SELL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELL
Entrez Gene ID	6402
Full Name	selectin L
Synonyms	CD62L,LAM1,LECAM1,LEU8,LNHR,LSEL,LYAM1,PLNHR,TQ1
General protein information	Preferred Names selectin L Names L-selectin CD62 antigen-like family member L gp90-MEL leukocyte surface antigen Leu-8 leukocyte-endothelial cell adhesion molecule 1 lymph node homing receptor lymphocyte adhesion molecule 1 pln homing receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.2
Summary	This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].
Disorder MIM:	153240

mRNA and Protein(s)

mRNA	Protein	Name
NM_000655.5	NP_000646.3	L-selectin precursor
NM_000655.4	NP_000646.2	L-selectin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SELL	NP_000646.2
	SELL	NP_001036228.1
Mus musculus (house mouse)	Sell	NP_035476.1
Pan troglodytes (chimpanzee)	SELL	NP_001009074.1
Canis lupus familiaris (dog)	SELL	XP_537201.2
Bos taurus (cattle)	SELL	NP_776607.1
Rattus norvegicus (Norway rat)	Sell	NP_062050.3
Xenopus tropicalis (tropical clawed frog)	sele	XP_002933828.2

Gene Ontology
Bibliography

Related articles in PubMed

Evaluation of ITGB2 (CD18) and SELL (CD62L) genes expression and methylation of ITGB2 promoter region in patients with systemic sclerosis.
Dashti N, Mahmoudi M, Gharibdoost F, Kavosi H, Rezaei R, Imeni V, Jamshidi A, Aslani S, Mostafaei S, Vodjgani M
Rheumatology international(2018 Jan)

PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level.
Luo J
Inflammation(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, we further developed and applied this method to express and purify the entire extracellular region of CD62L. This resulted in excess of 20 mg/L yield of recombinant CD62L. In an attempt to understand the different expression levels among four similar CD62L constructs that differ primarily in signal sequences, we calculated the presence of potential RNA pseudoknots in their signal sequences
Title: Over-expression of a human CD62L ecto-domain and a potential role of RNA pseudoknot structures in recombinant protein expression.

sLe(x) expressed on human L-selectin is preferentially bound by E-selectin and, on ligation, initiates secretion of MRP8/14 that binds TLR4 to elicit the extension of beta2-integrin to an intermediate affinity state.
Title: Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow.

The -642C>T and 725C>T SELL polymorphisms are protective factors against acute coronary syndrome. SELL gene expression was increased in ACS patients.
Title: Influence of haplotypes, gene expression and soluble levels of L-selectin on the risk of acute coronary syndrome.

Indian patients with primary Sjogren's syndrome have higher salivary sL-selectin and IL-7 levels than healthy controls
Title: High salivary soluble L-selectin and interleukin-7 levels in Asian Indian patients with primary Sj?gren's syndrome.

found a higher frequency of LIN1(-) CCR3(+) eosinophils, and decreased expression of CD23 and CD62L receptors in eosinophils of AD patients
Title: Impaired CD23 and CD62L expression and tissue inhibitors of metalloproteinases secretion by eosinophils in adults with atopic dermatitis.

The following SELL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu17898	NM_000655.4 Latest version!	Homo sapiens selectin L (SELL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu107516	NM_000655.5 Latest version!	Homo sapiens selectin L (SELL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELL ( NM_000655.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000646.2 Homo sapiens selectin L (SELL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17898
Clone ID Related Accession (Same CDS sequence)	NM_000655.4
Accession Version	NM_000655.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	L-selectin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB271854.1, DB482055.1, AK312673.1, X17519.1 and BP393094.1. This sequence is a reference standard in the RefSeqGene project. On Oct 29, 2009 this sequence version replaced NM_000655.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.173878.1, SRR1803611.131793.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCTGCA GAAGAACTAG AGAAGGACCA AGCAAAGCCA TGATATTTCC ATGGAAATGT 
CAGAGCACCC AGAGGGACTT ATGGAACATC TTCAAGTTGT GGGGGTGGAC AATGCTCTGT 
TGTGATTTCC TGGCACATCA TGGAACCGAC TGCTGGACTT ACCATTATTC TGAAAAACCC 
ATGAACTGGC AAAGGGCTAG AAGATTCTGC CGAGACAATT ACACAGATTT AGTTGCCATA 
CAAAACAAGG CGGAAATTGA GTATCTGGAG AAGACTCTGC CTTTCAGTCG TTCTTACTAC 
TGGATAGGAA TCCGGAAGAT AGGAGGAATA TGGACGTGGG TGGGAACCAA CAAATCTCTT 
ACTGAAGAAG CAGAGAACTG GGGAGATGGT GAGCCCAACA ACAAGAAGAA CAAGGAGGAC 
TGCGTGGAGA TCTATATCAA GAGAAACAAA GATGCAGGCA AATGGAACGA TGACGCCTGC 
CACAAACTAA AGGCAGCCCT CTGTTACACA GCTTCTTGCC AGCCCTGGTC ATGCAGTGGC 
CATGGAGAAT GTGTAGAAAT CATCAATAAT TACACCTGCA ACTGTGATGT GGGGTACTAT 
GGGCCCCAGT GTCAGTTTGT GATTCAGTGT GAGCCTTTGG AGGCCCCAGA GCTGGGTACC 
ATGGACTGTA CTCACCCTTT GGGAAACTTC AGCTTCAGCT CACAGTGTGC CTTCAGCTGC 
TCTGAAGGAA CAAACTTAAC TGGGATTGAA GAAACCACCT GTGGACCATT TGGAAACTGG 
TCATCTCCAG AACCAACCTG TCAAGTGATT CAGTGTGAGC CTCTATCAGC ACCAGATTTG 
GGGATCATGA ACTGTAGCCA TCCCCTGGCC AGCTTCAGCT TTACCTCTGC ATGTACCTTC 
ATCTGCTCAG AAGGAACTGA GTTAATTGGG AAGAAGAAAA CCATTTGTGA ATCATCTGGA 
ATCTGGTCAA ATCCTAGTCC AATATGTCAA AAATTGGACA AAAGTTTCTC AATGATTAAG 
GAGGGTGATT ATAACCCCCT CTTCATTCCA GTGGCAGTCA TGGTTACTGC ATTCTCTGGG 
TTGGCATTTA TCATTTGGCT GGCAAGGAGA TTAAAAAAAG GCAAGAAATC CAAGAGAAGT 
ATGAATGACC CATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000646.2
CDS	166..1323
Translation	MGCRRTREGPSKAMIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY

Target ORF information:

RefSeq Version	NM_000655.4
Organism	Homo sapiens(human)
Definition	Homo sapiens selectin L (SELL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000655.4

ORF Insert Sequence:

ATGGGCTGCA GAAGAACTAG AGAAGGACCA AGCAAAGCCA TGATATTTCC ATGGAAATGT 
CAGAGCACCC AGAGGGACTT ATGGAACATC TTCAAGTTGT GGGGGTGGAC AATGCTCTGT 
TGTGATTTCC TGGCACATCA TGGAACCGAC TGCTGGACTT ACCATTATTC TGAAAAACCC 
ATGAACTGGC AAAGGGCTAG AAGATTCTGC CGAGACAATT ACACAGATTT AGTTGCCATA 
CAAAACAAGG CGGAAATTGA GTATCTGGAG AAGACTCTGC CTTTCAGTCG TTCTTACTAC 
TGGATAGGAA TCCGGAAGAT AGGAGGAATA TGGACGTGGG TGGGAACCAA CAAATCTCTT 
ACTGAAGAAG CAGAGAACTG GGGAGATGGT GAGCCCAACA ACAAGAAGAA CAAGGAGGAC 
TGCGTGGAGA TCTATATCAA GAGAAACAAA GATGCAGGCA AATGGAACGA TGACGCCTGC 
CACAAACTAA AGGCAGCCCT CTGTTACACA GCTTCTTGCC AGCCCTGGTC ATGCAGTGGC 
CATGGAGAAT GTGTAGAAAT CATCAATAAT TACACCTGCA ACTGTGATGT GGGGTACTAT 
GGGCCCCAGT GTCAGTTTGT GATTCAGTGT GAGCCTTTGG AGGCCCCAGA GCTGGGTACC 
ATGGACTGTA CTCACCCTTT GGGAAACTTC AGCTTCAGCT CACAGTGTGC CTTCAGCTGC 
TCTGAAGGAA CAAACTTAAC TGGGATTGAA GAAACCACCT GTGGACCATT TGGAAACTGG 
TCATCTCCAG AACCAACCTG TCAAGTGATT CAGTGTGAGC CTCTATCAGC ACCAGATTTG 
GGGATCATGA ACTGTAGCCA TCCCCTGGCC AGCTTCAGCT TTACCTCTGC ATGTACCTTC 
ATCTGCTCAG AAGGAACTGA GTTAATTGGG AAGAAGAAAA CCATTTGTGA ATCATCTGGA 
ATCTGGTCAA ATCCTAGTCC AATATGTCAA AAATTGGACA AAAGTTTCTC AATGATTAAG 
GAGGGTGATT ATAACCCCCT CTTCATTCCA GTGGCAGTCA TGGTTACTGC ATTCTCTGGG 
TTGGCATTTA TCATTTGGCT GGCAAGGAGA TTAAAAAAAG GCAAGAAATC CAAGAGAAGT 
ATGAATGACC CATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELL ( NM_000655.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000646.3 Homo sapiens selectin L (SELL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107516
Clone ID Related Accession (Same CDS sequence)	NM_000655.5
Accession Version	NM_000655.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	L-selectin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA671852.1, AJ246000.1, BQ004720.1 and BP393094.1. This sequence is a reference standard in the RefSeqGene project. On Nov 9, 2018 this sequence version replaced NM_000655.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. CCDS Note: The coding region has been scaled back at the 5' end to begin from a start codon that is better supported by conservation data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.160681.1, SRR1163657.409302.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000236147.6/ ENSP00000236147.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATATTTC CATGGAAATG TCAGAGCACC CAGAGGGACT TATGGAACAT CTTCAAGTTG 
TGGGGGTGGA CAATGCTCTG TTGTGATTTC CTGGCACATC ATGGAACCGA CTGCTGGACT 
TACCATTATT CTGAAAAACC CATGAACTGG CAAAGGGCTA GAAGATTCTG CCGAGACAAT 
TACACAGATT TAGTTGCCAT ACAAAACAAG GCGGAAATTG AGTATCTGGA GAAGACTCTG 
CCTTTCAGTC GTTCTTACTA CTGGATAGGA ATCCGGAAGA TAGGAGGAAT ATGGACGTGG 
GTGGGAACCA ACAAATCTCT TACTGAAGAA GCAGAGAACT GGGGAGATGG TGAGCCCAAC 
AACAAGAAGA ACAAGGAGGA CTGCGTGGAG ATCTATATCA AGAGAAACAA AGATGCAGGC 
AAATGGAACG ATGACGCCTG CCACAAACTA AAGGCAGCCC TCTGTTACAC AGCTTCTTGC 
CAGCCCTGGT CATGCAGTGG CCATGGAGAA TGTGTAGAAA TCATCAATAA TTACACCTGC 
AACTGTGATG TGGGGTACTA TGGGCCCCAG TGTCAGTTTG TGATTCAGTG TGAGCCTTTG 
GAGGCCCCAG AGCTGGGTAC CATGGACTGT ACTCACCCTT TGGGAAACTT CAGCTTCAGC 
TCACAGTGTG CCTTCAGCTG CTCTGAAGGA ACAAACTTAA CTGGGATTGA AGAAACCACC 
TGTGGACCAT TTGGAAACTG GTCATCTCCA GAACCAACCT GTCAAGTGAT TCAGTGTGAG 
CCTCTATCAG CACCAGATTT GGGGATCATG AACTGTAGCC ATCCCCTGGC CAGCTTCAGC 
TTTACCTCTG CATGTACCTT CATCTGCTCA GAAGGAACTG AGTTAATTGG GAAGAAGAAA 
ACCATTTGTG AATCATCTGG AATCTGGTCA AATCCTAGTC CAATATGTCA AAAATTGGAC 
AAAAGTTTCT CAATGATTAA GGAGGGTGAT TATAACCCCC TCTTCATTCC AGTGGCAGTC 
ATGGTTACTG CATTCTCTGG GTTGGCATTT ATCATTTGGC TGGCAAGGAG ATTAAAAAAA 
GGCAAGAAAT CCAAGAGAAG TATGAATGAC CCATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000646.3
CDS	123..1241
Translation	MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY

Target ORF information:

RefSeq Version	NM_000655.5
Organism	Homo sapiens(human)
Definition	Homo sapiens selectin L (SELL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000655.5

ORF Insert Sequence:

ATGATATTTC CATGGAAATG TCAGAGCACC CAGAGGGACT TATGGAACAT CTTCAAGTTG 
TGGGGGTGGA CAATGCTCTG TTGTGATTTC CTGGCACATC ATGGAACCGA CTGCTGGACT 
TACCATTATT CTGAAAAACC CATGAACTGG CAAAGGGCTA GAAGATTCTG CCGAGACAAT 
TACACAGATT TAGTTGCCAT ACAAAACAAG GCGGAAATTG AGTATCTGGA GAAGACTCTG 
CCTTTCAGTC GTTCTTACTA CTGGATAGGA ATCCGGAAGA TAGGAGGAAT ATGGACGTGG 
GTGGGAACCA ACAAATCTCT TACTGAAGAA GCAGAGAACT GGGGAGATGG TGAGCCCAAC 
AACAAGAAGA ACAAGGAGGA CTGCGTGGAG ATCTATATCA AGAGAAACAA AGATGCAGGC 
AAATGGAACG ATGACGCCTG CCACAAACTA AAGGCAGCCC TCTGTTACAC AGCTTCTTGC 
CAGCCCTGGT CATGCAGTGG CCATGGAGAA TGTGTAGAAA TCATCAATAA TTACACCTGC 
AACTGTGATG TGGGGTACTA TGGGCCCCAG TGTCAGTTTG TGATTCAGTG TGAGCCTTTG 
GAGGCCCCAG AGCTGGGTAC CATGGACTGT ACTCACCCTT TGGGAAACTT CAGCTTCAGC 
TCACAGTGTG CCTTCAGCTG CTCTGAAGGA ACAAACTTAA CTGGGATTGA AGAAACCACC 
TGTGGACCAT TTGGAAACTG GTCATCTCCA GAACCAACCT GTCAAGTGAT TCAGTGTGAG 
CCTCTATCAG CACCAGATTT GGGGATCATG AACTGTAGCC ATCCCCTGGC CAGCTTCAGC 
TTTACCTCTG CATGTACCTT CATCTGCTCA GAAGGAACTG AGTTAATTGG GAAGAAGAAA 
ACCATTTGTG AATCATCTGG AATCTGGTCA AATCCTAGTC CAATATGTCA AAAATTGGAC 
AAAAGTTTCT CAATGATTAA GGAGGGTGAT TATAACCCCC TCTTCATTCC AGTGGCAGTC 
ATGGTTACTG CATTCTCTGG GTTGGCATTT ATCATTTGGC TGGCAAGGAG ATTAAAAAAA 
GGCAAGAAAT CCAAGAGAAG TATGAATGAC CCATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evaluation of ITGB2 (CD18) and SELL (CD62L) genes expression and methylation of ITGB2 promoter region in patients with systemic sclerosis.
Rheumatology international(2018 Jan)
Dashti N,Mahmoudi M,Gharibdoost F,Kavosi H,Rezaei R,Imeni V,Jamshidi A,Aslani S,Mostafaei S,Vodjgani M

PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level.
Inflammation(2017 Dec)
Luo J

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SELL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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