SNAPC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNAPC1
Entrez Gene ID	6617
Full Name	small nuclear RNA activating complex polypeptide 1
Synonyms	PTFgamma,SNAP43
General protein information	Preferred Names small nuclear RNA activating complex polypeptide 1 Names snRNA-activating protein complex subunit 1 PSE-binding factor subunit gamma PTF subunit gamma SNAPc 43 kDa subunit SNAPc subunit 1 proximal sequence element-binding transcription factor subunit gamma small nuclear RNA activating complex, polypeptide 1, 43kD small nuclear RNA activating complex, polypeptide 1, 43kDa snRNA-activating protein complex 43 kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q23.2
Disorder MIM:	600591

mRNA and Protein(s)

mRNA	Protein	Name
NM_003082.4	NP_003073.1	snRNA-activating protein complex subunit 1
NM_003082.3	NP_003073.1	snRNA-activating protein complex subunit 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SNAPC1	NP_001094714.1
Rattus norvegicus (Norway rat)	Snapc1	NP_001101503.1
Gallus gallus (chicken)	SNAPC1	XP_004936498.1
Canis lupus familiaris (dog)	SNAPC1	XP_005623534.1
Pan troglodytes (chimpanzee)	SNAPC1	XP_003339310.1
Danio rerio (zebrafish)	snapc1b	NP_956548.1
Homo sapiens (human)	SNAPC1	NP_003073.1
	SNAPC1	XP_001099253.1
Xenopus tropicalis (tropical clawed frog)	snapc1	NP_001072646.1
Mus musculus (house mouse)	Snapc1	NP_848479.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrent? L, Mar JC
PLoS genetics11(8)e1005428(2015 Aug)

Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.
Baillat D, Gardini A, Cesaroni M, Shiekhattar R
Molecular and cellular biology32(22)4642-50(2012 Nov)

Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC.
Gu L, Esselman WJ, Henry RW
The Journal of biological chemistry280(30)27697-704(2005 Jul)

The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.
Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW
The Journal of biological chemistry278(20)18649-57(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SNAPC1 is a general transcriptional coactivator that functions through elongating RNAPII.
Title: Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.

CK2 may have the capacity to differentially regulate U1 and U6 transcription even though SNAP(C) is universally utilized for human snRNA gene transcription [SNAPC protein, also called PTF or PSE-binding transcription factor]
Title: Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC.

The following SNAPC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNAPC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26469	NM_003082.4 Latest version!	Homo sapiens small nuclear RNA activating complex polypeptide 1 (SNAPC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu26469	NM_003082.3	Homo sapiens small nuclear RNA activating complex polypeptide 1 (SNAPC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNAPC1 ( NM_003082.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003073.1 Homo sapiens small nuclear RNA activating complex polypeptide 1 (SNAPC1), mRNA.

Price & Availability↑

CloneID	OHu26469
Clone ID Related Accession (Same CDS sequence)	NM_003082.4 , NM_003082.3
Accession Version	NM_003082.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	snRNA-activating protein complex subunit 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314933.1 and BC014984.1. On Nov 22, 2018 this sequence version replaced NM_003082.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.221889.1, SRR3476690.931522.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216294.5/ ENSP00000216294.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGACTC CTCCCGGCCT GCAGACCGAC TGCGAGGCGC TGCTCAGCCG CTTCCAGGAG 
ACGGACAGTG TACGCTTCGA GGACTTCACG GAGCTCTGGA GAAACATGAA GTTCGGGACT 
ATCTTCTGTG GCAGAATGAG AAATTTAGAA AAGAACATGT TTACAAAAGA AGCTTTAGCT 
TTGGCTTGGC GATATTTTTT ACCTCCATAC ACCTTCCAGA TCAGAGTTGG TGCTTTGTAT 
CTGCTATATG GATTATATAA TACCCAACTG TGTCAACCAA AACAAAAGAT CAGAGTTGCC 
CTGAAGGATT GGGATGAAGT TTTAAAATTT CAGCAAGATT TAGTAAATGC ACAGCATTTT 
GATGCAGCTT ATATTTTTAG GAAGCTACGA CTAGACAGAG CATTTCACTT TACAGCAATG 
CCCAAATTGC TGTCATATAG GATGAAGAAA AAAATTCACC GAGCTGAAGT TACAGAAGAA 
TTTAAGGACC CAAGTGATCG TGTGATGAAA CTTATCACTT CTGATGTATT AGAGGAAATG 
CTGAATGTTC ATGATCATTA TCAGAACATG AAACATGTAA TTTCAGTTGA TAAGTCCAAG 
CCAGATAAAG CCCTCAGCTT GATAAAGGAT GATTTTTTTG ACAATATTAA GAACATAGTT 
TTGGAGCATC AGCAGTGGCA CAAAGACAGA AAGAATCCAT CCTTAAAGTC AAAAACTAAT 
GATGGAGAAG AAAAAATGGA AGGAAATTCA CAAGAAACGG AGAGATGTGA AAGGGCAGAA 
TCATTAGCGA AAATAAAATC AAAGGCCTTT TCAGTTGTCA TACAGGCATC CAAATCAAGA 
AGGCATCGTC AAGTCAAACT CGACTCTTCT GACTCTGATT CTGCATCTGG TCAAGGGCAA 
GTCAAAGCAA CTAGGAAAAA AGAGAAGAAA GAAAGATTGA AACCAGCAGG AAGGAAGATG 
TCTCTCAGAA ACAAAGGCAA TGTGCAGAAT ATACACAAGG AAGATAAACC TTTAAGTCTG 
AGTATGCCTG TAATTACAGA AGAAGAAGAG AATGAAAGTT TGAGTGGAAC AGAGTTCACT 
GCATCCAAGA AGAGGAGAAA ACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003073.1
CDS	42..1148
Translation	MGTPPGLQTDCEALLSRFQETDSVRFEDFTELWRNMKFGTIFCGRMRNLEKNMFTKEALALAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVLKFQQDLVNAQHFDAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEEFKDPSDRVMKLITSDVLEEMLNVHDHYQNMKHVISVDKSKPDKALSLIKDDFFDNIKNIVLEHQQWHKDRKNPSLKSKTNDGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQASKSRRHRQVKLDSSDSDSASGQGQVKATRKKEKKERLKPAGRKMSLRNKGNVQNIHKEDKPLSLSMPVITEEEENESLSGTEFTASKKRRKH

Target ORF information:

RefSeq Version	NM_003082.4
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear RNA activating complex polypeptide 1 (SNAPC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003082.4

ORF Insert Sequence:

ATGGGGACTC CTCCCGGCCT GCAGACCGAC TGCGAGGCGC TGCTCAGCCG CTTCCAGGAG 
ACGGACAGTG TACGCTTCGA GGACTTCACG GAGCTCTGGA GAAACATGAA GTTCGGGACT 
ATCTTCTGTG GCAGAATGAG AAATTTAGAA AAGAACATGT TTACAAAAGA AGCTTTAGCT 
TTGGCTTGGC GATATTTTTT ACCTCCATAC ACCTTCCAGA TCAGAGTTGG TGCTTTGTAT 
CTGCTATATG GATTATATAA TACCCAACTG TGTCAACCAA AACAAAAGAT CAGAGTTGCC 
CTGAAGGATT GGGATGAAGT TTTAAAATTT CAGCAAGATT TAGTAAATGC ACAGCATTTT 
GATGCAGCTT ATATTTTTAG GAAGCTACGA CTAGACAGAG CATTTCACTT TACAGCAATG 
CCCAAATTGC TGTCATATAG GATGAAGAAA AAAATTCACC GAGCTGAAGT TACAGAAGAA 
TTTAAGGACC CAAGTGATCG TGTGATGAAA CTTATCACTT CTGATGTATT AGAGGAAATG 
CTGAATGTTC ATGATCATTA TCAGAACATG AAACATGTAA TTTCAGTTGA TAAGTCCAAG 
CCAGATAAAG CCCTCAGCTT GATAAAGGAT GATTTTTTTG ACAATATTAA GAACATAGTT 
TTGGAGCATC AGCAGTGGCA CAAAGACAGA AAGAATCCAT CCTTAAAGTC AAAAACTAAT 
GATGGAGAAG AAAAAATGGA AGGAAATTCA CAAGAAACGG AGAGATGTGA AAGGGCAGAA 
TCATTAGCGA AAATAAAATC AAAGGCCTTT TCAGTTGTCA TACAGGCATC CAAATCAAGA 
AGGCATCGTC AAGTCAAACT CGACTCTTCT GACTCTGATT CTGCATCTGG TCAAGGGCAA 
GTCAAAGCAA CTAGGAAAAA AGAGAAGAAA GAAAGATTGA AACCAGCAGG AAGGAAGATG 
TCTCTCAGAA ACAAAGGCAA TGTGCAGAAT ATACACAAGG AAGATAAACC TTTAAGTCTG 
AGTATGCCTG TAATTACAGA AGAAGAAGAG AATGAAAGTT TGAGTGGAAC AGAGTTCACT 
GCATCCAAGA AGAGGAGAAA ACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNAPC1 ( NM_003082.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003073.1 Homo sapiens small nuclear RNA activating complex polypeptide 1 (SNAPC1), mRNA.

Price & Availability↑

CloneID	OHu26469
Clone ID Related Accession (Same CDS sequence)	NM_003082.4 , NM_003082.3
Accession Version	NM_003082.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	snRNA-activating protein complex subunit 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314933.1 and BC014984.1. On Jul 26, 2008 this sequence version replaced NM_003082.2. ##Evidence-Data-START## Transcript exon combination :: BC014984.1, SRR1803612.201461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGGACTC CTCCCGGCCT GCAGACCGAC TGCGAGGCGC TGCTCAGCCG CTTCCAGGAG 
ACGGACAGTG TACGCTTCGA GGACTTCACG GAGCTCTGGA GAAACATGAA GTTCGGGACT 
ATCTTCTGTG GCAGAATGAG AAATTTAGAA AAGAACATGT TTACAAAAGA AGCTTTAGCT 
TTGGCTTGGC GATATTTTTT ACCTCCATAC ACCTTCCAGA TCAGAGTTGG TGCTTTGTAT 
CTGCTATATG GATTATATAA TACCCAACTG TGTCAACCAA AACAAAAGAT CAGAGTTGCC 
CTGAAGGATT GGGATGAAGT TTTAAAATTT CAGCAAGATT TAGTAAATGC ACAGCATTTT 
GATGCAGCTT ATATTTTTAG GAAGCTACGA CTAGACAGAG CATTTCACTT TACAGCAATG 
CCCAAATTGC TGTCATATAG GATGAAGAAA AAAATTCACC GAGCTGAAGT TACAGAAGAA 
TTTAAGGACC CAAGTGATCG TGTGATGAAA CTTATCACTT CTGATGTATT AGAGGAAATG 
CTGAATGTTC ATGATCATTA TCAGAACATG AAACATGTAA TTTCAGTTGA TAAGTCCAAG 
CCAGATAAAG CCCTCAGCTT GATAAAGGAT GATTTTTTTG ACAATATTAA GAACATAGTT 
TTGGAGCATC AGCAGTGGCA CAAAGACAGA AAGAATCCAT CCTTAAAGTC AAAAACTAAT 
GATGGAGAAG AAAAAATGGA AGGAAATTCA CAAGAAACGG AGAGATGTGA AAGGGCAGAA 
TCATTAGCGA AAATAAAATC AAAGGCCTTT TCAGTTGTCA TACAGGCATC CAAATCAAGA 
AGGCATCGTC AAGTCAAACT CGACTCTTCT GACTCTGATT CTGCATCTGG TCAAGGGCAA 
GTCAAAGCAA CTAGGAAAAA AGAGAAGAAA GAAAGATTGA AACCAGCAGG AAGGAAGATG 
TCTCTCAGAA ACAAAGGCAA TGTGCAGAAT ATACACAAGG AAGATAAACC TTTAAGTCTG 
AGTATGCCTG TAATTACAGA AGAAGAAGAG AATGAAAGTT TGAGTGGAAC AGAGTTCACT 
GCATCCAAGA AGAGGAGAAA ACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003073.1
CDS	105..1211
Translation	MGTPPGLQTDCEALLSRFQETDSVRFEDFTELWRNMKFGTIFCGRMRNLEKNMFTKEALALAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALKDWDEVLKFQQDLVNAQHFDAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEEFKDPSDRVMKLITSDVLEEMLNVHDHYQNMKHVISVDKSKPDKALSLIKDDFFDNIKNIVLEHQQWHKDRKNPSLKSKTNDGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQASKSRRHRQVKLDSSDSDSASGQGQVKATRKKEKKERLKPAGRKMSLRNKGNVQNIHKEDKPLSLSMPVITEEEENESLSGTEFTASKKRRKH

Target ORF information:

RefSeq Version	NM_003082.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear RNA activating complex polypeptide 1 (SNAPC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003082.3

ORF Insert Sequence:

ATGGGGACTC CTCCCGGCCT GCAGACCGAC TGCGAGGCGC TGCTCAGCCG CTTCCAGGAG 
ACGGACAGTG TACGCTTCGA GGACTTCACG GAGCTCTGGA GAAACATGAA GTTCGGGACT 
ATCTTCTGTG GCAGAATGAG AAATTTAGAA AAGAACATGT TTACAAAAGA AGCTTTAGCT 
TTGGCTTGGC GATATTTTTT ACCTCCATAC ACCTTCCAGA TCAGAGTTGG TGCTTTGTAT 
CTGCTATATG GATTATATAA TACCCAACTG TGTCAACCAA AACAAAAGAT CAGAGTTGCC 
CTGAAGGATT GGGATGAAGT TTTAAAATTT CAGCAAGATT TAGTAAATGC ACAGCATTTT 
GATGCAGCTT ATATTTTTAG GAAGCTACGA CTAGACAGAG CATTTCACTT TACAGCAATG 
CCCAAATTGC TGTCATATAG GATGAAGAAA AAAATTCACC GAGCTGAAGT TACAGAAGAA 
TTTAAGGACC CAAGTGATCG TGTGATGAAA CTTATCACTT CTGATGTATT AGAGGAAATG 
CTGAATGTTC ATGATCATTA TCAGAACATG AAACATGTAA TTTCAGTTGA TAAGTCCAAG 
CCAGATAAAG CCCTCAGCTT GATAAAGGAT GATTTTTTTG ACAATATTAA GAACATAGTT 
TTGGAGCATC AGCAGTGGCA CAAAGACAGA AAGAATCCAT CCTTAAAGTC AAAAACTAAT 
GATGGAGAAG AAAAAATGGA AGGAAATTCA CAAGAAACGG AGAGATGTGA AAGGGCAGAA 
TCATTAGCGA AAATAAAATC AAAGGCCTTT TCAGTTGTCA TACAGGCATC CAAATCAAGA 
AGGCATCGTC AAGTCAAACT CGACTCTTCT GACTCTGATT CTGCATCTGG TCAAGGGCAA 
GTCAAAGCAA CTAGGAAAAA AGAGAAGAAA GAAAGATTGA AACCAGCAGG AAGGAAGATG 
TCTCTCAGAA ACAAAGGCAA TGTGCAGAAT ATACACAAGG AAGATAAACC TTTAAGTCTG 
AGTATGCCTG TAATTACAGA AGAAGAAGAG AATGAAAGTT TGAGTGGAAC AGAGTTCACT 
GCATCCAAGA AGAGGAGAAA ACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
PLoS genetics11(8)e1005428(2015 Aug)
Hasegawa Y,Taylor D,Ovchinnikov DA,Wolvetang EJ,de Torrent? L,Mar JC

Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.
Molecular and cellular biology32(22)4642-50(2012 Nov)
Baillat D,Gardini A,Cesaroni M,Shiekhattar R

Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC.
The Journal of biological chemistry280(30)27697-704(2005 Jul)
Gu L,Esselman WJ,Henry RW

The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.
The Journal of biological chemistry278(20)18649-57(2003 May)
Hinkley CS,Hirsch HA,Gu L,LaMere B,Henry RW