RGS18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS18
Entrez Gene ID	64407
Full Name	regulator of G protein signaling 18
Synonyms	RGS13
General protein information	Preferred Names regulator of G protein signaling 18 Names regulator of G-protein signaling 18 regulator of G-protein signalling 13 regulator of G-protein signalling 18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q31.2
Summary	This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Disorder MIM:	607192

mRNA and Protein(s)

mRNA	Protein	Name
XM_011509891.2	XP_011508193.1	regulator of G-protein signaling 18 isoform X1
NM_130782.3	NP_570138.1	regulator of G-protein signaling 18
XM_011509891.3	XP_011508193.1	regulator of G-protein signaling 18 isoform X1
NM_130782.2	NP_570138.1	regulator of G-protein signaling 18

Pathways from BioSystems

Homologies

	RGS18	XP_001113061.1
Gallus gallus (chicken)	RGS18	NP_001244256.1
Homo sapiens (human)	RGS18	NP_570138.1
Mus musculus (house mouse)	Rgs18	NP_075019.1
Rattus norvegicus (Norway rat)	Rgs18	NP_001040549.1
Danio rerio (zebrafish)	rgs18	NP_001070775.1
Xenopus tropicalis (tropical clawed frog)	rgs18	NP_001008092.1
Canis lupus familiaris (dog)	RGS18	XP_849782.1
Bos taurus (cattle)	RGS18	NP_001179900.1
Pan troglodytes (chimpanzee)	RGS18	XP_514066.2

Gene Ontology
Bibliography

Related articles in PubMed

Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets.
Gegenbauer K, Elia G, Blanco-Fernandez A, Smolenski A
Blood119(16)3799-807(2012 Apr)

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.
Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF
Blood119(8)1935-45(2012 Feb)

Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.
Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY
Nature structural & molecular biology18(7)846-53(2011 Jun)

Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X
Carcinogenesis31(10)1755-61(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings indicate cross-talk between platelet activation and inhibition pathways at the level of RGS18 and Gq.
Title: Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets.

Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
Title: A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following RGS18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31138	NM_130782.3 Latest version!	Homo sapiens regulator of G protein signaling 18 (RGS18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu71373	XM_011509891.3 Latest version!	Homo sapiens regulator of G protein signaling 18 (RGS18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu71373	XM_011509891.2	Homo sapiens regulator of G-protein signaling 18 (RGS18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu31138	NM_130782.2	Homo sapiens regulator of G protein signaling 18 (RGS18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS18 ( NM_130782.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_570138.1 Homo sapiens regulator of G protein signaling 18 (RGS18), mRNA.

Price & Availability↑

CloneID	OHu31138
Clone ID Related Accession (Same CDS sequence)	NM_130782.3 , NM_130782.2
Accession Version	NM_130782.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 18
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV715708.1, BC020632.1, AF268036.1 and AF076642.1. On Nov 22, 2018 this sequence version replaced NM_130782.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.414692.1, SRR1803617.212994.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367460.4/ ENSP00000356430.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAAACAA CATTGCTTTT CTTTTCTCAA ATAAATATGT GTGAATCAAA AGAAAAAACT 
TTTTTCAAGT TAATACATGG TTCAGGAAAA GAAGAAACAA GCAAAGAAGC CAAAATCAGA 
GCTAAGGAAA AAAGAAATAG ACTAAGTCTT CTTGTGCAGA AACCTGAGTT TCATGAAGAC 
ACCCGCTCCA GTAGATCTGG GCACTTGGCC AAAGAAACAA GAGTCTCCCC TGAAGAGGCA 
GTGAAATGGG GTGAATCATT TGACAAACTG CTTTCCCATA GAGATGGACT AGAGGCTTTT 
ACCAGATTTC TTAAAACTGA ATTCAGTGAA GAAAATATTG AATTTTGGAT AGCCTGTGAA 
GATTTCAAGA AAAGCAAGGG ACCTCAACAA ATTCACCTTA AAGCAAAAGC AATATATGAG 
AAATTTATAC AGACTGATGC CCCAAAAGAG GTTAACCTTG ATTTTCACAC AAAAGAAGTC 
ATTACAAACA GCATCACTCA ACCTACCCTC CACAGTTTTG ATGCTGCACA AAGCAGAGTG 
TATCAGCTCA TGGAACAAGA CAGTTATACA CGTTTTCTGA AATCTGACAT CTATTTAGAC 
TTGATGGAAG GAAGACCTCA GAGACCAACA AATCTTAGGA GACGATCACG CTCATTTACC 
TGCAATGAAT TCCAAGATGT ACAATCAGAT GTTGCCATTT GGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570138.1
CDS	177..884
Translation	METTLLFFSQINMCESKEKTFFKLIHGSGKEETSKEAKIRAKEKRNRLSLLVQKPEFHEDTRSSRSGHLAKETRVSPEEAVKWGESFDKLLSHRDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFTCNEFQDVQSDVAIWL

Target ORF information:

RefSeq Version	NM_130782.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 18 (RGS18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130782.3

ORF Insert Sequence:

ATGGAAACAA CATTGCTTTT CTTTTCTCAA ATAAATATGT GTGAATCAAA AGAAAAAACT 
TTTTTCAAGT TAATACATGG TTCAGGAAAA GAAGAAACAA GCAAAGAAGC CAAAATCAGA 
GCTAAGGAAA AAAGAAATAG ACTAAGTCTT CTTGTGCAGA AACCTGAGTT TCATGAAGAC 
ACCCGCTCCA GTAGATCTGG GCACTTGGCC AAAGAAACAA GAGTCTCCCC TGAAGAGGCA 
GTGAAATGGG GTGAATCATT TGACAAACTG CTTTCCCATA GAGATGGACT AGAGGCTTTT 
ACCAGATTTC TTAAAACTGA ATTCAGTGAA GAAAATATTG AATTTTGGAT AGCCTGTGAA 
GATTTCAAGA AAAGCAAGGG ACCTCAACAA ATTCACCTTA AAGCAAAAGC AATATATGAG 
AAATTTATAC AGACTGATGC CCCAAAAGAG GTTAACCTTG ATTTTCACAC AAAAGAAGTC 
ATTACAAACA GCATCACTCA ACCTACCCTC CACAGTTTTG ATGCTGCACA AAGCAGAGTG 
TATCAGCTCA TGGAACAAGA CAGTTATACA CGTTTTCTGA AATCTGACAT CTATTTAGAC 
TTGATGGAAG GAAGACCTCA GAGACCAACA AATCTTAGGA GACGATCACG CTCATTTACC 
TGCAATGAAT TCCAAGATGT ACAATCAGAT GTTGCCATTT GGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS18 ( NM_130782.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_570138.1 Homo sapiens regulator of G protein signaling 18 (RGS18), mRNA.

Price & Availability↑

CloneID	OHu31138
Clone ID Related Accession (Same CDS sequence)	NM_130782.3 , NM_130782.2
Accession Version	NM_130782.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 18
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV715708.1, BC020632.1, AF268036.1 and AF076642.1. On Dec 16, 2004 this sequence version replaced NM_130782.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF268036.1, BC020632.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACAA CATTGCTTTT CTTTTCTCAA ATAAATATGT GTGAATCAAA AGAAAAAACT 
TTTTTCAAGT TAATACATGG TTCAGGAAAA GAAGAAACAA GCAAAGAAGC CAAAATCAGA 
GCTAAGGAAA AAAGAAATAG ACTAAGTCTT CTTGTGCAGA AACCTGAGTT TCATGAAGAC 
ACCCGCTCCA GTAGATCTGG GCACTTGGCC AAAGAAACAA GAGTCTCCCC TGAAGAGGCA 
GTGAAATGGG GTGAATCATT TGACAAACTG CTTTCCCATA GAGATGGACT AGAGGCTTTT 
ACCAGATTTC TTAAAACTGA ATTCAGTGAA GAAAATATTG AATTTTGGAT AGCCTGTGAA 
GATTTCAAGA AAAGCAAGGG ACCTCAACAA ATTCACCTTA AAGCAAAAGC AATATATGAG 
AAATTTATAC AGACTGATGC CCCAAAAGAG GTTAACCTTG ATTTTCACAC AAAAGAAGTC 
ATTACAAACA GCATCACTCA ACCTACCCTC CACAGTTTTG ATGCTGCACA AAGCAGAGTG 
TATCAGCTCA TGGAACAAGA CAGTTATACA CGTTTTCTGA AATCTGACAT CTATTTAGAC 
TTGATGGAAG GAAGACCTCA GAGACCAACA AATCTTAGGA GACGATCACG CTCATTTACC 
TGCAATGAAT TCCAAGATGT ACAATCAGAT GTTGCCATTT GGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570138.1
CDS	177..884
Translation	METTLLFFSQINMCESKEKTFFKLIHGSGKEETSKEAKIRAKEKRNRLSLLVQKPEFHEDTRSSRSGHLAKETRVSPEEAVKWGESFDKLLSHRDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFTCNEFQDVQSDVAIWL

Target ORF information:

RefSeq Version	NM_130782.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 18 (RGS18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130782.2

ORF Insert Sequence:

ATGGAAACAA CATTGCTTTT CTTTTCTCAA ATAAATATGT GTGAATCAAA AGAAAAAACT 
TTTTTCAAGT TAATACATGG TTCAGGAAAA GAAGAAACAA GCAAAGAAGC CAAAATCAGA 
GCTAAGGAAA AAAGAAATAG ACTAAGTCTT CTTGTGCAGA AACCTGAGTT TCATGAAGAC 
ACCCGCTCCA GTAGATCTGG GCACTTGGCC AAAGAAACAA GAGTCTCCCC TGAAGAGGCA 
GTGAAATGGG GTGAATCATT TGACAAACTG CTTTCCCATA GAGATGGACT AGAGGCTTTT 
ACCAGATTTC TTAAAACTGA ATTCAGTGAA GAAAATATTG AATTTTGGAT AGCCTGTGAA 
GATTTCAAGA AAAGCAAGGG ACCTCAACAA ATTCACCTTA AAGCAAAAGC AATATATGAG 
AAATTTATAC AGACTGATGC CCCAAAAGAG GTTAACCTTG ATTTTCACAC AAAAGAAGTC 
ATTACAAACA GCATCACTCA ACCTACCCTC CACAGTTTTG ATGCTGCACA AAGCAGAGTG 
TATCAGCTCA TGGAACAAGA CAGTTATACA CGTTTTCTGA AATCTGACAT CTATTTAGAC 
TTGATGGAAG GAAGACCTCA GAGACCAACA AATCTTAGGA GACGATCACG CTCATTTACC 
TGCAATGAAT TCCAAGATGT ACAATCAGAT GTTGCCATTT GGTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS18 ( XM_011509891.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508193.1 Homo sapiens regulator of G-protein signaling 18 (RGS18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu71373
Clone ID Related Accession (Same CDS sequence)	XM_011509891.2 , XM_011509891.3
Accession Version	XM_011509891.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509891.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCTAG ATGGACTAGA GGCTTTTACC AGATTTCTTA AAACTGAATT CAGTGAAGAA 
AATATTGAAT TTTGGATAGC CTGTGAAGAT TTCAAGAAAA GCAAGGGACC TCAACAAATT 
CACCTTAAAG CAAAAGCAAT ATATGAGAAA TTTATACAGA CTGATGCCCC AAAAGAGGTT 
AACCTTGATT TTCACACAAA AGAAGTCATT ACAAACAGCA TCACTCAACC TACCCTCCAC 
AGTTTTGATG CTGCACAAAG CAGAGTGTAT CAGCTCATGG AACAAGACAG TTATACACGT 
TTTCTGAAAT CTGACATCTA TTTAGACTTG ATGGAAGGAA GACCTCAGAG ACCAACAAAT 
CTTAGGAGAC GATCACGCTC ATTTACCTGC AATGAATTCC AAGATGTACA ATCAGATGTT 
GCCATTTGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508193.1
CDS	17..451
Translation	MQLDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFTCNEFQDVQSDVAIWL

Target ORF information:

RefSeq Version	XM_011509891.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G-protein signaling 18 (RGS18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509891.2

ORF Insert Sequence:

ATGCAGCTAG ATGGACTAGA GGCTTTTACC AGATTTCTTA AAACTGAATT CAGTGAAGAA 
AATATTGAAT TTTGGATAGC CTGTGAAGAT TTCAAGAAAA GCAAGGGACC TCAACAAATT 
CACCTTAAAG CAAAAGCAAT ATATGAGAAA TTTATACAGA CTGATGCCCC AAAAGAGGTT 
AACCTTGATT TTCACACAAA AGAAGTCATT ACAAACAGCA TCACTCAACC TACCCTCCAC 
AGTTTTGATG CTGCACAAAG CAGAGTGTAT CAGCTCATGG AACAAGACAG TTATACACGT 
TTTCTGAAAT CTGACATCTA TTTAGACTTG ATGGAAGGAA GACCTCAGAG ACCAACAAAT 
CTTAGGAGAC GATCACGCTC ATTTACCTGC AATGAATTCC AAGATGTACA ATCAGATGTT 
GCCATTTGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS18 ( XM_011509891.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508193.1 Homo sapiens regulator of G protein signaling 18 (RGS18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu71373
Clone ID Related Accession (Same CDS sequence)	XM_011509891.2 , XM_011509891.3
Accession Version	XM_011509891.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011509891.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCTAG ATGGACTAGA GGCTTTTACC AGATTTCTTA AAACTGAATT CAGTGAAGAA 
AATATTGAAT TTTGGATAGC CTGTGAAGAT TTCAAGAAAA GCAAGGGACC TCAACAAATT 
CACCTTAAAG CAAAAGCAAT ATATGAGAAA TTTATACAGA CTGATGCCCC AAAAGAGGTT 
AACCTTGATT TTCACACAAA AGAAGTCATT ACAAACAGCA TCACTCAACC TACCCTCCAC 
AGTTTTGATG CTGCACAAAG CAGAGTGTAT CAGCTCATGG AACAAGACAG TTATACACGT 
TTTCTGAAAT CTGACATCTA TTTAGACTTG ATGGAAGGAA GACCTCAGAG ACCAACAAAT 
CTTAGGAGAC GATCACGCTC ATTTACCTGC AATGAATTCC AAGATGTACA ATCAGATGTT 
GCCATTTGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508193.1
CDS	18..452
Translation	MQLDGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFTCNEFQDVQSDVAIWL

Target ORF information:

RefSeq Version	XM_011509891.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 18 (RGS18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509891.3

ORF Insert Sequence:

ATGCAGCTAG ATGGACTAGA GGCTTTTACC AGATTTCTTA AAACTGAATT CAGTGAAGAA 
AATATTGAAT TTTGGATAGC CTGTGAAGAT TTCAAGAAAA GCAAGGGACC TCAACAAATT 
CACCTTAAAG CAAAAGCAAT ATATGAGAAA TTTATACAGA CTGATGCCCC AAAAGAGGTT 
AACCTTGATT TTCACACAAA AGAAGTCATT ACAAACAGCA TCACTCAACC TACCCTCCAC 
AGTTTTGATG CTGCACAAAG CAGAGTGTAT CAGCTCATGG AACAAGACAG TTATACACGT 
TTTCTGAAAT CTGACATCTA TTTAGACTTG ATGGAAGGAA GACCTCAGAG ACCAACAAAT 
CTTAGGAGAC GATCACGCTC ATTTACCTGC AATGAATTCC AAGATGTACA ATCAGATGTT 
GCCATTTGGT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets.
Blood119(16)3799-807(2012 Apr)
Gegenbauer K,Elia G,Blanco-Fernandez A,Smolenski A

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.
Blood119(8)1935-45(2012 Feb)
Ma P,Cierniewska A,Signarvic R,Cieslak M,Kong H,Sinnamon AJ,Neubig RR,Newman DK,Stalker TJ,Brass LF

Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.
Nature structural & molecular biology18(7)846-53(2011 Jun)
Kosloff M,Travis AM,Bosch DE,Siderovski DP,Arshavsky VY

Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Carcinogenesis31(10)1755-61(2010 Oct)
Wang J,Lippman SM,Lee JJ,Yang H,Khuri FR,Kim E,Lin J,Chang DW,Lotan R,Hong WK,Wu X