGA TAATAGATTA GATTCAAAAG AATGGCCATA TTGTTCCCAG 
TGTCCAGCAG TATGGAATGG TTCAGGAGCT GTAAGTGCTC GCCAGAAACC CAGAGCTAAT 
TATTTAGAAG ACCGAAAAAA TGGGTCAAAG CTGATTGTTT TTGTAATTGG AGGGATCACA 
TACTCTGAAG TGCGTTGTGC TTATGAAGTT TCTCAGGCAC ATAAATCCTG TGAAGTTATT 
ATTGGTTCTA CACATGTTTT AACACCCAAA AAGCTGTTGG ATGATATAAA GATGCTGAAT 
AAACCCAAGG ATAAAGTCTC CTTAATTAAA GATGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_009200.2

Translation

MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE

Target ORF information:

RefSeq Version	NM_007269.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007269.2

ORF Insert Sequence:

ATGGCGCCGC CGGTGGCAGA GAGGGGGCTA AAGAGCGTCG TGTGGCAGAA GATAAAAGCA 
ACAGTGTTTG ATGACTGCAA GAAAGAAGGC GAATGGAAGA TAATGCTTTT AGATGAATTT 
ACCACTAAGC TTTTGGCATC GTGTTGCAAA ATGACAGATC TTCTAGAAGA AGGTATTACT 
GTTGTAGAGA ATATTTATAA GAACCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCACTCCGA CATCAAAGTC TGTAGATTGT TTCTTACATG ATTTTGCAAG TAAATCGGAG 
AACAAGTATA AAGCAGCATA TATTTACTTC ACTGACTTTT GCCCTGATAA TCTCTTTAAC 
AAAATTAAGG CTTCTTGCTC CAAGTCAATA AGAAGATGTA AAGAAATAAA TATTTCCTTC 
ATTCCACATG AATCTCAGGT GTATACTCTT GATGTACCAG ATGCATTCTA TTACTGTTAT 
AGTCCAGACC CTGGTAATGC AAAGGGAAAA GATGCCATTA TGGAAACAAT GGCTGACCAG 
ATAGTTACAG TGTGTGCCAC CTTGGATGAA AATCCCGGAG TAAGATATAA AAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTT GTTGAAAAAA AGCTTGAAGA CTACTACAAG 
ATTGATGAAA AGAGCCTAAT AAAGGGTAAA ACTCATTCAC AGCTCTTAAT AATTGATCGT 
GGCTTTGATC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAA TATAAAACAG ATGGAAAAGA AAAGGAGGCC 
ATCCTTGAAG AAGAAGATGA CCTCTGGGTT AGAATTCGAC ATCGACATAT TGCGGTTGTG 
TTAGAGGAAA TTCCCAAGCT TATGAAAGAA ATTTCATCAA CAAAGAAAGC AACAGAAGGA 
AAGACATCAC TTAGTGCTCT TACCCAGCTG ATGAAAAAGA TGCCCCATTT CCGAAAACAG 
ATTACTAAGC AAGTTGTCCA TCTTAACTTA GCAGAAGATT GCATGAATAA GTTCAAGCTT 
AATATAGAAA AGCTCTGCAA AACTGAACAG GACCTGGCAC TTGGAACTGA TGCAGAAGGA 
CAGAAGGTGA AAGATTCCAT GCGAGTACTC CTTCCAGTTC TACTCAACAA AAATCATGAT 
AATTGTGATA AAATAAGAGC AATTCTACTT TATATCTTCA GTATTAATGG AACTACGGAA 
GAAAATTTGG ACAGGTTGAT CCAGAATGTA AAGATAGAAA ATGAGAGTGA CATGATTCGT 
AACTGGAGTT ACCTTGGTGT TCCCATTGTT CCCCAATCTC AACAAGGCAA ACCGTTAAGA 
AAGGATCGGT CTGCAGAAGA AACTTTTCAG CTCTCTCGGT GGACACCTTT TATCAAAGAT 
ATTATGGAGG ATGCTATTGA TAATAGATTA GATTCAAAAG AATGGCCATA TTGTTCCCAG 
TGTCCAGCAG TATGGAATGG TTCAGGAGCT GTAAGTGCTC GCCAGAAACC CAGAGCTAAT 
TATTTAGAAG ACCGAAAAAA TGGGTCAAAG CTGATTGTTT TTGTAATTGG AGGGATCACA 
TACTCTGAAG TGCGTTGTGC TTATGAAGTT TCTCAGGCAC ATAAATCCTG TGAAGTTATT 
ATTGGTTCTA CACATGTTTT AACACCCAAA AAGCTGTTGG ATGATATAAA GATGCTGAAT 
AAACCCAAGG ATAAAGTCTC CTTAATTAAA GATGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STXBP3 ( NM_007269.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009200.2 Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.

Price & Availability↑

CloneID	OHu30357
Clone ID Related Accession (Same CDS sequence)	NM_007269.2 , NM_007269.4 , NM_007269.3
Accession Version	NM_007269.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-02
Organism	Homo sapiens(human)
Product	syntaxin-binding protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN409056.1 and AF032922.2. On Nov 22, 2018 this sequence version replaced NM_007269.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.276237.1, SRR3476690.37711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370008.4/ ENSP00000359025.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCCGC CGGTGGCAGA GAGGGGGCTA AAGAGCGTCG TGTGGCAGAA GATAAAAGCA 
ACAGTGTTTG ATGACTGCAA GAAAGAAGGC GAATGGAAGA TAATGCTTTT AGATGAATTT 
ACCACTAAGC TTTTGGCATC GTGTTGCAAA ATGACAGATC TTCTAGAAGA AGGTATTACT 
GTTGTAGAGA ATATTTATAA GAACCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCACTCCGA CATCAAAGTC TGTAGATTGT TTCTTACATG ATTTTGCAAG TAAATCGGAG 
AACAAGTATA AAGCAGCATA TATTTACTTC ACTGACTTTT GCCCTGATAA TCTCTTTAAC 
AAAATTAAGG CTTCTTGCTC CAAGTCAATA AGAAGATGTA AAGAAATAAA TATTTCCTTC 
ATTCCACATG AATCTCAGGT GTATACTCTT GATGTACCAG ATGCATTCTA TTACTGTTAT 
AGTCCAGACC CTGGTAATGC AAAGGGAAAA GATGCCATTA TGGAAACAAT GGCTGACCAG 
ATAGTTACAG TGTGTGCCAC CTTGGATGAA AATCCCGGAG TAAGATATAA AAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTT GTTGAAAAAA AGCTTGAAGA CTACTACAAG 
ATTGATGAAA AGAGCCTAAT AAAGGGTAAA ACTCATTCAC AGCTCTTAAT AATTGATCGT 
GGCTTTGATC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAA TATAAAACAG ATGGAAAAGA AAAGGAGGCC 
ATCCTTGAAG AAGAAGATGA CCTCTGGGTT AGAATTCGAC ATCGACATAT TGCGGTTGTG 
TTAGAGGAAA TTCCCAAGCT TATGAAAGAA ATTTCATCAA CAAAGAAAGC AACAGAAGGA 
AAGACATCAC TTAGTGCTCT TACCCAGCTG ATGAAAAAGA TGCCCCATTT CCGAAAACAG 
ATTACTAAGC AAGTTGTCCA TCTTAACTTA GCAGAAGATT GCATGAATAA GTTCAAGCTT 
AATATAGAAA AGCTCTGCAA AACTGAACAG GACCTGGCAC TTGGAACTGA TGCAGAAGGA 
CAGAAGGTGA AAGATTCCAT GCGAGTACTC CTTCCAGTTC TACTCAACAA AAATCATGAT 
AATTGTGATA AAATAAGAGC AATTCTACTT TATATCTTCA GTATTAATGG AACTACGGAA 
GAAAATTTGG ACAGGTTGAT CCAGAATGTA AAGATAGAAA ATGAGAGTGA CATGATTCGT 
AACTGGAGTT ACCTTGGTGT TCCCATTGTT CCCCAATCTC AACAAGGCAA ACCGTTAAGA 
AAGGATCGGT CTGCAGAAGA AACTTTTCAG CTCTCTCGGT GGACACCTTT TATCAAAGAT 
ATTATGGAGG ATGCTATTGA TAATAGATTA GATTCAAAAG AATGGCCATA TTGTTCCCAG 
TGTCCAGCAG TATGGAATGG TTCAGGAGCT GTAAGTGCTC GCCAGAAACC CAGAGCTAAT 
TATTTAGAAG ACCGAAAAAA TGGGTCAAAG CTGATTGTTT TTGTAATTGG AGGGATCACA 
TACTCTGAAG TGCGTTGTGC TTATGAAGTT TCTCAGGCAC ATAAATCCTG TGAAGTTATT 
ATTGGTTCTA CACATGTTTT AACACCCAAA AAGCTGTTGG ATGATATAAA GATGCTGAAT 
AAACCCAAGG ATAAAGTCTC CTTAATTAAA GATGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009200.2
CDS	65..1843
Translation	MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE

Target ORF information:

RefSeq Version	NM_007269.4
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007269.4

ORF Insert Sequence:

ATGGCGCCGC CGGTGGCAGA GAGGGGGCTA AAGAGCGTCG TGTGGCAGAA GATAAAAGCA 
ACAGTGTTTG ATGACTGCAA GAAAGAAGGC GAATGGAAGA TAATGCTTTT AGATGAATTT 
ACCACTAAGC TTTTGGCATC GTGTTGCAAA ATGACAGATC TTCTAGAAGA AGGTATTACT 
GTTGTAGAGA ATATTTATAA GAACCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCACTCCGA CATCAAAGTC TGTAGATTGT TTCTTACATG ATTTTGCAAG TAAATCGGAG 
AACAAGTATA AAGCAGCATA TATTTACTTC ACTGACTTTT GCCCTGATAA TCTCTTTAAC 
AAAATTAAGG CTTCTTGCTC CAAGTCAATA AGAAGATGTA AAGAAATAAA TATTTCCTTC 
ATTCCACATG AATCTCAGGT GTATACTCTT GATGTACCAG ATGCATTCTA TTACTGTTAT 
AGTCCAGACC CTGGTAATGC AAAGGGAAAA GATGCCATTA TGGAAACAAT GGCTGACCAG 
ATAGTTACAG TGTGTGCCAC CTTGGATGAA AATCCCGGAG TAAGATATAA AAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTT GTTGAAAAAA AGCTTGAAGA CTACTACAAG 
ATTGATGAAA AGAGCCTAAT AAAGGGTAAA ACTCATTCAC AGCTCTTAAT AATTGATCGT 
GGCTTTGATC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAA TATAAAACAG ATGGAAAAGA AAAGGAGGCC 
ATCCTTGAAG AAGAAGATGA CCTCTGGGTT AGAATTCGAC ATCGACATAT TGCGGTTGTG 
TTAGAGGAAA TTCCCAAGCT TATGAAAGAA ATTTCATCAA CAAAGAAAGC AACAGAAGGA 
AAGACATCAC TTAGTGCTCT TACCCAGCTG ATGAAAAAGA TGCCCCATTT CCGAAAACAG 
ATTACTAAGC AAGTTGTCCA TCTTAACTTA GCAGAAGATT GCATGAATAA GTTCAAGCTT 
AATATAGAAA AGCTCTGCAA AACTGAACAG GACCTGGCAC TTGGAACTGA TGCAGAAGGA 
CAGAAGGTGA AAGATTCCAT GCGAGTACTC CTTCCAGTTC TACTCAACAA AAATCATGAT 
AATTGTGATA AAATAAGAGC AATTCTACTT TATATCTTCA GTATTAATGG AACTACGGAA 
GAAAATTTGG ACAGGTTGAT CCAGAATGTA AAGATAGAAA ATGAGAGTGA CATGATTCGT 
AACTGGAGTT ACCTTGGTGT TCCCATTGTT CCCCAATCTC AACAAGGCAA ACCGTTAAGA 
AAGGATCGGT CTGCAGAAGA AACTTTTCAG CTCTCTCGGT GGACACCTTT TATCAAAGAT 
ATTATGGAGG ATGCTATTGA TAATAGATTA GATTCAAAAG AATGGCCATA TTGTTCCCAG 
TGTCCAGCAG TATGGAATGG TTCAGGAGCT GTAAGTGCTC GCCAGAAACC CAGAGCTAAT 
TATTTAGAAG ACCGAAAAAA TGGGTCAAAG CTGATTGTTT TTGTAATTGG AGGGATCACA 
TACTCTGAAG TGCGTTGTGC TTATGAAGTT TCTCAGGCAC ATAAATCCTG TGAAGTTATT 
ATTGGTTCTA CACATGTTTT AACACCCAAA AAGCTGTTGG ATGATATAAA GATGCTGAAT 
AAACCCAAGG ATAAAGTCTC CTTAATTAAA GATGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STXBP3 ( NM_007269.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009200.2 Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.

Price & Availability↑

CloneID	OHu30357
Clone ID Related Accession (Same CDS sequence)	NM_007269.2 , NM_007269.4 , NM_007269.3
Accession Version	NM_007269.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	syntaxin-binding protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC323482.1, CN409056.1 and AF032922.2. On Jan 5, 2017 this sequence version replaced NM_007269.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D63506.1, AK223170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGC CGGTGGCAGA GAGGGGGCTA AAGAGCGTCG TGTGGCAGAA GATAAAAGCA 
ACAGTGTTTG ATGACTGCAA GAAAGAAGGC GAATGGAAGA TAATGCTTTT AGATGAATTT 
ACCACTAAGC TTTTGGCATC GTGTTGCAAA ATGACAGATC TTCTAGAAGA AGGTATTACT 
GTTGTAGAGA ATATTTATAA GAACCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCACTCCGA CATCAAAGTC TGTAGATTGT TTCTTACATG ATTTTGCAAG TAAATCGGAG 
AACAAGTATA AAGCAGCATA TATTTACTTC ACTGACTTTT GCCCTGATAA TCTCTTTAAC 
AAAATTAAGG CTTCTTGCTC CAAGTCAATA AGAAGATGTA AAGAAATAAA TATTTCCTTC 
ATTCCACATG AATCTCAGGT GTATACTCTT GATGTACCAG ATGCATTCTA TTACTGTTAT 
AGTCCAGACC CTGGTAATGC AAAGGGAAAA GATGCCATTA TGGAAACAAT GGCTGACCAG 
ATAGTTACAG TGTGTGCCAC CTTGGATGAA AATCCCGGAG TAAGATATAA AAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTT GTTGAAAAAA AGCTTGAAGA CTACTACAAG 
ATTGATGAAA AGAGCCTAAT AAAGGGTAAA ACTCATTCAC AGCTCTTAAT AATTGATCGT 
GGCTTTGATC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAA TATAAAACAG ATGGAAAAGA AAAGGAGGCC 
ATCCTTGAAG AAGAAGATGA CCTCTGGGTT AGAATTCGAC ATCGACATAT TGCGGTTGTG 
TTAGAGGAAA TTCCCAAGCT TATGAAAGAA ATTTCATCAA CAAAGAAAGC AACAGAAGGA 
AAGACATCAC TTAGTGCTCT TACCCAGCTG ATGAAAAAGA TGCCCCATTT CCGAAAACAG 
ATTACTAAGC AAGTTGTCCA TCTTAACTTA GCAGAAGATT GCATGAATAA GTTCAAGCTT 
AATATAGAAA AGCTCTGCAA AACTGAACAG GACCTGGCAC TTGGAACTGA TGCAGAAGGA 
CAGAAGGTGA AAGATTCCAT GCGAGTACTC CTTCCAGTTC TACTCAACAA AAATCATGAT 
AATTGTGATA AAATAAGAGC AATTCTACTT TATATCTTCA GTATTAATGG AACTACGGAA 
GAAAATTTGG ACAGGTTGAT CCAGAATGTA AAGATAGAAA ATGAGAGTGA CATGATTCGT 
AACTGGAGTT ACCTTGGTGT TCCCATTGTT CCCCAATCTC AACAAGGCAA ACCGTTAAGA 
AAGGATCGGT CTGCAGAAGA AACTTTTCAG CTCTCTCGGT GGACACCTTT TATCAAAGAT 
ATTATGGAGG ATGCTATTGA TAATAGATTA GATTCAAAAG AATGGCCATA TTGTTCCCAG 
TGTCCAGCAG TATGGAATGG TTCAGGAGCT GTAAGTGCTC GCCAGAAACC CAGAGCTAAT 
TATTTAGAAG ACCGAAAAAA TGGGTCAAAG CTGATTGTTT TTGTAATTGG AGGGATCACA 
TACTCTGAAG TGCGTTGTGC TTATGAAGTT TCTCAGGCAC ATAAATCCTG TGAAGTTATT 
ATTGGTTCTA CACATGTTTT AACACCCAAA AAGCTGTTGG ATGATATAAA GATGCTGAAT 
AAACCCAAGG ATAAAGTCTC CTTAATTAAA GATGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009200.2
CDS	104..1882
Translation	MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE

Target ORF information:

RefSeq Version	NM_007269.3
Organism	Homo sapiens(human)
Definition	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007269.3

ORF Insert Sequence:

ATGGCGCCGC CGGTGGCAGA GAGGGGGCTA AAGAGCGTCG TGTGGCAGAA GATAAAAGCA 
ACAGTGTTTG ATGACTGCAA GAAAGAAGGC GAATGGAAGA TAATGCTTTT AGATGAATTT 
ACCACTAAGC TTTTGGCATC GTGTTGCAAA ATGACAGATC TTCTAGAAGA AGGTATTACT 
GTTGTAGAGA ATATTTATAA GAACCGTGAA CCTGTCAGAC AAATGAAAGC TCTTTATTTC 
ATCACTCCGA CATCAAAGTC TGTAGATTGT TTCTTACATG ATTTTGCAAG TAAATCGGAG 
AACAAGTATA AAGCAGCATA TATTTACTTC ACTGACTTTT GCCCTGATAA TCTCTTTAAC 
AAAATTAAGG CTTCTTGCTC CAAGTCAATA AGAAGATGTA AAGAAATAAA TATTTCCTTC 
ATTCCACATG AATCTCAGGT GTATACTCTT GATGTACCAG ATGCATTCTA TTACTGTTAT 
AGTCCAGACC CTGGTAATGC AAAGGGAAAA GATGCCATTA TGGAAACAAT GGCTGACCAG 
ATAGTTACAG TGTGTGCCAC CTTGGATGAA AATCCCGGAG TAAGATATAA AAGTAAACCT 
CTAGATAATG CCAGTAAGCT TGCACAGCTT GTTGAAAAAA AGCTTGAAGA CTACTACAAG 
ATTGATGAAA AGAGCCTAAT AAAGGGTAAA ACTCATTCAC AGCTCTTAAT AATTGATCGT 
GGCTTTGATC CTGTGTCCAC TGTCCTGCAT GAACTGACCT TTCAGGCAAT GGCATATGAT 
CTACTACCAA TTGAGAATGA TACATACAAA TATAAAACAG ATGGAAAAGA AAAGGAGGCC 
ATCCTTGAAG AAGAAGATGA CCTCTGGGTT AGAATTCGAC ATCGACATAT TGCGGTTGTG 
TTAGAGGAAA TTCCCAAGCT TATGAAAGAA ATTTCATCAA CAAAGAAAGC AACAGAAGGA 
AAGACATCAC TTAGTGCTCT TACCCAGCTG ATGAAAAAGA TGCCCCATTT CCGAAAACAG 
ATTACTAAGC AAGTTGTCCA TCTTAACTTA GCAGAAGATT GCATGAATAA GTTCAAGCTT 
AATATAGAAA AGCTCTGCAA AACTGAACAG GACCTGGCAC TTGGAACTGA TGCAGAAGGA 
CAGAAGGTGA AAGATTCCAT GCGAGTACTC CTTCCAGTTC TACTCAACAA AAATCATGAT 
AATTGTGATA AAATAAGAGC AATTCTACTT TATATCTTCA GTATTAATGG AACTACGGAA 
GAAAATTTGG ACAGGTTGAT CCAGAATGTA AAGATAGAAA ATGAGAGTGA CATGATTCGT 
AACTGGAGTT ACCTTGGTGT TCCCATTGTT CCCCAATCTC AACAAGGCAA ACCGTTAAGA 
AAGGATCGGT CTGCAGAAGA AACTTTTCAG CTCTCTCGGT GGACACCTTT TATCAAAGAT 
ATTATGGAGG ATGCTATTGA TAATAGATTA GATTCAAAAG AATGGCCATA TTGTTCCCAG 
TGTCCAGCAG TATGGAATGG TTCAGGAGCT GTAAGTGCTC GCCAGAAACC CAGAGCTAAT 
TATTTAGAAG ACCGAAAAAA TGGGTCAAAG CTGATTGTTT TTGTAATTGG AGGGATCACA 
TACTCTGAAG TGCGTTGTGC TTATGAAGTT TCTCAGGCAC ATAAATCCTG TGAAGTTATT 
ATTGGTTCTA CACATGTTTT AACACCCAAA AAGCTGTTGG ATGATATAAA GATGCTGAAT 
AAACCCAAGG ATAAAGTCTC CTTAATTAAA GATGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Munc18c depletion attenuates caerulein hyperstimulation induced pancreatitis.
The Journal of biological chemistry(2017 Dec)
Dolai S,Liang T,Orabi AI,Xie L,Holmyard D,Javed TA,Fernandez NA,Xie H,Cattral MS,Thurmond DC,Thorn P,Gaisano HY

Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells.
The Journal of biological chemistry292(39)16199-16210(2017 09)
Brasher MI,Martynowicz DM,Grafinger OR,Hucik A,Shanks-Skinner E,Uniacke J,Coppolino MG

Disruption of protein complexes containing protein phosphatase?2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells.
Journal of thrombosis and haemostasis : JTH15(5)1032-1039(2017 May)
Da Q,Shaw T,Pradhan S,Roche PA,Cruz MA,Vijayan KV

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons.
PloS one11(9)e0163671(2016)
Soo Hoo L,Banna CD,Radeke CM,Sharma N,Albertolle ME,Low SH,Weimbs T,Vandenberg CA

Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet ?-cells.
The Biochemical journal464(2)251-8(2014 Dec)
Ramalingam L,Lu J,Hudmon A,Thurmond DC